Published in Proc Natl Acad Sci U S A on March 06, 2006
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Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets. ACS Med Chem Lett (2011) 0.78
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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature (2005) 15.28
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Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res (2009) 2.00
Synthesis of methyl halides from biomass using engineered microbes. J Am Chem Soc (2009) 1.90
Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry (2003) 1.67
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Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Chem Biol (2003) 1.40
Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia. Appl Environ Microbiol (2008) 1.37
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. J Ind Microbiol Biotechnol (2003) 1.29
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem (2004) 1.29
Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J Biol Chem (2002) 1.22
Rational design and assembly of synthetic trimodular polyketide synthases. Chem Biol (2007) 1.18
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Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. Proc Natl Acad Sci U S A (2013) 1.15
Total synthesis of multi-kilobase DNA sequences from oligonucleotides. Nat Protoc (2006) 1.14
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry (2006) 1.14
The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation. Gene (2005) 1.13
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae. Antimicrob Agents Chemother (2004) 1.10
Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption. Appl Environ Microbiol (2005) 1.07
A sensitive and robust method for quantification of intracellular short-chain coenzyme A esters. Anal Biochem (2004) 1.06
Heterologous production of epothilone C and D in Escherichia coli. Biochemistry (2006) 1.06
Pyrosequencing reveals diverse and distinct sponge-specific microbial communities in sponges from a single geographical location in Irish waters. Microb Ecol (2012) 1.05
Is wealthier always healthier in poor countries? The health implications of income, inequality, poverty, and literacy in India. Soc Sci Med (2013) 1.05
Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster. J Ind Microbiol Biotechnol (2005) 1.04
Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry (2002) 1.02
Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068. Clin Cancer Res (2013) 1.02
Molecular modeling and crystal structure of ERK2-hypothemycin complexes. J Struct Biol (2008) 0.99
A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. Microbiology (2003) 0.97
Phylogenetic diversity and antimicrobial activities of fungi associated with Haliclona simulans isolated from Irish coastal waters. Mar Biotechnol (NY) (2008) 0.94
Isolation identification and biochemical characterization of a novel halo-tolerant lipase from the metagenome of the marine sponge Haliclona simulans. Microb Cell Fact (2012) 0.93
Elucidating the mechanism of cis double bond formation in epothilone biosynthesis. J Am Chem Soc (2004) 0.92
The leptomycin gene cluster and its heterologous expression in Streptomyces lividans. J Antibiot (Tokyo) (2005) 0.91
Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates. Proc Natl Acad Sci U S A (2012) 0.91
6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. Biochemistry (2003) 0.88
Long-term stabilization of maleimide-thiol conjugates. Bioconjug Chem (2014) 0.86
Analysis of the ambruticin and jerangolid gene clusters of Sorangium cellulosum reveals unusual mechanisms of polyketide biosynthesis. Chem Biol (2006) 0.86
Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. Appl Environ Microbiol (2005) 0.85
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus. J Med Chem (2009) 0.84
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The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res (2013) 0.82
Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains. Chem Biol (2006) 0.81
Precursor-directed biosynthesis of novel triketide lactones. Biotechnol Prog (2004) 0.81
Filter binding assay for the geldanamycin-heat shock protein 90 interaction. Anal Biochem (2003) 0.80
Semisynthesis and cytotoxicity of hypothemycin analogues. ChemMedChem (2007) 0.80
Pseudovibrio axinellae sp. nov., isolated from an Irish marine sponge. Int J Syst Evol Microbiol (2012) 0.79
A high-throughput screen to identify novel calcineurin inhibitors. J Microbiol Methods (2011) 0.78
Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system. Bioconjug Chem (2015) 0.77
Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes. Org Biomol Chem (2003) 0.76
Using chemobiosynthesis and synthetic mini-polyketide synthases to produce pharmaceutical intermediates in Escherichia coli. Appl Environ Microbiol (2010) 0.75
Evidence of bacteriophage-mediated horizontal transfer of bacterial 16S rRNA genes in the viral metagenome of the marine sponge Hymeniacidon perlevis. Microbiology (2012) 0.75
A halotolerant thermostable lipase from the marine bacterium Oceanobacillus sp. PUMB02 with an ability to disrupt bacterial biofilms. Bioengineered (2014) 0.75
Myths of MTAS and MMC. J R Soc Med (2007) 0.75
Inhibition of the growth of Bacillus subtilis DSM10 by a newly discovered antibacterial protein from the soil metagenome. Bioengineered (2015) 0.75
The conviction of Binayak Sen. Lancet (2011) 0.75
Report on the European Society of Endodontology meeting in Lisbon, Portugal, 12-14 September 2013. Aust Endod J (2013) 0.75
Does registration of serial MRI improve diagnosis of dementia? Neuroradiology (2010) 0.75
Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay. Anal Biochem (2002) 0.75
The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng (2003) 0.75
Report on the pre-congress meeting of the 35th Australian dental congress. Aust Endod J (2013) 0.75
β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols. Bioconjug Chem (2013) 0.75