Published in Nature on January 30, 2003
Cortical mechanisms of action selection: the affordance competition hypothesis. Philos Trans R Soc Lond B Biol Sci (2007) 3.02
Deciphering deuterostome phylogeny: molecular, morphological and palaeontological perspectives. Philos Trans R Soc Lond B Biol Sci (2008) 2.52
Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nat Rev Neurosci (2007) 1.89
What insects can tell us about the origins of consciousness. Proc Natl Acad Sci U S A (2016) 1.55
Decay of vertebrate characters in hagfish and lamprey (Cyclostomata) and the implications for the vertebrate fossil record. Proc Biol Sci (2010) 1.52
Darwin's dilemma: the realities of the Cambrian 'explosion'. Philos Trans R Soc Lond B Biol Sci (2006) 1.39
Arthropod visual predators in the early pelagic ecosystem: evidence from the Burgess Shale and Chengjiang biotas. Proc Biol Sci (2009) 1.30
A primitive fish from the Cambrian of North America. Nature (2014) 1.28
The characters of Palaeozoic jawed vertebrates. Zool J Linn Soc (2014) 1.25
Origin and evolution of the integumentary skeleton in non-tetrapod vertebrates. J Anat (2009) 1.24
The earliest fossil record of the animals and its significance. Philos Trans R Soc Lond B Biol Sci (2008) 1.22
Evidence for the prepattern/cooption model of vertebrate jaw evolution. Proc Natl Acad Sci U S A (2010) 1.07
Identification of vertebra-like elements and their possible differentiation from sclerotomes in the hagfish. Nat Commun (2011) 1.05
The evolution of early vertebrate photoreceptors. Philos Trans R Soc Lond B Biol Sci (2009) 1.01
The earliest history of the deuterostomes: the importance of the Chengjiang Fossil-Lagerstatte. Proc Biol Sci (2009) 1.01
Facts and fancies about early fossil chordates and vertebrates. Nature (2015) 1.01
Evolution of centralized nervous systems: two schools of evolutionary thought. Proc Natl Acad Sci U S A (2012) 1.00
Development in a naturally acidified environment: Na+/H+-exchanger 3-based proton secretion leads to CO2 tolerance in cephalopod embryos. Front Zool (2013) 0.98
microRNAs revive old views about jawless vertebrate divergence and evolution. Proc Natl Acad Sci U S A (2010) 0.96
The evolutionary and genetic origins of consciousness in the Cambrian Period over 500 million years ago. Front Psychol (2013) 0.89
Heart fossilization is possible and informs the evolution of cardiac outflow tract in vertebrates. Elife (2016) 0.87
The midline, oral ectoderm, and the arch-0 problem. Integr Comp Biol (2008) 0.86
Phylostratigraphic profiles in zebrafish uncover chordate origins of the vertebrate brain. Mol Biol Evol (2014) 0.85
Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proc Biol Sci (2015) 0.80
Palaeospondylus as a primitive hagfish. Zoological Lett (2016) 0.79
Progenitors of the protochordate ocellus as an evolutionary origin of the neural crest. Evodevo (2013) 0.77
Convergent evolution of hemoglobin switching in jawed and jawless vertebrates. BMC Evol Biol (2016) 0.76
What has driven the evolution of multiple cone classes in visual systems: object contrast enhancement or light flicker elimination? BMC Biol (2013) 0.75
Palaeontology: Inside-out turned upside-down. Nature (2013) 0.75
New reconstruction of the Wiwaxia scleritome, with data from Chengjiang juveniles. Sci Rep (2015) 0.75
Fin modules: an evolutionary perspective on appendage disparity in basal vertebrates. BMC Biol (2017) 0.75
Late development of hagfish vertebral elements. J Exp Zool B Mol Dev Evol (2013) 0.75
The sequence of the human genome. Science (2001) 101.55
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature (2000) 47.15
A whole-genome assembly of Drosophila. Science (2000) 38.48
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
A protein interaction map of Drosophila melanogaster. Science (2003) 20.06
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 16.91
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature (2003) 10.97
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93
Highly pathogenic H5N1 influenza virus infection in migratory birds. Science (2005) 9.64
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem (1995) 9.56
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development (2000) 8.07
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science (1995) 7.87
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44
Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology (1991) 7.33
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke (2001) 6.61
The p38 signal transduction pathway: activation and function. Cell Signal (2000) 6.18
RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science (1997) 6.00
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science (1999) 5.99
The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A (1994) 5.74
A simple method for clinical assay of superoxide dismutase. Clin Chem (1988) 5.66
Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell (1998) 5.60
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49
Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum (2001) 5.36
Genetic diversity and disease control in rice. Nature (2000) 5.34
Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J Virol (1992) 5.19
Spin-torque switching with the giant spin Hall effect of tantalum. Science (2012) 5.18
Extensive variation of human immunodeficiency virus type-1 in vivo. Nature (1988) 5.02
NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90
Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet (1998) 4.67
The Human Connectome Project: a data acquisition perspective. Neuroimage (2012) 4.64
Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke (2001) 4.64
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci U S A (1995) 4.54
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J (1997) 4.51
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49
Femtosecond electronic response of atoms to ultra-intense X-rays. Nature (2010) 4.46
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene (2008) 4.43
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem (1995) 4.36
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev (1994) 4.30
The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J Virol (1998) 4.26
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res (1999) 4.20
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature (2004) 4.12
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol (2001) 4.10
A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08
A viral phospholipase A2 is required for parvovirus infectivity. Dev Cell (2001) 3.97
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A (1996) 3.89
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82
A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80
Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem (1998) 3.80
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest (2001) 3.79
Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci U S A (1994) 3.76
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet (2000) 3.72
The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia (2008) 3.69
Auxin-induced expression of the soybean GH3 promoter in transgenic tobacco plants. Plant Mol Biol (1991) 3.67
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem (1996) 3.63
Green fluorescent protein as a noninvasive intracellular pH indicator. Biophys J (1998) 3.61
Significance of premature stop codons in env of simian immunodeficiency virus. J Virol (1989) 3.60
Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide. J Immunol (1990) 3.56
A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome. Nature (1995) 3.56
The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer. Ann Oncol (2005) 3.56
Is routine indwelling catheterisation of the bladder for caesarean section necessary? A systematic review. BJOG (2010) 3.54
Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature (1998) 3.54
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet (2001) 3.52
Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res (1998) 3.44
Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus. Why some tests fail. Arthritis Rheum (1996) 3.40
Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell (2000) 3.39
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol Cell Biol (1993) 3.38
Establishment and characterization of a cell line of human breast carcinoma origin. Eur J Cancer (1979) 3.37
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery. EMBO J (1999) 3.35
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
Sequence analysis of hepatitis C virus isolated from a fulminant hepatitis patient. J Med Virol (2001) 3.29
Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS (1999) 3.28
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22
Generating yeast transcriptional activators containing no yeast protein sequences. Nature (1991) 3.21
HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol Cell Biol (1999) 3.21
A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res (1999) 3.19
The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell (1995) 3.17
Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol (2000) 3.07
Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J Exp Med (1997) 3.07
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol (1999) 3.02
Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging (2005) 3.00
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93
The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo. Cell (2001) 2.92
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc Natl Acad Sci U S A (1994) 2.91
Antiviral RNA interference in mammalian cells. Science (2013) 2.89
Schistosomiasis in the People's Republic of China: prospects and challenges for the 21st century. Clin Microbiol Rev (2001) 2.85