Published in Mol Cancer Res on November 01, 2002
Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34
Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol (2009) 3.09
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80
Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol (2004) 2.57
Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages. Proc Natl Acad Sci U S A (2006) 2.32
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions. Clin Exp Metastasis (2008) 2.30
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology (2009) 2.25
Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. J Biol Chem (2003) 2.12
Epithelial-to-mesenchymal transitions in the liver. Hepatology (2009) 1.99
Epithelial-mesenchymal transition in hepatocellular carcinoma. Future Oncol (2009) 1.85
Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol (2006) 1.82
Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways. Hepatology (2008) 1.82
Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol (2009) 1.81
Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation. Am J Pathol (2006) 1.76
Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis. Mol Biol Cell (2007) 1.61
Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol (2003) 1.59
Stem cells, cell transplantation and liver repopulation. Biochim Biophys Acta (2007) 1.37
Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut (2006) 1.31
Snail transcription factor regulates neuroendocrine differentiation in LNCaP prostate cancer cells. Prostate (2010) 1.18
Molecular pathways: linking tumor microenvironment to epithelial-mesenchymal transition in metastasis. Clin Cancer Res (2014) 1.17
NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. PLoS One (2012) 1.17
Tight junction proteins: from barrier to tumorigenesis. Cancer Lett (2013) 1.14
Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity. Oncotarget (2014) 1.05
Prognostic impact of EMT (epithelial-mesenchymal-transition)-related protein expression in endometrial cancer. Cancer Biol Ther (2012) 1.03
Cellular sources of extracellular matrix in hepatic fibrosis. Clin Liver Dis (2008) 1.03
Tumor Budding: The Name is EMT. Partial EMT. J Clin Med (2016) 1.00
MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1. Carcinogenesis (2012) 0.99
Akt promotes endocardial-mesenchyme transition. J Angiogenes Res (2009) 0.99
Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells. Breast Cancer Res (2013) 0.96
Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin). Cell Cycle (2012) 0.95
Transcriptional networks in epithelial-mesenchymal transition. PLoS One (2011) 0.95
Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli. J Cell Physiol (2012) 0.92
Mechanisms of transforming growth factor β induced cell cycle arrest in palate development. J Cell Physiol (2011) 0.91
Epilysin (matrix metalloproteinase-28) contributes to airway epithelial cell survival. Respir Res (2011) 0.90
The role of the transcriptional regulator snail in cell detachment, reattachment and migration. Cell Adh Migr (2009) 0.89
Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte. Liver Int (2014) 0.88
Growth factor- and cytokine-driven pathways governing liver stemness and differentiation. World J Gastroenterol (2010) 0.88
TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. PLoS One (2013) 0.88
New Insights into the Crossroads between EMT and Stemness in the Context of Cancer. J Clin Med (2016) 0.88
The EMT (epithelial-mesenchymal-transition)-related protein expression indicates the metastatic status and prognosis in patients with ovarian cancer. J Ovarian Res (2014) 0.87
The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells. Cancer Gene Ther (2014) 0.86
Hepatic regeneration and the epithelial to mesenchymal transition. World J Gastroenterol (2013) 0.86
Complexity in interpretation of embryonic epithelial-mesenchymal transition in response to transforming growth factor-beta signaling. Cells Tissues Organs (2007) 0.85
Mechanisms of fibrogenesis in liver cirrhosis: The molecular aspects of epithelial-mesenchymal transition. World J Hepatol (2014) 0.85
Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17. Cell Death Dis (2014) 0.84
Epithelial-mesenchymal transition in liver fibrosis. Biomed Rep (2016) 0.84
Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia. Reprod Biol Endocrinol (2012) 0.83
Cholangiopathy with respect to biliary innate immunity. Int J Hepatol (2011) 0.83
Targeting collagen expression in alcoholic liver disease. World J Gastroenterol (2011) 0.83
Restoration of transforming growth factor-beta receptor II expression in colon cancer cells with microsatellite instability increases metastatic potential in vivo. J Biol Chem (2011) 0.83
TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status. BMC Cancer (2008) 0.82
The existence of multipotent stem cells with epithelial-mesenchymal transition features in the human liver bud. Int J Biochem Cell Biol (2010) 0.80
Impact of p120-catenin isoforms 1A and 3A on epithelial mesenchymal transition of lung cancer cells expressing E-cadherin in different subcellular locations. PLoS One (2014) 0.80
Biliary innate immunity: function and modulation. Mediators Inflamm (2010) 0.79
Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype. Stem Cells Int (2016) 0.78
The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner. Cell Death Differ (2015) 0.78
Anti-inflammatory and anti-fibrotic profile of fish oil emulsions used in parenteral nutrition-associated liver disease. PLoS One (2014) 0.78
Microarray analysis of differentially-expressed genes and linker genes associated with the molecular mechanism of colorectal cancer. Oncol Lett (2016) 0.78
A Switch in Akt Isoforms Is Required for Notch-Induced Snail1 Expression and Protection from Cell Death. Mol Cell Biol (2015) 0.77
The mesenchymal transcription factor SNAI-1 instructs human liver specification. Stem Cell Res (2016) 0.76
Analysis of epithelial-mesenchymal transition markers in the histogenesis of hepatic progenitor cell in HBV-related liver diseases. Diagn Pathol (2016) 0.75
A Positive TGF-β/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer. Neoplasia (2016) 0.75
Pathologic features of aggressive vulvar carcinoma are associated with epithelial-mesenchymal transition. Hum Pathol (2016) 0.75
Targeted silencing of CXCR4 inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma. Oncol Lett (2016) 0.75
Can a fibrotic liver afford epithelial-mesenchymal transition? World J Gastroenterol (2017) 0.75
