Published in J Mol Biol on October 01, 2004
Structural basis of filamin A functions. J Cell Biol (2007) 2.60
Evolutionarily conserved human targets of adenosine to inosine RNA editing. Nucleic Acids Res (2005) 1.96
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J (2007) 1.85
Cytoskeletal polymer networks: the molecular structure of cross-linkers determines macroscopic properties. Proc Natl Acad Sci U S A (2006) 1.73
Protein structure by mechanical triangulation. Proc Natl Acad Sci U S A (2006) 1.65
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J (2007) 0.98
Molecular mechanics of filamin's rod domain. Biophys J (2007) 0.95
Analyzing forced unfolding of protein tandems by ordered variates, 1: Independent unfolding times. Biophys J (2007) 0.91
Analyzing forced unfolding of protein tandems by ordered variates, 2: dependent unfolding times. Biophys J (2007) 0.83
Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum. BMC Cell Biol (2007) 0.80
Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2. PLoS One (2011) 0.78
Sequence analysis of the gliding protein Gli349 in Mycoplasma mobile. Biophysics (Nagoya-shi) (2005) 0.77
Titin and obscurin: giants holding hands and discovery of a new Ig domain subset. J Mol Biol (2014) 0.76
Mechanical Control of Myotendinous Junction Formation and Tendon Differentiation during Development. Front Cell Dev Biol (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Lifeact: a versatile marker to visualize F-actin. Nat Methods (2008) 12.23
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
GeneTrail--advanced gene set enrichment analysis. Nucleic Acids Res (2007) 5.10
The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. J Cell Sci (2005) 3.33
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature (2002) 3.05
Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second. Opt Express (2010) 3.04
Sequence and analysis of chromosome 2 of Dictyostelium discoideum. Nature (2002) 3.01
Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. Invest Ophthalmol Vis Sci (2008) 3.01
The genome sequence of the extreme thermophile Thermus thermophilus. Nat Biotechnol (2004) 2.95
NUANCE, a giant protein connecting the nucleus and actin cytoskeleton. J Cell Sci (2002) 2.83
Filamins: promiscuous organizers of the cytoskeleton. Trends Biochem Sci (2006) 2.79
Fighting fruit flies: a model system for the study of aggression. Proc Natl Acad Sci U S A (2002) 2.66
Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser. Opt Express (2011) 2.62
Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nat Biotechnol (2012) 2.54
The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia. Nat Cell Biol (2005) 2.47
Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol (2007) 2.43
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struct Biol (2003) 2.42
A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system. Nucleic Acids Res (2004) 2.31
Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton. Exp Cell Res (2004) 2.27
Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography. Opt Express (2008) 2.24
Ear deformations give bats a physical mechanism for fast adaptation of ultrasonic beam patterns. Phys Rev Lett (2011) 2.22
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature (2008) 2.22
Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Mol Biol Cell (2005) 2.15
A mechanical unfolding intermediate in an actin-crosslinking protein. Nat Struct Mol Biol (2003) 2.12
High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle (2009) 2.11
Evolutionary implications of bacterial polyketide synthases. Mol Biol Evol (2005) 2.06
The sensitivity of polar ozone depletion to proposed geoengineering schemes. Science (2008) 2.05
Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range. Opt Express (2009) 2.03
HTRA proteases: regulated proteolysis in protein quality control. Nat Rev Mol Cell Biol (2011) 2.01
Gender-selective patterns of aggressive behavior in Drosophila melanogaster. Proc Natl Acad Sci U S A (2004) 1.99
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. J Am Chem Soc (2006) 1.96
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Nature (2003) 1.92
Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J Cell Sci (2008) 1.86
Molecular machines for protein degradation. Chembiochem (2005) 1.81
Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities. EMBO J (2002) 1.79
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis. EMBO J (2004) 1.75
The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc Natl Acad Sci U S A (2006) 1.72
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle (2008) 1.71
The impact of bacterial genomics on natural product research. Angew Chem Int Ed Engl (2005) 1.70
Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers. Opt Lett (2007) 1.69
Pathological consequences of VCP mutations on human striated muscle. Brain (2006) 1.68
Transient protein states in designing inhibitors of the MDM2-p53 interaction. Structure (2013) 1.63
K-space linear Fourier domain mode locked laser and applications for optical coherence tomography. Opt Express (2008) 1.62
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc Natl Acad Sci U S A (2003) 1.62
Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. PLoS One (2012) 1.60
Improved spectral optical coherence tomography using optical frequency comb. Opt Express (2008) 1.58
Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci (2009) 1.58
Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution. Proc Natl Acad Sci U S A (2002) 1.57
Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5. Chem Biol (2006) 1.56
Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle (2007) 1.55
Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res (2011) 1.53
Aggression in invertebrates. Curr Opin Neurobiol (2003) 1.53
A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans. Proc Natl Acad Sci U S A (2003) 1.52
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle (2010) 1.52
Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic. Curr Opin Chem Biol (2005) 1.51
Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective. Brain Res Rev (2007) 1.50
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proc Natl Acad Sci U S A (2008) 1.48
Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease. Proc Natl Acad Sci U S A (2005) 1.47
Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases. Chembiochem (2006) 1.46
Gene transfer and genome plasticity in Thermotoga maritima, a model hyperthermophilic species. J Bacteriol (2005) 1.45
Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium. J Biotechnol (2003) 1.44
Biosynthetic pathway of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines. J Bacteriol (2005) 1.43
Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity. Appl Environ Microbiol (2008) 1.40
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. J Biol Chem (2003) 1.40
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure (2003) 1.39
Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes. J Virol (2003) 1.39
The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link. Proc Natl Acad Sci U S A (2002) 1.38
Multi-MHz retinal OCT. Biomed Opt Express (2013) 1.36
Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr Opin Biotechnol (2005) 1.36
Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase. J Am Chem Soc (2002) 1.36
Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach. Biochim Biophys Acta (2004) 1.36
Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. Chembiochem (2004) 1.35
Expansion of the genetic code enables design of a novel "gold" class of green fluorescent proteins. J Mol Biol (2003) 1.34
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. Proc Natl Acad Sci U S A (2004) 1.32
Production of the antifungal isochromanone ajudazols A and B in Chondromyces crocatus Cm c5: biosynthetic machinery and cytochrome P450 modifications. Angew Chem Int Ed Engl (2008) 1.32
Investigations on the maturation and regulation of archaebacterial proteasomes. J Mol Biol (2003) 1.32
High-resolution positional tracking for long-term analysis of Drosophila sleep and locomotion using the "tracker" program. PLoS One (2012) 1.30
Structure of the stapled p53 peptide bound to Mdm2. J Am Chem Soc (2011) 1.30
The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium. Mol Biol Cell (2003) 1.30
The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. Angew Chem Int Ed Engl (2011) 1.30
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues. Nat Struct Mol Biol (2010) 1.30
Practical aspects of the 2D 15N-[1h]-NOE experiment. J Biomol NMR (2002) 1.29
Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. J Biol Chem (2002) 1.29
Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. Angew Chem Int Ed Engl (2010) 1.29
Substrate access and processing by the 20S proteasome core particle. Int J Biochem Cell Biol (2003) 1.29
Protein quality control in the bacterial periplasm. Annu Rev Microbiol (2011) 1.29
Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse. Int J Cancer (2013) 1.27
Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem (2001) 1.27
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein. Proc Natl Acad Sci U S A (2003) 1.27
Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy. Oncogene (2004) 1.27
Noseleaf furrows in a horseshoe bat act as resonance cavities shaping the biosonar beam. Phys Rev Lett (2006) 1.27