IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 26519529)

Published in J Immunol on October 30, 2015

Authors

Tia Y Brodeur1, Tara E Robidoux1, Jason S Weinstein2, Joseph Craft2, Susan L Swain3, Ann Marshak-Rothstein4

Author Affiliations

1: Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605;
2: Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520; and.
3: Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
4: Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605; ann.rothstein@umassmed.edu.

Articles cited by this

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature (2007) 16.59

Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol (2012) 9.75

Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 9.28

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58

A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09

Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol (2004) 6.75

Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med (2012) 6.15

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature (2000) 5.86

New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol (2009) 5.57

IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med (2005) 5.13

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med (1989) 3.58

Integrating mechanisms of pulmonary fibrosis. J Exp Med (2011) 3.57

Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med (2010) 3.44

The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest (2006) 3.33

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity (1995) 3.23

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med (1994) 3.02

IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol (2004) 2.47

Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis Rheum (1999) 2.22

Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell Immunol (2000) 2.18

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. Am J Respir Crit Care Med (2011) 2.15

Migration kinetics and final destination of type 1 and type 2 CD8 effector cells predict protection against pulmonary virus infection. J Exp Med (1999) 2.09

Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2002) 1.95

Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction. Clin Immunol (2010) 1.80

IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood (2006) 1.79

Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nat Med (2004) 1.71

Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol (2002) 1.55

IL-23 drives pathogenic IL-17-producing CD8+ T cells. J Immunol (2009) 1.54

Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science (2014) 1.51

The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr Opin Immunol (2008) 1.51

Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut (2006) 1.47

Roles of T lymphocytes in pulmonary fibrosis. J Leukoc Biol (2007) 1.42

T cell independence of bleomycin-induced pulmonary fibrosis. J Leukoc Biol (1999) 1.39

The role of adoptively transferred CD8 T cells and host cells in the control of the growth of the EG7 thymoma: factors that determine the relative effectiveness and homing properties of Tc1 and Tc2 effectors. J Immunol (2001) 1.34

Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. J Immunol (2004) 1.30

The immunology of fibrosis. Annu Rev Immunol (2013) 1.27

Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4- and IL-13-responsive cells. J Immunol (2003) 1.27

Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice. J Exp Med (2011) 1.23

The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One (2009) 1.16

Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation. Nat Med (2006) 1.10

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood (2012) 1.10

IL-21-producing Th cells in immunity and autoimmunity. J Immunol (2013) 1.09

Usual interstitial pneumonitis is a T-cell alveolitis. Clin Immunol Immunopathol (1986) 1.08

IL-21 promotes the pathologic immune response to pneumovirus infection. J Immunol (2012) 1.06

STAT3 signaling in CD4+ T cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model. J Immunol (2009) 1.06

The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity (2013) 1.06

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog (2013) 1.03

Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis. Arthritis Rheum (2009) 1.03

A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice. Eur J Immunol (1994) 1.00

Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets. Immunity (2012) 0.98

Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis. Arthritis Rheum (2013) 0.98

Mouse models of bleomycin-induced pulmonary fibrosis. Curr Protoc Pharmacol (2008) 0.94

IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response. Diabetes (2011) 0.92

IL-13-producing BLT1-positive CD8 cells are increased in asthma and are associated with airway obstruction. Allergy (2013) 0.92

The perforin mediated apoptotic pathway in lung injury and fibrosis. J Clin Pathol (2004) 0.91

Relationship of BAL and lung tissue CD4+ and CD8+ T lymphocytes, and their ratio in idiopathic pulmonary fibrosis. Chest (2005) 0.89

Lymphokines in bleomycin-induced lung injury in bleomycin-sensitive C57BL/6 and -resistant BALB/c mice. Exp Lung Res (2001) 0.85

Therapeutic efficacy of Cintredekin Besudotox (IL13-PE38QQR) in murine lung fibrosis is unaffected by immunity to Pseudomonas aeruginosa exotoxin A. PLoS One (2010) 0.79