Sclerosing and obstructive cholangiopathy in biliary atresia: mechanisms and association with biliary innate immunity. Pediatr Surg Int (2017) 0.75
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest (2009) 6.70
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell (2012) 5.53
Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34
Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene (2002) 4.20
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med (2009) 3.05
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J (2005) 2.71
Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition. Trends Cell Biol (2008) 1.82
Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol (2009) 1.81
Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Development (2003) 1.74
P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol Biol Cell (2003) 1.65
In situ hybridization analysis of chick embryos in whole-mount and tissue sections. Methods Cell Biol (2008) 1.51
Survival and apoptosis: a dysregulated balance in liver cancer. Liver Int (2007) 1.51
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes (2003) 1.51
Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo. J Cell Sci (2004) 1.50
Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function. Biochem J (2013) 1.46
Overexpression of Snail family members highlights their ability to promote chick neural crest formation. Development (2002) 1.45
Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J Hepatol (2008) 1.44
Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes. Oncogene (2005) 1.38
The physiology and pathology of the EMT. Meeting on the epithelial-mesenchymal transition. EMBO Rep (2008) 1.36
c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. Proc Natl Acad Sci U S A (2005) 1.35
The class I bHLH factors E2-2A and E2-2B regulate EMT. J Cell Sci (2009) 1.34
Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action. Bioessays (2002) 1.30
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. J Clin Invest (2010) 1.30
LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest. Development (2004) 1.29
Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes. Biochemistry (2002) 1.27
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J (2011) 1.26
Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase. Carcinogenesis (2005) 1.26
Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes. Free Radic Biol Med (2004) 1.24
Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (2007) 1.23
Correlations of telomere length, telomerase activity, and telomeric-repeat binding factor 1 expression in colorectal carcinoma. Cancer (2006) 1.20
Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer Res (2009) 1.19
Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev Cell (2007) 1.19
Snail family members and cell survival in physiological and pathological cleft palates. Dev Biol (2004) 1.17
NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. PLoS One (2012) 1.17
Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proc Natl Acad Sci U S A (2002) 1.15
Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes. J Cell Sci (2010) 1.14
Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia. Am J Med Genet A (2010) 1.14
Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion. Hepatology (2006) 1.13
Evolutionary history of the Snail/Scratch superfamily. Trends Genet (2009) 1.13
Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. Hepatology (2013) 1.12
Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors. J Cell Sci (2009) 1.12
EGF blocks NADPH oxidase activation by TGF-beta in fetal rat hepatocytes, impairing oxidative stress, and cell death. J Cell Physiol (2006) 1.11
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism. Biochem J (2007) 1.10
Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. Oncogene (2002) 1.09
Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis. Cell Signal (2006) 1.07
Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors. Brain (2003) 1.07
Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: Role of EGF receptor ligands. Exp Cell Res (2006) 1.07
Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II. PLoS One (2013) 1.06
The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms. Biochim Biophys Acta (2008) 1.06
Integration of Ras subeffector signaling in TGF-beta mediated late stage hepatocarcinogenesis. Carcinogenesis (2005) 1.04
Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer. Lung Cancer (2008) 1.03
Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell Cycle (2007) 1.03
Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta. Cell Signal (2009) 1.03
Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway. Oncogene (2002) 1.02
Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes. Endocrinology (2006) 1.02
Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain. Int J Cancer (2002) 1.02
A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells. Int J Cancer (2014) 1.01
Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. J Biol Chem (2002) 1.00
Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes. J Cell Physiol (2007) 1.00
NADPH oxidase NOX1 controls autocrine growth of liver tumor cells through up-regulation of the epidermal growth factor receptor pathway. J Biol Chem (2010) 1.00
Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes. Exp Cell Res (2004) 1.00
Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J (2009) 1.00
Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression. Eur J Immunol (2011) 0.99
How to become neural crest: from segregation to delamination. Semin Cell Dev Biol (2005) 0.98
Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Oncol Rep (2007) 0.98
Immunohistochemistry and microsatellite instability testing for selecting MLH1, MSH2 and MSH6 mutation carriers in hereditary non-polyposis colorectal cancer. Oncol Rep (2004) 0.98
IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology (2004) 0.98
Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation. Dev Cell (2011) 0.98
The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. J Cell Physiol (2011) 0.97
Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice. Kidney Int (2009) 0.97
Protease inhibition in African subtypes of HIV-1. AIDS Rev (2003) 0.97
Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform. Diabetes (2009) 0.96
Relative expression of Slug, RhoB, and HNK-1 in the cranial neural crest of the early chicken embryo. Dev Dyn (2004) 0.95