Published in J Biol Chem on May 06, 2003
STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol (2005) 13.11
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. Nat Cell Biol (2008) 2.89
Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem (2007) 2.63
A store-operated calcium channel in Drosophila S2 cells. J Gen Physiol (2004) 2.54
Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J (2008) 2.31
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. J Exp Med (2005) 2.20
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A (2009) 2.08
Calcium signaling in immune cells. Nat Immunol (2009) 1.97
Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation (2012) 1.81
Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels. J Biol Chem (2008) 1.74
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
Store-Operated Calcium Channels. Physiol Rev (2015) 1.46
The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch (2005) 1.40
Immunodeficiency due to mutations in ORAI1 and STIM1. Clin Immunol (2010) 1.39
Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem (2009) 1.34
Physiological mechanisms of TRPC activation. Pflugers Arch (2005) 1.31
Calcium-dependent activation of T-lymphocytes. Pflugers Arch (2004) 1.05
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells. Nat Immunol (2014) 1.04
Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions. J Biol Chem (2011) 1.04
Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels. J Biol Chem (2012) 1.02
Weft, warp, and weave: the intricate tapestry of calcium channels regulating T lymphocyte function. Front Immunol (2013) 0.93
On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular disease. Cardiovasc Hematol Agents Med Chem (2012) 0.91
Emerging roles of L-type voltage-gated and other calcium channels in T lymphocytes. Front Immunol (2013) 0.90
TRPC3: a versatile transducer molecule that serves integration and diversification of cellular signals. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.84
Physiological role of Kv1.3 channel in T lymphocyte cell investigated quantitatively by kinetic modeling. PLoS One (2014) 0.84
B-lymphocyte calcium influx. Immunol Rev (2009) 0.84
LFA-1-dependent Ca2+ entry following suboptimal T cell receptor triggering proceeds without mobilization of intracellular Ca2+. J Biol Chem (2009) 0.83
TRPC3 cation channel plays an important role in proliferation and differentiation of skeletal muscle myoblasts. Exp Mol Med (2010) 0.83
A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. J Biol Chem (2009) 0.83
Tweeters, Woofers and Horns: The Complex Orchestration of Calcium Currents in T Lymphocytes. Front Immunol (2015) 0.81
What is the evidence for the role of TRP channels in inflammatory and immune cells? Br J Pharmacol (2016) 0.80
The functional contribution of calcium ion flux heterogeneity in T cells. Immunol Cell Biol (2015) 0.79
Differential pathways for calcium influx activated by concanavalin A and CD3 stimulation in Jurkat T cells. Pflugers Arch (2011) 0.75
NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels. PLoS One (2016) 0.75
Transient Receptor Potential (TRP) channels in T cells. Semin Immunopathol (2015) 0.75
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
The TRP channels, a remarkably functional family. Cell (2002) 4.06
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ Res (2002) 3.05
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol (2008) 2.71
Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell (2013) 2.43
TRPC3 channels are required for synaptic transmission and motor coordination. Neuron (2008) 2.30
Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem (2002) 2.24
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. Blood (2002) 2.16
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proc Natl Acad Sci U S A (2008) 2.11
T cell activation requires mitochondrial translocation to the immunological synapse. Proc Natl Acad Sci U S A (2007) 2.06
Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J Biol Chem (2004) 1.88
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc Natl Acad Sci U S A (2010) 1.85
Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T cells. J Physiol (2002) 1.84
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol (2007) 1.68
Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem (2005) 1.52
Sustained activity of calcium release-activated calcium channels requires translocation of mitochondria to the plasma membrane. J Biol Chem (2006) 1.48
External tufted cells drive the output of olfactory bulb glomeruli. J Neurosci (2009) 1.46
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal (2010) 1.44
Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels. J Biol Chem (2007) 1.42
De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med (2009) 1.42
Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene (2003) 1.31
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology (2009) 1.31
Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies. J Physiol (2005) 1.28
TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels. J Biol Chem (2009) 1.27
Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem (2006) 1.26
Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc Natl Acad Sci U S A (2003) 1.25
Mitochondria positioning controls local calcium influx in T cells. J Immunol (2009) 1.24
Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res (2006) 1.24
Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation. EMBO J (2011) 1.24
L-type CaV1.2 calcium channels: from in vitro findings to in vivo function. Physiol Rev (2014) 1.23
Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Cell (2004) 1.22
Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat. J Biol Chem (2004) 1.17
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol (2012) 1.16
Redox regulation of calcium ion channels: chemical and physiological aspects. Cell Calcium (2011) 1.13
Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium (2007) 1.13
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med (2012) 1.11
Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proc Natl Acad Sci U S A (2006) 1.11
The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. J Cell Sci (2002) 1.11
GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes. Proc Natl Acad Sci U S A (2009) 1.08
Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. J Biol Chem (2002) 1.07
Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J Clin Invest (2010) 1.07
Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta. J Biol Chem (2008) 1.07
TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression. Biochem Biophys Res Commun (2004) 1.05
Calcium-dependent activation of T-lymphocytes. Pflugers Arch (2004) 1.05
Molecular regulation of CRAC channels and their role in lymphocyte function. Cell Mol Life Sci (2012) 1.03
Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol (2012) 1.03
Modified cardiovascular L-type channels in mice lacking the voltage-dependent Ca2+ channel beta3 subunit. J Biol Chem (2003) 1.03
Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels. J Biol Chem (2012) 1.02
TRPV6 potentiates calcium-dependent cell proliferation. Cell Calcium (2005) 1.01
Mitochondrial dynamics and their impact on T cell function. Cell Calcium (2012) 1.01
Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes. Cell Calcium (2007) 1.01
Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. J Biol Chem (2009) 1.01
Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol Pharmacol (2011) 1.00
The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells. Mol Pharmacol (2011) 1.00
Altered inactivation of Ca2+ current and Ca2+ release in mouse muscle fibers deficient in the DHP receptor gamma1 subunit. J Gen Physiol (2004) 1.00
Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase. J Biol Chem (2005) 0.99
TRP expression pattern and the functional importance of TRPC3 in primary human T-cells. Biochim Biophys Acta (2011) 0.97
The immunological synapse controls local and global calcium signals in T lymphocytes. Immunol Rev (2009) 0.96
Ectopic vesicular neurotransmitter release along sensory axons mediates neurovascular coupling via glial calcium signaling. Proc Natl Acad Sci U S A (2010) 0.95
Morphological changes of T cells following formation of the immunological synapse modulate intracellular calcium signals. Cell Calcium (2008) 0.95
ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance. Cell Calcium (2011) 0.95
Calcium, cancer and killing: the role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells. Biochim Biophys Acta (2012) 0.95
Male fertility depends on Ca²+ absorption by TRPV6 in epididymal epithelia. Sci Signal (2011) 0.95
ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes. J Invest Dermatol (2012) 0.94
The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells. J Biol Chem (2002) 0.93
The TRPV6 gene, cDNA and protein. Cell Calcium (2003) 0.93
Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels. Nat Immunol (2009) 0.93
TRPM4 regulates migration of mast cells in mice. Cell Calcium (2008) 0.93
Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry. Pigment Cell Melanoma Res (2014) 0.92
The auxiliary subunit gamma 1 of the skeletal muscle L-type Ca2+ channel is an endogenous Ca2+ antagonist. Proc Natl Acad Sci U S A (2007) 0.92
Ca2+ signaling in identified T-lymphocytes from human intestinal mucosa. Relation to hyporeactivity, proliferation, and inflammatory bowel disease. J Biol Chem (2003) 0.91
TRP channels as new pharmacological targets. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.90
TRPC4 and TRPC4-deficient mice. Novartis Found Symp (2004) 0.90
TRP channels as potential drug targets. Biol Cell (2004) 0.89
Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure. Sci Signal (2013) 0.89
Thapsigargin induces expression of activating transcription factor 3 in human keratinocytes involving Ca2+ ions and c-Jun N-terminal protein kinase. Mol Pharmacol (2010) 0.88
Two-photon analysis of calcium signals in T lymphocytes of intact lamina propria from human intestine. Eur J Immunol (2004) 0.88
P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca(2+) rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1. J Cell Physiol (2007) 0.88