Published in J Exp Med on December 18, 2006
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04
Raising the NKT cell family. Nat Immunol (2010) 3.79
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc Natl Acad Sci U S A (2008) 2.57
Development and characterization of IL-21-producing CD4+ T cells. J Exp Med (2008) 2.34
A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J Exp Med (2008) 1.94
The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol (2008) 1.51
Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity. Immunology (2011) 1.17
The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity (2013) 1.06
Invariant NKT cells inhibit development of the Th17 lineage. Proc Natl Acad Sci U S A (2009) 1.03
Key role for IL-21 in experimental autoimmune uveitis. Proc Natl Acad Sci U S A (2011) 0.94
A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection. J Immunol (2010) 0.93
Generation of a novel regulatory NK cell subset from peripheral blood CD34+ progenitors promoted by membrane-bound IL-15. PLoS One (2008) 0.90
The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells. Proc Natl Acad Sci U S A (2011) 0.89
Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet. J Gastroenterol (2010) 0.87
Interleukin-21 suppresses the differentiation and functions of T helper 2 cells. Immunology (2015) 0.83
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow. J Immunol (2011) 0.81
The Emerging Role of Interleukin-21 in Transplantation. J Clin Cell Immunol (2012) 0.81
Single systemic administration of Ag85B of mycobacteria DNA inhibits allergic airway inflammation in a mouse model of asthma. J Asthma Allergy (2012) 0.80
BCR ligation antagonizes the IL-21 enhancement of anti-CD40/IL-4 plasma cell differentiation and IgE production found in low density human B cell cultures. Cell Immunol (2007) 0.79
Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins. Oncotarget (2015) 0.78
Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production. Eur J Immunol (2015) 0.78
Cytokine crowdsourcing: multicellular production of TH17-associated cytokines. J Leukoc Biol (2014) 0.78
Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice. J Gastroenterol (2015) 0.77
Effects of mycobacteria major secretion protein, Ag85B, on allergic inflammation in the lung. PLoS One (2014) 0.76
IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma. Clin Transl Immunology (2013) 0.76
Activation of invariant natural killer T cells in regional lymph nodes as new antigen-specific immunotherapy via induction of interleukin-21 and interferon-γ. Clin Exp Immunol (2014) 0.76
The emerging role of interleukin-21 in allergic diseases (Review). Biomed Rep (2013) 0.76
IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection. PLoS One (2014) 0.75
Mycobacterium vaccae Nebulization Can Protect against Asthma in Balb/c Mice by Regulating Th9 Expression. PLoS One (2016) 0.75
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol (2001) 9.19
Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science (1997) 8.95
The inverse association between tuberculin responses and atopic disorder. Science (1997) 7.46
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J Exp Med (2000) 6.15
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol (2003) 6.07
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature (2000) 5.86
The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu Rev Immunol (2001) 4.91
In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J Exp Med (2000) 4.37
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science (2001) 4.29
Measles and atopy in Guinea-Bissau. Lancet (1996) 4.03
Asthma: an epidemic of dysregulated immunity. Nat Immunol (2002) 4.00
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74
Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science (1995) 3.37
Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest (1999) 3.32
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity (2002) 3.17
The biology of IGE and the basis of allergic disease. Annu Rev Immunol (2001) 2.80
B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching. J Immunol (1996) 2.53
Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proc Natl Acad Sci U S A (2004) 2.49
CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am Rev Respir Dis (1990) 2.18
Asthma: an epidemic in the absence of infection? Science (1997) 2.12
Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors. Infect Immun (2000) 2.10
Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol (2004) 2.07
Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells. J Exp Med (1999) 1.88
Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J Immunol (2001) 1.85
Murine natural killer T(NKT) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls. Proc Natl Acad Sci U S A (1999) 1.84
Bacillus Calmette Guerin triggers the IL-12/IFN-gamma axis by an IRAK-4- and NEMO-dependent, non-cognate interaction between monocytes, NK, and T lymphocytes. Eur J Immunol (2004) 1.83
The environmental predictors of allergic disease. J Allergy Clin Immunol (2000) 1.68
IL-21 induces the apoptosis of resting and activated primary B cells. J Immunol (2003) 1.67
Down-regulation of the invariant Valpha14 antigen receptor in NKT cells upon activation. Int Immunol (2004) 1.66
Tregs and allergic disease. J Clin Invest (2004) 1.64
Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol (2002) 1.55
Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Blood (2002) 1.50
Inhibition of an established allergic response to ovalbumin in BALB/c mice by killed Mycobacterium vaccae. Immunology (1998) 1.44
BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model. J Allergy Clin Immunol (1998) 1.35
