PubRank

Elmar Heinzle

Author PubWeight™ 90.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Correcting mass isotopomer distributions for naturally occurring isotopes. Biotechnol Bioeng 2002 1.90
2 Identification and quantification of feathers, down, and hair of avian and mammalian origin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Chem 2002 1.67
3 The yeast Kluyveromyces marxianus and its biotechnological potential. Appl Microbiol Biotechnol 2008 1.61
4 Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing corynebacteria. Appl Environ Microbiol 2002 1.58
5 Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria. Anal Biochem 2004 1.55
6 Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose. Appl Environ Microbiol 2004 1.50
7 Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources. Appl Environ Microbiol 2005 1.44
8 Integrated optical sensing of dissolved oxygen in microtiter plates: a novel tool for microbial cultivation. Biotechnol Bioeng 2003 1.41
9 Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. Bioprocess Biosyst Eng 2010 1.40
10 Minibioreactors. Biotechnol Lett 2004 1.37
11 In vivo analysis of intracellular amino acid labelings by GC/MS. Anal Biochem 2002 1.37
12 In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. J Bacteriol 2004 1.32
13 In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum. Anal Biochem 2005 1.23
14 Characterization and application of an optical sensor for quantification of dissolved O2 in shake-flasks. Biotechnol Lett 2003 1.15
15 Selective permeabilization for the high-throughput measurement of compartmented enzyme activities in mammalian cells. Anal Biochem 2011 1.14
16 Two-dimensional reversed-phase x ion-pair reversed-phase HPLC: an alternative approach to high-resolution peptide separation for shotgun proteome analysis. J Proteome Res 2007 1.13
17 Metabolic flux analysis in eukaryotes. Curr Opin Biotechnol 2010 1.13
18 Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicol Appl Pharmacol 2009 1.07
19 Metabolic flux analysis in systems biology of mammalian cells. Adv Biochem Eng Biotechnol 2012 1.07
20 Isotope labeling experiments in metabolomics and fluxomics. Wiley Interdiscip Rev Syst Biol Med 2012 1.06
21 On-line oxygen uptake rate and culture viability measurement of animal cell culture using microplates with integrated oxygen sensors. Biotechnol Lett 2004 1.05
22 Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation. Appl Environ Microbiol 2006 1.05
23 Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale. Biotechnol Bioeng 2004 1.02
24 Ionic (liquid) matrices for matrix-assisted laser desorption/ionization mass spectrometry-applications and perspectives. Anal Bioanal Chem 2006 1.02
25 3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies. Toxicol Sci 2013 1.01
26 Optical device for parallel online measurement of dissolved oxygen and pH in shake flask cultures. Bioprocess Biosyst Eng 2009 1.00
27 Theoretical aspects of 13C metabolic flux analysis with sole quantification of carbon dioxide labeling. Comput Biol Chem 2005 1.00
28 Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae. Biotechnol Bioeng 2003 0.99
29 Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum. Metab Eng 2006 0.99
30 Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with multidimensional scaling, binary hierarchical cluster tree and selected diagnostic masses improves species identification of Neolithic keratin sequences from furs of the Tyrolean Iceman Oetzi. Rapid Commun Mass Spectrom 2012 0.96
31 Species identification of Oetzi's clothing with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry based on peptide pattern similarities of hair digests. Rapid Commun Mass Spectrom 2008 0.96
32 Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source. FEMS Yeast Res 2007 0.95
33 Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol 2011 0.95
34 Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification. BMC Syst Biol 2008 0.94
35 Modeling of mixing in 96-well microplates observed with fluorescence indicators. Biotechnol Prog 2002 0.94
36 Microplates with integrated oxygen sensing for medium optimization in animal cell culture. Cytotechnology 2005 0.93
37 Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling. Biotechnol J 2009 0.91
38 PH-sensing 96-well microtitre plates for the characterization of acid production by dairy starter cultures. J Dairy Res 2003 0.91
