Published in J Biol Chem on January 23, 2003
Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell (2008) 1.11
A novel role for integrin-linked kinase in epithelial sheet morphogenesis. Mol Biol Cell (2005) 0.98
Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. Am J Pathol (2007) 0.96
Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell (2009) 0.93
Colorectal cancer is a paracrine deficiency syndrome amenable to oral hormone replacement therapy. Clin Transl Sci (2008) 0.83
Fatty acid ethyl esters induce intestinal epithelial barrier dysfunction via a reactive oxygen species-dependent mechanism in a three-dimensional cell culture model. PLoS One (2013) 0.83
Integrin-linked kinase can facilitate syncytialization and hormonal differentiation of the human trophoblast-derived BeWo cell line. Reprod Biol Endocrinol (2009) 0.80
Hypoxia enhances the wound-healing potential of adipose-derived stem cells in a novel human primary keratinocyte-based scratch assay. Int J Mol Med (2017) 0.75
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
Paxillin: adapting to change. Physiol Rev (2004) 4.48
Paxillin comes of age. J Cell Sci (2008) 3.57
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Mol Cell Biol (2003) 1.75
Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell (2002) 1.72
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell (2005) 1.69
Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane. Am J Physiol Cell Physiol (2003) 1.56
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. J Biol Chem (2001) 1.45
Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition. J Cell Biol (2012) 1.45
Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J Cell Sci (2008) 1.34
Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta. J Cell Sci (2005) 1.31
FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci (2009) 1.29
Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell (2005) 1.24
Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway. J Cell Physiol (2007) 1.22
The paxillin LD motifs. FEBS Lett (2002) 1.17
Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop. J Invest Dermatol (2008) 1.16
Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts. Mol Biol Cell (2003) 1.16
Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development. J Physiol (2003) 1.15
Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell (2008) 1.11
The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner. J Biol Chem (2004) 1.08
EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118. J Biol Chem (2004) 1.08
Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing. Mol Biol Cell (2003) 1.05
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci (2005) 1.05
A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice. Am J Pathol (2005) 1.04
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem (2002) 1.03
CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility. Curr Biol (2006) 1.03
Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol (2008) 1.01
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One (2012) 1.00
LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration. FASEB J (2012) 1.00
E2F-1 is essential for normal epidermal wound repair. J Biol Chem (2002) 0.99
RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell (2004) 0.99
A novel role for integrin-linked kinase in epithelial sheet morphogenesis. Mol Biol Cell (2005) 0.98
Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. J Biol Chem (2005) 0.98
Diverse roles for the paxillin family of proteins in cancer. Genes Cancer (2012) 0.98
Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Int J Biochem Cell Biol (2002) 0.97
Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration. Mol Biol Cell (2009) 0.97
Integrin-linked kinase is required for TGF-β1 induction of dermal myofibroblast differentiation. J Invest Dermatol (2010) 0.97
Phosphorylation of actopaxin regulates cell spreading and migration. J Cell Biol (2004) 0.97
Epidermal growth factor induction of front-rear polarity and migration in keratinocytes is mediated by integrin-linked kinase and ELMO2. Mol Biol Cell (2011) 0.97
Active nuclear import and export pathways regulate E2F-5 subcellular localization. J Biol Chem (2002) 0.95
A novel mechanism of E2F1 regulation via nucleocytoplasmic shuttling: determinants of nuclear import and export. Cell Cycle (2007) 0.95
Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell (2009) 0.93
TGF-beta1 slows the growth of pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5. J Invest Dermatol (2007) 0.93
Differentiation and injury-repair signals modulate the interaction of E2F and pRB proteins with novel target genes in keratinocytes. Cell Cycle (2006) 0.87
Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation. Exp Cell Res (2005) 0.86
Essential role of integrin-linked kinase in regulation of phagocytosis in keratinocytes. FASEB J (2012) 0.86
RGS14 is a microtubule-associated protein. Cell Cycle (2005) 0.85
Apoptosis in murine hepatoma hepa 1c1c7 wild-type, C12, and C4 cells mediated by bilirubin. Mol Pharmacol (2002) 0.85
The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification. J Biol Chem (2004) 0.84
Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1. Cell Cycle (2008) 0.84
Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways. Cell Adh Migr (2012) 0.84
Signalling in the epidermis: the E2F cell cycle regulatory pathway in epidermal morphogenesis, regeneration and transformation. Int J Biol Sci (2005) 0.84
Actopaxin is phosphorylated during mitosis and is a substrate for cyclin B1/cdc2 kinase. Biochem J (2002) 0.84
Integrins and small GTPases as modulators of phagocytosis. Int Rev Cell Mol Biol (2013) 0.83
Targeted inactivation of integrin-linked kinase in hair follicle stem cells reveals an important modulatory role in skin repair after injury. Mol Biol Cell (2011) 0.83
LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One (2013) 0.83
Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration. Cell Adh Migr (2010) 0.83
CdGAP regulates cell migration and adhesion dynamics in two-and three-dimensional matrix environments. Cytoskeleton (Hoboken) (2012) 0.80
Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion. J Biol Chem (2012) 0.80
ILK modulates epithelial polarity and matrix formation in hair follicles. Mol Biol Cell (2013) 0.79
Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development. Dev Dyn (2005) 0.79
Analysis of interactions between regulator of G-protein signaling-14 and microtubules. Methods Enzymol (2004) 0.79
Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling. PLoS One (2012) 0.79
Delayed apoptosis post-cadmium injury in renal proximal tubule epithelial cells. Am J Nephrol (2002) 0.78
Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol Biol Cell (2013) 0.78
Accurate and reproducible measurements of RhoA activation in small samples of primary cells. Anal Biochem (2009) 0.78
The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development. Dev Biol (2010) 0.78
Integrin-linked kinase: a possible role in scar contracture. Ann Plast Surg (2004) 0.77
Analysis of E2F factors during epidermal differentiation. Methods Mol Biol (2005) 0.77
EBP1 is a novel E2F target gene regulated by transforming growth factor-β. PLoS One (2010) 0.77
Epidermal growth factor stimulates serine/threonine phosphorylation of the focal adhesion protein paxillin in a MEK-dependent manner in normal rat kidney cells. J Cell Physiol (2002) 0.76
Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation. PLoS One (2012) 0.76
Analysis of nuclear export using photoactivatable GFP fusion proteins and interspecies heterokaryons. Methods Mol Biol (2010) 0.75
Isolation of hair follicle bulge stem cells from YFP-expressing reporter mice. Methods Mol Biol (2013) 0.75