Generation of novel landomycins M and O through targeted gene disruption.

A comprehensive review of glycosylated bacterial natural products. Chem Soc Rev (2015) 1.13

Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136. J Nat Prod (2010) 0.92

Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem (2007) 0.92

On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl (2006) 0.89

11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain. J Antibiot (Tokyo) (2010) 0.87

Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology. Curr Opin Chem Biol (2012) 0.83

Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: insights from the promoter fusion studies. Microb Cell Fact (2016) 0.78

Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanogenus S136. Genetika (2010) 0.76

Rapid generation of hydrogen peroxide contributes to the complex cell death induction by the angucycline antibiotic landomycin E. Free Radic Biol Med (2017) 0.75

PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med (2014) 10.10

Genomic mining for Aspergillus natural products. Chem Biol (2006) 3.22

The plant cell wall-decomposing machinery underlies the functional diversity of forest fungi. Science (2011) 2.67

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep (2006) 2.25

Modification of post-PKS tailoring steps through combinatorial biosynthesis. Nat Prod Rep (2002) 2.06

An audience response system strategy to improve student motivation, attention, and feedback. Am J Pharm Educ (2009) 1.92

Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chem Biol (2004) 1.81

Knockdown of midgut genes by dsRNA-transgenic plant-mediated RNA interference in the hemipteran insect Nilaparvata lugens. PLoS One (2011) 1.77

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase. Mol Microbiol (2005) 1.76

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol (2002) 1.75

Combinatorial biosynthesis of antitumor indolocarbazole compounds. Proc Natl Acad Sci U S A (2004) 1.72

Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proc Natl Acad Sci U S A (2012) 1.61

Identification and characterization of Bph14, a gene conferring resistance to brown planthopper in rice. Proc Natl Acad Sci U S A (2009) 1.60

A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol (2013) 1.59

Retracted Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells. Cancer Prev Res (Phila) (2009) 1.57

Rice UDP-glucose pyrophosphorylase1 is essential for pollen callose deposition and its cosuppression results in a new type of thermosensitive genic male sterility. Plant Cell (2007) 1.51

Herbivore-induced callose deposition on the sieve plates of rice: an important mechanism for host resistance. Plant Physiol (2008) 1.47

Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis. J Am Chem Soc (2003) 1.44

Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics. Proc Natl Acad Sci U S A (2010) 1.42

Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. J Neurosci (2011) 1.36

Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J Mol Biol (2007) 1.28

Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target. Biochemistry (2003) 1.27

Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus. J Am Chem Soc (2005) 1.26

The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins. J Am Chem Soc (2003) 1.26

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis. Nat Prod Rep (2011) 1.26

Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases. Fungal Genet Biol (2012) 1.25

Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin. Appl Environ Microbiol (2006) 1.24

Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet Biol (2007) 1.23

Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin. Chem Biol (2004) 1.20

Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem Biol (2008) 1.19

Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy. Nucleic Acids Res (2006) 1.19

Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19

Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. Chem Biol (2004) 1.17

Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen. New Phytol (2012) 1.17

Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus. Angew Chem Int Ed Engl (2012) 1.16

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway. J Am Chem Soc (2002) 1.15

Insights into naturally minimised Streptomyces albus J1074 genome. BMC Genomics (2014) 1.15

The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis. J Am Chem Soc (2004) 1.13

A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem (2007) 1.13

The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl (2004) 1.13

Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. J Mol Biol (2005) 1.10

Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos. Cell Stem Cell (2011) 1.10

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins. Chem Commun (Camb) (2005) 1.09

Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone. J Org Chem (2005) 1.09

The oxidative ring cleavage in jadomycin biosynthesis: a multistep oxygenation cascade in a biosynthetic black box. Chembiochem (2005) 1.08

Oxidative rearrangement processes in the biosynthesis of gilvocarcin V. J Am Chem Soc (2004) 1.08

Towards understanding of molecular interactions between rice and the brown planthopper. Mol Plant (2013) 1.07

Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin. J Struct Biol (2006) 1.07

In vivo and in vitro production options for fungal secondary metabolites. Mol Pharm (2008) 1.07

Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway . Biochemistry (2009) 1.07

Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase. J Biol Chem (2005) 1.06

Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives. Chem Biol (2006) 1.06

Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett (2008) 1.05

Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol (2002) 1.05

Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem (2009) 1.04

Identification of quantitative trait loci across recombinant inbred lines and testcross populations for traits of agronomic importance in rice. Genetics (2005) 1.04

Bacterial symbionts of the brown planthopper, Nilaparvata lugens (Homoptera: Delphacidae). Appl Environ Microbiol (2010) 1.03

High-resolution genetic mapping at the Bph15 locus for brown planthopper resistance in rice (Oryza sativa L.). Theor Appl Genet (2004) 1.03

Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters. Chembiochem (2010) 1.03

Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII. Chembiochem (2005) 1.03

Understanding rice plant resistance to the Brown Planthopper (Nilaparvata lugens): a proteomic approach. Proteomics (2009) 1.03

Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses. J Am Chem Soc (2007) 1.03

Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity. Appl Environ Microbiol (2006) 1.03

Responses of two contrasting genotypes of rice to brown planthopper. Mol Plant Microbe Interact (2008) 1.01

Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT. J Nat Prod (2002) 1.01

Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chem Biol (2005) 1.01

Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol Biosyst (2005) 1.01

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis. Chembiochem (2008) 1.01

Identification of genes responsive to brown planthopper Nilaparvata lugens Stal (Homoptera: Delphacidae) feeding in rice. Planta (2004) 1.01

Genetic factors that influence moenomycin production in streptomycetes. J Ind Microbiol Biotechnol (2010) 1.00

Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99

Characterization of LipL as a non-heme, Fe(II)-dependent α-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis. J Biol Chem (2011) 0.99

Investigation on Semecarpus Lehyam--a Siddha medicine for breast cancer. Planta (2004) 0.99

A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones. Chem Biol (2007) 0.99

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity. J Nat Prod (2008) 0.99

Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002. J Nat Prod (2008) 0.99

Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated. Chembiochem (2006) 0.99

High-resolution mapping of the brown planthopper resistance gene Bph6 in rice and characterizing its resistance in the 9311 and Nipponbare near isogenic backgrounds. Theor Appl Genet (2010) 0.98

The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Mol Microbiol (2003) 0.98

Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses. Appl Environ Microbiol (2006) 0.98

Mapping the binding site of a large set of quinazoline type EGF-R inhibitors using molecular field analyses and molecular docking studies. J Chem Inf Comput Sci (2003) 0.98

A rice β-1,3-glucanase gene Osg1 is required for callose degradation in pollen development. Planta (2010) 0.97

Development and characterization of japonica rice lines carrying the brown planthopper-resistance genes BPH12 and BPH6. Theor Appl Genet (2011) 0.97