Published in Nature on December 19, 2002
Protective immune mechanisms in helminth infection. Nat Rev Immunol (2007) 5.66
Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (2009) 5.59
Regulation of inflammatory responses by IL-17F. J Exp Med (2008) 5.56
Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med (2006) 5.35
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med (2003) 4.68
Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med (2004) 4.45
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med (2005) 3.82
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway. Nature (2011) 3.80
gammadelta T cells: an important source of IL-17. Curr Opin Immunol (2008) 3.03
A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity (2005) 3.02
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol (2003) 2.93
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. Proc Natl Acad Sci U S A (2007) 2.46
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood (2007) 2.20
Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially. J Leukoc Biol (2008) 1.79
Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages. Infect Immun (2006) 1.76
Biology of the eosinophil. Adv Immunol (2009) 1.74
Basophils initiate IL-4 production during a memory T-dependent response. J Exp Med (2004) 1.68
Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. J Exp Med (2014) 1.59
Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proc Natl Acad Sci U S A (2006) 1.54
Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med (2007) 1.46
Basic pathogenesis of eosinophilic esophagitis. Gastrointest Endosc Clin N Am (2008) 1.45
Eosinophils: multifaceted biological properties and roles in health and disease. Immunol Rev (2011) 1.45
Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood (2006) 1.42
IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation. J Clin Invest (2005) 1.40
The expanding role(s) of eosinophils in health and disease. Blood (2012) 1.35
Eosinophils in innate immunity: an evolving story. Cell Tissue Res (2010) 1.34
IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites. J Immunol (2005) 1.29
Immunoregulatory roles of eosinophils: a new look at a familiar cell. Clin Exp Allergy (2008) 1.26
Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol (2010) 1.22
The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response. J Immunol (2009) 1.19
Basophils are the major producers of IL-4 during primary helminth infection. J Immunol (2011) 1.14
Innate B cell helpers reveal novel types of antibody responses. Nat Immunol (2013) 1.11
IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop. J Immunol (2013) 1.10
Hookworm-induced persistent changes to the immunological environment of the lung. Infect Immun (2008) 1.09
CD8 T cells modulate CD4 T-cell and eosinophil-mediated pulmonary pathology in pneumocystis pneumonia in B-cell-deficient mice. Am J Pathol (2006) 1.08
IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Cell Res (2009) 1.08
T cell directives for transcriptional regulation in asthma. Springer Semin Immunopathol (2003) 0.98
Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis. Am J Pathol (2011) 0.93
Granulocytes in helminth infection -- who is calling the shots? Curr Med Chem (2012) 0.92
Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol (2008) 0.91
Eosinophils: multifunctional and distinctive properties. Int Arch Allergy Immunol (2013) 0.90
Fatal eosinophilic myocarditis develops in the absence of IFN-γ and IL-17A. J Immunol (2013) 0.88
In vivo imaging of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs. Int J Parasitol (2005) 0.87
The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention. EPMA J (2014) 0.87
The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice. Infect Immun (2004) 0.86
Cytokine reporter mice in immunological research: perspectives and lessons learned. Immunology (2010) 0.85
T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4. Infect Immun (2003) 0.85
Cytokine signaling in the differentiation of innate effector cells. JAKSTAT (2013) 0.85
TFH cells progressively differentiate to regulate the germinal center response. Nat Immunol (2016) 0.84
The significance and regulatory mechanisms of innate immune cells in the development of sepsis. J Interferon Cytokine Res (2013) 0.84
Probiotics and immunity: provisional role for personalized diets and disease prevention. EPMA J (2015) 0.84
The differential expression of IL-4 and IL-13 and its impact on type-2 immunity. Cytokine (2015) 0.84
Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice. Infect Immun (2004) 0.82
Systemic effects of oral tolerance on inflammation: mobilization of lymphocytes and bone marrow eosinopoiesis. Immunology (2006) 0.81
Chronic intestinal nematode infection induces Stat6-independent interleukin-5 production and causes eosinophilic inflammatory responses in mice. Immunology (2004) 0.79
Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin. Am J Pathol (2005) 0.78
A Player and Coordinator: The Versatile Roles of Eosinophils in the Immune System. Transfus Med Hemother (2016) 0.77
Correlation of interleukin-17-producing effector memory T cells and CD4+CD25+Foxp3 regulatory T cells with the phosphate levels in chronic hemodialysis patients. ScientificWorldJournal (2014) 0.77
IL-9 and Th9 in parasite immunity. Semin Immunopathol (2016) 0.75
Chemokines Responses to Ascaris Lumbricoides Sole Infection and Co-infection with Hookworm among Nigerians. N Am J Med Sci (2014) 0.75
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83
Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A (2010) 6.78
Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity (2004) 6.46
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (2009) 5.59
Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity (2004) 4.81
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature (2011) 4.71
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med (2003) 4.68
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity (2008) 4.21
Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med (2006) 4.11
T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med (2009) 3.40
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J Immunol (2007) 3.25
