Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.

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Published in J Mol Cell Cardiol on June 16, 2015

Authors

Tetsuro Oda1, Yi Yang2, Hitoshi Uchinoumi3, David D Thomas4, Ye Chen-Izu3, Takayoshi Kato5, Takeshi Yamamoto5, Masafumi Yano5, Razvan L Cornea4, Donald M Bers6

Author Affiliations

1: Department of Pharmacology University of California, Davis, CA, USA; Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
2: Department of Pharmacology University of California, Davis, CA, USA; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
3: Department of Pharmacology University of California, Davis, CA, USA.
4: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
5: Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
6: Department of Pharmacology University of California, Davis, CA, USA. Electronic address: dmbers@ucdavis.edu.

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