Published in Cell on January 22, 2009
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The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87
Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50
Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol (2010) 7.75
MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91
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Argonaute proteins: functional insights and emerging roles. Nat Rev Genet (2013) 3.09
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev (2009) 2.95
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genet (2011) 2.68
MicroRNA assassins: factors that regulate the disappearance of miRNAs. Nat Struct Mol Biol (2010) 2.42
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Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers. PLoS One (2010) 2.12
Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res (2009) 1.94
EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J (2012) 1.91
Argonaute proteins couple chromatin silencing to alternative splicing. Nat Struct Mol Biol (2012) 1.80
Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter. Nucleic Acids Res (2010) 1.74
RNAi factors are present and active in human cell nuclei. Cell Rep (2014) 1.73
microRNAs associated with the different human Argonaute proteins. Nucleic Acids Res (2012) 1.66
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miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. Am J Pathol (2010) 1.54
microRNA regulation of synaptic plasticity. Neuromolecular Med (2009) 1.49
Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs). Proc Natl Acad Sci U S A (2011) 1.35
Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat Immunol (2010) 1.33
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CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells. EMBO J (2011) 1.32
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The Tetrahymena argonaute-binding protein Giw1p directs a mature argonaute-siRNA complex to the nucleus. Cell (2010) 1.25
MicroRNAs in inflammatory lung disease--master regulators or target practice? Respir Res (2010) 1.24
Characterization of viral and human RNAs smaller than canonical MicroRNAs. J Virol (2009) 1.23
HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis. Cell Death Differ (2011) 1.23
Hypomethylation of intragenic LINE-1 represses transcription in cancer cells through AGO2. PLoS One (2011) 1.18
Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells. Nucleic Acids Res (2011) 1.15
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Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression. Genes Dev (2013) 1.10
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RNAi: a potential new class of therapeutic for human genetic disease. Hum Genet (2011) 1.10
Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing. Nucleic Acids Res (2011) 1.10
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Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processing. Nucleic Acids Res (2011) 1.06
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The MicroRNA Biology of the Mammalian Nucleus. Mol Ther Nucleic Acids (2014) 1.05
Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Nat Struct Mol Biol (2012) 1.05
A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay. Nucleic Acids Res (2009) 1.03
MicroRNAs as Haematopoiesis Regulators. Adv Hematol (2013) 1.03
pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5'/3' arm variation including concomitant cleavage and polyuridylation patterns. Nucleic Acids Res (2011) 1.02
siPools: highly complex but accurately defined siRNA pools eliminate off-target effects. Nucleic Acids Res (2014) 1.01
Importin 8 regulates the transport of mature microRNAs into the cell nucleus. J Biol Chem (2014) 0.99
Small RNA in the nucleus: the RNA-chromatin ping-pong. Curr Opin Genet Dev (2012) 0.99
Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides. Nucleic Acids Res (2015) 0.99
Nuclear transport: a switch for the oxidative stress-signaling circuit? J Signal Transduct (2011) 0.98
Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus. RNA (2012) 0.98
Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading. Nat Protoc (2014) 0.97
The Tudor domain protein Spindlin1 is involved in intrinsic antiviral defense against incoming hepatitis B Virus and herpes simplex virus type 1. PLoS Pathog (2014) 0.96
Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells. Nucleic Acids Res (2010) 0.96
Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs. RNA (2014) 0.96
MicroRNA-96 directly inhibits γ-globin expression in human erythropoiesis. PLoS One (2011) 0.95
A comprehensive characterization of the nuclear microRNA repertoire of post-mitotic neurons. Front Mol Neurosci (2013) 0.94
Dicer-dependent and -independent Argonaute2 protein interaction networks in mammalian cells. Mol Cell Proteomics (2012) 0.94
Single molecule fluorescence approaches shed light on intracellular RNAs. Chem Rev (2014) 0.94
Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies. RNA (2011) 0.94
Human UPF1 participates in small RNA-induced mRNA downregulation. Mol Cell Biol (2009) 0.93
The Missing lnc(RNA) between the pancreatic β-cell and diabetes. Front Genet (2014) 0.91
Regulation of alternative splicing by short non-coding nuclear RNAs. RNA Biol (2010) 0.91
The panorama of miRNA-mediated mechanisms in mammalian cells. Cell Mol Life Sci (2014) 0.90
A non-canonical landscape of the microRNA system. Front Genet (2014) 0.89
An importin β protein negatively regulates MicroRNA activity in Arabidopsis. Plant Cell (2011) 0.89
Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport. PLoS One (2013) 0.88
Antisense tools for functional studies of human Argonaute proteins. RNA (2010) 0.88
Nucleolin mediates microRNA-directed CSF-1 mRNA deadenylation but increases translation of CSF-1 mRNA. Mol Cell Proteomics (2013) 0.88
Wolbachia interferes with the intracellular distribution of Argonaute 1 in the dengue vector Aedes aegypti by manipulating the host microRNAs. RNA Biol (2013) 0.87
miRNA goes nuclear. RNA Biol (2012) 0.87
MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and development. Crit Rev Immunol (2013) 0.87
Studying microRNAs in the brain: technical lessons learned from the first ten years. Exp Neurol (2011) 0.87
Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9). Nucleic Acids Res (2013) 0.86
Nuclear microRNAs and their unconventional role in regulating non-coding RNAs. Protein Cell (2013) 0.85
Stimulated nuclear import by β-like importins. F1000Prime Rep (2013) 0.85
Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels. Nucleic Acids Res (2015) 0.85
Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation. RNA (2011) 0.85
RIP-chip-SRM--a new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans. Genome Res (2012) 0.85
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ADAR enzyme and miRNA story: a nucleotide that can make the difference. Int J Mol Sci (2013) 0.84
Regulation of mammalian transcription and splicing by Nuclear RNAi. Nucleic Acids Res (2015) 0.83
Transcriptional targeting by microRNA-polycomb complexes: a novel route in cell fate determination. Cell Cycle (2012) 0.83
Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells. Int J Cell Biol (2012) 0.83
microRNA Regulation and Its Consequences in Cancer. Curr Pathobiol Rep (2012) 0.82
MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions. Int J Mol Sci (2016) 0.82
The search for endogenous siRNAs in the mammalian brain. Exp Neurol (2011) 0.81
Neurospora importin α is required for normal heterochromatic formation and DNA methylation. PLoS Genet (2015) 0.81
The varied roles of nuclear argonaute-small RNA complexes and avenues for therapy. Mol Ther Nucleic Acids (2014) 0.81
Retracted Nuclear Ago2/HSP60 contributes to broad spectrum of hATSCs function via Oct4 regulation. Antioxid Redox Signal (2011) 0.80
A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption. PLoS One (2013) 0.80
Gene expression profiling of Atlantic cod (Gadus morhua) embryogenesis using microarray. Mar Biotechnol (NY) (2011) 0.80
Alternative processing of the U2 small nuclear RNA produces a 19-22nt fragment with relevance for the detection of non-small cell lung cancer in human serum. PLoS One (2013) 0.80
microRNA biogenesis and turnover in plants. Cold Spring Harb Symp Quant Biol (2013) 0.79
MicroRNAs and lncRNAs in senescence: A re-view. IUBMB Life (2015) 0.79
Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells. RNA (2016) 0.78
Biochemical isolation of Argonaute protein complexes by Ago-APP. Proc Natl Acad Sci U S A (2015) 0.78
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem (2009) 40.90
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science (2008) 9.42
Cyclical DNA methylation of a transcriptionally active promoter. Nature (2008) 7.62
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle (2007) 7.00
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (2013) 6.34
Identification of novel argonaute-associated proteins. Curr Biol (2005) 6.13
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell (2012) 6.07
A human snoRNA with microRNA-like functions. Mol Cell (2008) 5.84
Transient cyclical methylation of promoter DNA. Nature (2008) 5.19
Argonaute proteins: mediators of RNA silencing. Mol Cell (2007) 5.16
Identification of human microRNA targets from isolated argonaute protein complexes. RNA Biol (2007) 4.96
DELLY: structural variant discovery by integrated paired-end and split-read analysis. Bioinformatics (2012) 4.79
Dissecting the genomic complexity underlying medulloblastoma. Nature (2012) 4.77
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Retracted Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature (2002) 4.18
Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science (2007) 4.18
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
Retracted Noncoding RNAs of trithorax response elements recruit Drosophila Ash1 to Ultrabithorax. Science (2006) 4.10
