Published in J Mol Neurosci on April 01, 2003
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol (2007) 1.72
MEK Is a Key Regulator of Gliogenesis in the Developing Brain. Neuron (2012) 1.68
Immune modulation by MANF promotes tissue repair and regenerative success in the retina. Science (2016) 1.63
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J Clin Invest (2006) 1.44
Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease? Front Neuroanat (2016) 1.39
Treatment of Parkinson's disease with trophic factors. Neurotherapeutics (2008) 1.35
Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart. Circ Res (2008) 1.28
Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats. J Comp Neurol (2009) 1.23
Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons. Proc Natl Acad Sci U S A (2009) 1.23
Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion. J Biol Chem (2012) 1.16
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons. J Biol Chem (2010) 1.15
Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra. Mol Neurodegener (2007) 1.05
Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury. Exp Neurol (2010) 1.02
Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. J Cereb Blood Flow Metab (2009) 1.02
Mesencephalic astrocyte-derived neurotrophic factor (MANF) secretion and cell surface binding are modulated by KDEL receptors. J Biol Chem (2012) 1.01
Endogenous GDNF in ventral tegmental area and nucleus accumbens does not play a role in the incubation of heroin craving. Addict Biol (2010) 1.00
CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice. Cell Transplant (2011) 0.99
Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation. J Neuroinflammation (2012) 0.96
Wolfram Syndrome: Diagnosis, Management, and Treatment. Curr Diab Rep (2016) 0.95
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure. J Mol Cell Cardiol (2010) 0.94
Role of glial cells in neurotoxin-induced animal models of Parkinson's disease. Neurol Sci (2010) 0.92
Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity. PLoS Pathog (2005) 0.92
Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes. BMC Genomics (2012) 0.92
Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease. Brain Behav (2013) 0.91
Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression. PLoS One (2013) 0.89
Endoplasmic Reticulum Stress Interacts With Inflammation in Human Diseases. J Cell Physiol (2016) 0.87
Protoplasmic astrocytes enhance the ability of neural stem cells to differentiate into neurons in vitro. PLoS One (2012) 0.87
Characterization of the structural and functional determinants of MANF/CDNF in Drosophila in vivo model. PLoS One (2013) 0.87
Neuroglial plasticity at striatal glutamatergic synapses in Parkinson's disease. Front Syst Neurosci (2011) 0.85
Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity. Cell Death Dis (2015) 0.85
NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease. Nanomedicine (2012) 0.83
Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease. Mol Ther (2014) 0.83
The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers. J Biol Chem (2015) 0.81
Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo. Cell Mol Neurobiol (2009) 0.81
Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra. J Neuroinflammation (2014) 0.81
Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson's Disease. PLoS One (2016) 0.79
Spatiotemporal expression of MANF in the developing rat brain. PLoS One (2014) 0.78
Expression and Distribution of Mesencephalic Astrocyte-Derived Neurotrophic Factor in the Retina and Optic Nerve. Front Hum Neurosci (2017) 0.77
Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes. Sci Rep (2016) 0.76
Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PLoS One (2016) 0.76
Identification of Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Novel Neuroprotective Factor for Retinal Ganglion Cells. Front Mol Neurosci (2017) 0.75
Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease. Curr Med Chem (2016) 0.75
A Comparative Analysis of the Molecular Features of MANF and CDNF. PLoS One (2016) 0.75
Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease. Neurol Sci (2017) 0.75
MANF regulates hypothalamic control of food intake and body weight. Nat Commun (2017) 0.75
Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles. Transl Res (2017) 0.75
An evolutionary perspective on the role of mesencephalic astrocyte-derived neurotrophic factor (MANF): At the crossroads of poriferan innate immune and apoptotic pathways. Biochem Biophys Rep (2017) 0.75
Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating HSP70 in SHSY-5Y cells. Transl Neurodegener (2017) 0.75
In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. BMC Genet (2017) 0.75
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (2006) 5.67
Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors. Oncogene (2002) 5.40
HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell (2007) 4.81
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell (2003) 4.55
Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene. PLoS Genet (2010) 4.29
Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med (2013) 4.26
Malignant and premalignant lesions of the penis. BMJ (2013) 4.11
A role for TSLP in the development of inflammation in an asthma model. J Exp Med (2005) 4.08
Light drinking in pregnancy, a risk for behavioural problems and cognitive deficits at 3 years of age? Int J Epidemiol (2008) 3.62
DNA methylation signatures within the human brain. Am J Hum Genet (2007) 3.50
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A (2005) 3.16
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet (2011) 3.16
Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. Clin Cancer Res (2005) 2.98
Structure of the N-linked glycan present on multiple glycoproteins in the Gram-negative bacterium, Campylobacter jejuni. J Biol Chem (2002) 2.85
A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med (2004) 2.81
SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis. Bioinformatics (2002) 2.69
A role for common fragile site induction in amplification of human oncogenes. Cancer Cell (2002) 2.63
A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine. Infect Immun (2005) 2.53
Alterations in the common fragile site gene Parkin in ovarian and other cancers. Oncogene (2003) 2.44
Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. J Biol Chem (2003) 2.40
Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev (2004) 2.30
Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy. Clin Cancer Res (2005) 2.29
Malignant pheochromocytoma: current status and initiatives for future progress. Endocr Relat Cancer (2004) 2.20
Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain. Genomics (2003) 2.19
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene (2002) 2.16
