Published in Hum Genet on October 17, 2002
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet (2005) 16.79
An enhanced MITOMAP with a global mtDNA mutational phylogeny. Nucleic Acids Res (2006) 4.51
Mitochondrial energetics and therapeutics. Annu Rev Pathol (2010) 3.07
Comprehensive association testing of common mitochondrial DNA variation in metabolic disease. Am J Hum Genet (2006) 2.60
Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences. Am J Hum Genet (2003) 2.26
Energetics, epigenetics, mitochondrial genetics. Mitochondrion (2009) 2.08
Haplogroup effects and recombination of mitochondrial DNA: novel clues from the analysis of Leber hereditary optic neuropathy pedigrees. Am J Hum Genet (2006) 1.95
The pathophysiology of mitochondrial disease as modeled in the mouse. Genes Dev (2009) 1.87
The role of mitochondria in osteoarthritis. Nat Rev Rheumatol (2011) 1.59
Control region mtDNA variants: longevity, climatic adaptation, and a forensic conundrum. Proc Natl Acad Sci U S A (2003) 1.57
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Mitochondria as chi. Genetics (2008) 1.53
Genetics of healthy aging and longevity. Hum Genet (2013) 1.50
The power to detect disease associations with mitochondrial DNA haplogroups. Am J Hum Genet (2006) 1.49
Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study. Age (Dordr) (2006) 1.31
Mitochondrial DNA sequence variation and mutation rate in patients with CADASIL. Neurogenetics (2006) 1.30
Mitochondrial DNA haplogroups influence AIDS progression. AIDS (2008) 1.29
Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapy. J Acquir Immune Defic Syndr (2009) 1.24
Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions. Hum Mol Genet (2014) 1.23
Does the mitochondrial genome play a role in the etiology of Alzheimer's disease? Hum Genet (2006) 1.16
MITOMASTER: a bioinformatics tool for the analysis of mitochondrial DNA sequences. Hum Mutat (2009) 1.10
Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. PLoS One (2010) 1.06
Genetic contribution to biological aging: the Framingham Study. J Gerontol A Biol Sci Med Sci (2004) 1.00
African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy. J Infect Dis (2010) 0.99
The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics. Lab Invest (2011) 0.99
Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population. PLoS One (2009) 0.99
Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. PLoS One (2013) 0.96
Functional recurrent mutations in the human mitochondrial phylogeny: dual roles in evolution and disease. Genome Biol Evol (2013) 0.93
European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142. AIDS (2011) 0.93
Mitochondrial DNA sequence variation and risk of pancreatic cancer. Cancer Res (2011) 0.90
mtDNA nt13708A variant increases the risk of multiple sclerosis. PLoS One (2008) 0.90
Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity. Int J Mol Sci (2013) 0.89
Mitochondrial-nuclear epistasis: implications for human aging and longevity. Ageing Res Rev (2010) 0.89
Maternal lineages and Alzheimer disease risk in the Old Order Amish. Hum Genet (2005) 0.88
The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation. Exp Gerontol (2009) 0.88
Mitochondrial DNA variation in human metabolic rate and energy expenditure. Mitochondrion (2011) 0.87
Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort. Age (Dordr) (2011) 0.87
Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis. BMC Musculoskelet Disord (2011) 0.87
Multiplex analysis of mitochondrial DNA pathogenic and polymorphic sequence variants. Biol Chem (2010) 0.86
Mitochondrial DNA haplogroups in early-onset Alzheimer's disease and frontotemporal lobar degeneration. Mol Neurodegener (2010) 0.86
mtDNA haplogroup and single nucleotide polymorphisms structure human microbiome communities. BMC Genomics (2014) 0.86
Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. J Neurovirol (2012) 0.85
Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384. J Acquir Immune Defic Syndr (2011) 0.85
mtDNA haplogroup J modulates telomere length and nitric oxide production. BMC Musculoskelet Disord (2011) 0.85
The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms. Biomed Res Int (2014) 0.84
The other genome: a systematic review of studies of mitochondrial DNA haplogroups and outcomes of HIV infection and antiretroviral therapy. AIDS Rev (2013) 0.84
Mitochondrial polymorphisms are associated both with increased and decreased longevity. Hum Hered (2008) 0.83
Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old. Neurobiol Aging (2013) 0.82
Genetics, environment, and diabetes-related end-stage renal disease in the Canary Islands. Genet Test Mol Biomarkers (2012) 0.82
Biomarker Validation for Aging: Lessons from mtDNA Heteroplasmy Analyses in Early Cancer Detection. Biomark Insights (2009) 0.82
Osteoarthritis: Metabolomic characterization of metabolic phenotypes in OA. Nat Rev Rheumatol (2012) 0.81
Ashkenazi Jewish centenarians do not demonstrate enrichment in mitochondrial haplogroup J. PLoS One (2008) 0.81
Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly. J Alzheimers Dis (2012) 0.81
