Published in EMBO Rep on March 07, 2008
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med (2009) 3.05
GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells. Cancer Res (2011) 1.81
A twist of insight - the role of Twist-family bHLH factors in development. Int J Dev Biol (2009) 1.62
MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination. Proc Natl Acad Sci U S A (2013) 1.60
Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition. Mol Cancer (2014) 1.59
Pancreatic cancer cells resistant to chemoradiotherapy rich in "stem-cell-like" tumor cells. Dig Dis Sci (2010) 1.45
EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition. Cell Death Dis (2014) 1.34
CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Sci Rep (2013) 1.11
Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One (2011) 1.06
Deregulation of Snai2 is associated with metastasis and poor prognosis in tongue squamous cell carcinoma. Int J Cancer (2011) 1.04
Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion. J Exp Clin Cancer Res (2014) 1.04
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. Mol Cancer Res (2010) 1.03
HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers. J Cell Sci (2010) 1.00
Proinflammatory and profibrotic mediators: principal effectors of leiomyoma development as a fibrotic disorder. Semin Reprod Med (2010) 0.98
miRNA589 regulates epithelial-mesenchymal transition in human peritoneal mesothelial cells. J Biomed Biotechnol (2012) 0.89
A new regulatory loop in cancer-cell invasion. EMBO Rep (2008) 0.86
Heterogeneity in MYC-induced mammary tumors contributes to escape from oncogene dependence. Oncogene (2011) 0.83
High expression of long non-coding RNA lncRNA-ATB is correlated with metastases and promotes cell migration and invasion in renal cell carcinoma. Jpn J Clin Oncol (2016) 0.82
Snail promotes epithelial-mesenchymal transition and invasiveness in human ovarian cancer cells. Int J Clin Exp Med (2015) 0.81
An oncologist׳s friend: How Xenopus contributes to cancer research. Dev Biol (2015) 0.81
Indentation quantification for in-liquid nanomechanical measurement of soft material using an atomic force microscope: rate-dependent elastic modulus of live cells. Phys Rev E Stat Nonlin Soft Matter Phys (2013) 0.80
Phenotypic transition of the collecting duct epithelium in congenital urinary tract obstruction. J Biomed Biotechnol (2009) 0.80
Heat-shock factor 2 is a suppressor of prostate cancer invasion. Oncogene (2015) 0.80
Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. PLoS One (2014) 0.78
Molecular mechanism of HEIH and HULC in the proliferation and invasion of hepatoma cells. Int J Clin Exp Med (2015) 0.77
Inhibition of Epithelial-to-Mesenchymal Transition (EMT) in Cancer by Nitric Oxide: Pivotal Roles of Nitrosylation of NF-κB, YY1 and Snail. For Immunopathol Dis Therap (2012) 0.76
Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β-Slug signaling. Proc Natl Acad Sci U S A (2016) 0.76
Differential expression pattern of Twist1 in mouse preimplantation embryos suggests its multiple roles during early development. J Assist Reprod Genet (2016) 0.75
High expression of the long non-coding RNA HEIRCC promotes Renal Cell Carcinoma metastasis by inducing epithelial-mesenchymal transition. Oncotarget (2016) 0.75
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell (2006) 27.36
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol (2000) 21.15
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer (2007) 18.69
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell (2006) 16.05
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol (2000) 15.78
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest (2002) 12.22
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med (2007) 9.51
An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) (1995) 9.18
Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer (2005) 9.04
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med (2003) 7.91
Genetic determinants of cancer metastasis. Nat Rev Genet (2007) 6.38
Intravital imaging of cell movement in tumours. Nat Rev Cancer (2003) 6.35
Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem (2007) 5.37
Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34
The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene (2007) 4.90
Collective migration of an epithelial monolayer in response to a model wound. Proc Natl Acad Sci U S A (2007) 4.35
The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res (2008) 4.04
Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer (2006) 3.45
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol (2006) 3.44
Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell (2006) 3.28
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol (2003) 3.09
Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol (1982) 2.90
Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene (2007) 2.87
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80
SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells. Cancer Res (2007) 2.80
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J (2005) 2.71
Cell contact during early morphogenesis in the chick embryo. Dev Biol (1967) 2.40
