Published in Proc Natl Acad Sci U S A on August 09, 2010
Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum. EMBO J (2010) 1.56
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol (2011) 1.48
Real-time monitoring of redox changes in the mammalian endoplasmic reticulum. J Cell Sci (2011) 1.21
The dynamic disulphide relay of quiescin sulphydryl oxidase. Nature (2012) 1.06
Disulfide bond formation in prokaryotes: history, diversity and design. Biochim Biophys Acta (2014) 1.03
Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum. Mol Biol Cell (2012) 1.01
Lumen Thiol Oxidoreductase1, a disulfide bond-forming catalyst, is required for the assembly of photosystem II in Arabidopsis. Plant Cell (2011) 1.00
Redox regulation of protein damage in plasma. Redox Biol (2014) 0.97
Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function. J Biol Chem (2011) 0.96
Protein disulfide isomerase a multifunctional protein with multiple physiological roles. Front Chem (2014) 0.96
Human vitamin K epoxide reductase and its bacterial homologue have different membrane topologies and reaction mechanisms. J Biol Chem (2012) 0.94
Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding. Antioxid Redox Signal (2013) 0.92
Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells. J Biol Chem (2011) 0.91
Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes. Mol Aspects Med (2015) 0.88
Disulfide bond formation in the mammalian endoplasmic reticulum. Cold Spring Harb Perspect Biol (2012) 0.88
Human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1. J Virol (2011) 0.88
Mycobacterium tuberculosis vitamin K epoxide reductase homologue supports vitamin K-dependent carboxylation in mammalian cells. Antioxid Redox Signal (2011) 0.88
Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum. Free Radic Biol Med (2014) 0.87
Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells. J Thromb Haemost (2013) 0.85
Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis. J Biol Chem (2014) 0.84
A chloroplast membrane protein LTO1/AtVKOR involving in redox regulation and ROS homeostasis. Plant Cell Rep (2013) 0.84
Oxidative protein folding: selective pressure for prolamin evolution in rice. Plant Signal Behav (2011) 0.83
Extracellular Thiol Isomerases and Their Role in Thrombus Formation. Antioxid Redox Signal (2015) 0.82
Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum. Philos Trans R Soc Lond B Biol Sci (2013) 0.82
Going through the barrier: coupled disulfide exchange reactions promote efficient catalysis in quiescin sulfhydryl oxidase. J Biol Chem (2013) 0.82
Oxidative protein-folding systems in plant cells. Int J Cell Biol (2013) 0.82
Operation of trans-thylakoid thiol-metabolizing pathways in photosynthesis. Front Plant Sci (2013) 0.80
A hetero-dimer model for concerted action of vitamin K carboxylase and vitamin K reductase in vitamin K cycle. J Theor Biol (2011) 0.80
Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α). J Biol Chem (2014) 0.79
Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides. Mol Biol Cell (2015) 0.79
Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration. J Biol Chem (2014) 0.79
Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation. J Biol Chem (2012) 0.78
The oxidative protein folding machinery in plant cells. Protoplasma (2012) 0.78
Structural and functional insights into enzymes of the vitamin K cycle. J Thromb Haemost (2016) 0.78
Cellular disulfide bond formation in bioactive peptides and proteins. Int J Mol Sci (2015) 0.78
A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites. Blood (2013) 0.77
Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme. Biochem J (2015) 0.77
Structural Modeling Insights into Human VKORC1 Phenotypes. Nutrients (2015) 0.76
VKORC1 and VKORC1L1: Why do Vertebrates Have Two Vitamin K 2,3-Epoxide Reductases? Nutrients (2015) 0.76
Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure. Fish Physiol Biochem (2015) 0.76
Atypical protein disulfide isomerases (PDI): Comparison of the molecular and catalytic properties of poplar PDI-A and PDI-M with PDI-L1A. PLoS One (2017) 0.75
Warfarin and vitamin K compete for binding to Phe55 in human VKOR. Nat Struct Mol Biol (2016) 0.75
Altered Escherichia coli membrane protein assembly machinery allows proper membrane assembly of eukaryotic protein vitamin K epoxide reductase. Proc Natl Acad Sci U S A (2015) 0.75
Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer. Nat Struct Mol Biol (2016) 0.75
A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell (2006) 8.53
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature (2004) 5.95
Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science (2000) 3.87
Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation. Antioxid Redox Signal (2009) 3.12
Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum. Mol Cell (1999) 3.03
Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO J (2001) 2.59