Type 2 innate lymphoid cells control eosinophil homeostasis. Nature (2013) 3.20
IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med (2009) 3.18
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol (2009) 3.17
A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity (2005) 3.02
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell (2013) 3.00
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med (2013) 2.79
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol (2011) 2.67
Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science (2007) 2.67
Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J Immunol (2005) 2.63
Activation of the integrated stress response during T helper cell differentiation. Nat Immunol (2006) 2.62
Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol (2009) 2.48
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol (2013) 2.47
Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity (2009) 2.45
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A (2010) 2.37
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol (2009) 2.29
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A (2003) 2.28
Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J Exp Med (2009) 2.24
Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells. Cell Host Microbe (2009) 2.17
Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nat Immunol (2010) 2.14
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity (2009) 2.13
Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J Leukoc Biol (2007) 1.99
Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity (2008) 1.97
Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J Immunol (2008) 1.91
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol (2006) 1.86
Genetic analysis of basophil function in vivo. Nat Immunol (2011) 1.82
Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nat Immunol (2011) 1.82
Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population. J Immunol (2006) 1.73
T helper cell differentiation: on again, off again. Curr Opin Immunol (2002) 1.67
Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol (2013) 1.64
Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity (2013) 1.62
Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J Immunol (2007) 1.47
Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc Natl Acad Sci U S A (2008) 1.44
Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression. J Clin Invest (2009) 1.43
Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity (2002) 1.42
Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection. J Exp Med (2011) 1.40
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol (2013) 1.38
Basophils: a nonredundant contributor to host immunity. Immunity (2009) 1.38
Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol (2008) 1.36
Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth. J Immunol (2006) 1.33
Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A (2013) 1.33
Systemic dissemination and persistence of Th2 and type 2 cells in response to infection with a strictly enteric nematode parasite. J Immunol (2005) 1.33
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med (2012) 1.32
Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol (2003) 1.27
T helper cell effector fates--who, how and where? Curr Opin Immunol (2006) 1.26
The functional heterogeneity of type 1 effector T cells in response to infection is related to the potential for IFN-gamma production. J Immunol (2005) 1.23
Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J Immunol (2005) 1.22
Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection. J Immunol (2009) 1.22
Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum (2005) 1.18
Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. J Immunol (2011) 1.15
Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol (2011) 1.15
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med (2006) 1.12
Dendritic cell differentiation state and their interaction with NKT cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection. J Immunol (2008) 1.10
CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem (2004) 1.10
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem (2009) 1.08
Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol (2008) 1.08
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol (2003) 1.06
Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol (2013) 1.06
Basal chromatin modification at the IL-4 gene in helper T cells. J Immunol (2003) 1.05
Lymphocyte development requires S-nitrosoglutathione reductase. J Immunol (2010) 1.05
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest (2006) 1.05
Marking and quantifying IL-17A-producing cells in vivo. PLoS One (2012) 1.04
Leishmania major LACK antigen is required for efficient vertebrate parasitization. J Exp Med (2003) 1.04
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. PLoS Pathog (2012) 1.00
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection. Proc Natl Acad Sci U S A (2005) 1.00
Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol (2007) 0.99
Innate immune responses in peptidoglycan recognition protein L-deficient mice. Mol Cell Biol (2004) 0.99
Th2 cells: orchestrating barrier immunity. Adv Immunol (2004) 0.97
B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses. J Immunol (2006) 0.94
Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol (2010) 0.93
The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med (2011) 0.93
A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection. J Immunol (2010) 0.93
Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol (2009) 0.93
Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J Immunol (2009) 0.92
Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol (2008) 0.91
In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. J Immunol (2009) 0.90
Cutting edge: Helminth infection induces IgE in the absence of mu- or delta-chain expression. J Immunol (2008) 0.89
The mechanism of splenic invariant NKT cell activation dictates localization in vivo. J Immunol (2013) 0.89
Stat signals release activated naive Th cells from an anergic checkpoint. J Immunol (2003) 0.87
Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proc Natl Acad Sci U S A (2012) 0.87