Mitochondrial DNA sequence variation in Finnish patients with matrilineal diabetes mellitus. BMC Res Notes (2012) 0.81
Genetics in osteoarthritis. Curr Genomics (2008) 0.80
Mitochondrial DNA and traumatic brain injury. Ann Neurol (2014) 0.80
Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration. Mol Vis (2013) 0.80
Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity. PLoS One (2012) 0.80
Mitochondrial genomes and exceptional longevity in a Chinese population: the Rugao longevity study. Age (Dordr) (2015) 0.80
Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly. Biochim Biophys Acta (2012) 0.79
mtDNA Mutations and Their Role in Aging, Diseases and Forensic Sciences. Aging Dis (2013) 0.79
Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study. Age (Dordr) (2012) 0.79
Genetic epidemiology in aging research. J Gerontol A Biol Sci Med Sci (2009) 0.77
Associations between sequence variations in the mitochondrial DNA D-loop region and outcome of hepatocellular carcinoma. Oncol Lett (2016) 0.76
Association between mitochondrial DNA haplogroup and myelodysplastic syndromes. Genes Chromosomes Cancer (2016) 0.75
Mitochondrial DNA mutations and cardiovascular disease. Curr Opin Cardiol (2017) 0.75
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. Lancet (2004) 2.91
Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age. Ann Neurol (2009) 2.83
Bacterial signatures in thrombus aspirates of patients with myocardial infarction. Circulation (2013) 2.81
Short stature is associated with coronary heart disease: a systematic review of the literature and a meta-analysis. Eur Heart J (2010) 2.62
Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin. Am J Hum Genet (2005) 2.23
The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event. Am J Hum Genet (2006) 2.18
Self-reported hearing problems among older adults: prevalence and comparison to measured hearing impairment. J Am Acad Audiol (2011) 2.17
Prevalence of the primary LHON mutations in Northern Finland associated with bilateral optic atrophy and tobacco-alcohol amblyopia. Acta Ophthalmol (2012) 2.00
Treatment for mitochondrial disorders. Cochrane Database Syst Rev (2012) 1.94
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet (2012) 1.68
Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study. Circ Cardiovasc Genet (2011) 1.67
Predictors of institutionalization in an older population during a 13-year period: the effect of urge incontinence. J Gerontol A Biol Sci Med Sci (2003) 1.57
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis (2011) 1.54
Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes. Eur J Hum Genet (2005) 1.54
Indoleamine 2,3-dioxygenase activation and depressive symptoms: results from the Young Finns Study. Psychosom Med (2012) 1.53
Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation. Liver Transpl (2014) 1.48
Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study. PLoS Genet (2010) 1.39
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA. Nucleic Acids Res (2007) 1.38
A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects. Eur J Hum Genet (2005) 1.36
Prevalence, segregation, and phenotype of the mitochondrial DNA 3243A>G mutation in children. Ann Neurol (2007) 1.35
Increased frequency of interleukin-1beta (-511) allele 2 in febrile seizures. Pediatr Neurol (2002) 1.35
Mitochondrial DNA sequence variation and mutation rate in patients with CADASIL. Neurogenetics (2006) 1.30
Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: a prospective cohort study. PLoS One (2011) 1.28
Global self-rated health data from a longitudinal study predicted mortality better than comparative self-rated health in old age. J Clin Epidemiol (2005) 1.28
New treatments for mitochondrial disease-no time to drop our standards. Nat Rev Neurol (2013) 1.26
Coronary artery wall atherosclerosis in relation to the estrogen receptor 1 gene polymorphism: an autopsy study. J Mol Med (Berl) (2002) 1.24
Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). Ann N Y Acad Sci (2007) 1.21
Phylogenetic network and physicochemical properties of nonsynonymous mutations in the protein-coding genes of human mitochondrial DNA. Mol Biol Evol (2003) 1.19
Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia. Hum Genet (2004) 1.19
High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients. Shock (2010) 1.19
Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-alpha(-308) G/A polymorphism. J Infect Dis (2002) 1.18
CMV and Immunosenescence: from basics to clinics. Immun Ageing (2012) 1.17
Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study. J Gerontol A Biol Sci Med Sci (2007) 1.16
Cross-national determinants of quality of life from six longitudinal studies on aging: the CLESA project. Aging Clin Exp Res (2003) 1.14
Inflammatory markers and physical performance among nonagenarians. J Gerontol A Biol Sci Med Sci (2010) 1.14
Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J. Mol Biol Evol (2003) 1.13
Self-rated health and mortality in older men and women: a time-dependent covariate analysis. Arch Gerontol Geriatr (2007) 1.13
