Published in Biochemistry on March 11, 2003
Light-dependent regulation of structural flexibility in a photochromic fluorescent protein. Proc Natl Acad Sci U S A (2008) 1.28
The rough energy landscape of superfolder GFP is linked to the chromophore. J Mol Biol (2007) 1.23
Complementation and reconstitution of fluorescence from circularly permuted and truncated green fluorescent protein. Biochemistry (2009) 1.16
Unfolding of Green Fluorescent Protein mut2 in wet nanoporous silica gels. Protein Sci (2005) 1.08
Chromophore packing leads to hysteresis in GFP. J Mol Biol (2009) 1.02
Protein dynamics control proton transfer from bulk solvent to protein interior: a case study with a green fluorescent protein. Protein Sci (2005) 0.94
Optically modulatable blue fluorescent proteins. J Am Chem Soc (2013) 0.92
The extremely slow-exchanging core and acid-denatured state of green fluorescent protein. HFSP J (2008) 0.86
Folding study of Venus reveals a strong ion dependence of its yellow fluorescence under mildly acidic conditions. J Biol Chem (2009) 0.82
Metal toxicity and opportunistic binding of Pb(2+) in proteins. J Inorg Biochem (2013) 0.80
Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein. Acta Crystallogr D Biol Crystallogr (2014) 0.80
Rational design of analyte channels of the green fluorescent protein for biosensor applications. Int J Biol Sci (2007) 0.80
Ground-state proton transfer kinetics in green fluorescent protein. Biochemistry (2014) 0.78
Exploring the folding pathway of green fluorescent protein through disulfide engineering. Protein Sci (2015) 0.77
Water Diffusion In And Out Of The β-Barrel Of GFP and The Fast Maturing Fluorescent Protein, TurboGFP. Chem Phys (2011) 0.76
Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle. Chem Sci (2016) 0.75
Directed evolution of key residues in fluorescent protein inverses the polarity of voltage sensitivity in the genetically-encoded indicator ArcLight. ACS Chem Neurosci (2017) 0.75
Toward Computationally Designed Self-Reporting Biosensors Using Leave-One-Out Green Fluorescent Protein. Biochemistry (2015) 0.75
The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08
Lifeact: a versatile marker to visualize F-actin. Nat Methods (2008) 12.23
Filamins: promiscuous organizers of the cytoskeleton. Trends Biochem Sci (2006) 2.79
High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle (2009) 2.11
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle (2008) 1.71
Transient protein states in designing inhibitors of the MDM2-p53 interaction. Structure (2013) 1.63
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy (2012) 1.63
Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. PLoS One (2012) 1.60
Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle (2007) 1.55
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle (2010) 1.52
Expansion of the genetic code enables design of a novel "gold" class of green fluorescent proteins. J Mol Biol (2003) 1.34
Pitfalls of supervised feature selection. Bioinformatics (2009) 1.33
Structure of the stapled p53 peptide bound to Mdm2. J Am Chem Soc (2011) 1.30
The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. Angew Chem Int Ed Engl (2011) 1.30
Practical aspects of the 2D 15N-[1h]-NOE experiment. J Biomol NMR (2002) 1.29
Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. Angew Chem Int Ed Engl (2010) 1.29
Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. ChemMedChem (2008) 1.27
Protein folding and stability of human CDK inhibitor p19(INK4d). J Mol Biol (2002) 1.25
Protein solubility: sequence based prediction and experimental verification. Bioinformatics (2006) 1.23
Application of NMR in structural proteomics: screening for proteins amenable to structural analysis. Structure (2002) 1.15
The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res (2005) 1.13
Molecular determinants for the complex formation between the retinoblastoma protein and LXCXE sequences. J Biol Chem (2005) 1.12
Molecular structure of the rod domain of dictyostelium filamin. J Mol Biol (2004) 1.12
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proc Natl Acad Sci U S A (2006) 1.11
Mutagenic stabilization of the photocycle intermediate of green fluorescent protein (GFP). Chembiochem (2003) 1.10
Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of melanoma inhibitory activity. Lab Invest (2003) 1.10
Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex. Chembiochem (2007) 1.09
NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nat Med (2005) 1.09
c-Abl phosphorylates Hdmx and regulates its interaction with p53. J Biol Chem (2008) 1.09
Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature (2011) 1.07
Characterization of 14-3-3sigma dimerization determinants: requirement of homodimerization for inhibition of cell proliferation. Cell Cycle (2006) 1.07
1,4-Thienodiazepine-2,5-diones via MCR (I): synthesis, virtual space and p53-Mdm2 activity. Chem Biol Drug Des (2010) 1.07
Shugoshin is a Mad1/Cdc20-like interactor of Mad2. EMBO J (2011) 1.06
An evolutionary and structural characterization of mammalian protein complex organization. BMC Genomics (2008) 1.03
Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists. J Comb Chem (2010) 1.03