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep (2007) 3.89
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA (2006) 3.71
Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Science (2008) 3.64
Accounting for technical noise in single-cell RNA-seq experiments. Nat Methods (2013) 3.61
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science (2002) 3.59
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab (2008) 3.52
Probing lipid mobility of raft-exhibiting model membranes by fluorescence correlation spectroscopy. J Biol Chem (2003) 3.44
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Fluorescence cross-correlation spectroscopy in living cells. Nat Methods (2006) 3.31
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method. Proc Natl Acad Sci U S A (2002) 3.14
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med (2008) 3.13
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Isolation of an active step I spliceosome and composition of its RNP core. Nature (2008) 3.10
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell (2013) 3.08
Fluorescence correlation spectroscopy: novel variations of an established technique. Annu Rev Biophys Biomol Struct (2007) 3.00
Plasma membranes are poised for activation of raft phase coalescence at physiological temperature. Proc Natl Acad Sci U S A (2008) 2.97
Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature (2009) 2.95
The Argonaute protein family. Genome Biol (2008) 2.83
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol (2009) 2.76
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. Nucleic Acids Res (2007) 2.74
Fluorescence correlation spectroscopy relates rafts in model and native membranes. Biophys J (2004) 2.73
GraFix: sample preparation for single-particle electron cryomicroscopy. Nat Methods (2007) 2.71
Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One (2009) 2.62
CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. J Immunol (2007) 2.61
MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer. Breast Cancer Res (2009) 2.59
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Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis. RNA (2007) 2.48
EF-P is essential for rapid synthesis of proteins containing consecutive proline residues. Science (2012) 2.44
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature (2006) 2.40
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J (2002) 2.39
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol Cell (2009) 2.39
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J (2010) 2.35
Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii. Science (2005) 2.31
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol (2006) 2.29
Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy. Genes Dev (2005) 2.22
Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas. J Virol (2009) 2.20
DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J Cell Biol (2007) 2.20
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. EMBO J (2004) 2.20
A dynamic view of cellular processes by in vivo fluorescence auto- and cross-correlation spectroscopy. Methods (2003) 2.19
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Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. Mol Cell (2008) 2.15
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Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. Genes Dev (2003) 2.10
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Precise measurement of diffusion coefficients using scanning fluorescence correlation spectroscopy. Biophys J (2007) 2.08
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Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase. RNA (2006) 2.05
CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II. Science (2012) 2.05
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
GM1 structure determines SV40-induced membrane invagination and infection. Nat Cell Biol (2009) 2.04
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Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells. Nucleic Acids Res (2008) 2.01
Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J Biol Chem (2010) 2.00
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med (2004) 1.97
Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay. Cell Host Microbe (2010) 1.91
Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. Mol Cell (2004) 1.89
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components. Nat Struct Mol Biol (2009) 1.89
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nat Cell Biol (2012) 1.88
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Mol Cell (2010) 1.84
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The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link. Nat Cell Biol (2008) 1.82
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A cytoplasmic complex mediates specific mRNA recognition and localization in yeast. PLoS Biol (2011) 1.78