Published in Nat Immunol on February 11, 2007
New developments in mast cell biology. Nat Immunol (2008) 3.72
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. J Clin Invest (2009) 2.54
Ion channels in innate and adaptive immunity. Annu Rev Immunol (2015) 1.99
Calcium signaling in immune cells. Nat Immunol (2009) 1.97
Ion channels and transporters in lymphocyte function and immunity. Nat Rev Immunol (2012) 1.74
TRPM5 regulates glucose-stimulated insulin secretion. Pflugers Arch (2010) 1.74
Calcium signalling and cell-fate choice in B cells. Nat Rev Immunol (2007) 1.64
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat Immunol (2011) 1.55
9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br J Pharmacol (2008) 1.48
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med (2009) 1.42
Modulation of TRPs by PIPs. J Physiol (2007) 1.35
Mechanisms of mast cell signaling in anaphylaxis. J Allergy Clin Immunol (2009) 1.34
Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29
The long and arduous road to CRAC. Cell Calcium (2007) 1.21
Regulation of Ca2+ signaling with particular focus on mast cells. Crit Rev Immunol (2009) 1.20
Understanding the mechanisms of anaphylaxis. Curr Opin Allergy Clin Immunol (2008) 1.16
Transient receptor potential channels in the vasculature. Physiol Rev (2015) 1.14
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med (2012) 1.11
Balancing calcium signals through TRPC5 and TRPC6 in podocytes. J Am Soc Nephrol (2011) 1.11
The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nat Immunol (2008) 1.10
Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J Clin Invest (2010) 1.07
TRP channels in neurogastroenterology: opportunities for therapeutic intervention. Br J Pharmacol (2011) 1.07
Bernd Nilius: the bard of ion channels. Congratulations on 65th birthday. Pflugers Arch (2010) 1.06
The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. J Cell Sci (2009) 1.05
Non-selective cation channels, transient receptor potential channels and ischemic stroke. Biochim Biophys Acta (2007) 1.03
The Role of TRP Proteins in Mast Cells. Front Immunol (2012) 1.02
Immunoglobulin E receptor signaling and asthma. J Biol Chem (2011) 1.02
Transient receptor potential melastatin 4 and cell death. Pflugers Arch (2012) 1.02
Store-operated calcium entry: Mechanisms and modulation. Biochem Biophys Res Commun (2015) 0.97
Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. J Immunol (2010) 0.94
Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. PLoS One (2012) 0.93
Increase in cytosolic Ca2+ produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body. J Physiol (2014) 0.93
Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol (2011) 0.92
Phosphatidylinositol-3-kinase C2β and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells. Mol Cell Biol (2012) 0.92
Calcium homeostasis in human melanocytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light. Am J Physiol Cell Physiol (2009) 0.92
Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. Prostaglandins Other Lipid Mediat (2008) 0.92
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest (2015) 0.91
The TRPM4 channel inhibitor 9-phenanthrol. Br J Pharmacol (2014) 0.87
TRPM4 inhibition promotes angiogenesis after ischemic stroke. Pflugers Arch (2013) 0.84
Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations. PLoS One (2014) 0.83
Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons. Front Cell Neurosci (2014) 0.83
Ion channels in asthma. J Biol Chem (2011) 0.82
A novel role of the L-type calcium channel α1D subunit as a gatekeeper for intracellular zinc signaling: zinc wave. PLoS One (2012) 0.80
Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production. Cell Calcium (2013) 0.80
What is the evidence for the role of TRP channels in inflammatory and immune cells? Br J Pharmacol (2016) 0.80
Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response. J Exp Med (2014) 0.79
TRP Channels as Therapeutic Targets in Diabetes and Obesity. Pharmaceuticals (Basel) (2016) 0.79
Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity. J Biol Chem (2014) 0.78
A TRP channel contributes to insulin secretion by pancreatic β-cells. Islets (2010) 0.78
The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy. Basic Res Cardiol (2015) 0.78
TRPM2 contributes to antigen-stimulated Ca²⁺ influx in mucosal mast cells. Pflugers Arch (2013) 0.78
Physiological functions of the TRPM4 channels via protein interactions. BMB Rep (2015) 0.78
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca²⁺-activated non-selective cation channel TRPM4. Pflugers Arch (2014) 0.78
TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells. Br J Pharmacol (2014) 0.77
The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia. J Neuroinflammation (2016) 0.77
TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells. Elife (2013) 0.77
The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target? Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122. Br J Pharmacol (2016) 0.75
TRPM4-mediated control of FcεRI-evoked Ca(2+) elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells. Sci Rep (2016) 0.75
Transient Receptor Potential (TRP) channels in T cells. Semin Immunopathol (2015) 0.75
Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells. Oncotarget (2015) 0.75
TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons. Pflugers Arch (2015) 0.75
Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One (2017) 0.75
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature (2003) 4.45
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
The TRP channels, a remarkably functional family. Cell (2002) 4.06
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation. Immunity (2008) 3.50
