Published in Chem Biol on July 31, 2009
Cell adhesion induced using surface modification with cell-penetrating peptide-conjugated PEG-lipid: A new cell glue for 3D cell-based structures. ACS Appl Mater Interfaces (2016) 0.75
Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature (2007) 7.87
The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer (2005) 5.98
Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat Immunol (2005) 3.82
Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol (2011) 2.96
Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe (2007) 2.64
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest (2007) 2.53
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol (2009) 2.16
Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest (2002) 1.91
Evolutionary differences in glycosaminoglycan fine structure detected by quantitative glycan reductive isotope labeling. J Biol Chem (2008) 1.91
Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development (2005) 1.84
Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans. Nat Methods (2008) 1.84
Demystifying heparan sulfate-protein interactions. Annu Rev Biochem (2014) 1.76
Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem (2008) 1.73
Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature (2003) 1.73
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function. Development (2005) 1.69
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol (2011) 1.61
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep (2012) 1.60
Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest (2009) 1.56
Symbol nomenclature for glycan representation. Proteomics (2009) 1.56
Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest (2008) 1.52
A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology (2005) 1.49
Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development (2006) 1.46
Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nat Chem Biol (2012) 1.43
Use of the standard rubber ball as an impact source with heavyweight concrete floors. J Acoust Soc Am (2009) 1.41
Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. J Biol Chem (2003) 1.41
Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood (2009) 1.37
Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis. J Cell Biol (2007) 1.36
Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem (2003) 1.34
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes. Biochim Biophys Acta (2002) 1.34
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. J Cell Biol (2006) 1.29
Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development (2007) 1.27
Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A (2008) 1.26
Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells. Stem Cells (2007) 1.23
Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion. J Virol (2004) 1.23
Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase. J Biol Chem (2008) 1.23
Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate. J Biol Chem (2011) 1.19
Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology (2002) 1.18
A disaccharide precursor of sialyl Lewis X inhibits metastatic potential of tumor cells. Cancer Res (2003) 1.16
Hereditary multiple exostoses and heparan sulfate polymerization. Biochim Biophys Acta (2002) 1.15
Quantitative trait loci analysis for growth and carcass traits in a Meishan x Duroc F2 resource population. J Anim Sci (2003) 1.13
Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem (2009) 1.13
Small molecule transcription factor mimic. J Am Chem Soc (2004) 1.10
Tumor attenuation by combined heparan sulfate and polyamine depletion. Proc Natl Acad Sci U S A (2001) 1.09
Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin. Metab Eng (2012) 1.09
Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2005) 1.09
Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene (2002) 1.09
The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. J Biol Chem (2003) 1.08
Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites. J Biol Chem (2002) 1.07
Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway. J Biol Chem (2007) 1.07
Stable RAGE-heparan sulfate complexes are essential for signal transduction. ACS Chem Biol (2013) 1.07
CHO glycosylation mutants: proteoglycans. Methods Enzymol (2006) 1.06
Glycan antagonists and inhibitors: a fount for drug discovery. Crit Rev Biochem Mol Biol (2007) 1.05
Cell surface heparan sulfate is a receptor for attachment of envelope protein-free retrovirus-like particles and VSV-G pseudotyped MLV-derived retrovirus vectors to target cells. Mol Ther (2002) 1.05
Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol (2004) 1.05
Selectin blocking activity of a fucosylated chondroitin sulfate glycosaminoglycan from sea cucumber. Effect on tumor metastasis and neutrophil recruitment. J Biol Chem (2007) 1.04
Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development. Dev Dyn (2007) 1.04
Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans. J Biol Chem (2006) 1.03
Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability. J Biol Chem (2010) 1.02
Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem (2002) 1.01
Deficiency of endothelial heparan sulfates attenuates allergic airway inflammation. J Immunol (2009) 1.00
Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate. Immunology (2008) 0.99
Heparan sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE). J Biol Chem (2011) 0.98
Biochemical target isolation for novices: affinity-based strategies. Chem Biol (2010) 0.98
Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones. Bone (2011) 0.98
Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood (2012) 0.97
Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res (2013) 0.97
Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem (2008) 0.97
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget (2010) 0.97
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis. J Biol Chem (2008) 0.96
Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathog (2011) 0.96
Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism. Curr Opin Lipidol (2008) 0.95
Expression patterns of alpha 2,3-sialyltransferases and alpha 1,3-fucosyltransferases determine the mode of sialyl Lewis X inhibition by disaccharide decoys. J Biol Chem (2003) 0.95
A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. J Am Chem Soc (2004) 0.95
Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest (2013) 0.95
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A (2002) 0.94
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J Am Chem Soc (2007) 0.94
Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol (2010) 0.94
Secondary storage of dermatan sulfate in Sanfilippo disease. J Biol Chem (2010) 0.94
Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One (2010) 0.94
Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol (2011) 0.93
Cooperative, heparan sulfate-dependent cellular uptake of dimeric guanidinoglycosides. Chembiochem (2010) 0.93
A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination. Clin Cancer Res (2006) 0.92
Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis. Arterioscler Thromb Vasc Biol (2012) 0.91
Covalent blocking of fibril formation and aggregation of intracellular amyloidgenic proteins by transglutaminase-catalyzed intramolecular cross-linking. Biochemistry (2005) 0.91
Insulin-dependent diabetes mellitus in mice does not alter liver heparan sulfate. J Biol Chem (2010) 0.91
Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One (2010) 0.90
Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity. J Cell Sci (2004) 0.90
Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling. J Mol Cell Cardiol (2010) 0.89
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Proc Natl Acad Sci U S A (2012) 0.89
Hepatic heparan sulfate proteoglycans and endocytic clearance of triglyceride-rich lipoproteins. Prog Mol Biol Transl Sci (2010) 0.89
Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes. Mol Ther (2010) 0.89
Effects of chemically modified heparin on Chlamydia trachomatis serovar L2 infection of eukaryotic cells in culture. Glycobiology (2002) 0.89
Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif. J Am Soc Mass Spectrom (2008) 0.89
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest (2016) 0.89
A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. J Am Chem Soc (2003) 0.88
Cell surface heparan sulfate promotes replication of Toxoplasma gondii. Infect Immun (2005) 0.88
Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. ACS Chem Biol (2011) 0.88
Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol (2011) 0.88