Published in J Nutr on May 01, 2003
Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr (2006) 2.83
Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst (2007) 2.07
Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71
Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr (2005) 1.66
Importance of methyl donors during reproduction. Am J Clin Nutr (2008) 1.62
Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord (2007) 1.47
Epigenetic mechanisms for nutrition determinants of later health outcomes. Am J Clin Nutr (2009) 1.28
Perinatal choline influences brain structure and function. Nutr Rev (2006) 1.26
Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc (2011) 1.25
Health effects of dietary phospholipids. Lipids Health Dis (2012) 1.21
The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr (2007) 1.16
Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study. Nutr J (2009) 1.16
Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models. Brain Res (2008) 1.11
Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline. IUBMB Life (2007) 1.03
Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype. J Nutr (2008) 1.00
Deletion of murine choline dehydrogenase results in diminished sperm motility. FASEB J (2010) 0.99
Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes (2005) 0.96
Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PLoS Med (2005) 0.95
Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase. Biochem J (2006) 0.92
Dietary choline and betaine intakes and risk of cardiovascular diseases: review of epidemiological evidence. ARYA Atheroscler (2011) 0.89
Effect of folic acid and betaine supplementation on flow-mediated dilation: a randomized, controlled study in healthy volunteers. PLoS Clin Trials (2006) 0.86
Are dietary choline and betaine intakes determinants of total homocysteine concentration? Am J Clin Nutr (2010) 0.85
Nutrition, One-Carbon Metabolism and Neural Tube Defects: A Review. Nutrients (2016) 0.78
Studies on the protective effects of betaine against oxidative damage during experimentally induced restraint stress in Wistar albino rats. Cell Stress Chaperones (2011) 0.78
Acute effect of folic acid, betaine, and serine supplements on flow-mediated dilation after methionine loading: a randomized trial. PLoS Clin Trials (2006) 0.77
Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine. J Cancer Prev (2014) 0.75
Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. J Chiropr Med (2013) 0.75
Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr (2003) 6.83
Trans fatty acids and cardiovascular disease. N Engl J Med (2006) 6.67
A trial of sugar-free or sugar-sweetened beverages and body weight in children. N Engl J Med (2012) 5.83
Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet (2007) 5.75
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA (2002) 5.29
The importance of reducing SFA to limit CHD. Br J Nutr (2011) 2.60
Effects of folic acid supplementation on hearing in older adults: a randomized, controlled trial. Ann Intern Med (2007) 2.41
Diet, nutrition and the prevention of hypertension and cardiovascular diseases. Public Health Nutr (2004) 2.24
Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr (2004) 2.11
The term prospective trial is a pleonasm. Lancet (2002) 2.04
Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation (2005) 1.80
Weight-loss diets for the prevention and treatment of obesity. N Engl J Med (2009) 1.61
Dietary fructooligosaccharides affect intestinal barrier function in healthy men. J Nutr (2006) 1.61
Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. Am J Clin Nutr (2006) 1.59
Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr (2004) 1.57
Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial. Am J Clin Nutr (2008) 1.51
Serum iron parameters, HFE C282Y genotype, and cognitive performance in older adults: results from the FACIT study. J Gerontol A Biol Sci Med Sci (2010) 1.45
Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans--a quantitative review. PLoS One (2010) 1.39
n 3 fatty acid proportions in plasma and cognitive performance in older adults. Am J Clin Nutr (2007) 1.34
Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans. Am J Clin Nutr (2002) 1.27
Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med (2012) 1.27
Omega-6 polyunsaturated fatty acids and coronary heart disease. Am J Clin Nutr (2009) 1.24
Flavonol and flavone intakes in US health professionals. J Am Diet Assoc (2002) 1.23
Within-subject variability of flow-mediated vasodilation of the brachial artery in healthy men and women: implications for experimental studies. Ultrasound Med Biol (2003) 1.22
Effect of low doses of n-3 fatty acids on cardiovascular diseases in 4,837 post-myocardial infarction patients: design and baseline characteristics of the Alpha Omega Trial. Am Heart J (2010) 1.19
Folic acid fortification: is masking of vitamin B-12 deficiency what we should really worry about? Am J Clin Nutr (2007) 1.18
Alternatives to low-fat diets. Am J Clin Nutr (2006) 1.17
Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J Nutr (2003) 1.16
Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr (2003) 1.13
Nitrate in foods: harmful or healthy? Am J Clin Nutr (2009) 1.13
Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men. Am J Clin Nutr (2005) 1.12
Homocysteine and carotid intima-media thickness: a critical appraisal of the evidence. Atherosclerosis (2004) 1.11
Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. J Lipid Res (2005) 1.10
Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators. Eur Heart J (2009) 1.10
Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig hearts. Cardiovasc Res (2006) 1.07
Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study. Am J Epidemiol (2009) 1.07
Olive oil phenols are absorbed in humans. J Nutr (2002) 1.05
Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. Int J Cancer (2005) 1.03
High stability of markers of cardiovascular risk in blood samples. Clin Chem (2003) 1.02
The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol (2007) 1.01
Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. Am J Clin Nutr (2003) 1.00
Effects of coffee consumption on fasting blood glucose and insulin concentrations: randomized controlled trials in healthy volunteers. Diabetes Care (2004) 1.00
The effect of sugar-free versus sugar-sweetened beverages on satiety, liking and wanting: an 18 month randomized double-blind trial in children. PLoS One (2013) 0.99
Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients. Clin Chem (2002) 0.99
Within-person variation in serum lipids: implications for clinical trials. Int J Epidemiol (2004) 0.98
Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations. Am J Clin Nutr (2005) 0.97
Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. J Endocrinol (2004) 0.97
Folate and the methylenetetrahydrofolate reductase 677C-->T mutation correlate with cognitive performance. Neurobiol Aging (2005) 0.97
Salmonella induces prominent gene expression in the rat colon. BMC Microbiol (2007) 0.96
Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PLoS Med (2005) 0.95
Antiarrhythmic effects of n-3 fatty acids: evidence from human studies. Curr Opin Lipidol (2004) 0.93
Health claims for functional foods. BMJ (2004) 0.92
A high-protein diet increases postprandial but not fasting plasma total homocysteine concentrations: a dietary controlled, crossover trial in healthy volunteers. Am J Clin Nutr (2005) 0.91
Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans. Am J Clin Nutr (2005) 0.91
Bioavailability of food folates is 80% of that of folic acid. Am J Clin Nutr (2007) 0.91
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. Thromb Res (2003) 0.91
Green vegetables, red meat and colon cancer: chlorophyll prevents the cytotoxic and hyperproliferative effects of haem in rat colon. Carcinogenesis (2004) 0.90
CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafestol interventions in humans. J Nutr (2004) 0.88
Saturated fat and heart disease. Am J Clin Nutr (2010) 0.87
n-3 Fatty acids, cardiac arrhythmia and fatal coronary heart disease. Prog Lipid Res (2006) 0.87
Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults. Am J Clin Nutr (2011) 0.87
A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans. J Nutr (2011) 0.86
Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes. Br J Nutr (2005) 0.86
Homocysteine levels--before and after methionine loading--in 51 Dutch families. Eur J Hum Genet (2005) 0.86
Effect of folic acid and betaine supplementation on flow-mediated dilation: a randomized, controlled study in healthy volunteers. PLoS Clin Trials (2006) 0.86
Association of folate with hearing is dependent on the 5,10-methylenetetrahdyrofolate reductase 677C-->T mutation. Neurobiol Aging (2005) 0.85
Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects. PLoS One (2010) 0.85
Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk. Atherosclerosis (2002) 0.85
The elimination of trans fats from spreads: how science helped to turn an industry around. Nutr Rev (2006) 0.84
Influence of processing on total, monoglutamate and polyglutamate folate contents of leeks, cauliflower, and green beans. J Agric Food Chem (2002) 0.83
Low concentrations of folate, not hyperhomocysteinemia, are associated with carotid intima-media thickness. Atherosclerosis (2004) 0.83
Effect of lowering of homocysteine levels on inflammatory markers: a randomized controlled trial. Arch Intern Med (2005) 0.83
Replacement of dietary saturated fat with trans fat reduces serum paraoxonase activity in healthy men and women. Metabolism (2002) 0.83
No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine. PLoS One (2011) 0.82
Reproducibility of the serum lipid response to coffee oil in healthy volunteers. Nutr J (2003) 0.82
Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: a randomized crossover trial in humans. Am J Clin Nutr (2004) 0.81
Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjects. Am Heart J (2003) 0.81
Validation of a food frequency questionnaire to assess folate intake of Dutch elderly people. Br J Nutr (2007) 0.80
Dietary monoglutamate and polyglutamate folate are associated with plasma folate concentrations in Dutch men and women aged 20-65 years. J Nutr (2002) 0.80
Association of dietary, circulating, and supplement fatty acids with coronary risk. Ann Intern Med (2014) 0.80
Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers. Am J Cardiol (2002) 0.80
Genetic variation in folate metabolism is not associated with cognitive functioning or mood in healthy adults. Prog Neuropsychopharmacol Biol Psychiatry (2011) 0.79
A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Am J Clin Nutr (2006) 0.79
DNA methylation and cognitive functioning in healthy older adults. Br J Nutr (2011) 0.79
Homocysteine--an indicator of a healthy diet? Am J Clin Nutr (2007) 0.79
Blood donation, body iron status and carotid intima-media thickness. Atherosclerosis (2007) 0.79
Quantifying folate bioavailability: a critical appraisal of methods. Curr Opin Clin Nutr Metab Care (2004) 0.78
Gender and body size affect the response of erythrocyte folate to folic acid treatment. J Nutr (2008) 0.78
Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals. Atherosclerosis (2003) 0.78