39 Doxorubicin increases oxidative metabolism in HL-1 cardiomyocytes as shown by 13C metabolic flux analysis. Toxicol Sci 2011 0.90
40 An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells. Toxicol Appl Pharmacol 2009 0.88
41 Numerical bias estimation for mass spectrometric mass isotopomer analysis. Anal Biochem 2009 0.88
42 Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and α1-antitrypsin production at reduced pyruvate load. Appl Microbiol Biotechnol 2011 0.86
43 Qualitative and quantitative analysis of low molecular weight compounds by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry using ionic liquid matrices. Rapid Commun Mass Spectrom 2004 0.86
44 Engineering the supply chain for protein production/secretion in yeasts and mammalian cells. J Ind Microbiol Biotechnol 2015 0.85
45 Quantification of peptides for the monitoring of protease-catalyzed reactions by matrix-assisted laser desorption/ionization mass spectrometry using ionic liquid matrixes. Anal Chem 2006 0.85
46 Repeatability of peptide identifications in shotgun proteome analysis employing off-line two-dimensional chromatographic separations and ion-trap MS. J Sep Sci 2009 0.85
47 Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains. J Bacteriol 2006 0.85
48 In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor. J Tissue Eng Regen Med 2011 0.85
49 Eukaryotic metabolism: measuring compartment fluxes. Biotechnol J 2011 0.85
50 Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry. J Mass Spectrom 2002 0.85
51 A system of miniaturized stirred bioreactors for parallel continuous cultivation of yeast with online measurement of dissolved oxygen and off-gas. Biotechnol Bioeng 2012 0.85
52 Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function. J Biotechnol 2007 0.84
53 Software tool for automated processing of 13C labeling data from mass spectrometric spectra. Biotechniques 2003 0.84
54 Stable isotope-assisted metabolomics to detect metabolic flux changes in mammalian cell cultures. Curr Opin Biotechnol 2012 0.83
55 Mixed glucose and lactate uptake by Corynebacterium glutamicum through metabolic engineering. Biotechnol J 2011 0.83
56 Respirometric 13C flux analysis--Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum. Metab Eng 2006 0.83
57 Real-time in situ viability assessment in a 3D bioreactor with liver cells using resazurin assay. Cytotechnology 2012 0.83
58 Dynamics of growth and metabolism controlled by glutamine availability in Chinese hamster ovary cells. Appl Microbiol Biotechnol 2013 0.82
59 Online monitoring of oxygen in spinner flasks. Biotechnol Lett 2009 0.82
60 Investigation of the central carbon metabolism of Sorangium cellulosum: metabolic network reconstruction and quantification of pathway fluxes. J Microbiol Biotechnol 2009 0.81
61 Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR. Microbiology 2008 0.81
62 Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine. Microb Cell Fact 2012 0.81
63 The SEURAT-1 approach towards animal free human safety assessment. ALTEX 2014 0.81
64 13C metabolic flux analysis for larger scale cultivation using gas chromatography-combustion-isotope ratio mass spectrometry. Metab Eng 2010 0.81
65 Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry. J Am Soc Mass Spectrom 2006 0.80
66 Zinc ion-induced domain organization in metallo-beta-lactamases: a flexible "zinc arm" for rapid metal ion transfer? J Biol Chem 2009 0.80
67 Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol. Rapid Commun Mass Spectrom 2007 0.80
68 Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening. Microb Cell Fact 2009 0.80
69 Esterase autodisplay: enzyme engineering and whole-cell activity determination in microplates with pH sensors. Appl Environ Microbiol 2008 0.80
70 Respirometric 13C flux analysis, Part I: design, construction and validation of a novel multiple reactor system using on-line membrane inlet mass spectrometry. Metab Eng 2006 0.79
71 Metabolite channeling and compartmentation in the human cell line AGE1.HN determined by 13C labeling experiments and 13C metabolic flux analysis. J Biosci Bioeng 2011 0.79
72 Matrix-assisted laser desorption/ionization mass spectrometry for the characterization of ionic liquids and the analysis of amino acids, peptides and proteins in ionic liquids. J Mass Spectrom 2004 0.79
73 N-acetylation and phosphorylation of Sec complex subunits in the ER membrane. BMC Cell Biol 2012 0.79