The severity of Puumala hantavirus induced nephropathia epidemica can be better evaluated using plasma interleukin-6 than C-reactive protein determinations. BMC Infect Dis (2010) 1.13
Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection. Hum Immunol (2009) 1.10
Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk. JAMA Neurol (2013) 1.09
Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. J Biol Chem (2009) 1.09
Genome wide assessment of young onset Parkinson's disease from Finland. PLoS One (2012) 1.09
High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis. Eur Heart J (2012) 1.09
Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians. Clin Endocrinol (Oxf) (2006) 1.08
Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol (2005) 1.08
Adult-onset ataxia and polyneuropathy caused by mitochondrial 8993T-->C mutation. Ann Neurol (2005) 1.08
Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. Thromb Haemost (2006) 1.07
Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures. Epilepsia (2002) 1.07
Childhood environmental and genetic predictors of adulthood obesity: the cardiovascular risk in young Finns study. J Clin Endocrinol Metab (2011) 1.06
Inflammatory markers and the progression of IgA glomerulonephritis. Nephrol Dial Transplant (2007) 1.06
Mutated ND2 impairs mitochondrial complex I assembly and leads to Leigh syndrome. Mol Genet Metab (2006) 1.05
Body mass index, waist circumference, and waist-to-hip ratio as predictors of mortality in nonagenarians: the Vitality 90+ Study. J Gerontol A Biol Sci Med Sci (2011) 1.05
Urinary excretion of interleukin-6 correlates with proteinuria in acute Puumala hantavirus-induced nephritis. Am J Kidney Dis (2004) 1.05
Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia. Eur Arch Psychiatry Clin Neurosci (2007) 1.05
High plasma level of long pentraxin 3 (PTX3) is associated with fatal disease in bacteremic patients: a prospective cohort study. PLoS One (2011) 1.04
Onset of loneliness in older adults: results of a 28 year prospective study. Eur J Ageing (2011) 1.04
Common genetic variants associated with sudden cardiac death: the FinSCDgen study. PLoS One (2012) 1.04
Mendelian randomization suggests no causal association between C-reactive protein and carotid intima-media thickness in the young Finns study. Arterioscler Thromb Vasc Biol (2007) 1.04
The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica. PLoS One (2012) 1.04
Homozygous W748S mutation in the POLG1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus. Epilepsia (2008) 1.03
Cardiac abnormalities in patients with mitochondrial DNA mutation 3243A>G. BMC Cardiovasc Disord (2002) 1.01
Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty. Aging Cell (2013) 1.01
Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis. Ageing Res Rev (2008) 1.00
Indoors forensic entomology: colonization of human remains in closed environments by specific species of sarcosaprophagous flies. Forensic Sci Int (2010) 1.00
IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants. Pediatr Pulmonol (2008) 1.00
Medical history, cognitive status and mobility at the age of 90. A population-based study in Tampere, Finland. Aging Clin Exp Res (2003) 0.99
Polymorphism of the cytokine genes and IgA nephropathy. Kidney Int (2002) 0.99
The IL1A genotype associates with atopy in nonasthmatic adults. J Allergy Clin Immunol (2002) 0.98
Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death. J Am Coll Cardiol (2003) 0.98
Intermittent ethanol exposure increases the number of cerebellar microglia. Alcohol Alcohol (2002) 0.97
Secondary metabolic effects in complex I deficiency. Ann Neurol (2005) 0.97
Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study. Ann Med (2011) 0.96
Predictors of mortality in men and women aged 90 and older: a nine-year follow-up study in the Vitality 90+ study. Age Ageing (2013) 0.96
The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals. Eur Cytokine Netw (2002) 0.96
Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals. Eur Cytokine Netw (2003) 0.95
Relationship between leptin and C-reactive protein in young Finnish adults. J Clin Endocrinol Metab (2007) 0.95
Self-rated health and mortality: could clinical and performance-based measures of health and functioning explain the association? Arch Gerontol Geriatr (2005) 0.95
Gender differences in depressive symptoms among older adults: a cross-national comparison: the CLESA project. Soc Psychiatry Psychiatr Epidemiol (2007) 0.94
Muscular dystonia and athetosis in six patients with congenital nephrotic syndrome of the Finnish type (NPHS1). Pediatr Nephrol (2005) 0.94
Mortality of patients with acute coronary syndromes still remains high: a follow-up study of 1188 consecutive patients admitted to a university hospital. Ann Med (2007) 0.94
Evaluation of postmortem bacterial migration using culturing and real-time quantitative PCR. J Forensic Sci (2013) 0.94
Peripheral neuropathy in patients with the 3243A>G mutation in mitochondrial DNA. J Neurol (2003) 0.94
Cytokine gene polymorphism in recurrent acute otitis media. Arch Otolaryngol Head Neck Surg (2002) 0.94