Published in Br J Pharmacol on January 01, 2003
Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol (2011) 0.91
Combination of honokiol and magnolol inhibits hepatic steatosis through AMPK-SREBP-1 c pathway. Exp Biol Med (Maywood) (2014) 0.83
Antiprotozoal activity of medicinal plants against Ichthyophthirius multifiliis in goldfish (Carassius auratus). Parasitol Res (2012) 0.80
Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of Magnolia officinalis and their inhibitory effects on superoxide anion generation and elastase release. PLoS One (2013) 0.79
Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro Studies on A375 Cells. Evid Based Complement Alternat Med (2011) 0.79
Magnolol induces the distributional changes of p160 and adipose differentiation-related protein in adrenal cells. Histochem Cell Biol (2005) 0.76
Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. J Zhejiang Univ Sci B (2017) 0.75
Magnolol reduces bleomycin-induced rodent lung fibrosis. Int J Clin Exp Med (2015) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Signal transduction by the JNK group of MAP kinases. Cell (2000) 18.24
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (1995) 17.76
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (1997) 16.09
The Bcl-2 protein family: arbiters of cell survival. Science (1998) 16.08
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell (1995) 8.75
Emerging roles of caspase-3 in apoptosis. Cell Death Differ (1999) 8.05
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature (1996) 6.75
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development. Curr Opin Cell Biol (1998) 6.28
Cell death in development. Cell (1999) 6.01
Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol (1999) 5.93
bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development (1994) 3.34
Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta (1997) 2.72
Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat Med (1996) 2.65
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol Cell Biol (1997) 2.15
Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J Biol Chem (1996) 2.12
Cancer epidemiology and control in Taiwan: a brief review. Jpn J Clin Oncol (2002) 1.88
Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci U S A (1997) 1.82
The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells. Cancer Res (1997) 1.76
Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res (1997) 1.60
Gemcitabine and small cell lung cancer. Lung Cancer (2001) 1.40
Bcl-x(S) anatagonizes the protective effects of Bcl-x(L). J Biol Chem (1996) 1.35
Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sci (1994) 1.33
Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis. Phytother Res (2001) 1.10
Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium. Proc Natl Acad Sci U S A (1993) 1.10
Studies on inhibitors of skin tumor promotion, IX. Neolignans from Magnolia officinalis. J Nat Prod (1991) 1.09
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine. J Nat Prod (1998) 1.09
Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines. Mol Pharmacol (2001) 1.06
Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs. J Pharm Pharmacol (1991) 1.05
Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites. Cancer Res (2001) 1.01
Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects. Planta Med (1983) 1.00
Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. J Cell Biochem (2002) 1.00
Expression level of Bcl-2 determines anti- or proapoptotic function. Cancer Res (1999) 1.00
Specific residues within the alpha 2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathways. J Biol Chem (2001) 0.99
Antifungal activity of magnolol and honokiol. Arch Pharm Res (2000) 0.99
Therapeutic advances in small cell lung cancer. Expert Opin Investig Drugs (2000) 0.99
Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro. Planta Med (2001) 0.97
Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch Pharmacol (1992) 0.97
Biphenyl compounds are hydroxyl radical scavengers: their effective inhibition for UV-induced mutation in Salmonella typhimurium TA102. Free Radic Biol Med (1994) 0.95
Magnolol attenuates peroxidative damage and improves survival of rats with sepsis. Shock (2000) 0.94
Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide. Int J Cancer (2001) 0.94
Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats. Eur J Pharmacol (2001) 0.94
Inhibitory effects of phenolics on xanthine oxidase. Anticancer Res (1994) 0.92
Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells. Mol Carcinog (2001) 0.85
Studies on the active principles of magnolia bark. Centrally acting muscle relaxant activity of magnolol and hōnokiol. Jpn J Pharmacol (1975) 0.84
Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. Planta Med (1999) 0.83
Magnolol inhibits collagen-induced platelet serotonin release. Thromb Res (1995) 0.78
Gemcitabine and cisplatin in a multimodality treatment for locally advanced non-small cell lung cancer. Br J Cancer (2002) 0.78
Overexpression of Bcl-2 regulates sodium butyrate- and/or docetaxel-induced apoptosis in human bladder cancer cells both in vitro and in vivo. Int J Cancer (2001) 0.77
Cytochrome c depletion upon expression of Bcl-XS. J Biol Chem (2000) 0.76
Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res (2008) 3.32
Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS One (2008) 2.90
Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme. BMC Genomics (2007) 2.32
Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells. J Vasc Surg (2010) 1.76
Lymphatic absorption of quercetin and rutin in rat and their pharmacokinetics in systemic plasma. J Agric Food Chem (2010) 1.50
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochem Pharmacol (2005) 1.39
Pharmacokinetics and urine metabolite identification of dehydroevodiamine in the rat. J Agric Food Chem (2012) 1.38
Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci (2007) 1.32
Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells. Int J Cancer (2002) 1.31
Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration. Int J Pharm (2011) 1.30
Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 1.25
Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J Ethnopharmacol (2006) 1.23
Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr (2008) 1.22
Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitro. Mol Hum Reprod (2009) 1.15
p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation. Cell Cycle (2012) 1.15
Aurora-A promotes gefitinib resistance via a NF-κB signaling pathway in p53 knockdown lung cancer cells. Biochem Biophys Res Commun (2011) 1.15
Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical tomotherapy. Radiat Oncol (2009) 1.12
Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells. Anticancer Drugs (2005) 1.10
Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells. Eur J Pharmacol (2008) 1.08
Hepatobiliary excretion of berberine. Drug Metab Dispos (2004) 1.08
Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas. Neuro Oncol (2008) 1.08
Moclobemide upregulated Bcl-2 expression and induced neural stem cell differentiation into serotoninergic neuron via extracellular-regulated kinase pathway. Br J Pharmacol (2006) 1.07
Plumbagin, isolated from Plumbago zeylanica, induces cell death through apoptosis in human pancreatic cancer cells. Pancreatology (2010) 1.06
Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells. Cancer Chemother Pharmacol (2005) 1.06
Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats. Evid Based Complement Alternat Med (2012) 1.03
Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. Eur Neuropsychopharmacol (2007) 1.01
Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial. Altern Med Rev (2011) 1.01
Drug-drug interactions of silymarin on the perspective of pharmacokinetics. J Ethnopharmacol (2008) 1.00
Anti-inflammatory neolignans from Piper kadsura. J Nat Prod (2006) 0.99
Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. J Agric Food Chem (2010) 0.99
Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. Eur J Pharm Biopharm (2010) 0.99
Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application. J Pharm Biomed Anal (2007) 0.98
Placenta-derived multipotent stem cells induced to differentiate into insulin-positive cells. Biochem Biophys Res Commun (2007) 0.98
FBXW7 is involved in Aurora B degradation. Cell Cycle (2012) 0.98
Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol (2004) 0.98
Gene expression profiles of the aurora family kinases. Gene Expr (2006) 0.97
Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway. Chem Res Toxicol (2010) 0.97
Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: interaction with drugs acting at 5-HT receptors. Life Sci (2004) 0.97
Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS. J Pharm Biomed Anal (2008) 0.97
Biological analysis of herbal medicines used for the treatment of liver diseases. Biomed Chromatogr (2011) 0.97
An epidermal growth factor inhibitor, Gefitinib, induces apoptosis through a p53-dependent upregulation of pro-apoptotic molecules and downregulation of anti-apoptotic molecules in human lung adenocarcinoma A549 cells. Eur J Pharmacol (2008) 0.97
Dang-Gui-Bu-Xai-Tang modulated the immunity of tumor bearing mice. Immunopharmacol Immunotoxicol (2003) 0.97
Pharmacokinetics of (-)-epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distribution. J Agric Food Chem (2007) 0.97
Sustained activation of ERK and Cdk2/cyclin-A signaling pathway by pemetrexed leading to S-phase arrest and apoptosis in human non-small cell lung cancer A549 cells. Eur J Pharmacol (2011) 0.96
Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway. Cardiovasc Res (2004) 0.96
Oral bioavailability, urinary excretion and organ distribution of melamine in Sprague-Dawley rats by high-performance liquid chromatography with tandem mass spectrometry. J Agric Food Chem (2010) 0.96
Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury. Biochem Pharmacol (2006) 0.96
Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. J Agric Food Chem (2011) 0.95
Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: implications for therapy of lung fibrosis. J Agric Food Chem (2010) 0.94
Measurement and pharmacokinetic study of plumbagin in a conscious freely moving rat using liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2006) 0.94
Hydroxyl radical in living systems and its separation methods. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 0.93
Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells. Biochem Pharmacol (2004) 0.93
Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways. Mol Carcinog (2011) 0.92
