Published in J Cell Sci on April 01, 2009
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MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut (2012) 2.40
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ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer. Cancer Biol Ther (2010) 1.44
Replication of the TCF4 intronic variant in late-onset Fuchs corneal dystrophy and evidence of independence from the FCD2 locus. Invest Ophthalmol Vis Sci (2011) 1.39
Requirement of podocalyxin in TGF-beta induced epithelial mesenchymal transition. PLoS One (2011) 1.25
miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT. Oncogene (2011) 1.24
Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process. Eur J Hum Genet (2012) 1.17
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Mol Psychiatry (2013) 1.16
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Molecular bases of corneal endothelial dystrophies. Exp Eye Res (2011) 1.07
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RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy. J Biol Chem (2015) 0.93
Emerging role of mucins in epithelial to mesenchymal transition. Curr Cancer Drug Targets (2013) 0.91
Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation. PLoS One (2013) 0.90
Overexpression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition. Oncogenesis (2012) 0.88
E47 and Id1 interplay in epithelial-mesenchymal transition. PLoS One (2013) 0.88
A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition. PLoS One (2011) 0.88
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An emerging role for class I bHLH E2-2 proteins in EMT regulation and tumor progression. Cell Adh Migr (2010) 0.87
Regulation of mesenchymal phenotype by MicroRNAs in cancer. Curr Cancer Drug Targets (2013) 0.86
LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition. Biol Open (2014) 0.85
The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans. Dev Biol (2011) 0.84
Phenolic secoiridoids in extra virgin olive oil impede fibrogenic and oncogenic epithelial-to-mesenchymal transition: extra virgin olive oil as a source of novel antiaging phytochemicals. Rejuvenation Res (2012) 0.84
Zac1 regulates cell cycle arrest in neuronal progenitors via Tcf4. Mol Cell Biol (2014) 0.84
ERα inhibits epithelial-mesenchymal transition by suppressing Bmi1 in breast cancer. Oncotarget (2015) 0.83
Fuchs endothelial corneal dystrophy: current perspectives. Clin Ophthalmol (2016) 0.82
Glioblastoma Circulating Cells: Reality, Trap or Illusion? Stem Cells Int (2015) 0.81
Overexpression of inhibitor of DNA-binding 2 attenuates pulmonary fibrosis through regulation of c-Abl and Twist. Am J Pathol (2015) 0.80
Downregulation of microRNA-122 promotes proliferation, migration, and invasion of human hepatocellular carcinoma cells by activating epithelial-mesenchymal transition. Onco Targets Ther (2016) 0.79
Association of common variants in TCF4 and PTPRG with Fuchs' corneal dystrophy: a systematic review and meta-analysis. PLoS One (2014) 0.78
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Transcription factor E2-2 inhibits the proliferation of endothelial progenitor cells by suppressing autophagy. Int J Mol Med (2016) 0.77
IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights. Mol Cancer (2017) 0.76
A core invasiveness gene signature reflects epithelial-to-mesenchymal transition but not metastatic potential in breast cancer cell lines and tissue samples. PLoS One (2014) 0.75
CTG18.1 repeat expansion may reduce TCF4 gene expression in corneal endothelial cells of German patients with Fuchs' dystrophy. Graefes Arch Clin Exp Ophthalmol (2017) 0.75
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer (2007) 18.69
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2012) 11.14
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development (2005) 8.42
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res (2008) 6.95
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest (2009) 6.70
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci (2003) 6.24
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene (2005) 5.74
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell (2012) 5.53
Snail blocks the cell cycle and confers resistance to cell death. Genes Dev (2004) 5.34
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem (2003) 4.55
Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene (2002) 4.20
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol (2004) 4.15
Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol (2004) 3.64
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med (2009) 3.05
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80
SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells. Cancer Res (2007) 2.80
Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res (2006) 2.73
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J (2005) 2.71
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J Biol Chem (2008) 2.22
Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol (2007) 2.09
Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin Cancer Res (2004) 2.04
The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells. Biochem J (2006) 2.03
The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes. Mol Cancer Res (2002) 2.01
Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor. J Cell Sci (2005) 1.87
Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition. Trends Cell Biol (2008) 1.82
Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Development (2003) 1.74
Tiling path genomic profiling of grade 3 invasive ductal breast cancers. Clin Cancer Res (2009) 1.68
The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity. Semin Cancer Biol (2012) 1.65
Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma. J Pathol (2010) 1.63
Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol Biol Cell (2003) 1.62
The morphological and molecular features of the epithelial-to-mesenchymal transition. Nat Protoc (2009) 1.60
In situ hybridization analysis of chick embryos in whole-mount and tissue sections. Methods Cell Biol (2008) 1.51
Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo. J Cell Sci (2004) 1.50
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas. Cancer Res (2008) 1.48
Overexpression of Snail family members highlights their ability to promote chick neural crest formation. Development (2002) 1.45
A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res (2004) 1.44
Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int J Cancer (2003) 1.43
Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene (2004) 1.39
The physiology and pathology of the EMT. Meeting on the epithelial-mesenchymal transition. EMBO Rep (2008) 1.36
SPARC represses E-cadherin and induces mesenchymal transition during melanoma development. Cancer Res (2006) 1.31
LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest. Development (2004) 1.29
Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas. EMBO Mol Med (2011) 1.28
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J (2011) 1.26
Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (2007) 1.23
Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. Mol Biol Cell (2009) 1.21
Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas. J Clin Pathol (2006) 1.20
Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev Cell (2007) 1.19
Tumorigenesis: Twist1 links EMT to self-renewal. Nat Cell Biol (2010) 1.17
Snail family members and cell survival in physiological and pathological cleft palates. Dev Biol (2004) 1.17
Modularity and reshuffling of Snail and Slug expression during vertebrate evolution. Proc Natl Acad Sci U S A (2002) 1.15
Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes. J Cell Sci (2010) 1.14
Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia. Am J Med Genet A (2010) 1.14
Switching on-off Snail: LOXL2 versus GSK3beta. Cell Cycle (2005) 1.14
Evolutionary history of the Snail/Scratch superfamily. Trends Genet (2009) 1.13
Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat (2006) 1.13
Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors. J Cell Sci (2009) 1.12
Phase transitions in biogenic amorphous calcium carbonate. Proc Natl Acad Sci U S A (2012) 1.10
A hypoxic twist in metastasis. Nat Cell Biol (2008) 1.10
Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins. Am J Physiol Cell Physiol (2005) 1.09
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition. Mol Cancer (2010) 1.07
The EMT signaling pathways in endometrial carcinoma. Clin Transl Oncol (2012) 1.07
Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition. J Biol Chem (2013) 1.06
Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context. Nucleic Acids Res (2011) 1.04
Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas. Hum Pathol (2006) 1.04
Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell Cycle (2007) 1.03
VE-cadherin expression and clustering maintain low levels of survivin in endothelial cells. Am J Pathol (2004) 1.03
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma. Proc Natl Acad Sci U S A (2009) 1.02
Functional characterization of E- and P-cadherin in invasive breast cancer cells. BMC Cancer (2009) 1.02
Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma. J Pathol (2003) 1.02
Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer (2006) 1.01
A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance. PLoS One (2011) 1.01