FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 3207159)

Published in Biophys J on November 01, 2011

Authors

Tao Guo1, Bradley R Fruen, Florentin R Nitu, Trinh D Nguyen, Yi Yang, Razvan L Cornea, Donald M Bers

Author Affiliations

1: Department of Pharmacology, University of California, Davis, California, USA.

Articles citing this

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels. J Gen Physiol (2013) 1.30

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27

Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res (2013) 0.98

Calmodulin-binding locations on the skeletal and cardiac ryanodine receptors. J Biol Chem (2012) 0.95

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol (2016) 0.90

FRET-based trilateration of probes bound within functional ryanodine receptors. Biophys J (2014) 0.89

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity. J Mol Cell Cardiol (2015) 0.88

N-terminal and central segments of the type 1 ryanodine receptor mediate its interaction with FK506-binding proteins. J Biol Chem (2013) 0.87

In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding. Circ Res (2012) 0.84

Essential Role of Calmodulin in RyR Inhibition by Dantrolene. Mol Pharmacol (2015) 0.83

Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signaling. J Mol Med (Berl) (2013) 0.81

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release. J Biol Chem (2015) 0.80

Site-specific labeling of the type 1 ryanodine receptor using biarsenical fluorophores targeted to engineered tetracysteine motifs. PLoS One (2013) 0.77

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol (2016) 0.77

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex. J Biol Chem (2016) 0.75

Articles cited by this

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res (2005) 5.34

Calmodulin: a prototypical calcium sensor. Trends Cell Biol (2000) 4.67

Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible. Biochemistry (1992) 4.25

Three-dimensional structure of calmodulin. Nature (1985) 3.54

Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res (2006) 3.26

Calmodulin as an ion channel subunit. Annu Rev Physiol (2002) 2.59

Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol (2010) 2.46

Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis. Circ Res (2011) 2.37

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Macromolecular complexes regulating cardiac ryanodine receptor function. J Mol Cell Cardiol (2004) 1.93

Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor). J Biol Chem (2003) 1.80

Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol (2009) 1.77

Apocalmodulin and Ca2+-calmodulin bind to neighboring locations on the ryanodine receptor. J Biol Chem (2001) 1.75

Locations of calmodulin and FK506-binding protein on the three-dimensional architecture of the skeletal muscle ryanodine receptor. J Biol Chem (1997) 1.66

Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J (2008) 1.61

Calmodulin binding and inhibition of cardiac muscle calcium release channel (ryanodine receptor). J Biol Chem (2001) 1.58

Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest (2007) 1.53

Differential Ca(2+) sensitivity of skeletal and cardiac muscle ryanodine receptors in the presence of calmodulin. Am J Physiol Cell Physiol (2000) 1.37

FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel. Proc Natl Acad Sci U S A (2009) 1.29

Modulation of intracellular calcium-release channels by calmodulin. J Membr Biol (2002) 1.23

Free and bound intracellular calmodulin measurements in cardiac myocytes. Cell Calcium (2006) 1.21

Mechanism of calmodulin inhibition of cardiac sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor). Biophys J (2004) 1.10

Regulation of the RYR1 and RYR2 Ca2+ release channel isoforms by Ca2+-insensitive mutants of calmodulin. Biochemistry (2003) 1.09

Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. J Biol Chem (2008) 1.06

Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer. J Biol Chem (2010) 1.05

Calmodulin and the philosopher's stone: Changing Ca2+ into arrhythmias. J Cardiovasc Electrophysiol (2002) 0.93

Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. Mol Pharmacol (2004) 0.92

Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem J (2001) 0.90

Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1. J Biol Chem (2002) 0.87

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels. Proteins (2009) 0.81

Articles by these authors

Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88

Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science (2009) 8.84

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res (2005) 5.34

A validated regulatory network for Th17 cell specification. Cell (2012) 4.82

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature (2011) 4.56

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res (2003) 4.13

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72

A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J (2004) 3.72

Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve. Circ Res (2003) 3.47

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res (2007) 3.46

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33

Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res (2006) 3.26

Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ Res (2003) 3.04

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res (2003) 3.04

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med (2004) 2.97

Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res (2002) 2.93

Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86

Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury. Circ Res (2006) 2.84

SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol Cell Physiol (2007) 2.84

Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods (2012) 2.79

Mesothelin variant 1 is released from tumor cells as a diagnostic marker. Cancer Epidemiol Biomarkers Prev (2006) 2.77

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods (2009) 2.75

CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol (2011) 2.65

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57

Relay and control of abscisic acid signaling. Curr Opin Plant Biol (2003) 2.51

Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res (2005) 2.50

A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol (2009) 2.36

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33

Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation (2002) 2.32

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32

Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res (2006) 2.30

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J (2008) 2.29

Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res (2003) 2.28

Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte. Circ Res (2006) 2.27

Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res (2006) 2.25

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet (2009) 2.21

Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res (2002) 2.21

Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining. Genome Res (2012) 2.12

Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion. Circ Res (2008) 2.12

Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res (2009) 2.12

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Arch Neurol (2011) 2.08

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07

Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res (2002) 2.06

Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes. J Physiol (2010) 2.01

Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00

Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii. Antimicrob Agents Chemother (2012) 1.97

Voltage dependence of cardiac excitation-contraction coupling: unitary Ca2+ current amplitude and open channel probability. Circ Res (2007) 1.96

Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res (2005) 1.94

Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J Mol Cell Cardiol (2002) 1.94

Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life (2007) 1.92

Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure. Circ Res (2005) 1.92

Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ Res (2006) 1.89

Alignment of optical maps. J Comput Biol (2006) 1.88

Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban. J Mol Cell Cardiol (2002) 1.82

Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res (2011) 1.82

Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger. J Physiol (2004) 1.81

Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg Focus (2007) 1.78

Increased PADI4 expression in blood and tissues of patients with malignant tumors. BMC Cancer (2009) 1.78

MicroRNA-374a activates Wnt/β-catenin signaling to promote breast cancer metastasis. J Clin Invest (2013) 1.76

Converting ceria polyhedral nanoparticles into single-crystal nanospheres. Science (2006) 1.70

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res (2011) 1.69

Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes. J Physiol (2002) 1.67

Calcium and cardiac rhythms: physiological and pathophysiological. Circ Res (2002) 1.67

Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration. Am J Hum Genet (2008) 1.65

Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II. J Biol Chem (2005) 1.64

CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem (2007) 1.64

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun (2010) 1.62

Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes. J Mol Cell Cardiol (2006) 1.62

Mapping hydration dynamics around a protein surface. Proc Natl Acad Sci U S A (2007) 1.61

Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophys J (2008) 1.61

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res (2011) 1.61

AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res (2013) 1.59

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58

Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res (2008) 1.58

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun (2008) 1.57

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res (2006) 1.56

Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol (2009) 1.56

Diagnosis and management of pituitary abscess: experiences from 33 cases. Clin Endocrinol (Oxf) (2011) 1.55

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54

Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circ Res (2012) 1.53

Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation (2007) 1.51

Deranged sodium to sudden death. J Physiol (2015) 1.51

CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol (2006) 1.51

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. J Lipid Res (2009) 1.50

Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death. Biophys J (2008) 1.49

Computer-driven automated weaning reduces weaning duration in difficult-to-wean patients. Chin Med J (Engl) (2013) 1.48

The pathogenesis and clinical significance of a high-intensity zone (HIZ) of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain. Eur Spine J (2005) 1.48

Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab (2011) 1.47

Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae. Biophys J (2002) 1.47

Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophys J (2005) 1.47

A dammarane glycoside derived from ginsenoside Rb3. Chem Pharm Bull (Tokyo) (2005) 1.47

Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J (2007) 1.45

Targeted gene disruption by use of a group II intron (targetron) vector in Clostridium acetobutylicum. Cell Res (2007) 1.45