Slow exchange in the chromophore of a green fluorescent protein variant. J Am Chem Soc (2002) 1.02
Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists. ChemMedChem (2011) 1.01
Negatome 2.0: a database of non-interacting proteins derived by literature mining, manual annotation and protein structure analysis. Nucleic Acids Res (2013) 1.01
Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc Natl Acad Sci U S A (2010) 1.00
DNA-binding properties of the recombinant high-mobility-group-like AT-hook-containing region from human BRG1 protein. Biol Chem (2006) 0.99
Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. J Mol Biol (2006) 0.99
Monitoring the effects of antagonists on protein-protein interactions with NMR spectroscopy. J Am Chem Soc (2005) 0.96
Structural basis for the regulation of insulin-like growth factors by IGF binding proteins. Structure (2005) 0.95
Robust NMR screening for lead compounds using tryptophan-containing proteins. J Am Chem Soc (2009) 0.95
A novel medium for expression of proteins selectively labeled with 15N-amino acids in Spodoptera frugiperda (Sf9) insect cells. J Biomol NMR (2003) 0.95
Functional and structural characterization of Spl proteases from Staphylococcus aureus. J Mol Biol (2006) 0.95
An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments. J Med Chem (2007) 0.94
Programmed death-1: therapeutic success after more than 100 years of cancer immunotherapy. Angew Chem Int Ed Engl (2014) 0.91
Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy. Cell Mol Life Sci (2012) 0.91
Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present). Expert Opin Ther Pat (2013) 0.91
Structure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum. Structure (2003) 0.89
The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode. J Mol Biol (2005) 0.88
Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem Biol (2014) 0.87
Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium. J Biol Chem (2006) 0.87
Efforts towards the design of 'teflon' proteins: in vivo translation with trifluorinated leucine and methionine analogues. Chem Biodivers (2004) 0.86
Picosecond time-resolved fluorescence from blue-emitting chromophore variants Y66F and Y66H of the green fluorescent protein. Chembiochem (2002) 0.84
A novel class of cysteine protease inhibitors: solution structure of staphostatin A from Staphylococcus aureus. Biochemistry (2003) 0.83
Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d). Biol Chem (2006) 0.82
NMR structural characterization of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum. J Biomol NMR (2004) 0.81
Predicting experimental properties of integral membrane proteins by a naive Bayes approach. Proteins (2008) 0.81
Backbone H(N), N, C(alpha) and C(beta) assignment of the GFPuv mutant. J Biomol NMR (2003) 0.81
In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction. J Med Chem (2002) 0.80
Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly. Proc Natl Acad Sci U S A (2011) 0.80
NMR screening for lead compounds using tryptophan-mutated proteins. J Med Chem (2008) 0.80
Purification, crystallization, NMR spectroscopy and biochemical analyses of alpha-phycoerythrocyanin peptides. Eur J Biochem (2002) 0.80
Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives. ACS Chem Biol (2011) 0.79
Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol (2012) 0.79
Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2. Bioorg Med Chem (2012) 0.78
NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor. Structure (2005) 0.78
Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor. ACS Comb Sci (2014) 0.78
NMR and mass spectrometry studies of putative interactions of cell cycle proteins pRb and CDK6 with cell differentiation proteins MyoD and ID-2. Biochim Biophys Acta (2005) 0.78
Backbone dynamics of the human MIA protein studied by (15)N NMR relaxation: implications for extended interactions of SH3 domains. Protein Sci (2003) 0.78
Specific isotope labeling of colicin E1 and B channel domains for membrane topological analysis by oriented solid-state NMR spectroscopy. Chembiochem (2008) 0.77
Subclinical CNS inflammation as response to a myelin antigen in humanized mice. J Neuroimmune Pharmacol (2013) 0.77
Phosphorylation and flexibility of cyclic-AMP-dependent protein kinase (PKA) using (31)P NMR spectroscopy. Biochemistry (2002) 0.77
2,30-Bis(10H-indole) heterocycles: New p53/MDM2/MDMX antagonists. Bioorg Med Chem Lett (2015) 0.76
Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain. Biol Chem (2005) 0.76
Structures of the arm-type binding domains of HPI and HAI7 integrases. J Biol Chem (2009) 0.75
Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond. J Mol Biol (2005) 0.75
Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies? Angew Chem Int Ed Engl (2017) 0.75
Sequence-specific (1H, 15N, 13C) resonance assignment of the N-terminal domain of the cyclase-associated protein (CAP) from Dictyostelium discoideum. J Biomol NMR (2002) 0.75
1H, 15N and 13C NMR resonance assignments of staphostatin A, a specific Staphylococcus aureus cysteine proteinase inhibitor. J Biomol NMR (2004) 0.75
1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem (2017) 0.75