Innate immune responses to influenza A H5N1: friend or foe?

PubWeight™: 1.89‹?› | Rank: Top 3%

🔗 View Article (PMID 19864182)

Published in Trends Immunol on October 26, 2009

Authors

Joseph Sriyal Malik Peiris1, Chung Yan Cheung, Connie Yin Hung Leung, John Malcolm Nicholls

Author Affiliations

1: Department of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam, Hong Kong SAR. malik@hkucc.hku.hk

Articles citing this

Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58

The airway epithelium: soldier in the fight against respiratory viruses. Clin Microbiol Rev (2011) 2.05

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus. Nat Commun (2011) 1.65

Host response to influenza virus: protection versus immunopathology. Curr Opin Immunol (2010) 1.55

Pathogenicity of the novel A/H7N9 influenza virus in mice. MBio (2013) 1.49

Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults. PLoS One (2011) 1.35

Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol (2011) 1.30

A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead. BMC Public Health (2011) 1.27

The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding. Virology (2011) 1.25

A single E627K mutation in the PB2 protein of H9N2 avian influenza virus increases virulence by inducing higher glucocorticoids (GCs) level. PLoS One (2012) 1.21

Pathogenic potential of interferon αβ in acute influenza infection. Nat Commun (2014) 1.19

Negative regulation of lung inflammation and immunopathology by TNF-α during acute influenza infection. Am J Pathol (2011) 1.16

Comparison of pandemic (H1N1) 2009 and seasonal influenza viral loads, Singapore. Emerg Infect Dis (2011) 1.12

Age-related sensitivity and pathological differences in infections by 2009 pandemic influenza A (H1N1) virus. Virol J (2011) 1.09

Host gene expression profiling in influenza A virus-infected lung epithelial (A549) cells: a comparative analysis between highly pathogenic and modified H5N1 viruses. Virol J (2010) 1.08

Suppression of innate immune pathology by regulatory T cells during Influenza A virus infection of immunodeficient mice. J Virol (2010) 1.01

PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest (2012) 1.00

Microarray analysis of microRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1). BMC Infect Dis (2013) 0.98

Animal models for influenza virus pathogenesis, transmission, and immunology. J Immunol Methods (2014) 0.98

Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems. BMC Syst Biol (2011) 0.97

Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus. Antimicrob Agents Chemother (2013) 0.96

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection. PLoS Pathog (2012) 0.96

Characteristics of human infection with avian influenza viruses and development of new antiviral agents. Acta Pharmacol Sin (2013) 0.94

The cytokine storm of severe influenza and development of immunomodulatory therapy. Cell Mol Immunol (2015) 0.94

Human H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism. J Virol (2014) 0.93

Transcription analysis on response of swine lung to H1N1 swine influenza virus. BMC Genomics (2011) 0.93

Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent FcγR pathway. J Virol (2011) 0.93

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release. J Virol (2012) 0.92

Prevalence of gastrointestinal symptoms in patients with influenza, clinical significance, and pathophysiology of human influenza viruses in faecal samples: what do we know? Virol J (2015) 0.92

A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection. PLoS One (2011) 0.91

Association of Mx1 Asn631 variant alleles with reductions in morbidity, early mortality, viral shedding, and cytokine responses in chickens infected with a highly pathogenic avian influenza virus. Immunogenetics (2011) 0.90

Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs. Front Immunol (2015) 0.90

Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection. PLoS One (2013) 0.88

Seasonal influenza A virus in feces of hospitalized adults. Emerg Infect Dis (2011) 0.85

Moving H5N1 studies into the era of systems biology. Virus Res (2013) 0.84

Efficient sensing of avian influenza viruses by porcine plasmacytoid dendritic cells. Viruses (2011) 0.84

Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in Toll-like receptor 3 knockout mice. J Gen Virol (2014) 0.84

Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis. PLoS One (2014) 0.81

Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases. PLoS One (2014) 0.81

An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo. J Gen Virol (2012) 0.81

The immuno-regulatory impact of orally-administered Hypericum perforatum extract on Balb/C mice inoculated with H1n1 influenza A virus. PLoS One (2013) 0.80

Editorial: macrophage heterogeneity and responses to influenza virus infection. J Leukoc Biol (2012) 0.80

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A (2016) 0.79

CD8+ Treg cells suppress CD8+ T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection. Eur J Immunol (2013) 0.79

