Published in Chem Biol on June 25, 2010
Discovery of small molecule cancer drugs: successes, challenges and opportunities. Mol Oncol (2012) 1.55
Identification of direct protein targets of small molecules. ACS Chem Biol (2010) 1.44
A mammalian functional-genetic approach to characterizing cancer therapeutics. Nat Chem Biol (2010) 1.26
Identifying compound-target associations by combining bioactivity profile similarity search and public databases mining. J Chem Inf Model (2011) 1.12
Target deconvolution techniques in modern phenotypic profiling. Curr Opin Chem Biol (2013) 1.08
Total synthesis and biological evaluation of tyroscherin. Org Lett (2010) 0.92
Biological targets and mechanisms of action of natural products from marine cyanobacteria. Nat Prod Rep (2015) 0.90
Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation. Bioorg Med Chem Lett (2010) 0.84
Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. PLoS Negl Trop Dis (2013) 0.79
Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis. ACS Chem Neurosci (2014) 0.78
Fluorescent Probes for Subcellular Localization during Osteclast Formation. ACS Med Chem Lett (2014) 0.75
A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. PLoS One (2016) 0.75
Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification. Sci Rep (2016) 0.75
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol (2009) 2.16
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol (2011) 1.61
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep (2012) 1.60
A dumbbell-shaped small molecule that promotes cell adhesion and growth. Chem Biol (2009) 1.39
Small molecule transcription factor mimic. J Am Chem Soc (2004) 1.10
Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene (2002) 1.09
Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem (2002) 1.01
Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res (2013) 0.97
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget (2010) 0.97
A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. J Am Chem Soc (2004) 0.95
External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A (2002) 0.94
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J Am Chem Soc (2007) 0.94
VEGF-A and alphaVbeta3 integrin synergistically rescue angiogenesis via N-Ras and PI3-K signaling in human microvascular endothelial cells. FASEB J (2003) 0.92
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J Invest Dermatol (2003) 0.92
Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes: a modality for boron neutron capture therapy. J Neurooncol (2008) 0.89
A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. J Am Chem Soc (2003) 0.88
Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. ACS Chem Biol (2011) 0.88
Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years. Gastric Cancer (2007) 0.86
Small-molecule fluorescent probes for specific RNA targets. Chem Commun (Camb) (2011) 0.84
Deactivation of STAT6 through serine 707 phosphorylation by JNK. J Biol Chem (2010) 0.84
Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem (2011) 0.83
Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. Chem Biol (2004) 0.83
Expression of various glutamate receptors including N-methyl-D-aspartate receptor (NMDAR) in an ovarian teratoma removed from a young woman with anti-NMDAR encephalitis. Intern Med (2010) 0.82
Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A. J Am Chem Soc (2013) 0.82
A mitochondrial surface-specific fluorescent probe activated by bioconversion. Angew Chem Int Ed Engl (2011) 0.81
Small-molecule-induced clustering of heparan sulfate promotes cell adhesion. J Am Chem Soc (2013) 0.80
Identification of small molecules that promote human embryonic stem cell self-renewal. Biochem Biophys Res Commun (2013) 0.80
Live-cell imaging of endogenous mRNAs with a small molecule. Angew Chem Int Ed Engl (2014) 0.80
Wrenchnolol derivative optimized for gene activation in cells. J Am Chem Soc (2009) 0.80
A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc (2015) 0.80
Small organic molecules that modulate gene transcription. Drug Discov Today (2006) 0.79
Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chem Biol (2006) 0.79
Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis. J Biomol Screen (2011) 0.78
[Role of LXRs in control of lipogenesis]. Tanpakushitsu Kakusan Koso (2007) 0.78
Development of a novel rapid immunochromatographic test specific for the H5 influenza virus. J Virol Methods (2011) 0.78
[Correlation between clinical pathologic factors and enzymatic activity of orotate Phosphoribosyl transferase (OPRT), Dihydropyrimidine dehydrogenase (DPD) and Thymidylate synthase (TS) in colorectal cancer]. Gan To Kagaku Ryoho (2006) 0.77
A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. J Am Chem Soc (2016) 0.77
Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Angew Chem Int Ed Engl (2014) 0.76
Translational repression stabilizes messenger RNA of autophagy-related genes. Genes Cells (2011) 0.76
Selective elimination of human pluripotent stem cells by a marine natural product derivative. J Am Chem Soc (2014) 0.76
Formation of a ligand-assisted complex of two RNA hairpin loops. Chemistry (2014) 0.76
[In-vivo activation of the p53 pathway by small-molecule antagonists of MDM2]. Tanpakushitsu Kakusan Koso (2007) 0.76
[Prediction of sensitivity to 5-fluorouracil (5-fu) by metabolic and target enzyme activities in colon cancer]. Gan To Kagaku Ryoho (2006) 0.75
Correction to "Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators". ACS Chem Biol (2020) 0.75
[Substance P and anticancer drug-induced emesis]. Gan To Kagaku Ryoho (2007) 0.75
[Discovering high-affinity ligands for proteins: SAR by NMR]. Tanpakushitsu Kakusan Koso (2007) 0.75
Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Biochem J (2012) 0.75
Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J (2010) 0.75
[Antitumor effect of paclitaxel for gastric cancer is AUC dependent]. Gan To Kagaku Ryoho (2008) 0.75
Efficient N-Acyldopamine Synthesis. Chem Pharm Bull (Tokyo) (2016) 0.75
Synthesis of synthetic small molecule transcription factors (STF). Nucleic Acids Symp Ser (Oxf) (2006) 0.75
Ligand-inducible formation of RNA pseudoknot. Bioorg Med Chem Lett (2013) 0.75
High efficacy of imatinib for recurrent gastrointestinal stromal tumor in the jejunum: a case report. J Nippon Med Sch (2004) 0.75
Structure-activity studies on the fluorescent indicator in a displacement assay for the screening of small molecules binding to RNA. Chemistry (2012) 0.75
[Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography]. Tanpakushitsu Kakusan Koso (2007) 0.75
[Evaluation of S-1 for stage IV gastric cancer]. Gan To Kagaku Ryoho (2011) 0.75
Synthesis of 24,24-Difluoro-1,3-cis-25-dihydroxy-19-norvitamin D3 Derivatives and Evaluation of Their Vitamin D Receptor-Binding Affinity. Biol Pharm Bull (2016) 0.75
[Three advanced gastric cancer patients successfully treated by combination therapy of paclitaxel and cisplatin]. Gan To Kagaku Ryoho (2007) 0.75
[Trends in chemical libraries for chemical genetics]. Tanpakushitsu Kakusan Koso (2005) 0.75
Synthesis of Diastereomers of 1,3-cis-25-Dihydroxy-19-norvitamin D3. Chem Pharm Bull (Tokyo) (2016) 0.75