A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation. Nat Cell Biol (2001) 2.39
Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins. Science (1997) 2.30
ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem (2000) 2.24
Why is DsbA such an oxidizing disulfide catalyst? Cell (1995) 2.21
Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Cell (2006) 2.20
Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation. Proc Natl Acad Sci U S A (2008) 2.12
Evidence that the pathway of disulfide bond formation in Escherichia coli involves interactions between the cysteines of DsbB and DsbA. Proc Natl Acad Sci U S A (1995) 1.92
Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid. Blood (1999) 1.91
Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Arch Biochem Biophys (2002) 1.89
ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol (2010) 1.87
Vitamin K epoxide reductase: homology, active site and catalytic mechanism. Trends Biochem Sci (2004) 1.52
Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins. J Cell Sci (2009) 1.51
The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha. EMBO J (2000) 1.46
Structure of a bacterial homologue of vitamin K epoxide reductase. Nature (2010) 1.44
The CXXC motif is more than a redox rheostat. J Biol Chem (2007) 1.35
VKORC1: molecular target of coumarins. J Thromb Haemost (2007) 1.32
Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. Thromb Haemost (2005) 1.32
Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. J Cell Biol (2008) 1.32
Inter-domain redox communication in flavoenzymes of the quiescin/sulfhydryl oxidase family: role of a thioredoxin domain in disulfide bond formation. Biochemistry (2003) 1.25
Identification of an atypical membrane protein involved in the formation of protein disulfide bonds in oxygenic photosynthetic organisms. J Biol Chem (2008) 1.23
Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation. J Biol Chem (2005) 1.23
Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member. J Biol Chem (2003) 1.20
Identification of a novel thioredoxin-related transmembrane protein. J Biol Chem (2001) 1.18
Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. J Biol Chem (2005) 1.17
The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines. Biochemistry (2007) 1.09
Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci U S A (2009) 1.08
Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide. Biochem Biophys Res Commun (1988) 1.03
Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase. Biochem J (1992) 0.98
Structure and function of vitamin K epoxide reductase. Vitam Horm (2008) 0.98
Novel thioredoxin-related transmembrane protein TMX4 has reductase activity. J Biol Chem (2010) 0.95
A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4. Biochem J (2009) 0.95
Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase . Biochemistry (2009) 0.92
Vitamin K-dependent carboxylase. Possible role for thioredoxin in the reduction of vitamin K metabolites in liver. FEBS Lett (1987) 0.90
TMX, a human transmembrane oxidoreductase of the thioredoxin family: the possible role in disulfide-linked protein folding in the endoplasmic reticulum. Arch Biochem Biophys (2004) 0.89
ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress. J Biol Chem (2008) 0.84
New insights into oxidative folding. J Cell Biol (2010) 0.84
X-ray structure of a protein-conducting channel. Nature (2003) 9.20
A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell (2006) 8.53
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature (2004) 6.37
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell (2006) 5.54
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol (2003) 4.35
Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol (2002) 4.29
Mathematical models of protein kinase signal transduction. Mol Cell (2002) 4.08
A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell (2009) 3.88
Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature (2008) 3.73
Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science (2008) 3.60
Mechanisms determining the morphology of the peripheral ER. Cell (2010) 3.35
Structural organization of the endoplasmic reticulum. EMBO Rep (2002) 3.25
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem (2008) 3.13
Protein translocation by the Sec61/SecY channel. Annu Rev Cell Dev Biol (2005) 3.09
Gangliosides are receptors for murine polyoma virus and SV40. EMBO J (2003) 2.99
Rough sheets and smooth tubules. Cell (2006) 2.97
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 2.81
Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol (2009) 2.71
Mechanisms of Sec61/SecY-mediated protein translocation across membranes. Annu Rev Biophys (2011) 2.40
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell (2010) 2.33
The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell (2007) 2.18
Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell (2007) 2.17
Three-dimensional structure of the bacterial protein-translocation complex SecYEG. Nature (2002) 2.16
