Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock.

PubWeight™: 1.49‹?› | Rank: Top 4%

🔗 View Article (PMC 2668236)

Published in Clin Microbiol Rev on April 01, 2009

Authors

Ineke Vanlaere1, Claude Libert

Author Affiliations

1: Department for Molecular Biomedical Research, VIB, B-9052 Ghent, Belgium.

Articles citing this

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice. Immunity (2015) 2.60

A novel role for matrix metalloproteinase-8 in sepsis. Crit Care Med (2012) 2.11

The X chromosome in immune functions: when a chromosome makes the difference. Nat Rev Immunol (2010) 1.71

Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. Crit Care (2009) 1.57

CleavPredict: A Platform for Reasoning about Matrix Metalloproteinases Proteolytic Events. PLoS One (2015) 1.48

Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis. Intensive Care Med (2016) 1.43

Genome-wide expression profiling in pediatric septic shock. Pediatr Res (2013) 1.39

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis. EMBO Mol Med (2011) 1.28

Gene expression profiling in sepsis: timing, tissue, and translational considerations. Trends Mol Med (2014) 1.25

Clinical review: sepsis and septic shock--the potential of gene arrays. Crit Care (2012) 1.25

Genetics and genomics in pediatric septic shock. Crit Care Med (2012) 1.23

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF. EMBO Mol Med (2013) 1.17

Matrix Metalloproteinase-2 Mediates Intestinal Immunopathogenesis in Campylobacter Jejuni-Infected Infant Mice. Eur J Microbiol Immunol (Bp) (2015) 0.99

The Role of Gelatinases in Campylobacter Jejuni Infection of Gnotobiotic Mice. Eur J Microbiol Immunol (Bp) (2015) 0.98

Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. Oncogene (2013) 0.92

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation. Mucosal Immunol (2013) 0.92

Diagnostic and prognostic value of neutrophil gelatinase-associated lipocalin, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinases-1 for sepsis in the Emergency Department: an observational study. Crit Care (2014) 0.88

Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. Antimicrob Agents Chemother (2010) 0.83

Pleural fluid analysis of lung cancer vs benign inflammatory disease patients. Br J Cancer (2010) 0.83

The first MMP in sepsis. EMBO Mol Med (2011) 0.82

Matrix metalloproteinase-19 promotes metastatic behavior in vitro and is associated with increased mortality in non-small cell lung cancer. Am J Respir Crit Care Med (2014) 0.80

Interaction of Leptospira interrogans with human proteolytic systems enhances dissemination through endothelial cells and protease levels. Infect Immun (2013) 0.80

Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites. Gut Microbes (2012) 0.79

Low glucose dependent decrease of apoptosis and induction of autophagy in breast cancer MCF-7 cells. Mol Cell Biochem (2016) 0.79

C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function. Mediators Inflamm (2016) 0.78

Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes. J Immunol (2015) 0.77

Significance of circulating and crevicular matrix metalloproteinase-9 in rheumatoid arthritis-chronic periodontitis association. J Immunol Res (2015) 0.77

Vibrio vulnificus MO6-24/O lipopolysaccharide stimulates superoxide anion, thromboxane B₂, matrix metalloproteinase-9, cytokine and chemokine release by rat brain microglia in vitro. Mar Drugs (2014) 0.76

Doxycycline attenuates acute lung injury following cardiopulmonary bypass: involvement of matrix metalloproteinases. Int J Clin Exp Pathol (2014) 0.75

Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study. PLoS One (2016) 0.75

Matrix metalloproteinases -8 and -9 and tissue inhibitor of metalloproteinase-1 in burn patients. A prospective observational study. PLoS One (2015) 0.75

Matrix metalloproteinases contribute to the regulation of chemokine expression and pulmonary inflammation in Cryptococcus infection. Clin Exp Immunol (2015) 0.75

MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment. Int J Mol Sci (2016) 0.75

Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review. Front Microbiol (2016) 0.75

Articles cited by this

(truncated to the top 100)

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58

The immunopathogenesis of sepsis. Nature (2002) 11.83

Sepsis in European intensive care units: results of the SOAP study. Crit Care Med (2006) 11.78

DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol (2006) 10.73

Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol (2007) 10.17

Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med (2003) 9.78

Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science (1998) 8.16

Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol (2004) 6.83

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science (1999) 6.49

Toll-like receptor signaling pathways. Science (2003) 5.86

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med (2002) 5.70

Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol (2003) 5.46

Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature (1994) 4.78

The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem (2001) 4.74

Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol (2003) 4.16

The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med (2005) 4.07

HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem (2002) 4.03

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99

Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol (2001) 3.76

Animal models of sepsis and shock: a review and lessons learned. Shock (1998) 3.65

Animal models of sepsis: setting the stage. Nat Rev Drug Discov (2005) 3.63

Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat Rev Drug Discov (2007) 3.36

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci (2005) 3.33

Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol (2002) 3.32

Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture. Shock (2000) 3.12

Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing. J Immunol (1998) 3.04

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell (2001) 2.97

Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci (2006) 2.81

Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature (1995) 2.40

Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J Clin Invest (2000) 2.39

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J Leukoc Biol (2007) 2.36

TIMPs as multifacial proteins. Crit Rev Oncol Hematol (2004) 2.18

Control of matrix metalloproteinase catalytic activity. Matrix Biol (2007) 2.18

The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis. Int J Med Microbiol (2007) 2.16

Matrix metalloproteinases as modulators of inflammation. Semin Cell Dev Biol (2007) 2.14

Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation (1998) 2.11

Cytokine cascade in sepsis. Scand J Infect Dis (2003) 2.09

Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology (2005) 2.03

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PLoS One (2007) 2.01

The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases. Crit Rev Biochem Mol Biol (2007) 1.90

Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis. J Immunol (2007) 1.85

Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice. J Pathol (2008) 1.84

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. J Biol Chem (1991) 1.81

The paradox of matrix metalloproteinases in infectious disease. Clin Exp Immunol (2005) 1.71

Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock (2004) 1.69

Degradation of interleukin 1beta by matrix metalloproteinases. J Biol Chem (1996) 1.69

Neutrophil emigration in the lungs, peritoneum, and skin does not require gelatinase B. Am J Respir Cell Mol Biol (1999) 1.69

Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro. FASEB J (2004) 1.69

Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation. Neurobiol Dis (2006) 1.68

The Gram Stain and Differential Staining. J Bacteriol (1933) 1.65

Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsis. Scand J Infect Dis (2006) 1.65

Cutting edge: an endogenous pathway to systemic inflammatory response syndrome (SIRS)-like reactions through Toll-like receptor 4. J Immunol (2004) 1.62

Matrix metalloproteinase-9 concentrations in critically ill patients. Anaesthesia (2001) 1.60

Introduction: the role of innate immunity in the adaptive immune response Semin Immunol (1998) 1.58

Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol (2004) 1.57

Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs. Semin Immunopathol (2007) 1.54

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res (1996) 1.53

Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators. Am J Respir Cell Mol Biol (1999) 1.52

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood (2008) 1.52

Stimulation of MMP-7 (matrilysin) by Helicobacter pylori in human gastric epithelial cells: role in epithelial cell migration. J Cell Sci (2003) 1.51

Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem (2000) 1.48

Matrix metalloproteinase inhibition by green tea catechins. Biochim Biophys Acta (2000) 1.48

MT1-MMP: a tethered collagenase. J Cell Physiol (2004) 1.45

Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. J Immunol (2006) 1.45

Conditional signaling by Toll-like receptor 4. FASEB J (2005) 1.42

Bacterial exposure induces and activates matrilysin in mucosal epithelial cells. J Cell Biol (2000) 1.41

Gelatinase B modulates selective opening of the blood-brain barrier during inflammation. Am J Physiol (1998) 1.39

LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med (1999) 1.35

Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am J Pathol (2008) 1.33

Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase. Biochem Biophys Res Commun (2003) 1.33

Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. Biotechniques (2002) 1.33

Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J Immunol (2003) 1.32

Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis. J Immunol (2006) 1.29

Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. J Immunol (2005) 1.29

The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. Gastroenterology (2006) 1.29

Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infect Immun (1996) 1.24

A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol (2007) 1.23

Preclinical models of shock and sepsis: what can they tell us? Shock (2005) 1.23

A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection. BMC Med Genet (2006) 1.21

Modulation of plasma metalloproteinase-9 concentrations and peripheral blood monocyte mRNA levels in patients with septic shock: effect of fiber-immobilized polymyxin B treatment. Am J Med Sci (1998) 1.21

Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa. Infect Immun (2007) 1.20

Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice. Infect Immun (2005) 1.20

Sepsis in the 21st century: recent definitions and therapeutic advances. Am J Emerg Med (2007) 1.20

Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity. Immunobiology (2007) 1.18

Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand. Am J Physiol Regul Integr Comp Physiol (2000) 1.17

Inhibition of matrix metalloproteinases protects mice from ascending infection and chronic disease manifestations resulting from urogenital Chlamydia muridarum infection. Infect Immun (2006) 1.17

The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. Biochemistry (2002) 1.17

p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol Biol Cell (2008) 1.15

The dynamics of LPS recognition: complex orchestration of multiple receptors. J Endotoxin Res (2005) 1.15

Increased production of gelatinase B (matrix metalloproteinase-9) and interleukin-6 by activated rat microglia in culture. J Neurosci Res (1995) 1.14

Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury. Evidence for alveolar macrophage as source of proteinases. Am J Respir Cell Mol Biol (1999) 1.13

Toll-like receptor family and signalling pathway. Biochem Soc Trans (2000) 1.11

Ethanol ingestion increases activation of matrix metalloproteinases in rat lungs during acute endotoxemia. Am J Respir Crit Care Med (1999) 1.10

Corticosteroids for septic shock. Crit Care Med (2001) 1.09

Regulation of matrilysin expression in airway epithelial cells by Pseudomonas aeruginosa flagellin. J Biol Chem (2001) 1.07

Activation of human matrix metalloproteinases by various bacterial proteinases. J Biol Chem (1997) 1.07

Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones. J Immunol (1995) 1.07

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity. Biochemistry (2008) 1.07

Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro. Exp Mol Pathol (2004) 1.06

Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats. J Surg Res (2003) 1.06

Articles by these authors

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity (2011) 3.53

Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol (2007) 2.82

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J Leukoc Biol (2007) 2.36

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J Exp Med (2009) 2.28

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? Trends Microbiol (2011) 2.23

Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem (2006) 1.91

X-chromosome-located microRNAs in immunity: might they explain male/female differences? The X chromosome-genomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females. Bioessays (2011) 1.77

Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Rev (2003) 1.72

IL-17 produced by Paneth cells drives TNF-induced shock. J Exp Med (2008) 1.71

Matrix metalloproteinase-8: cleavage can be decisive. Cytokine Growth Factor Rev (2006) 1.69

A fully dissociated compound of plant origin for inflammatory gene repression. Proc Natl Acad Sci U S A (2005) 1.55

Modeling lymphangiogenesis in a three-dimensional culture system. Nat Methods (2008) 1.55

Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab (2010) 1.49

MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J (2003) 1.42

The liver stage of Plasmodium berghei inhibits host cell apoptosis. Mol Microbiol (2005) 1.40

Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage. J Cell Biol (2007) 1.38

N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus. Hepatology (2007) 1.37

HSP70 protects against TNF-induced lethal inflammatory shock. Immunity (2002) 1.37

Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB J (2004) 1.34

How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering. Mol Cell Endocrinol (2012) 1.30

New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation. Endocrinology (2013) 1.29

Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. J Immunol (2005) 1.29

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A (2006) 1.25

Type I interferon drives tumor necrosis factor-induced lethal shock. J Exp Med (2009) 1.25

Inflammation: A nervous connection. Nature (2003) 1.21

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF. EMBO Mol Med (2013) 1.17

Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1. Cytokine Growth Factor Rev (2011) 1.17

In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography. Mol Cell Proteomics (2009) 1.16

On the trail of the glucocorticoid receptor: into the nucleus and back. Traffic (2011) 1.16

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways. Diabetes (2008) 1.14

N-glycomic changes in serum proteins during human aging. Rejuvenation Res (2007) 1.13

Thirty years of Mus spretus: a promising future. Trends Genet (2009) 1.12

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J (2011) 1.10

Serum N-glycan profile shift during human ageing. Exp Gerontol (2010) 1.08

Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I:C) in D-galactosamine-sensitized mice. Cytokine (2008) 1.07

Matrix metalloproteinases as drug targets in ischemia/reperfusion injury. Drug Discov Today (2011) 1.04

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases. J Neurosci (2012) 1.04

Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation. J Clin Invest (2012) 1.03

Matrilysin (matrix metalloproteinase-7): a new promising drug target in cancer and inflammation? Cytokine Growth Factor Rev (2004) 1.01

Serum protein N-glycans profiling for the discovery of potential biomarkers for nonalcoholic steatohepatitis. J Proteome Res (2009) 1.00

Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression. Cytokine Growth Factor Rev (2011) 1.00

N-glycan profiling in the study of human aging. Biogerontology (2008) 0.97

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest (2013) 0.96

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality. Hepatology (2005) 0.96

IFNβ produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response. Cancer Res (2011) 0.93

Tumor necrosis factor inhibits glucocorticoid receptor function in mice: a strong signal toward lethal shock. J Biol Chem (2011) 0.92

Crosstalk between TNF and glucocorticoid receptor signaling pathways. Cytokine Growth Factor Rev (2010) 0.92

Should we inhibit type I interferons in sepsis? Infect Immun (2006) 0.92

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome. EMBO Mol Med (2013) 0.92

Controlling complexity: the clinical relevance of mouse complex genetics. Eur J Hum Genet (2013) 0.92

Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy. Proc Natl Acad Sci U S A (2002) 0.91

N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing. Mech Ageing Dev (2008) 0.91

Altered serum glycomics in Alzheimer disease: a potential blood biomarker? Rejuvenation Res (2010) 0.91

Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis. J Infect Dis (2013) 0.90

Mx1 causes resistance against influenza A viruses in the Mus spretus-derived inbred mouse strain SPRET/Ei. Cytokine (2008) 0.88

Comprehensive overview of the structure and regulation of the glucocorticoid receptor. Endocr Rev (2014) 0.87

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells. Biomaterials (2011) 0.87

Mice lacking alpha(2)-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock. Eur Cytokine Netw (2002) 0.86

The mouse as a model organism in aging research: usefulness, pitfalls and possibilities. Ageing Res Rev (2012) 0.86

Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo. J Exp Med (2009) 0.86

Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis. Transplantation (2004) 0.85

Altered serum N-glycomics in chronic hepatitis B patients. Liver Int (2009) 0.85

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1. Cell Mol Life Sci (2013) 0.84

A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen. Eur J Immunol (2008) 0.84

An acute phase protein ready to go therapeutic for sepsis. EMBO Mol Med (2014) 0.84

Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice. J Biol Chem (2010) 0.83

Alteration in N-glycomics during mouse aging: a role for FUT8. Aging Cell (2011) 0.83

The glucocorticoid receptor in inflammatory processes: transrepression is not enough. Biol Chem (2015) 0.83

Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-β production capable of improving dendritic cell function. Eur J Immunol (2013) 0.82

The first MMP in sepsis. EMBO Mol Med (2011) 0.82

Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar typhimurium in the inbred mouse strain SPRET/Ei. Infect Immun (2010) 0.82

Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids. Stem Cells (2004) 0.81

Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death. Rejuvenation Res (2008) 0.81

Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat. Mol Cancer (2010) 0.81

Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer. Liver Int (2010) 0.81

Human disease: Strength to strength for mouse models. Nature (2012) 0.80

Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy. Cancer Res (2007) 0.80

How glucocorticoids control their own strength and the balance between pro- and anti-inflammatory mediators. Eur J Immunol (2005) 0.80

Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders. Mamm Genome (2004) 0.79

Nonclassical export pathway: overexpression of NCE102 reduces protein and DNA damage and prolongs lifespan in an SGS1 deficient Saccharomyces cerevisiae. Biogerontology (2007) 0.79

Hop bitter acids efficiently block inflammation independent of GRalpha, PPARalpha, or PPARgamma. Mol Nutr Food Res (2009) 0.79

Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis. PLoS One (2013) 0.78

Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma. Cancer Biomark (2012) 0.77

Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models. Int J Cancer (2014) 0.76

TNF-mediated toxicity after massive induction of specific CD8+ T cells following immunization of mice with a tumor-specific peptide. J Immunol (2002) 0.76

Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen. J Control Release (2011) 0.76

Cofactor profiling of the glucocorticoid receptor from a cellular environment. Methods Mol Biol (2014) 0.75

Claude Libert. Lancet (2003) 0.75

Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice. Mol Cancer Ther (2007) 0.75

Strategies to inhibit the toxicity of systemic TNF treatment. Adv Exp Med Biol (2011) 0.75

Magnetic layer-by-layer coated particles for efficient MRI of dendritic cells and mesenchymal stem cells. Nanomedicine (Lond) (2013) 0.75

Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock. J Immunol (2007) 0.75

[N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus]. Zhonghua Gan Zang Bing Za Zhi (2008) 0.75

Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis. Crit Care Med (2017) 0.75