Host cytokine responses of pigeons infected with highly pathogenic Thai avian influenza viruses of subtype H5N1 isolated from wild birds. PLoS One (2011) 0.79

Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with lethal influenza H1N1 Virus. PLoS One (2012) 0.79

Kinetic analysis of the immunity in a pregnant patient infected with avian influenza H7N9. Int J Clin Exp Med (2014) 0.79

Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection. BMC Med Genomics (2015) 0.78

Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline. PLoS One (2014) 0.77

Reduction of influenza virus-induced lung inflammation and mortality in animals treated with a phosophodisestrase-4 inhibitor and a selective serotonin reuptake inhibitor. Emerg Microbes Infect (2013) 0.77

Combinations of Oseltamivir and T-705 Extend the Treatment Window for Highly Pathogenic Influenza A(H5N1) Virus Infection in Mice. Sci Rep (2016) 0.77

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ (2014) 0.77

Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis. PLoS One (2015) 0.76

Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus. Sci Rep (2016) 0.76

Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells. Sci Rep (2016) 0.76

Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species. PLoS Pathog (2017) 0.75

H5N1 Virus Hemagglutinin Inhibition of cAMP-Dependent CFTR via TLR4-Mediated Janus Tyrosine Kinase 3 Activation Exacerbates Lung Inflammation. Mol Med (2015) 0.75

AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality. J Immunol (2017) 0.75

Expression of chicken interleukin-2 by a highly virulent strain of Newcastle disease virus leads to decreased systemic viral load but does not significantly affect mortality in chickens. Virol J (2015) 0.75

Systems biology from virus to humans. J Anal Sci Technol (2015) 0.75

Short-Term Heat Shock Affects Host-Virus Interaction in Mice Infected with Highly Pathogenic Avian Influenza Virus H5N1. Front Microbiol (2016) 0.75

Passive broad-spectrum influenza immunoprophylaxis. Influenza Res Treat (2014) 0.75

Protective immunity and safety of a genetically modified influenza virus vaccine. PLoS One (2014) 0.75

Lung cytokine gene expression is correlated with increased severity of disease in a novel H4N8 influenza virus isolated from shorebirds. J Vet Med Sci (2013) 0.75

NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice. PLoS One (2016) 0.75

Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm. MBio (2017) 0.75

Articles cited by this

Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med (2009) 42.75

Evolution and ecology of influenza A viruses. Microbiol Rev (1992) 39.99

Incidence and outcomes of acute lung injury. N Engl J Med (2005) 21.56

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science (2001) 18.43

Characterization of the 1918 influenza virus polymerase genes. Nature (2005) 15.73

Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med (2009) 14.48

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21

Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet (1998) 12.89

The immunopathogenesis of sepsis. Nature (2002) 11.83

Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature (2009) 11.34

Avian flu: influenza virus receptors in the human airway. Nature (2006) 11.28

Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40

Update on avian influenza A (H5N1) virus infection in humans. N Engl J Med (2008) 10.27

Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR Morb Mortal Wkly Rep (2009) 9.94

Re-emergence of fatal human influenza A subtype H5N1 disease. Lancet (2004) 9.36

Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet (2002) 8.70

Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology (1999) 7.32

Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One (2008) 6.98

H5N1 influenza: a protean pandemic threat. Proc Natl Acad Sci U S A (2004) 6.61

Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N Engl J Med (2005) 6.47

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature (2006) 6.46

Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev (2007) 6.38

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

H5N1 Virus Attachment to Lower Respiratory Tract. Science (2006) 6.34

PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology (2004) 5.96

The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med (2006) 5.94

Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. J Clin Invest (1998) 5.70

Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe (2007) 5.46

The pathology of influenza virus infections. Annu Rev Pathol (2008) 5.37

Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol (2006) 4.88

Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals. Am J Pathol (2007) 4.86

H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog (2008) 4.79

H5N1 infection of the respiratory tract and beyond: a molecular pathology study. Lancet (2007) 4.62

Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathog (2007) 4.49

Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respir Res (2005) 4.41

Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A (2009) 4.36

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. J Clin Invest (2008) 4.30

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A (2009) 4.12

Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans. J Clin Virol (2009) 4.10

Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol (2001) 4.08

Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol (2006) 4.00

A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci U S A (2008) 3.99

Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans. J Virol (2000) 3.88

Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. Virology (2001) 3.76

Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract. Nat Med (2007) 3.75

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A (2009) 3.70

Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol (2004) 3.65

Factors associated with case fatality of human H5N1 virus infections in Indonesia: a case series. Lancet (2008) 3.62

Cell-mediated protection in influenza infection. Emerg Infect Dis (2006) 3.62

Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog (2005) 3.44

Influenza A H5N1 replication sites in humans. Emerg Infect Dis (2005) 3.21

Risk factors associated with subclinical human infection with avian influenza A (H5N1) virus--Cambodia, 2006. J Infect Dis (2009) 3.05

Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog (2006) 3.04

Influenza-associated mortality in Hong Kong. Clin Infect Dis (2004) 3.02

Pathology of human influenza revisited. Vaccine (2008) 2.71

Continuing progress towards a unified nomenclature for the highly pathogenic H5N1 avian influenza viruses: divergence of clade 2.2 viruses. Influenza Other Respir Viruses (2009) 2.47

Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses. Respir Res (2007) 2.45

Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response. Immunol Rev (2008) 2.41

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc Natl Acad Sci U S A (2008) 2.33

Highly pathogenic avian influenza H5N1 viruses elicit an attenuated type i interferon response in polarized human bronchial epithelial cells. J Virol (2007) 2.23

Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. J Virol (2008) 2.23

Influenza A infection is an important cause of febrile seizures. Pediatrics (2001) 2.17

Transmission of influenza virus via aerosols and fomites in the guinea pig model. J Infect Dis (2009) 2.12

Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses. J Infect Dis (2003) 2.05

The development and genetic diversity of H5N1 influenza virus in China, 1996-2006. Virology (2008) 2.04

Influenza A/H5N1 virus infection in humans in Cambodia. J Clin Virol (2007) 1.97

Functional tumor necrosis factor-related apoptosis-inducing ligand production by avian influenza virus-infected macrophages. J Infect Dis (2006) 1.91

Animal models for the study of influenza pathogenesis and therapy. Antiviral Res (2009) 1.90

H5N1 influenza A virus and infected human plasma. Emerg Infect Dis (2006) 1.84

Interaction between humans and poultry, rural Cambodia. Emerg Infect Dis (2007) 1.75

Avian influenza receptor expression in H5N1-infected and noninfected human tissues. FASEB J (2007) 1.67

Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK. J Immunol (2009) 1.66

Avian influenza A (H5N1) age distribution in humans. Emerg Infect Dis (2007) 1.66

Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction. Virology (2008) 1.56

High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-alpha and TLR ligands. J Immunol (2007) 1.49

Avian influenza A H5N1 infections in Bali Province, Indonesia: a behavioral, virological and seroepidemiological study. Influenza Other Respir Viruses (2009) 1.48

Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection. J Infect Dis (2008) 1.46

p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. J Virol (2005) 1.45

Pathogenicity of highly pathogenic avian influenza virus in mammals. Vaccine (2008) 1.42

Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages. J Gen Virol (2007) 1.41

Toward a broadly protective influenza vaccine. J Clin Invest (2008) 1.40

Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses. J Infect Dis (2009) 1.37

Cerebrospinal fluid and serum levels of cytokines and soluble tumor necrosis factor receptor in influenza virus-associated encephalopathy. Scand J Infect Dis (2003) 1.36

Influenza virus directly infects human natural killer cells and induces cell apoptosis. J Virol (2009) 1.32

The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1--a review. Hum Pathol (2006) 1.30

Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. J Immunol (2005) 1.30

A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia. Arch Virol (2009) 1.27

Viral genetic determinants of H5N1 influenza viruses that contribute to cytokine dysregulation. J Infect Dis (2009) 1.27

Early control of H5N1 influenza virus replication by the type I interferon response in mice. J Virol (2009) 1.24

Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J Immunol (2009) 1.19

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy. J Antimicrob Chemother (2009) 1.18

Pathology of human H5N1 infection: new findings. Lancet (2007) 1.07

Clinical significance of alimentary tract microbes in bone marrow transplant recipients. Diagn Microbiol Infect Dis (1998) 1.00

Age-specific infection and death rates for human A(H5N1) avian influenza in Egypt. Euro Surveill (2009) 0.98

Enzyme histochemistry of bronchial epithelium and alveolar cells in the early stages of influenza-virus pneumonia of mice. Nature (1962) 0.85