The signal sequence coding region promotes nuclear export of mRNA. PLoS Biol (2007) 2.09
Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (2011) 2.06
The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell (2007) 2.03
Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell (2013) 1.97
Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell (2002) 1.97
Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol (2005) 1.97
Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. J Cell Biol (2005) 1.93
Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1. J Cell Biol (2002) 1.86
A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A (2004) 1.86
A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines. Nat Med (2006) 1.82
Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development. J Virol (2008) 1.76
A role for the two-helix finger of the SecA ATPase in protein translocation. Nature (2008) 1.75
Crystal structure of the long-chain fatty acid transporter FadL. Science (2004) 1.74
Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep (2002) 1.71
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (2008) 1.68
Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor. Proc Natl Acad Sci U S A (2009) 1.61
Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol Cell (2007) 1.59
Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane. J Biol Chem (2003) 1.55
Weaving the web of ER tubules. Cell (2011) 1.53
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol (2011) 1.48
Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A (2012) 1.46
Structure of a bacterial homologue of vitamin K epoxide reductase. Nature (2010) 1.44
Structure of the mammalian ribosome-channel complex at 17A resolution. J Mol Biol (2002) 1.43
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol (2012) 1.38
The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice. J Virol (2008) 1.35
Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem (2005) 1.33
RecA-like motor ATPases--lessons from structures. Biochim Biophys Acta (2004) 1.33
A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol (2006) 1.27
Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane. EMBO J (2003) 1.27
Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature (2011) 1.23
Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic (2012) 1.21
Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell (2007) 1.19
Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A (2009) 1.18
Generation of nonidentical compartments in vesicular transport systems. J Cell Biol (2005) 1.17
Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination. Proc Natl Acad Sci U S A (2006) 1.17
Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell (2003) 1.12
Conformational flexibility and peptide interaction of the translocation ATPase SecA. J Mol Biol (2009) 1.11
Bacterial protein translocation requires only one copy of the SecY complex in vivo. J Cell Biol (2012) 1.08
Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane. Mol Biol Cell (2006) 1.04
E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A (2006) 1.04
Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent. J Immunol (2010) 1.02
Virally delivered cytokines alter the immune response to future lung infections. J Virol (2007) 1.01
Structural insight into the protein translocation channel. Curr Opin Struct Biol (2004) 0.99
Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem (2008) 0.98
Structural insights into ubiquinone biosynthesis in membranes. Science (2014) 0.98
Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection. J Virol (2010) 0.97
The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung. PLoS One (2010) 0.96
Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol (2013) 0.95
A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep (2013) 0.91
Preexposure to CpG protects against the delayed effects of neonatal respiratory syncytial virus infection. J Virol (2012) 0.88
A novel centrosome-associated protein with affinity for microtubules. J Cell Sci (2002) 0.87
The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p. FEBS Lett (2008) 0.87
Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem (2007) 0.85
Alteration of amino acid neurotransmitters in brain tissues of immature rats treated with realgar. J Pharm Biomed Anal (2011) 0.77
Membrane protein structure in live cells: Methodology for studying drug interaction by mass spectrometry-based footprinting. Biochemistry (2017) 0.75
Effect of realgar on extracellular amino acid neurotransmitters in hippocampal CA1 region determined by online microdialysis–dansyl chloride derivatization–high-performance liquid chromatography and fluorescence detection. Biomed Chromatogr (2014) 0.75
Intramembrane thiol oxidoreductases: evolutionary convergence and structural controversy. Biochemistry (2017) 0.75
Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife (2017) 0.75