Published in Mol Cell Biol on September 01, 2004
Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev (2005) 2.50
PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe (2009) 1.89
Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma. Cell Host Microbe (2010) 1.85
Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nat Rev Immunol (2011) 1.45
The peptidoglycan recognition protein PGRP-SC1a is essential for Toll signaling and phagocytosis of Staphylococcus aureus in Drosophila. Proc Natl Acad Sci U S A (2006) 1.20
Innate and adaptive immune responses against Staphylococcus aureus skin infections. Semin Immunopathol (2011) 1.12
Bacterial peptidoglycan degrading enzymes and their impact on host muropeptide detection. J Innate Immun (2009) 1.04
Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections. Immunity (2007) 1.02
Phagocytes containing a disease-promoting Toll-like receptor/Nod ligand are present in the brain during demyelinating disease in primates. Am J Pathol (2006) 1.00
Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells. PLoS One (2011) 0.90
Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses. J Immunol (2011) 0.89
The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior. Mol Psychiatry (2016) 0.87
Mouse peptidoglycan recognition protein PGLYRP-1 plays a role in the host innate immune response against Listeria monocytogenes infection. Infect Immun (2010) 0.85
Gene silencing and overexpression of porcine peptidoglycan recognition protein long isoforms: involvement in beta-defensin-1 expression. Infect Immun (2005) 0.83
Staphylococcus aureus Promotes Smed-PGRP-2/Smed-setd8-1 Methyltransferase Signalling in Planarian Neoblasts to Sensitize Anti-bacterial Gene Responses During Re-infection. EBioMedicine (2017) 0.80
Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo. Infect Immun (2012) 0.80
Cytoprotective agent in Lactobacillus bulgaricus extracts. Curr Microbiol (2007) 0.77
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Innate immune recognition. Annu Rev Immunol (2001) 26.65
Toll-like receptors. Annu Rev Immunol (2001) 26.06
Peptidoglycan types of bacterial cell walls and their taxonomic implications. Bacteriol Rev (1972) 19.14
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell (1991) 14.23
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell (1993) 11.76
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A (2000) 9.67
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med (1999) 7.62
Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A (1997) 7.42
The immune response of Drosophila. Nature (2003) 7.03
Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science (2002) 4.47
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature (2002) 4.33
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature (2001) 4.07
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature (2002) 3.63
The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat Immunol (2003) 3.29
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 3.08
Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J Immunol (2001) 2.86
A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc Natl Acad Sci U S A (1998) 2.81
Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity (2004) 2.77
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell (2001) 2.68
Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. J Biol Chem (2001) 2.18
Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science (2003) 2.11
Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci U S A (2002) 1.99
Purification of a peptidoglycan recognition protein from hemolymph of the silkworm, Bombyx mori. J Biol Chem (1996) 1.97
A scavenger function for a Drosophila peptidoglycan recognition protein. J Biol Chem (2002) 1.87
In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults. J Biol Chem (2004) 1.87
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. J Biol Chem (2003) 1.74
A mammalian peptidoglycan recognition protein with N-acetylmuramoyl-L-alanine amidase activity. Biochem Biophys Res Commun (2003) 1.40
Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha. J Biol Chem (2004) 1.10
Ash1 protein, an asymmetrically localized transcriptional regulator, controls filamentous growth and virulence of Candida albicans. Mol Cell Biol (2002) 0.99
Partial purification and characterization of N-acetylmuramyl-L-alanine amidase from human and mouse serum. Biochim Biophys Acta (1982) 0.94
Inflammatory properties of peptidoglycan are decreased after degradation by human N-acetylmuramyl-L-alanine amidase. Eur Cytokine Netw (1997) 0.90
Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography. Protein Expr Purif (1995) 0.81
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 29.29
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71
Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol (2013) 7.94
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 6.83
Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A (2010) 6.78
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (2009) 5.59
Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity (2004) 4.81
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature (2011) 4.71
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med (2003) 4.68
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity (2008) 4.21
Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med (2006) 4.11
Type 2 innate lymphoid cells control eosinophil homeostasis. Nature (2013) 3.20
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol (2009) 3.17
A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity (2005) 3.02
Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell (2013) 3.00
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med (2013) 2.79
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol (2011) 2.67
Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science (2007) 2.67
Activation of the integrated stress response during T helper cell differentiation. Nat Immunol (2006) 2.62
Helper T cells regulate type-2 innate immunity in vivo. Nature (2002) 2.47
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol (2013) 2.47
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A (2010) 2.37
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol (2009) 2.29
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A (2003) 2.28
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity (2009) 2.13
Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J Leukoc Biol (2007) 1.99
Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity (2008) 1.97
Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J Immunol (2008) 1.91
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol (2006) 1.86
Genetic analysis of basophil function in vivo. Nat Immunol (2011) 1.82
T helper cell differentiation: on again, off again. Curr Opin Immunol (2002) 1.67
Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol (2013) 1.64
Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity (2013) 1.62
Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc Natl Acad Sci U S A (2008) 1.44
Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity (2002) 1.42
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol (2013) 1.38
Basophils: a nonredundant contributor to host immunity. Immunity (2009) 1.38
Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A (2013) 1.33
Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol (2003) 1.27
T helper cell effector fates--who, how and where? Curr Opin Immunol (2006) 1.26
Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum (2005) 1.18
Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. J Immunol (2011) 1.15
Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol (2011) 1.15
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med (2006) 1.12
CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem (2004) 1.10
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem (2009) 1.08
Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol (2008) 1.08
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol (2003) 1.06
Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol (2013) 1.06
Basal chromatin modification at the IL-4 gene in helper T cells. J Immunol (2003) 1.05
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest (2006) 1.05
Lymphocyte development requires S-nitrosoglutathione reductase. J Immunol (2010) 1.05
Marking and quantifying IL-17A-producing cells in vivo. PLoS One (2012) 1.04
Leishmania major LACK antigen is required for efficient vertebrate parasitization. J Exp Med (2003) 1.04
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection. Proc Natl Acad Sci U S A (2005) 1.00
Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol (2007) 0.99
Th2 cells: orchestrating barrier immunity. Adv Immunol (2004) 0.97
Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol (2010) 0.93
The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med (2011) 0.93
Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol (2009) 0.93
Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol (2008) 0.91
In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. J Immunol (2009) 0.90
Stat signals release activated naive Th cells from an anergic checkpoint. J Immunol (2003) 0.87
The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice. Infect Immun (2004) 0.86
Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol (2012) 0.86
The inflammasome and alum-mediated adjuvanticity. F1000 Biol Rep (2009) 0.86
Improved calibration method for depolarization lidar measurement. Opt Express (2013) 0.85
Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence. J Immunol (2006) 0.85
Infectious (Non)tolerance--frustrated commensalism gone awry? Cold Spring Harb Perspect Biol (2012) 0.84
Compact airborne Raman lidar for profiling aerosol, water vapor and clouds. Opt Express (2014) 0.83
Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds. Mol Cells (2005) 0.81
Blood lines. Nat Immunol (2002) 0.80
LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. Eur J Immunol (2006) 0.76
Formation and spread of aircraft-induced holes in clouds. Science (2011) 0.75
Airborne compact rotational Raman lidar for temperature measurement. Opt Express (2016) 0.75
Vertically resolved separation of dust and other aerosol types by a new lidar depolarization method. Opt Express (2015) 0.75
Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity. Immunol Cell Biol (2007) 0.75
Retrieval of effective complex refractive index from intensive measurements of characteristics of ambient aerosols in the boundary layer. Opt Express (2013) 0.75