Published in Clin Exp Pharmacol Physiol on January 24, 2003
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature (2004) 8.87
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science (2003) 3.70
Fibromyalgia after motor vehicle collision: evidence and implications. Traffic Inj Prev (2005) 3.35
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell (2008) 3.02
Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis Rheum (2004) 2.88
Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6. Mol Ther (2004) 2.84
Sustained AAV-mediated dystrophin expression in a canine model of Duchenne muscular dystrophy with a brief course of immunosuppression. Mol Ther (2007) 2.76
Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. Arthritis Rheum (2003) 2.72
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med (2005) 2.63
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A (2008) 2.48
Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science (2003) 2.46
Side effects of retroviral gene transfer into hematopoietic stem cells. Blood (2003) 2.35
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. Blood (2009) 2.33
Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. Am J Hum Genet (2001) 2.32
Cognitive behavioral therapy and aerobic exercise for Gulf War veterans' illnesses: a randomized controlled trial. JAMA (2003) 2.26
Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises. Arthritis Rheum (2008) 2.22
Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy. Neurobiol Dis (2008) 2.20
CTC1 Mutations in a patient with dyskeratosis congenita. Pediatr Blood Cancer (2012) 2.14
Overcoming reprogramming resistance of Fanconi anemia cells. Blood (2012) 2.07
TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4. J Biol Chem (2011) 2.06
Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis. J Am Soc Nephrol (2011) 2.06
Signaling and cytoskeletal requirements in erythroblast enucleation. Blood (2012) 2.05
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature (2012) 2.04
Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. Arthritis Rheum (2005) 1.98
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp Hematol (2006) 1.95
Characterization and consequences of pain variability in individuals with fibromyalgia. Arthritis Rheum (2005) 1.88
Fibromyalgia syndrome module at OMERACT 9: domain construct. J Rheumatol (2009) 1.87
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. J Clin Invest (2003) 1.85
Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure. Mol Ther (2007) 1.85
Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. Mol Ther (2005) 1.82
Stem cell collection and gene transfer in Fanconi anemia. Mol Ther (2007) 1.81
Upping the ante: recent advances in direct reprogramming. Mol Ther (2009) 1.73
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell (2007) 1.72
Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proc Natl Acad Sci U S A (2012) 1.72
Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy. Hum Gene Ther (2007) 1.70
Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology (2008) 1.67
The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum (2005) 1.66
Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J Biol Chem (2006) 1.66
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences. Mol Ther (2004) 1.65
Design of tissue-specific regulatory cassettes for high-level rAAV-mediated expression in skeletal and cardiac muscle. Mol Ther (2007) 1.65
Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice. Am J Physiol Endocrinol Metab (2009) 1.62
Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells. Hum Gene Ther (2003) 1.58
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nat Immunol (2004) 1.56
The MAPP research network: design, patient characterization and operations. BMC Urol (2014) 1.56
Gene therapy continues to mature and to face challenges. Mol Ther (2009) 1.54
FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood (2008) 1.53
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells. J Clin Invest (2007) 1.53
Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome. Arthritis Rheum (2005) 1.52
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. Blood (2005) 1.52
Intrathecal opioids for chronic pain: a call for evidence. Pain Med (2014) 1.50
Fibromyalgia syndrome. J Rheumatol (2005) 1.49
Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration. Am J Pathol (2002) 1.48
A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. Mol Ther (2005) 1.48
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region. J Biol Chem (2002) 1.48
Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. FASEB J (2008) 1.46
Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav (2011) 1.45
Treatment of fibromyalgia with formula acupuncture: investigation of needle placement, needle stimulation, and treatment frequency. J Altern Complement Med (2005) 1.45
Functional deficits in nNOSmu-deficient skeletal muscle: myopathy in nNOS knockout mice. PLoS One (2008) 1.42
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med (2014) 1.42
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood (2006) 1.41
Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence. J Cell Sci (2007) 1.40
The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J Neurosci (2009) 1.40
Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood (2013) 1.38
ASGT advises NIH on funding of gene therapy trials. Mol Ther (2007) 1.38
The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology (2008) 1.38
Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. Blood (2008) 1.37
Survey criteria for fibromyalgia independently predict increased postoperative opioid consumption after lower-extremity joint arthroplasty: a prospective, observational cohort study. Anesthesiology (2013) 1.37
Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors. J Cell Biol (2006) 1.36
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol (2002) 1.35
Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica (2010) 1.34
Microutrophin delivery through rAAV6 increases lifespan and improves muscle function in dystrophic dystrophin/utrophin-deficient mice. Mol Ther (2008) 1.34
The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood (2010) 1.33
Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood (2011) 1.32
Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool. Exp Hematol (2002) 1.31
Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Curr Top Med Chem (2006) 1.31
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood (2007) 1.28
Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model. J Clin Invest (2003) 1.27
Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice. J Immunol (2007) 1.27
Efficacy of milnacipran in patients with fibromyalgia. J Rheumatol (2005) 1.26
Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats. J Physiol (2003) 1.25
Viral-mediated gene therapy for the muscular dystrophies: successes, limitations and recent advances. Biochim Biophys Acta (2006) 1.25
A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls. J Pain (2008) 1.25
Sleeping beauty vector system moves toward human trials in the United States. Mol Ther (2008) 1.24
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J Physiol (2008) 1.23
Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms. Arthritis Res Ther (2011) 1.22
Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods Enzymol (2006) 1.22
Evaluating an internet weight loss program for diabetes prevention. Health Promot Int (2005) 1.21
Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood (2008) 1.21
The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle. Endocrinology (2006) 1.21
Gene therapy of mdx mice with large truncated dystrophins generated by recombination using rAAV6. Mol Ther (2010) 1.21
Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes (2012) 1.20
Chromosome-specific microsatellite multiplex sets for linkage studies in the domestic dog. Genomics (2004) 1.20
Promoting student-centered active learning in lectures with a personal response system. Adv Physiol Educ (2009) 1.19
Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function. FASEB J (2010) 1.19
Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood (2006) 1.19
Structural brain anomalies and chronic pain: a quantitative meta-analysis of gray matter volume. J Pain (2013) 1.18
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. Nat Immunol (2006) 1.17
Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses. Br J Pharmacol (2006) 1.17