Published in J Biol Chem on December 19, 2002
Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling. Mol Cancer Ther (2014) 0.94
Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem (2011) 0.83
Discovery of p1736, a novel antidiabetic compound that improves peripheral insulin sensitivity in mice models. PLoS One (2013) 0.77
Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. J Lipid Res (2016) 0.76
Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division. J Biol Chem (2016) 0.75
Thiazole formation through a modified Gewald reaction. Beilstein J Org Chem (2015) 0.75
Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome. Int J Med Chem (2013) 0.75
De Novo Lipid Synthesis facilitates Gemcitabine Resistance Through Endoplasmic Reticulum Stress In Pancreatic Cancer. Cancer Res (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem (2006) 5.57
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem (2002) 4.16
Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer (2007) 2.43
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab (2011) 2.42
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol (2009) 2.16
Accuracy of 18F-FDG PET/CT in detecting pelvic and paraaortic lymph node metastasis in patients with endometrial cancer. AJR Am J Roentgenol (2008) 1.66
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol (2011) 1.61
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep (2012) 1.60
A dumbbell-shaped small molecule that promotes cell adhesion and growth. Chem Biol (2009) 1.39
Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value. Magn Reson Med Sci (2004) 1.39
Distributions of beta+ decayed nuclei generated in the CH2 and H2O targets by the target nuclear fragment reaction using therapeutic MONO and SOBP proton beam. Med Phys (2005) 1.29
Spectrum of FDG PET/CT findings of uterine tumors. AJR Am J Roentgenol (2010) 1.23
The relationship between FDG uptake in PET scans and biological behavior in breast cancer. Breast Cancer (2007) 1.23
Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma. Ann Nucl Med (2009) 1.21
Recurrence-free survival after radiofrequency ablation of hepatocellular carcinoma. A registry report of the impact of risk factors on outcome. Jpn J Clin Oncol (2007) 1.19
Performance of integrated FDG-PET/contrast-enhanced CT in the diagnosis of recurrent uterine cancer: comparison with PET and enhanced CT. Eur J Nucl Med Mol Imaging (2008) 1.12
Small molecule transcription factor mimic. J Am Chem Soc (2004) 1.10
Japanese Gastric Cancer Association Task Force for Research Promotion: clinical utility of ¹⁸F-fluoro-2-deoxyglucose positron emission tomography in gastric cancer. A systematic review of the literature. Gastric Cancer (2011) 1.09
Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene (2002) 1.09
Performance of integrated FDG-PET/contrast-enhanced CT in the diagnosis of recurrent ovarian cancer: comparison with integrated FDG-PET/non-contrast-enhanced CT and enhanced CT. Eur J Nucl Med Mol Imaging (2008) 1.09
FDG-PET for the diagnosis of fever of unknown origin: a Japanese multi-center study. Ann Nucl Med (2011) 1.09
Structure of orbitofrontal cortex and its longitudinal course in cancer-related post-traumatic stress disorder. Neurosci Res (2007) 1.03
Diagnostic accuracy of integrated FDG-PET/contrast-enhanced CT in staging ovarian cancer: comparison with enhanced CT. Eur J Nucl Med Mol Imaging (2008) 1.02
Diffusion-weighted single shot echo planar imaging of colorectal cancer using a sensitivity-encoding technique. Jpn J Clin Oncol (2004) 1.01
No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors. Breast Cancer Res Treat (2005) 0.99
Biochemical target isolation for novices: affinity-based strategies. Chem Biol (2010) 0.98
Performance of integrated FDG PET/contrast-enhanced CT in the diagnosis of recurrent colorectal cancer: Comparison with integrated FDG PET/non-contrast-enhanced CT and enhanced CT. Eur J Nucl Med Mol Imaging (2009) 0.98
Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res (2013) 0.97
Pitfalls in lymph node staging with positron emission tomography in non-small cell lung cancer patients. Lung Cancer (2005) 0.97
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget (2010) 0.97
Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosis. Biol Psychiatry (2005) 0.96
Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells. Atherosclerosis (2009) 0.95
A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. J Am Chem Soc (2004) 0.95
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J Am Chem Soc (2007) 0.94
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A (2002) 0.94
Comparison of DWI and PET/CT in evaluation of lymph node metastasis in uterine cancer. World J Radiol (2012) 0.93
Accuracy of integrated FDG-PET/contrast-enhanced CT in detecting pelvic and paraaortic lymph node metastasis in patients with uterine cancer. Eur Radiol (2009) 0.93
Escherichia coli pneumonia in combination with fungal sinusitis and meningitis in a tsunami survivor after the Great East Japan Earthquake. Tohoku J Exp Med (2012) 0.93
Enhancement of insulin signaling through inhibition of tissue lipid accumulation by activation of peroxisome proliferator-activated receptor (PPAR) alpha in obese mice. Med Sci Monit (2004) 0.91
Clinical value of whole-body FDG-PET for recurrent gastric cancer: a multicenter study. Jpn J Clin Oncol (2009) 0.90
Potential role of regucalcin as a specific biochemical marker of chronic liver injury with carbon tetrachloride administration in rats. Mol Cell Biochem (2002) 0.90
Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer. Eur Radiol (2008) 0.90