HPLC-MS/MS analysis of a traditional Chinese medical formulation of Bu-Yang-Huan-Wu-Tang and its pharmacokinetics after oral administration to rats. PLoS One (2012) 0.92
Abdominal irradiation modulates 5-Fluorouracil pharmacokinetics. J Transl Med (2010) 0.92
Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells. Toxicon (2008) 0.91
The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway. Life Sci (2003) 0.91
Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil. PLoS One (2011) 0.89
Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents. Biosci Biotechnol Biochem (2008) 0.89
Antidepressant administration modulates neural stem cell survival and serotoninergic differentiation through bcl-2. Curr Neurovasc Res (2007) 0.89
Global gene expression profiling of dimethylnitrosamine-induced liver fibrosis: from pathological and biochemical data to microarray analysis. Gene Expr (2006) 0.89
Genetic copy number variants in myocardial infarction patients with hyperlipidemia. BMC Genomics (2011) 0.89
Determination of melamine in rat plasma, liver, kidney, spleen, bladder and brain by liquid chromatography-tandem mass spectrometry. J Chromatogr A (2009) 0.88
Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo. J Ethnopharmacol (2011) 0.88
XIAP-mediated protection of H460 lung cancer cells against cisplatin. Eur J Pharmacol (2009) 0.88
Pharmacokinetics of adenosine and cordycepin, a bioactive constituent of Cordyceps sinensis in rat. J Agric Food Chem (2010) 0.88
Moutan cortex radicis improves lipopolysaccharide-induced acute lung injury in rats through anti-inflammation. Phytomedicine (2012) 0.88
Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation. Evid Based Complement Alternat Med (2012) 0.88
Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. J Agric Food Chem (2012) 0.88
Pharmacokinetics and oral bioavailability of epimedin C after oral administration of epimedin C and Herba Epimedii extract in rats. Biomed Chromatogr (2013) 0.87
The molecular basis of wound healing processes induced by lithospermi radix: a proteomics and biochemical analysis. Evid Based Complement Alternat Med (2012) 0.87
Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice. Evid Based Complement Alternat Med (2012) 0.87
Involvement of mitochondrial pathway in Taxol-induced apoptosis of human T24 bladder cancer cells. Urol Res (2002) 0.87
Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells. Eur J Pharmacol (2009) 0.87
Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat. Anal Chim Acta (2007) 0.87
The relationship between endotoxemia and hepatic endocannabinoids in cirrhotic rats with portal hypertension. J Hepatol (2010) 0.87
Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse. Int J Radiat Oncol Biol Phys (2005) 0.87
Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway. J Agric Food Chem (2005) 0.87
Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells. Br J Pharmacol (2003) 0.87
Longitudinal evaluation of tumor metastasis by an FDG-microPet/microCT dual-imaging modality in a lung carcinoma-bearing mouse model. Anticancer Res (2006) 0.87
Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro. PLoS One (2013) 0.86
Anti-nociceptive and anti-inflammatory activity caused by Cistanche deserticola in rodents. J Ethnopharmacol (2002) 0.86
Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats. J Ethnopharmacol (2008) 0.86
Simultaneous determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometric detection. Biomed Chromatogr (2006) 0.86
Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. Int J Mol Med (2012) 0.86
Up-regulation of osteopontin expression by aryl hydrocarbon receptor via both ligand-dependent and ligand-independent pathways in lung cancer. Gene (2011) 0.85
Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture. J Ethnopharmacol (2005) 0.85
Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells. Arch Toxicol (2007) 0.85
Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma. Evid Based Complement Alternat Med (2013) 0.85
Bioavailability of salvianolic acid B in conscious and freely moving rats. Int J Pharm (2006) 0.85
Cinnamomum cassia essential oil inhibits α-MSH-induced melanin production and oxidative stress in murine B16 melanoma cells. Int J Mol Sci (2013) 0.85
Comparative evaluation of FET and FDG for differentiating lung carcinoma from inflammation in mice. Anticancer Res (2006) 0.85
Neuroprotective effect of luteolin on amyloid beta protein (25-35)-induced toxicity in cultured rat cortical neurons. Phytother Res (2010) 0.85
Pharmacokinetic study of free mangiferin in rats by microdialysis coupled with microbore high-performance liquid chromatography and tandem mass spectrometry. J Chromatogr A (2003) 0.84
Gardenia herbal active constituents: applicable separation procedures. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 0.84
Effect of folic acid and vitamin B12 on pemetrexed antifolate chemotherapy in nutrient lung cancer cells. Biomed Res Int (2013) 0.84
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage. Bioorg Med Chem (2008) 0.84
Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation. Evid Based Complement Alternat Med (2012) 0.84
A Study of the Wound Healing Mechanism of a Traditional Chinese Medicine, Angelica sinensis, Using a Proteomic Approach. Evid Based Complement Alternat Med (2012) 0.84