Published in Am J Physiol Endocrinol Metab on December 13, 2005
Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. PLoS One (2014) 1.23
Homocysteine imbalance: a pathological metabolic marker. Adv Nutr (2012) 1.14
Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice. Diabetes (2008) 1.13
Proteomic changes associated with diabetes in the BB-DP rat. Am J Physiol Endocrinol Metab (2008) 1.05
Epigenetics in adipose tissue, obesity, weight loss, and diabetes. Adv Nutr (2014) 0.96
Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine. Clin Sci (Lond) (2011) 0.94
Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study. Am J Clin Nutr (2008) 0.91
Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis. Clin Chem Lab Med (2013) 0.87
Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. PLoS One (2013) 0.84
Metabolomics reveals the metabolic shifts following an intervention with rye bread in postmenopausal women--a randomized control trial. Nutr J (2012) 0.83
Effect of polyunsaturated fatty acids on homocysteine metabolism through regulating the gene expressions involved in methionine metabolism. ScientificWorldJournal (2013) 0.81
Liver proteomic analysis of the large yellow croaker (Pseudosciaena crocea) following polyriboinosinic:polyribocytidylic acid induction. Fish Physiol Biochem (2013) 0.80
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha. Am J Physiol Endocrinol Metab (2009) 0.77
Opposite Expression of SPARC between the Liver and Pancreas in Streptozotocin-Induced Diabetic Rats. PLoS One (2015) 0.76
Guanidinoacetate is more effective than creatine at enhancing tissue creatine stores while consequently limiting methionine availability in Yucatan miniature pigs. PLoS One (2015) 0.75
Bottom-up proteomics analysis of the secretome of murine islets of Langerhans in elevated glucose levels. Analyst (2016) 0.75
Homocysteine homeostasis and betaine-homocysteine S-methyltransferase expression in the brain of hibernating bats. PLoS One (2013) 0.75
Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study. Sci Rep (2017) 0.75
The sulfur-containing amino acids: an overview. J Nutr (2006) 2.16
Orotic acid excretion and arginine metabolism. J Nutr (2007) 1.88
Branched-chain amino acids: enzyme and substrate regulation. J Nutr (2006) 1.83
Is it time to reevaluate methyl balance in humans? Am J Clin Nutr (2006) 1.61
Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annu Rev Nutr (2007) 1.46
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr (2007) 1.33
The metabolic burden of creatine synthesis. Amino Acids (2011) 1.30
Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol (2004) 1.29
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A (2002) 1.28
Hepatic glutamate metabolism: a tale of 2 hepatocytes. Am J Clin Nutr (2009) 1.27
Betaine-homocysteine methyltransferase: zinc in a distorted barrel. Structure (2002) 1.26
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17
Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem (2002) 1.14
Hormonal regulation of cystathionine beta-synthase expression in liver. J Biol Chem (2002) 1.10
Renal arginine metabolism. J Nutr (2004) 1.10
Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J Nutr (2006) 1.07
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida. Am J Med Genet A (2003) 1.06
Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome. Am J Physiol Endocrinol Metab (2010) 1.06
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem (2005) 1.04
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J Biol Chem (2008) 1.02
Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol (2004) 1.01
Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry (2004) 1.00
Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. J Nutr (2008) 0.99
Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes (2005) 0.96
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutr Res (2010) 0.95
Oligomerization is required for betaine-homocysteine S-methyltransferase function. Arch Biochem Biophys (2004) 0.94
Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. Am J Physiol Endocrinol Metab (2008) 0.93
Formate: an essential metabolite, a biomarker, or more? Clin Chem Lab Med (2013) 0.92
Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo. Am J Physiol Renal Physiol (2007) 0.92
High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney. Am J Physiol Regul Integr Comp Physiol (2004) 0.92
An isotope-dilution, GC-MS assay for formate and its application to human and animal metabolism. Amino Acids (2014) 0.92
Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. J Biol Chem (2004) 0.90
Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. Am J Physiol Endocrinol Metab (2011) 0.89
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol (2009) 0.88
On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome. Adv Enzyme Regul (2009) 0.87
Methylation demand and homocysteine metabolism. Adv Enzyme Regul (2004) 0.86
Betaine can partially spare choline in chicks but only when added to diets containing a minimal level of choline. J Nutr (2007) 0.86
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance. J Nutr (2009) 0.85
Creatine metabolism and the urea cycle. Mol Genet Metab (2010) 0.85
Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. Arch Biochem Biophys (2008) 0.85
Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.85
Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Am J Physiol Endocrinol Metab (2006) 0.85
Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase. Chem Biol (2003) 0.85
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2006) 0.84
Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J Nutr (2006) 0.83
Glutamate: a truly functional amino acid. Amino Acids (2012) 0.83
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism (2004) 0.83
Dietary S-methylmethionine, a component of foods, has choline-sparing activity in chickens. J Nutr (2005) 0.82
Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol (2011) 0.82
Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet. J Nutr (2011) 0.81
Random mutagenesis of the zinc-binding motif of betaine-homocysteine methyltransferase reveals that Gly 214 is essential. Arch Biochem Biophys (2002) 0.81
Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase. J Biol Chem (2005) 0.81
Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro. Biochem J (2005) 0.81
Effects of chronic in-vivo treatments with protease-activated receptor 2 agonist on endothelium function and blood pressures in mice. Can J Physiol Pharmacol (2012) 0.80
Amino acids and the regulation of methyl balance in humans. Curr Opin Clin Nutr Metab Care (2007) 0.79
Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism. Amino Acids (2015) 0.79
Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development. J Biol Chem (2012) 0.78
Analysis and characterization of phosphinic pseudopeptides by capillary zone electrophoresis. Electrophoresis (2002) 0.78
Determination of dissociation constant of phosphinate group in phosphinic pseudopeptides by capillary zone electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 0.78
Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes. Gene (2010) 0.78
The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase. Eur J Med Chem (2013) 0.77
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutr Res (2011) 0.77
New insights into creatine function and synthesis. Adv Enzyme Regul (2007) 0.77
Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase. J Med Chem (2009) 0.77
The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase. Mol Cell Biochem (2010) 0.77
Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis. J Nutr (2008) 0.77
Assay and subcellular localization of pyrroline-5-carboxylate dehydrogenase in rat liver. Biochim Biophys Acta (2004) 0.77
A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates. Metab Eng (2004) 0.77
Suckling rat pups accumulate creatine primarily via de novo synthesis rather than from dam milk. J Nutr (2010) 0.76
Hepatic glutaminase--a special role in urea synthesis? Nutrition (2002) 0.76
Creatine and guanidinoacetate content of human milk and infant formulas: implications for creatine deficiency syndromes and amino acid metabolism. Br J Nutr (2013) 0.75
The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes. Can J Physiol Pharmacol (2012) 0.75
Hyperglycinemia due to folate deficiency in rats: evidence for the lack of involvement of the hepatic glycine cleavage system. J Nutr Biochem (2005) 0.75
Application of 15N to the study of hepatic nitrogen metabolism. Adv Enzyme Regul (2002) 0.75