3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer. BMC Genomics (2009) 2.12
Attention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood. JAMA Psychiatry (2013) 2.11
Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence. Mol Microbiol (2006) 2.11
Progressive exercise for anabolism in kidney disease (PEAK): a randomized, controlled trial of resistance training during hemodialysis. J Am Soc Nephrol (2007) 2.06
Evaluating signatures of glacial refugia for North Atlantic benthic marine taxa. Ecology (2008) 2.04
Long, abundantly expressed non-coding transcripts are altered in cancer. Hum Mol Genet (2007) 2.00
Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia (2011) 2.00
Common fragile sites are preferential targets for HPV16 integrations in cervical tumors. Oncogene (2003) 2.00
The aspect ratio (dome/neck) of ruptured and unruptured aneurysms. J Neurosurg (2003) 2.00
The performance of SolarScan: an automated dermoscopy image analysis instrument for the diagnosis of primary melanoma. Arch Dermatol (2005) 1.97
Mutations in CHEK2 associated with prostate cancer risk. Am J Hum Genet (2003) 1.96
Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas. Blood (2012) 1.96
hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. Gastroenterology (2004) 1.95
Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. Blood (2010) 1.90
Genome-wide expression analyses of Campylobacter jejuni NCTC11168 reveals coordinate regulation of motility and virulence by flhA. J Biol Chem (2004) 1.87
Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma. Pigment Cell Melanoma Res (2011) 1.87
Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations. PLoS One (2010) 1.85
HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma. Oncogene (2004) 1.82
Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer. Gynecol Oncol (2009) 1.82
Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J Lipid Res (2007) 1.82
Identification of genes involved in the biosynthesis and attachment of Methanococcus voltae N-linked glycans: insight into N-linked glycosylation pathways in Archaea. Mol Microbiol (2006) 1.82
Metformin intake is associated with better survival in ovarian cancer: a case-control study. Cancer (2012) 1.78
Hidden Markov models for the assessment of chromosomal alterations using high-throughput SNP arrays. Ann Appl Stat (2008) 1.75
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73
Progress in the use of microarray technology to study the neurobiology of disease. Nat Neurosci (2004) 1.72
HSulf-1 inhibits angiogenesis and tumorigenesis in vivo. Cancer Res (2006) 1.71
Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women. Int J Cancer (2009) 1.68
Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. Genome Biol (2005) 1.64
Proteomic analysis of Campylobacter jejuni 11168 biofilms reveals a role for the motility complex in biofilm formation. J Bacteriol (2006) 1.62
Identification and characterization of the unique N-linked glycan common to the flagellins and S-layer glycoprotein of Methanococcus voltae. J Biol Chem (2005) 1.60
AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer (2005) 1.58
Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes. Cancer Res (2004) 1.56
Analysis and visualization of chromosomal abnormalities in SNP data with SNPscan. BMC Bioinformatics (2006) 1.50
Quality of life in individuals with chronic foot conditions: a cross sectional observational study. Foot (Edinb) (2012) 1.50
Light drinking during pregnancy: still no increased risk for socioemotional difficulties or cognitive deficits at 5 years of age? J Epidemiol Community Health (2010) 1.48
Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proc Natl Acad Sci U S A (2005) 1.47
A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene (2004) 1.47
Early detection of ovarian cancer: promise and reality. Cancer Treat Res (2002) 1.45
Inference of relationships in population data using identity-by-descent and identity-by-state. PLoS Genet (2011) 1.43
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma. Cancer Res (2013) 1.43
DRAGON View: information visualization for annotated microarray data. Bioinformatics (2002) 1.43
FusionHunter: identifying fusion transcripts in cancer using paired-end RNA-seq. Bioinformatics (2011) 1.41
Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus. J Virol (2002) 1.41
FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum Mol Genet (2007) 1.39
Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer. J Biol Chem (2007) 1.39
Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J Clin Invest (2006) 1.37
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nat Commun (2013) 1.36
Role of hedgehog signaling in ovarian cancer. Clin Cancer Res (2008) 1.36
High detection rates of colorectal neoplasia by stool DNA testing with a novel digital melt curve assay. Gastroenterology (2008) 1.34
Network-based survival analysis reveals subnetwork signatures for predicting outcomes of ovarian cancer treatment. PLoS Comput Biol (2013) 1.34
Pretreatment and during treatment risk factors for dropout among patients with substance use disorders. Addict Behav (2005) 1.32
Genome-wide gene expression profiling of cervical cancer in Hong Kong women by oligonucleotide microarray. Int J Cancer (2006) 1.32
Local mean normalization of microarray element signal intensities across an array surface: quality control and correction of spatially systematic artifacts. Biotechniques (2002) 1.31
Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol (2005) 1.31
Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridization. Cancer Res (2002) 1.29
SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma. Gastroenterology (2006) 1.27
Population-based, case-control-family design to investigate genetic and environmental influences on melanoma risk: Australian Melanoma Family Study. Am J Epidemiol (2009) 1.27
Randomized controlled trial of intradialytic resistance training to target muscle wasting in ESRD: the Progressive Exercise for Anabolism in Kidney Disease (PEAK) study. Am J Kidney Dis (2007) 1.26
HtrA serine proteases as potential therapeutic targets in cancer. Curr Cancer Drug Targets (2009) 1.25
Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer. Oncogene (2005) 1.24
Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinase. J Biol Chem (2004) 1.24
Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. Gynecol Oncol (2005) 1.24
Estimating genome-wide copy number using allele-specific mixture models. J Comput Biol (2008) 1.23
Visualization of shared genomic regions and meiotic recombination in high-density SNP data. PLoS One (2009) 1.23
Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure. Pigment Cell Melanoma Res (2010) 1.22
The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1. Genes Chromosomes Cancer (2002) 1.22
LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation. RNA Biol (2011) 1.21