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem (2003) 3.15
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity (2011) 3.10
Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ Res (2002) 3.05
[MSRA (multi-resistant Staphylococcus A) from the point of view of personal care]. Pflege Aktuell (2004) 3.03
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
TRP channels: an overview. Cell Calcium (2005) 2.98
Potential risks of bone marrow cell transplantation into infarcted hearts. Blood (2007) 2.97
Permeation and selectivity of TRP channels. Annu Rev Physiol (2006) 2.96
TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol (2008) 2.88
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways. Proc Natl Acad Sci U S A (2004) 2.79
Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci (2007) 2.78
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol (2008) 2.71
Calcium absorption across epithelia. Physiol Rev (2005) 2.57
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
Sensing with TRP channels. Nat Chem Biol (2005) 2.51
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol (2007) 2.48
Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell (2013) 2.43
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron (2004) 2.43
TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
TRPC3 channels are required for synaptic transmission and motor coordination. Neuron (2008) 2.30
Red blood cells express a functional endothelial nitric oxide synthase. Blood (2005) 2.30
Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem (2002) 2.24
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol (2009) 2.24
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med (2006) 2.23
A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21
Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem (2003) 2.21
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell (2010) 2.17
Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. Blood (2002) 2.16
The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol (2009) 2.13
TRPs in our senses. Curr Biol (2008) 2.12
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proc Natl Acad Sci U S A (2008) 2.11
Modulation of long-range neural synchrony reflects temporal limitations of visual attention in humans. Proc Natl Acad Sci U S A (2004) 2.07
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development (2002) 2.04
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet (2009) 2.02
Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J Immunol (2005) 2.02
Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol (2009) 2.00
Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J (2003) 1.97
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A (2010) 1.96
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc Natl Acad Sci U S A (2010) 1.85
Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J Immunol (2003) 1.81
Outer pore architecture of a Ca2+-selective TRP channel. J Biol Chem (2004) 1.79
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab (2008) 1.79
PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem (2006) 1.71
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium (2005) 1.70
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Neuronal TRP channels: thermometers, pathfinders and life-savers. Trends Neurosci (2008) 1.63
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol (2007) 1.63
Resource sharing in the attentional blink. Neuroreport (2006) 1.57
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur J Immunol (2005) 1.56
The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr Biol (2011) 1.56
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J (2006) 1.53
TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes. J Biol Chem (2003) 1.53
Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem (2005) 1.52
Basic fibroblast growth factor controls migration in human mesenchymal stem cells. Stem Cells (2006) 1.52
Molecular mechanism of active Ca2+ reabsorption in the distal nephron. Annu Rev Physiol (2002) 1.51
The loss and progressive recovery of voiding after spinal cord interruption in rats is associated with simultaneous changes in autonomous contractile bladder activity. Eur Urol (2008) 1.48
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
Comparison of contractile behavior of native murine ventricular tissue and cardiomyocytes derived from embryonic or induced pluripotent stem cells. FASEB J (2010) 1.45
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature (2012) 1.44
Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells. J Mol Cell Cardiol (2008) 1.44
Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at basolateral, but not apical, membrane of Caco-2 cells. Am J Physiol Cell Physiol (2005) 1.43
Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels. J Biol Chem (2007) 1.42
De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat Med (2009) 1.42
Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol (2007) 1.40
In vitro secreting profile of human mesenchymal stem cells. Stem Cells Dev (2008) 1.40
Vanilloid transient receptor potential cation channels: an overview. Curr Pharm Des (2008) 1.40
13C-methionine breath test detects distinct hepatic mitochondrial dysfunction in HIV-infected patients with normal serum lactate. J Acquir Immune Defic Syndr (2005) 1.40
Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol Renal Physiol (2009) 1.39
Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem (2007) 1.36
Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med (2012) 1.35
Modulation of TRPs by PIPs. J Physiol (2007) 1.35
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Pain (2011) 1.35