PubRank

Douglas F Covey

Author PubWeight™ 121.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Anticonvulsant medications extend worm life-span. Science 2005 2.18
2 Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. J Biol Chem 2004 2.06
3 The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity 2012 1.96
4 Neurosteroid access to the GABAA receptor. J Neurosci 2005 1.95
5 Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem 2006 1.72
6 Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol 2012 1.72
7 Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A 2006 1.62
8 Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther 2007 1.60
9 Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther 2007 1.55
10 Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. J Biol Chem 2003 1.52
11 Neuroactive steroids have multiple actions to potentiate GABAA receptors. J Physiol 2004 1.47
12 Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Mol Pharmacol 2008 1.46
13 Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Mol Pharmacol 2007 1.33
14 Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. J Cell Mol Med 2008 1.33
15 Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Mol Pharmacol 2006 1.31
16 Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. Eur J Med Chem 2007 1.31
17 Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. Biophys J 2003 1.24
18 Slow actions of neuroactive steroids at GABAA receptors. J Neurosci 2004 1.24
19 Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Mol Pharmacol 2004 1.23
20 The sticky issue of neurosteroids and GABA(A) receptors. Trends Neurosci 2010 1.21
21 3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. J Neurosci 2002 1.18
22 Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem 2008 1.17
23 Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res 2005 1.16
24 Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes 2009 1.15
25 Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife 2013 1.15
26 The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. J Neurophysiol 2009 1.14
27 Neurosteroids, stress and depression: potential therapeutic opportunities. Neurosci Biobehav Rev 2012 1.12
28 Energetics by NMR: site-specific binding in a positively cooperative system. Proc Natl Acad Sci U S A 2002 1.11
29 Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. Am J Physiol Endocrinol Metab 2002 1.11
30 Estrogen-like compounds for ischemic neuroprotection. Stroke 2004 1.10
31 First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. Steroids 2003 1.10
32 Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. J Physiol 2007 1.07
33 Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells. Mol Pharmacol 2006 1.06
34 Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. Biochem J 2005 1.06
35 Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Mol Pharmacol 2012 1.05
36 New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain 2005 1.03
37 Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors. J Biol Chem 2002 1.03
38 Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nat Neurosci 2007 1.03
39 Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. J Biol Chem 2008 1.01
40 GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. Eur J Neurosci 2007 1.01
41 Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. J Biol Chem 2003 1.01
42 Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis. Stroke 2002 1.01
43 Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther 2007 1.00
44 Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. J Med Chem 2007 0.99
45 Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. J Med Chem 2008 0.98
46 Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. J Lipid Res 2010 0.98
47 Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol. FEBS Lett 2003 0.97
48 Total synthesis of ent-cholesterol via a steroid C,D-ring side-chain synthon. J Org Chem 2002 0.97
49 Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol. PLoS One 2011 0.96
50 The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury. Neuropharmacology 2006 0.95
51 Cholesterol tuning of BK ethanol response is enantioselective, and is a function of accompanying lipids. PLoS One 2011 0.94
52 Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. J Med Chem 2003 0.94
53 Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation. Br J Pharmacol 2009 0.93
54 Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems. J Org Chem 2007 0.93
55 Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action. Mol Pharmacol 2006 0.92
56 Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. Br J Pharmacol 2012 0.92
57 Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases. J Steroid Biochem Mol Biol 2011 0.91
58 The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology 2009 0.91
59 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol Pharmacol 2004 0.91
60 Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers. Biochim Biophys Acta 2006 0.91
61 Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Curr Neuropharmacol 2010 0.90
62 The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Mol Pharmacol 2007 0.90
63 Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. J Pharmacol Exp Ther 2007 0.89
