Published in Am J Physiol Endocrinol Metab on February 11, 2003
Islet beta cell failure in type 2 diabetes. J Clin Invest (2006) 7.67
Relation between serum free fatty acids and adiposity, insulin resistance, and cardiovascular risk factors from adolescence to adulthood. Diabetes (2013) 0.96
Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1. Mol Metab (2014) 0.85
Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetol (2014) 0.81
Does inhibition of β-cell proliferation by free fatty acid in mice explain the progressive failure of insulin secretion in type 2 diabetes? Diabetes (2012) 0.75
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med (2008) 12.41
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A (2009) 5.19
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr (2011) 4.60
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes: A 2-Year Randomized, Controlled Trial. Ann Intern Med (2015) 3.78
Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet (2002) 3.68
Insulin-sensitive obesity. Am J Physiol Endocrinol Metab (2010) 3.46
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes (2002) 2.98
Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab (2007) 2.81
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Effect of a diabetic environment in utero on predisposition to type 2 diabetes. Lancet (2003) 2.74
Lead poisoning due to adulterated marijuana in leipzig. Dtsch Arztebl Int (2008) 2.72
Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes (2003) 2.71
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab (2007) 2.69
A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array. Diabetes (2007) 2.67
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet (2007) 2.48
Identification of individuals with insulin resistance using routine clinical measurements. Diabetes (2005) 2.46
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes (2006) 2.40
High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes (2002) 2.36
Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes (2005) 2.34
Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring. Diabetes (2006) 2.21
Variants in CPA1 are strongly associated with early onset chronic pancreatitis. Nat Genet (2013) 2.10
Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care (2003) 2.05
Serum levels of the adipokine progranulin depend on renal function. Diabetes Care (2012) 2.03
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes (2007) 1.96
A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes (2003) 1.92
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
Serum levels of adipokine retinol-binding protein-4 in relation to renal function. Diabetes Care (2007) 1.85
Standardized assessment of whole body adipose tissue topography by MRI. J Magn Reson Imaging (2005) 1.85
MicroRNA expression in human omental and subcutaneous adipose tissue. PLoS One (2009) 1.81
CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated? Gut (2012) 1.77
Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol (2006) 1.76
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children. J Clin Endocrinol Metab (2006) 1.71
Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet (2012) 1.68
Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography. Ann N Y Acad Sci (2002) 1.66
Multiple loci are associated with white blood cell phenotypes. PLoS Genet (2011) 1.65
Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res (2003) 1.65
Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. Atherosclerosis (2002) 1.60
High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. J Clin Endocrinol Metab (2002) 1.59
Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J Clin Endocrinol Metab (2003) 1.58
Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus. Hepatology (2013) 1.53
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study. Proc Natl Acad Sci U S A (2006) 1.51
Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction. Clin Endocrinol (Oxf) (2014) 1.49
Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes (2008) 1.48
Eigenvector centrality mapping for analyzing connectivity patterns in fMRI data of the human brain. PLoS One (2010) 1.48
Brain activity in hunger and satiety: an exploratory visually stimulated FMRI study. Obesity (Silver Spring) (2008) 1.46
Circulating adipocyte fatty acid-binding protein induces insulin resistance in mice in vivo. Obesity (Silver Spring) (2015) 1.45
Intrauterine exposure to diabetes is a determinant of hemoglobin A(1)c and systolic blood pressure in pima Indian children. J Clin Endocrinol Metab (2005) 1.43
Serum levels of the adipokine FGF21 depend on renal function. Diabetes Care (2008) 1.42
Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue. Diabetes (2008) 1.42
Assay-dependent variability of serum insulin levels during oral glucose tolerance test: influence on reference intervals for insulin and on cut-off values for insulin sensitivity indices. Clin Chem Lab Med (2008) 1.42
Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity? Diabetes Care (2004) 1.42
The 24-h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake. Am J Clin Nutr (2007) 1.37
Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab (2003) 1.36
Subcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesity. Am J Physiol Endocrinol Metab (2004) 1.32
The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet (2003) 1.31
Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging. PLoS One (2011) 1.30
Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun (2005) 1.30
Dietary intervention to reverse carotid atherosclerosis. Circulation (2010) 1.28
Sensory experience of food and obesity: a positron emission tomography study of the brain regions affected by tasting a liquid meal after a prolonged fast. Neuroimage (2005) 1.28
Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care (2006) 1.27
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet (2010) 1.26
Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab (2002) 1.26
Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes. PLoS One (2010) 1.25
Sex differences in the human brain's response to hunger and satiation. Am J Clin Nutr (2002) 1.25
Interleukin-1beta induces the novel adipokine chemerin in adipocytes in vitro. Regul Pept (2009) 1.24
High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians. Diabetes (2004) 1.24
Assessing risk factors for obesity between childhood and adolescence: I. Birth weight, childhood adiposity, parental obesity, insulin, and leptin. Pediatrics (2002) 1.23
Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. Diabetes (2006) 1.20
Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes. Mol Cell Endocrinol (2005) 1.20
Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs. Diabetes (2003) 1.19
TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals. Diabetes (2007) 1.19
Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes (2003) 1.19
Serum levels of the adipokine vaspin in relation to metabolic and renal parameters. J Clin Endocrinol Metab (2007) 1.19
Glucose allostasis. Diabetes (2003) 1.18
Serum levels of the atherosclerosis biomarker sTWEAK are decreased in type 2 diabetes and end-stage renal disease. Atherosclerosis (2007) 1.18