Published in Angew Chem Int Ed Engl on August 16, 2010
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol (2011) 1.87
Exploring protein lipidation with chemical biology. Chem Rev (2011) 1.15
The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction. Eur Biophys J (2012) 0.90
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. Nat Commun (2016) 0.84
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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol (2009) 3.44
Structural insight into filament formation by mammalian septins. Nature (2007) 2.90
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell (2010) 2.72
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol (2010) 2.39
Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol (2010) 2.37
Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proc Natl Acad Sci U S A (2005) 2.35
It takes two to tango: regulation of G proteins by dimerization. Nat Rev Mol Cell Biol (2009) 2.34
A crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol (2009) 2.29
The complex of Arl2-GTP and PDE delta: from structure to function. EMBO J (2002) 2.24
Structure and regulation of the cAMP-binding domains of Epac2. Nat Struct Biol (2003) 2.11
The regulation of mDia1 by autoinhibition and its release by Rho*GTP. EMBO J (2005) 2.10
Capturing cyclic nucleotides in action: snapshots from crystallographic studies. Nat Rev Mol Cell Biol (2007) 2.07
The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature (2004) 2.06
The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification. J Chem Inf Model (2007) 2.04
From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. Angew Chem Int Ed Engl (2002) 2.03
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol (2006) 1.96
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc Natl Acad Sci U S A (2006) 1.96
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature (2006) 1.92
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature (2006) 1.88
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol (2011) 1.87
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase. Science (2003) 1.80
Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. EMBO J (2006) 1.75
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Mol Cell (2004) 1.74
Inhibitors of protein tyrosine phosphatases: next-generation drugs? Angew Chem Int Ed Engl (2005) 1.73
A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet (2009) 1.71
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy. Mol Cell (2007) 1.67
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex. EMBO J (2003) 1.67
Amyloidogenic self-assembly of insulin aggregates probed by high resolution atomic force microscopy. Biophys J (2004) 1.65
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol (2008) 1.64
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J (2002) 1.64
A new family of RhoGEFs activates the Rop molecular switch in plants. Nature (2005) 1.64
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J (2008) 1.62
Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution. Proc Natl Acad Sci U S A (2002) 1.57
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A (2004) 1.57
Interactive exploration of chemical space with Scaffold Hunter. Nat Chem Biol (2009) 1.55
Chemical strategies for generating protein biochips. Angew Chem Int Ed Engl (2008) 1.55
Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. J Biol Chem (2003) 1.53
RanGAP mediates GTP hydrolysis without an arginine finger. Nature (2002) 1.50
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol (2009) 1.50
Structural insights into HypB, a GTP-binding protein that regulates metal binding. J Biol Chem (2006) 1.47
Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase. Chem Biol (2007) 1.43
Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci U S A (2012) 1.41
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. EMBO J (2007) 1.38
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
GTP-induced conformational changes in septins and implications for function. Proc Natl Acad Sci U S A (2009) 1.35
Regulation of dynamic polarity switching in bacteria by a Ras-like G-protein and its cognate GAP. EMBO J (2010) 1.35
Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption. J Am Chem Soc (2006) 1.35
Nucleotide binding and filament assembly of recombinant yeast septin complexes. Biol Chem (2005) 1.34
The structure of the TrmE GTP-binding protein and its implications for tRNA modification. EMBO J (2004) 1.34
The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. EMBO Rep (2008) 1.31
Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nat Chem Biol (2008) 1.30
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proc Natl Acad Sci U S A (2008) 1.30
Target identification for small bioactive molecules: finding the needle in the haystack. Angew Chem Int Ed Engl (2013) 1.28
Rap-specific GTPase activating protein follows an alternative mechanism. J Biol Chem (2002) 1.28
Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins. J Biol Chem (2007) 1.28
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J (2008) 1.28
Specificity of interactions between mDia isoforms and Rho proteins. J Biol Chem (2008) 1.27
Interaction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators. Proc Natl Acad Sci U S A (2007) 1.26
Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl (2010) 1.25
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes. Nat Chem Biol (2010) 1.24
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat (2010) 1.24
Synthesis of natural product inspired compound collections. Angew Chem Int Ed Engl (2009) 1.23
GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J Biol Chem (2006) 1.22
Aggregation of bovine insulin probed by DSC/PPC calorimetry and FTIR spectroscopy. Biochemistry (2003) 1.21
A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc Natl Acad Sci U S A (2012) 1.21
The Pictet-Spengler reaction in nature and in organic chemistry. Angew Chem Int Ed Engl (2011) 1.20
Structural evidence for a common intermediate in small G protein-GEF reactions. Mol Cell (2007) 1.20
Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products. Nat Chem (2010) 1.19
Biology-oriented synthesis. Angew Chem Int Ed Engl (2011) 1.18
Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer (2012) 1.18
Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol. Chembiochem (2009) 1.18
Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac. J Biol Chem (2003) 1.18
Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem (2012) 1.17
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays. Angew Chem Int Ed Engl (2003) 1.17
Compound library development guided by protein structure similarity clustering and natural product structure. Proc Natl Acad Sci U S A (2004) 1.17
Rho-kinase: regulation, (dys)function, and inhibition. Biol Chem (2013) 1.17
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS Lett (2008) 1.17
The therapeutic potential of phosphatase inhibitors. Curr Opin Chem Biol (2009) 1.16
Temperature- and pressure-induced unfolding and refolding of ubiquitin: a static and kinetic Fourier transform infrared spectroscopy study. Biochemistry (2002) 1.16
Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity. EMBO J (2011) 1.16
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J Am Chem Soc (2006) 1.15
Preconditioning the brain: moving on to the next frontier of neurotherapeutics. Stroke (2012) 1.15
Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Structure (2006) 1.15
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization. Chembiochem (2007) 1.15
(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl (2015) 1.14