Published in Chem Biol on February 01, 2003
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J Biol Chem (2008) 1.02
An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity. Genome Res (2009) 0.98
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2006) 0.84
Phenotyping breast cancer cell lines EM-G3, HCC1937, MCF7 and MDA-MB-231 using 2-D electrophoresis and affinity chromatography for glutathione-binding proteins. BMC Cancer (2010) 0.80
Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2009) 0.77
Usefulness of the "Candida score" for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study. Crit Care Med (2009) 2.16
Inorganic polyphosphate and specific induction of apoptosis in human plasma cells. Haematologica (2006) 1.93
Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors. Circ Res (2003) 1.69
Host adaptive immunity deficiency in severe pandemic influenza. Crit Care (2010) 1.64
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J (2003) 1.59
An adult tissue-specific stem cell in its niche: a gene profiling analysis of in vivo quiescent and activated muscle satellite cells. Stem Cell Res (2009) 1.46
[Prevalence and risk factors of methicillin-resistant Staphylococcus aureus colonization among residents living in long-term care facilities in southern Spain]. Enferm Infecc Microbiol Clin (2011) 1.44
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Development of selective inhibitors and substrate of matrix metalloproteinase-12. J Biol Chem (2006) 1.30
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A (2002) 1.28
Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury. Hepatology (2008) 1.27
Betaine-homocysteine methyltransferase: zinc in a distorted barrel. Structure (2002) 1.26
A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice. Arterioscler Thromb Vasc Biol (2011) 1.23
Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides. Structure (2002) 1.20
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity. J Mol Biol (2007) 1.13
Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory. Eur J Neurosci (2005) 1.10
Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr (2006) 1.07
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A (2003) 1.06
The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407. J Biol Chem (2010) 1.03
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J Biol Chem (2008) 1.02
Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity. Biochemistry (2008) 1.01
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am J Physiol Endocrinol Metab (2005) 1.01
A new role for TIMP-1 in modulating neurite outgrowth and morphology of cortical neurons. PLoS One (2009) 1.01
Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry (2004) 1.00
Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. J Nutr (2008) 0.99
Protection of the Hydroxyphosphinyl Function of Phosphinic Dipeptides by Adamantyl. Application to the Solid-Phase Synthesis of Phosphinic Peptides. J Org Chem (1996) 0.99
Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. Schizophr Bull (2013) 0.98
Value of β-D-glucan and Candida albicans germ tube antibody for discriminating between Candida colonization and invasive candidiasis in patients with severe abdominal conditions. Intensive Care Med (2012) 0.98
ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells. Stem Cells (2011) 0.98
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. Matrix Biol (2009) 0.97
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem (2008) 0.96
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res (2010) 0.95
High-resolution crystal structures of Drosophila melanogaster angiotensin-converting enzyme in complex with novel inhibitors and antihypertensive drugs. J Mol Biol (2010) 0.95
Oligomerization is required for betaine-homocysteine S-methyltransferase function. Arch Biochem Biophys (2004) 0.94
Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1' cavity. Biochimie (2010) 0.94
Synthetic active site-directed inhibitors of metzincins: achievement and perspectives. Mol Aspects Med (2008) 0.92
S-Nitrosylation of the epidermal growth factor receptor: a regulatory mechanism of receptor tyrosine kinase activity. Free Radic Biol Med (2008) 0.92
High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. Am J Physiol Regul Integr Comp Physiol (2004) 0.92
Selective inhibition of the C-domain of angiotensin I converting enzyme by bradykinin potentiating peptides. Biochemistry (2002) 0.92
Structural integrity of the B24 site in human insulin is important for hormone functionality. J Biol Chem (2013) 0.91