Regional cerebral glucose metabolism in patients with secondary depressive episodes after fatal pancreatic cancer diagnosis. J Affect Disord (2006) 0.90
A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. J Am Chem Soc (2003) 0.88
Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. ACS Chem Biol (2011) 0.88
Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages. J Lipid Res (2010) 0.88
Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition. J Hepatobiliary Pancreat Sci (2015) 0.88
Effect of hepatocyte growth factor on invasion of prostate cancer cell lines. Oncol Rep (2003) 0.88
Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc Natl Acad Sci U S A (2011) 0.88
Detection of unsuspected distant metastases and/or regional nodes by FDG-PET [corrected] scan in apparent limited-disease small-cell lung cancer. Lung Cancer (2007) 0.88
Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes. J Lipid Res (2011) 0.87
Cancer-related intrusive thoughts as an indicator of poor psychological adjustment at 3 or more years after breast surgery: a preliminary study. Breast Cancer Res Treat (2002) 0.86
Sarcoid-like reaction mimics progression of disease after induction chemotherapy for lung cancer. Ann Thorac Surg (2010) 0.86
Prospective study of positron emission tomography for evaluation of the activity of lapatinib, a dual inhibitor of the ErbB1 and ErbB2 tyrosine kinases, in patients with advanced tumors. Jpn J Clin Oncol (2006) 0.86
Phase II study of motesanib in Japanese patients with advanced gastrointestinal stromal tumors with prior exposure to imatinib mesylate. Cancer Chemother Pharmacol (2009) 0.85
Highly sensitive upregulation of apolipoprotein A-IV by peroxisome proliferator-activated receptor alpha (PPARalpha) agonist in human hepatoma cells. Biochem Pharmacol (2007) 0.85
A novel PPARalpha agonist ameliorates insulin resistance in dogs fed a high-fat diet. Am J Physiol Endocrinol Metab (2008) 0.85
Small-molecule fluorescent probes for specific RNA targets. Chem Commun (Camb) (2011) 0.84
Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier. Microvasc Res (2011) 0.84
Standardized uptake values of uterine leiomyoma with 18F-FDG PET/CT: variation with age, size, degeneration, and contrast enhancement on MRI. Ann Nucl Med (2008) 0.84
Deactivation of STAT6 through serine 707 phosphorylation by JNK. J Biol Chem (2010) 0.84
Relationship between distressing cancer-related recollections and hippocampal volume in cancer survivors. Am J Psychiatry (2002) 0.84
Involvement of protein kinase C in glutamate release from cultured microglia. Brain Res (2003) 0.84
Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. Chem Biol (2004) 0.83
Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. J Lipid Res (2010) 0.83
Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor. Biochim Biophys Acta (2010) 0.83
Additional value of FDG-PET to contrast enhanced-computed tomography (CT) for the diagnosis of mediastinal lymph node metastasis in non-small cell lung cancer: a Japanese multicenter clinical study. Ann Nucl Med (2011) 0.83
Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene. Biochem Pharmacol (2009) 0.83
Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem (2011) 0.83
Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy. Cancer Med (2014) 0.83
Structure-based design of a selective heparanase inhibitor as an antimetastatic agent. Mol Cancer Ther (2004) 0.83
Performance of integrated FDG-PET/contrast-enhanced CT in the diagnosis of recurrent pancreatic cancer: comparison with integrated FDG-PET/non-contrast-enhanced CT and enhanced CT. Mol Imaging Biol (2009) 0.83
Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A. J Am Chem Soc (2013) 0.82
Enhancement of albumin expression in bone tissues with healing rat fractures. J Cell Biochem (2003) 0.82
Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis. Mol Cell Endocrinol (2011) 0.82
A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes. J Lipid Res (2013) 0.81
Performance of FDG-PET/CT in the diagnosis of recurrent endometrial cancer. Ann Nucl Med (2008) 0.81
Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity. J Cell Biochem (2002) 0.81
Clinical significance of performing 18F-FDG PET on patients with gastrointestinal stromal tumors: a summary of a Japanese multicenter study. Ann Nucl Med (2009) 0.81
Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates. Brain Res (2011) 0.81
Pharmacological characterization of a human-specific peroxisome proliferater-activated receptor alpha (PPARalpha) agonist in dogs. Biochem Pharmacol (2004) 0.81
A mitochondrial surface-specific fluorescent probe activated by bioconversion. Angew Chem Int Ed Engl (2011) 0.81
Novel protein RGPR-p117: the gene expression in physiologic state and the binding activity to regucalcin gene promoter region in rat liver. J Cell Biochem (2003) 0.81
Thymic MALT lymphoma: MR imaging findings and their correlation with histopathological findings on four cases. Clin Imaging (2004) 0.80
Small-molecule-induced clustering of heparan sulfate promotes cell adhesion. J Am Chem Soc (2013) 0.80
Hippocampal volume and first major depressive episode after cancer diagnosis in breast cancer survivors. Am J Psychiatry (2004) 0.80
A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc (2015) 0.80
Identification of small molecules that promote human embryonic stem cell self-renewal. Biochem Biophys Res Commun (2013) 0.80
Efficacy of MR mammography (MRM) in providing preoperative locoregional information on breast cancer: correlation between MRM and histological findings. Magn Reson Med Sci (2002) 0.80
Live-cell imaging of endogenous mRNAs with a small molecule. Angew Chem Int Ed Engl (2014) 0.80