Published in Nat Immunol on May 07, 2006
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Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells. Proc Natl Acad Sci U S A (2017) 0.75
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29
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IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71
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Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83
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Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity (2004) 6.46
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet (2009) 5.84
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (2009) 5.59
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity (2003) 5.52
Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity (2004) 4.81
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Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity (2012) 3.49
Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. Immunity (2002) 3.42
T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med (2009) 3.40
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J Immunol (2007) 3.25
Type 2 innate lymphoid cells control eosinophil homeostasis. Nature (2013) 3.20
IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med (2009) 3.18
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol (2009) 3.17
A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity (2005) 3.02
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell (2013) 3.00
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med (2013) 2.79
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol (2011) 2.67
Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science (2007) 2.67
Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J Immunol (2005) 2.63
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Helper T cells regulate type-2 innate immunity in vivo. Nature (2002) 2.47
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Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity (2009) 2.45
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A (2010) 2.37
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol (2009) 2.29
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A (2003) 2.28
Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J Exp Med (2009) 2.24
Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells. Cell Host Microbe (2009) 2.17
Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nat Immunol (2010) 2.14
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity (2009) 2.13
Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest (2013) 2.04
Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J Leukoc Biol (2007) 1.99
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Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol (2006) 1.86
Genetic analysis of basophil function in vivo. Nat Immunol (2011) 1.82
Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nat Immunol (2011) 1.82
Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population. J Immunol (2006) 1.73
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Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol (2013) 1.64
Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity (2013) 1.62
Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. J Exp Med (2012) 1.48
Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J Immunol (2007) 1.47
Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc Natl Acad Sci U S A (2008) 1.44
Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression. J Clin Invest (2009) 1.43
Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity (2002) 1.42
Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection. J Exp Med (2011) 1.40
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol (2013) 1.38
Basophils: a nonredundant contributor to host immunity. Immunity (2009) 1.38
Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol (2008) 1.36
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Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A (2013) 1.33
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Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J Immunol (2005) 1.22
Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection. J Immunol (2009) 1.22
Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum (2005) 1.18
Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. J Immunol (2011) 1.15
Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol (2011) 1.15
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med (2006) 1.12
Dendritic cell differentiation state and their interaction with NKT cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection. J Immunol (2008) 1.10
CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem (2004) 1.10
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem (2009) 1.08
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Primary induction of CD4 T cell responses in nasal associated lymphoid tissue during group A streptococcal infection. Eur J Immunol (2004) 1.07
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Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT. Infect Immun (2012) 1.06
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Basal chromatin modification at the IL-4 gene in helper T cells. J Immunol (2003) 1.05
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Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest (2006) 1.05
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Leishmania major LACK antigen is required for efficient vertebrate parasitization. J Exp Med (2003) 1.04
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. PLoS Pathog (2012) 1.00