Diastereoselective solution and multipin-based combinatorial array synthesis of a novel class of potent phosphinic metalloprotease inhibitors. Chemistry (2003) 0.91
The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380. Biochemistry (2007) 0.90
Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. J Biol Chem (2004) 0.90
The C-type natriuretic peptide precursor of snake brain contains highly specific inhibitors of the angiotensin-converting enzyme. J Neurochem (2003) 0.90
Matrix metalloproteinase 11 (MMP-11; stromelysin-3) and synthetic inhibitors. Med Res Rev (2007) 0.89
Rat liver injury after normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor. FASEB J (2001) 0.89
Vascular smooth muscle cells efficiently activate a new proteinase cascade involving plasminogen and fibronectin. J Cell Biochem (2003) 0.89
Regulation of mammalian liver methionine adenosyltransferase. J Nutr (2002) 0.88
Investigating the domain specificity of phosphinic inhibitors RXPA380 and RXP407 in angiotensin-converting enzyme. Biochemistry (2009) 0.88
Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11. J Med Chem (2004) 0.88
Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain. FASEB J (2013) 0.87
Do the cardiovascular effects of angiotensin-converting enzyme (ACE) I involve ACE-independent mechanisms? new insights from proline-rich peptides of Bothrops jararaca. J Pharmacol Exp Ther (2007) 0.87
Carbon nanotube translocation to distant organs after pulmonary exposure: insights from in situ (14)C-radiolabeling and tissue radioimaging. ACS Nano (2014) 0.86
Betaine can partially spare choline in chicks but only when added to diets containing a minimal level of choline. J Nutr (2007) 0.86
Endopeptidases 3.4.24.15 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism. Am J Physiol Heart Circ Physiol (2003) 0.86
High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli. Microb Cell Fact (2013) 0.86
Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza. BMC Infect Dis (2011) 0.86
Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. Arch Biochem Biophys (2008) 0.85
Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Am J Physiol Endocrinol Metab (2006) 0.85
Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain. Biochemistry (2004) 0.85
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.85
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. J Med Chem (2010) 0.84
Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases. J Med Chem (2008) 0.84
2-DE analysis of a new human cell line EM-G3 derived from breast cancer progenitor cells and comparison with normal mammary epithelial cells. Proteomics (2007) 0.84
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2006) 0.84
Rapid access to the tricyclic spirotetronic core of abyssomicins. Org Lett (2005) 0.84
Structural framework for covalent inhibition of Clostridium botulinum neurotoxin A by targeting Cys165. J Biol Chem (2012) 0.83
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism (2004) 0.83
Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J Nutr (2006) 0.83
Plasma antioxidant capacity is reduced in Asperger syndrome. J Psychiatr Res (2012) 0.83
Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation. J Biol Chem (2010) 0.83
Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J Med Chem (2008) 0.82
Structural determinants of RXPA380, a potent and highly selective inhibitor of the angiotensin-converting enzyme C-domain. Biochemistry (2004) 0.82
The use of Fmoc-Lys(Pac)-OH and penicillin G acylase in the preparation of novel semisynthetic insulin analogs. J Pept Sci (2007) 0.82
Serum procalcitonin levels in critically ill patients colonized with Candida spp: new clues for the early recognition of invasive candidiasis? Intensive Care Med (2009) 0.82
In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis. Arthritis Rheumatol (2014) 0.82
Molecular detection and identification of Aspergillus spp. from clinical samples using real-time PCR. Mycoses (2008) 0.82
Dietary S-methylmethionine, a component of foods, has choline-sparing activity in chickens. J Nutr (2005) 0.82
β-D-Glucan and Candida albicans germ tube antibody in ICU patients with invasive candidiasis. Intensive Care Med (2015) 0.81
Role of matrix metalloproteinases in migration and neurotrophic properties of nasal olfactory stem and ensheathing cells. Cell Transplant (2012) 0.81
Crystallization of bi-functional ligand protein complexes. J Struct Biol (2013) 0.81
Cross-linking yield variation of a potent matrix metalloproteinase photoaffinity probe and consequences for functional proteomics. Angew Chem Int Ed Engl (2007) 0.81