74 Metabolic flux rearrangement in the amino acid metabolism reduces ammonia stress in the α1-antitrypsin producing human AGE1.HN cell line. Metab Eng 2012 0.79
75 Quantitative matrix-assisted laser desorption/ionization mass spectrometry for the determination of enzyme activities. Anal Biochem 2004 0.79
76 A 2D reversed-phase x ion-pair reversed-phase HPLC-MALDI TOF/TOF-MS approach for shotgun proteome analysis. Anal Bioanal Chem 2008 0.79
77 High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements. Toxicol In Vitro 2009 0.78
78 Production of L-lysine on different silage juices using genetically engineered Corynebacterium glutamicum. J Biotechnol 2012 0.78
79 Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells. J Biotechnol 2011 0.78
80 Gas sensing in microplates with optodes: influence of oxygen exchange between sample, air, and plate material. Biotechnol Bioeng 2005 0.78
81 Quercetin treatment changes fluxes in the primary metabolism and increases culture longevity and recombinant α₁-antitrypsin production in human AGE1.HN cells. Appl Microbiol Biotechnol 2011 0.78
82 Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes. Toxicol Appl Pharmacol 2011 0.78
83 Proteolytic peptide patterns as indicators for fungal infections and nonfungal affections of human nails measured by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem 2005 0.77
84 Metabolic fluxes in Schizosaccharomyces pombe grown on glucose and mixtures of glycerol and acetate. Appl Microbiol Biotechnol 2013 0.77
85 Macroscopic modeling of mammalian cell growth and metabolism. Appl Microbiol Biotechnol 2015 0.77
86 Metabolism and metabolic burden by α1-antitrypsin production in human AGE1.HN cells. Metab Eng 2013 0.77
87 Controlled feeding of hydrogen peroxide as oxygen source improves production of 5-ketofructose from L-sorbose using engineered pyranose 2-oxidase from Peniophora gigantea. Biotechnol Bioeng 2012 0.77
88 Pyridinium-based ionic liquid matrices can improve the identification of proteins by peptide mass-fingerprint analysis with matrix-assisted laser desorption/ionization mass spectrometry. Anal Bioanal Chem 2005 0.77
89 Multistep synthesis of UDP-glucose using tailored, permeabilized cells of E. coli. Appl Biochem Biotechnol 2015 0.77
90 Quantitation of intracellular purine intermediates in different Corynebacteria using electrospray LC-MS/MS. Anal Bioanal Chem 2012 0.76
91 Directed multistep biocatalysis using tailored permeabilized cells. Adv Biochem Eng Biotechnol 2013 0.76
92 Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project. Altern Lab Anim 2011 0.76
93 Rapid selection of peptide containing fractions in off-line 2-D HPLC in shotgun proteome analysis by screening with MALDI TOF MS. Proteomics 2009 0.76
94 Mass isotopomer analysis of nucleosides isolated from RNA and DNA using GC/MS. Anal Chem 2014 0.76
95 Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a new tool in diagnostic investigation of nail disorders? Exp Dermatol 2009 0.76
96 Microplates with integrated oxygen sensors for kinetic cell respiration measurement and cytotoxicity testing in primary and secondary cell lines. Assay Drug Dev Technol 2005 0.75
97 Identification of oxidized methionine residues in peptides containing two methionine residues by derivatization and matrix-assisted laser desorption/ionization mass spectrometry. Proteomics 2002 0.75
98 Report and recommendation of a workshop on education and training for measurement, monitoring, modelling and control (M3C) in biochemical engineering. Biotechnol J 2010 0.75
99 High-throughput phospholipid quantitation in mammalian cells using matrix-assisted laser desorption ionization-time of flight mass spectrometry with N-trifluoroacetyl-phosphatidylethanolamine as internal standard. Anal Biochem 2011 0.75
100 Methods for biocatalyst screening. Adv Biochem Eng Biotechnol 2002 0.75
101 Quantification of S-adenosyl methionine in microbial cell extracts. Biotechnol Lett 2006 0.75
102 Dynamic calibration and dissolved gas analysis using membrane inlet mass spectrometry for the quantification of cell respiration. Rapid Commun Mass Spectrom 2003 0.75
103 Quenching methods for the analysis of intracellular metabolites. Methods Mol Biol 2014 0.75
104 Screening of sugar converting enzymes using quantitative MALDI-ToF mass spectrometry. Biotechnol Lett 2004 0.75