Published in Nature on December 19, 2002
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Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol (2005) 7.13
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell (2007) 4.56
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest (2006) 4.41
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci U S A (2009) 4.23
Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci U S A (2005) 4.07
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care (2007) 3.80
Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest (2004) 3.70
TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med (2008) 3.62
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med (2005) 3.37
A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med (2004) 2.80
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest (2004) 2.72
Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58
An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med (2004) 2.51
Sepsis: definition, epidemiology, and diagnosis. BMJ (2007) 2.43
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun (2006) 2.37
Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med (2004) 2.32
Antibody orientation at bacterial surfaces is related to invasive infection. J Exp Med (2012) 2.30
Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells. Cell Host Microbe (2009) 2.17
Innate response activator B cells protect against microbial sepsis. Science (2012) 2.07
Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev (2010) 2.06
The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data. Crit Care (2009) 1.99
Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest (2004) 1.96
Innate immune responses to influenza A H5N1: friend or foe? Trends Immunol (2009) 1.89
Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. Proc Natl Acad Sci U S A (2004) 1.87
Pathogenesis of malaria and clinically similar conditions. Clin Microbiol Rev (2004) 1.87
Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med (2010) 1.84
Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int (2006) 1.83
The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med (2012) 1.81
Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80
Thrombin. Mol Aspects Med (2008) 1.80
Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med (2006) 1.78
Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest (2004) 1.75
The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus. J Infect Dis (2009) 1.74
Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sci (2006) 1.71
Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis. J Exp Med (2008) 1.70
Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice. Am J Pathol (2005) 1.65
Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory. Cell Cycle (2012) 1.65
Endotoxin-induced structural transformations in liquid crystalline droplets. Science (2011) 1.65
Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol (2004) 1.61
Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol (2008) 1.59
Peptide nanofibers preconditioned with stem cell secretome are renoprotective. J Am Soc Nephrol (2011) 1.57
Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. J Immunol (2008) 1.57
Cytokines in sepsis: potent immunoregulators and potential therapeutic targets--an updated view. Mediators Inflamm (2013) 1.54
Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med (2008) 1.52
Basolateral LPS inhibits NHE3 and HCOFormula absorption through TLR4/MyD88-dependent ERK activation in medullary thick ascending limb. Am J Physiol Cell Physiol (2011) 1.50
A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle. J Physiol (2008) 1.49
Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study. Crit Care (2005) 1.49
Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock. Clin Microbiol Rev (2009) 1.49
Nicotine administration and withdrawal affect survival in systemic inflammation models. J Appl Physiol (1985) (2008) 1.48
SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One (2015) 1.46
Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med (2012) 1.45
Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood (2004) 1.44
Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. J Inflamm (Lond) (2010) 1.44
Importance of Toll-like receptor 2 in mitochondrial dysfunction during polymicrobial sepsis. Anesthesiology (2014) 1.43
Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med (2016) 1.42
Recognition of lipopolysaccharide pattern by TLR4 complexes. Exp Mol Med (2013) 1.41
Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1. Nat Immunol (2013) 1.41
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care (2012) 1.41
Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury. PLoS One (2015) 1.40
Changes in B-type Natriuretic Peptide and Related Hemodynamic Parameters Following a Fluid Challenge in Critically Ill Patients with Severe Sepsis or Septic Shock. Indian J Crit Care Med (2017) 1.40
Development and Validation of a Clinical Prediction Rule for Bacteremia among Maintenance Hemodialysis Patients in Outpatient Settings. PLoS One (2017) 1.39
Bacterial immune evasion through manipulation of host inhibitory immune signaling. PLoS Pathog (2015) 1.39
Impact of interleukin-10, soluble CD25 and interferon-γ on the prognosis and early diagnosis of bacteremic systemic inflammatory response syndrome: a prospective observational study. Crit Care (2013) 1.39
Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study. Crit Care (2004) 1.37
The contact system--a novel branch of innate immunity generating antibacterial peptides. EMBO J (2006) 1.36
Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis. Proc Natl Acad Sci U S A (2007) 1.34
A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation. J Immunol (2010) 1.33
TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice. J Exp Med (2008) 1.32
The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies. Thorax (2010) 1.31
The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm (2012) 1.30
The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie (2010) 1.30
Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain. J Neuroinflammation (2009) 1.29
Antimicrobial and chemoattractant activity, lipopolysaccharide neutralization, cytotoxicity, and inhibition by serum of analogs of human cathelicidin LL-37. Antimicrob Agents Chemother (2005) 1.28
Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice. J Immunol (2009) 1.27
Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment. J Am Soc Nephrol (2011) 1.26
Complexity of complement activation in sepsis. J Cell Mol Med (2008) 1.26
The main Aeromonas pathogenic factors. ISRN Microbiol (2012) 1.25
Antithrombotic activity of TNF-alpha. J Clin Invest (2003) 1.25
Invasive disease and toxic shock due to zoonotic Streptococcus suis: an emerging infection in the East? PLoS Med (2006) 1.25
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A (2009) 1.25
Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock. Crit Care (2012) 1.23
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med (2008) 1.23
Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products. Clin Exp Immunol (2006) 1.23
A microfluidics approach towards high-throughput pathogen removal from blood using margination. Biomicrofluidics (2012) 1.23
Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J Immunol (2012) 1.22
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest (2009) 1.20
Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Pediatr Res (2010) 1.19
Understanding organ dysfunction in Ebola virus disease. Intensive Care Med (2014) 1.19
Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response. J Biol Chem (2009) 1.18
Bench-to-bedside review: Beta-adrenergic modulation in sepsis. Crit Care (2009) 1.18
Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell (2004) 1.17
Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta-analysis. Crit Care (2011) 1.17
Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice. J Clin Invest (2004) 1.17
Proteomics reveals age-related differences in the host immune response to sepsis. J Proteome Res (2013) 1.16
Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis. Crit Care (2009) 1.16
Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. Infect Immun (2004) 1.15
Interleukin-1beta modulates proinflammatory cytokine production in human epithelial cells. Infect Immun (2008) 1.15
The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost (2011) 1.15