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell (2006) 2.30
The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol (2007) 1.98
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene (2006) 1.88
PDGF receptors as targets in tumor treatment. Adv Cancer Res (2007) 1.76
TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex. J Cell Sci (2007) 1.73
Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition. Mol Biol Cell (2007) 1.71
Gene regulation: gene control network in development. Annu Rev Biophys Biomol Struct (2007) 1.56
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene (2006) 1.48
Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs (2007) 1.48
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res (2007) 1.46
Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (2007) 1.23
Calcium-independent desmosomes of keratinocytes are hyper-adhesive. J Invest Dermatol (2006) 1.20
Prototypical type I E-cadherin and type II cadherin-7 mediate very distinct adhesiveness through their extracellular domains. J Biol Chem (2005) 1.20
Photoactivatable GFP resolves Drosophila mesoderm migration behaviour. Development (2007) 1.15
The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development. J Cell Biol (2007) 1.11
An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm. PLoS One (2006) 1.09
The Snail repressor is required for PMC ingression in the sea urchin embryo. Development (2007) 1.05
TGFbeta superfamily signaling: notes from the desert. Development (2007) 0.81
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest (2009) 6.70
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell (2012) 5.53
Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34
Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene (2002) 4.20
Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42. J Cell Biol (2004) 3.06
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med (2009) 3.05
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80
Epithelial-mesenchymal transitions: insights from development. Development (2012) 2.58
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol (2008) 2.46
Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer. Clin Exp Metastasis (2007) 2.41
Regional copy number-independent deregulation of transcription in cancer. Nat Genet (2006) 2.33
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol (2006) 2.32
Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res (2003) 2.30
Johnson-Kendall-Roberts theory applied to living cells. Phys Rev Lett (2005) 2.13
Epithelial to mesenchymal transition and breast cancer. Breast Cancer Res (2009) 2.05
The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes. Mol Cancer Res (2002) 2.01
Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development (2002) 1.99
Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development (2005) 1.88
Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation. Differentiation (2003) 1.85
Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition. Trends Cell Biol (2008) 1.82
Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Development (2003) 1.74
Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet (2005) 1.74
Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dbeta cell line. Dev Biol (2006) 1.59
Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia. Development (2004) 1.58
The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo. Dev Biol (2003) 1.56
Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b. Carcinogenesis (2005) 1.54
In situ hybridization analysis of chick embryos in whole-mount and tissue sections. Methods Cell Biol (2008) 1.51
Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo. J Cell Sci (2004) 1.50
Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma. Oncogene (2005) 1.50
Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development (2006) 1.49
Overexpression of Snail family members highlights their ability to promote chick neural crest formation. Development (2002) 1.45
Identification of the mammary line in mouse by Wnt10b expression. Dev Dyn (2004) 1.40
Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer. EMBO Mol Med (2013) 1.38
Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis. Cancer Res (2013) 1.36
The class I bHLH factors E2-2A and E2-2B regulate EMT. J Cell Sci (2009) 1.34
Integrins in mammary gland development and differentiation of mammary epithelium. J Mammary Gland Biol Neoplasia (2003) 1.30
Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapse. Clin Cancer Res (2008) 1.30
LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest. Development (2004) 1.29
SnapShot: The epithelial-mesenchymal transition. Cell (2011) 1.28
Early events in cell adhesion and polarity during epithelial-mesenchymal transition. J Cell Sci (2012) 1.27
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J (2011) 1.26
Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (2007) 1.23
Prototypical type I E-cadherin and type II cadherin-7 mediate very distinct adhesiveness through their extracellular domains. J Biol Chem (2005) 1.20
The importance of being a myoepithelial cell. Breast Cancer Res (2002) 1.20
Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev Cell (2007) 1.19
Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr Biol (Camb) (2013) 1.17
Snail family members and cell survival in physiological and pathological cleft palates. Dev Biol (2004) 1.17
Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proc Natl Acad Sci U S A (2002) 1.15
Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes. J Cell Sci (2010) 1.14
Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia. Am J Med Genet A (2010) 1.14
α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength. J Biol Chem (2012) 1.14
Evolutionary history of the Snail/Scratch superfamily. Trends Genet (2009) 1.13
Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors. J Cell Sci (2009) 1.12
Dermal fin rays and scales derive from mesoderm, not neural crest. Curr Biol (2013) 1.11
A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma. PLoS One (2012) 1.06
Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3. J Biol Chem (2004) 1.05
Visualizing chromosomes as transcriptome correlation maps: evidence of chromosomal domains containing co-expressed genes--a study of 130 invasive ductal breast carcinomas. Cancer Res (2005) 1.05
EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties. J Cell Biol (2002) 1.03
Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell Cycle (2007) 1.03
Targeting pathways contributing to epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer. Curr Drug Targets (2012) 1.03
Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation. Mol Cancer (2005) 1.02
Target cell movement in tumor and cardiovascular diseases based on the epithelial-mesenchymal transition concept. Adv Drug Deliv Rev (2011) 1.01
YY1 regulates the neural crest-associated slug gene in Xenopus laevis. J Biol Chem (2004) 1.00
Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J (2009) 1.00
Changes in cholesterol levels in the plasma membrane modulate cell signaling and regulate cell adhesion and migration on fibronectin. Cell Motil Cytoskeleton (2007) 0.99
Meta-analysis of transcriptome reveals let-7b as an unfavorable prognostic biomarker and predicts molecular and clinical subclasses in high-grade serous ovarian carcinoma. Int J Cancer (2013) 0.98
Breast cancer progression with a Twist. Nat Med (2004) 0.98
How to become neural crest: from segregation to delamination. Semin Cell Dev Biol (2005) 0.98
Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation. Dev Cell (2011) 0.98
DEAD-box helicase DP103 defines metastatic potential of human breast cancers. J Clin Invest (2014) 0.97
Perturbation of beta1-integrin function in involuting mammary gland results in premature dedifferentiation of secretory epithelial cells. Mol Biol Cell (2002) 0.97
Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice. Kidney Int (2009) 0.97
Relative expression of Slug, RhoB, and HNK-1 in the cranial neural crest of the early chicken embryo. Dev Dyn (2004) 0.95
Ectopic expression of Cvh (Chicken Vasa homologue) mediates the reprogramming of chicken embryonic stem cells to a germ cell fate. Dev Biol (2009) 0.95
Myoepithelial cells in the control of mammary development and tumorigenesis: data from genetically modified mice. J Mammary Gland Biol Neoplasia (2005) 0.94
Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity. Stem Cells (2012) 0.94
EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction. Autophagy (2013) 0.93
Wnt11r is required for cranial neural crest migration. Dev Dyn (2008) 0.92
Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A. J Cell Sci (2009) 0.92
An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme. Development (2013) 0.92
Biological potential of a functional human SNAIL retrogene. J Biol Chem (2002) 0.92
Microfluidic cell trap array for controlled positioning of single cells on adhesive micropatterns. Lab Chip (2013) 0.90
The expression of Scratch genes in the developing and adult brain. Dev Dyn (2006) 0.90
Regulation of XSnail2 expression by Rho GTPases. Dev Dyn (2007) 0.89
α-catenin, vinculin, and F-actin in strengthening E-cadherin cell-cell adhesions and mechanosensing. Cell Adh Migr (2013) 0.89
Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer. Am J Cancer Res (2013) 0.88
A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme. Proc Natl Acad Sci U S A (2008) 0.88
Translating metastasis-related biomarkers to the clinic--progress and pitfalls. Nat Rev Clin Oncol (2013) 0.88
A new regulatory loop in cancer-cell invasion. EMBO Rep (2008) 0.86
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme. Development (2013) 0.86
A celebration of the new head and an evaluation of the new mouth. Neuron (2003) 0.86
The endogenous retrovirus ENS-1 provides active binding sites for transcription factors in embryonic stem cells that specify extra embryonic tissue. Retrovirology (2012) 0.84
eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex. Cell Rep (2013) 0.83
Expression of chicken slug and snail in mesenchymal components of the developing central nervous system. Dev Dyn (2004) 0.82
beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells. FEBS Lett (2007) 0.81
Evolution of the neural crest. Adv Exp Med Biol (2006) 0.81
Differential expression of beta3 integrin gene in chick and mouse cranial neural crest cells. Dev Dyn (2003) 0.81