Role of regulatory T cells in allergy and asthma. Curr Opin Immunol (2003) 1.33
Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells. J Immunol (2004) 1.19
IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses. J Allergy Clin Immunol (2003) 1.18
Activation of phosphatidylinositol 3-kinase and c-Jun-N-terminal kinase cascades enhances NF-kappaB-dependent gene transcription in BCG-stimulated macrophages through promotion of p65/p300 binding. J Leukoc Biol (2004) 1.06
Long-term control of Mycobacterium bovis BCG infection in the absence of Toll-like receptors (TLRs): investigation of TLR2-, TLR6-, or TLR2-TLR4-deficient mice. Infect Immun (2004) 1.06
Decline in total serum IgE after treatment for tuberculosis. Lancet (1999) 1.00
The bidirectional capacity of bacterial antigens to modulate allergy and asthma. Eur Respir J (2002) 0.97
The impact of the route and frequency of antigen exposure on the IgE response in allergy. Int Arch Allergy Immunol (2001) 0.91
IL-21 effects on human IgE production in response to IL-4 or IL-13. Cell Immunol (2005) 0.90
Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgE. J Exp Med (1994) 0.89
Systemic mycobacterial infection inhibits antigen-specific immunoglobulin E production, bronchial mucus production and eosinophilic inflammation induced by allergen. Immunology (1999) 0.88
Effect of BCG vaccination in asthmatic schoolchildren. Pediatr Allergy Immunol (2004) 0.84
Decrease of specific and total IgE levels in allergic patients after BCG vaccination: preliminary report. Arch Otolaryngol Head Neck Surg (2002) 0.82
Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females. Genes Immun (2003) 0.79
Bacillus Calmette-Guérin-induced interleukin-12 did not additionally improve clinical and immunologic parameters in asthmatic children treated with sublingual immunotherapy. Clin Exp Allergy (2004) 0.78
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Toll-like receptors. Annu Rev Immunol (2001) 26.06
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
Pattern recognition receptors and inflammation. Cell (2010) 21.05
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26
5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10
Toll-like receptors in innate immunity. Int Immunol (2005) 12.24
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77
Innate immune recognition of viral infection. Nat Immunol (2006) 9.59
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40
Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
TLR signaling pathways. Semin Immunol (2004) 9.08
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87
TLR signaling. Semin Immunol (2007) 8.16
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet (2003) 7.98
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med (2007) 7.25
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med (2005) 7.18
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07
Innate immunity to virus infection. Immunol Rev (2009) 7.04
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62
LPS/TLR4 signal transduction pathway. Cytokine (2008) 6.60
Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med (2003) 6.42
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature (2008) 6.40
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37
Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98
Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci (2008) 5.95
Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48
Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell (2005) 5.37
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol (2007) 5.21
The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol (2008) 5.10
Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D. Nature (2004) 5.08
Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med (2006) 5.01
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 4.92
The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu Rev Immunol (2001) 4.91
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol (2005) 4.91
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol (2005) 4.83
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 4.81
Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest (2006) 4.72
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol (2010) 4.66
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 4.50
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A (2009) 4.48
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46
Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol (2006) 4.37
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev (2007) 4.35
Toll-like receptors and innate immunity. Biochem Biophys Res Commun (2009) 4.26
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A (2010) 4.18
Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18
Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol (2006) 4.15
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med (2004) 4.14
Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe (2008) 4.14
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell (2011) 4.12
MDA5/RIG-I and virus recognition. Curr Opin Immunol (2008) 4.05
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. Immunity (2010) 4.03
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol (2006) 4.01
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood (2003) 3.98
The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci U S A (2007) 3.93
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol (2008) 3.91
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol (2006) 3.89
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem (2004) 3.88