64 Oxysterols as non-genomic regulators of cholesterol homeostasis. Trends Endocrinol Metab 2012 0.89
65 Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. J Pharmacol Exp Ther 2003 0.88
66 Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue. J Physiol 2009 0.88
67 T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. Neuropharmacology 2010 0.88
68 Enantiospecific interactions between cholesterol and phospholipids. Langmuir 2008 0.88
69 Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes 2013 0.87
70 Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog. Biochem Pharmacol 2004 0.87
71 The assessment of non-feminizing estrogens for use in neuroprotection. Brain Res 2010 0.87
72 Racemic progesterone: predicted in silico and produced in the solid state. Chem Commun (Camb) 2006 0.87
73 A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. J Pharmacol Exp Ther 2010 0.87
74 The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21. Arch Biochem Biophys 2003 0.86
75 The structural basis of cholesterol accessibility in membranes. Biophys J 2013 0.86
76 Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. J Med Chem 2013 0.85
77 A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis 2012 0.85
78 Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors. Biophys J 2008 0.85
79 Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorg Med Chem Lett 2010 0.85
80 Synthesis of ent-25-hydroxycholesterol. Steroids 2006 0.85
81 Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity. Free Radic Biol Med 2005 0.85
82 A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions. Bioorg Med Chem Lett 2002 0.84
83 Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. J Med Chem 2005 0.84
84 The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog. Neurobiol Dis 2002 0.84
85 Mechanism of okadaic acid-induced neuronal death and the effect of estrogens. J Neurochem 2008 0.83
86 NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue. J Physiol 2009 0.83
87 Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors. J Med Chem 2012 0.83
88 Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology 2009 0.83
89 Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. Biochemistry 2003 0.82
90 A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein. J Am Chem Soc 2004 0.82
91 Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions. J Org Chem 2002 0.82
92 Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines. J Org Chem 2007 0.81
93 Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain 2006 0.81
94 Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Mol Pharmacol 2009 0.80
95 Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy. Horm Behav 2012 0.80
96 First synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes. J Org Chem 2005 0.79
97 Synthesis of a smoothened cholesterol: 18,19-di-nor-cholesterol. J Org Chem 2014 0.79
98 Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice. Eur Neuropsychopharmacol 2010 0.79
99 Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. J Biol Chem 2014 0.79
100 Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol. Eur J Pharmacol 2007 0.79
101 Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid. Ann N Y Acad Sci 2007 0.79
102 The use of symmetry in enantioselective synthesis: four pairs of chrysene enantiomers prepared from 19-nortestosterone. Org Biomol Chem 2011 0.79
103 Stereospecific requirement of cholesterol in the function of the serotonin1A receptor. Biochim Biophys Acta 2013 0.79
104 Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. J Lipid Res 2006 0.79
105 Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. Biochemistry 2014 0.79
106 Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function. J Pharmacol Exp Ther 2004 0.78
107 The Efficient and Enantiospecific Total Synthesis of Cyclopenta[b]phenanthrenes Structurally-related to Neurosteroids. Adv Synth Catal 2010 0.78
108 Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis. Lipids 2005 0.77
109 Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone. J Labelled Comp Radiopharm 2008 0.77
110 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology (Berl) 2014 0.77
111 Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity. J Med Chem 2011 0.77
112 Neurosteroid Analogues. 13. Synthetic methods for the preparation of 2beta-hydroxygonane derivatives as structural mimics of ent-3alpha-hydroxysteroid modulators of GABA(A) receptors. Tetrahedron 2007 0.77
113 A facile total synthesis of ent-17beta-estradiol and structurally related analogues. Steroids 2006 0.76
114 Modulation of the human ρ1 GABAA receptor by inhibitory steroids. Psychopharmacology (Berl) 2013 0.76
115 Synthesis of the enantiomer of the oxysterol-antagonist LY295427. Steroids 2011 0.76
116 Eliminating the roughness in cholesterol's β-face: does it matter? Langmuir 2014 0.76
117 Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem 2006 0.76
118 Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms. Psychopharmacology (Berl) 2014 0.76
119 Abnormal Beckmann fragmentation/ring closing metathesis route for preparation of 18-nor-Delta-androgens and their 18-nor-13,17-epoxide derivatives. Tetrahedron Lett 2006 0.75
120 Correction to Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol. J Org Chem 2015 0.75