Published in Genes Dev on June 03, 2003
Topology and dynamics of the zebrafish segmentation clock core circuit. PLoS Biol (2012) 2.41
Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells. Proc Natl Acad Sci U S A (2006) 2.10
Single-cell-resolution imaging of the impact of Notch signaling and mitosis on segmentation clock dynamics. Dev Cell (2012) 1.87
Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell (2011) 1.65
Setting the tempo in development: an investigation of the zebrafish somite clock mechanism. PLoS Biol (2007) 1.61
Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct. PLoS Genet (2007) 1.54
From dinosaurs to birds: a tail of evolution. Evodevo (2014) 1.44
Evolutionary plasticity of segmentation clock networks. Development (2011) 1.39
Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A (2011) 1.37
Notch signaling, the segmentation clock, and the patterning of vertebrate somites. J Biol (2009) 1.34
Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Genes Dev (2005) 1.29
Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression. Proc Natl Acad Sci U S A (2006) 1.20
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet (2009) 1.14
The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun (2011) 1.07
Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes Dev (2008) 1.06
Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol (2009) 1.05
Cooperative function of deltaC and her7 in anterior segment formation. Dev Biol (2005) 1.04
Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes Dev (2011) 1.02
Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. Dev Biol (2007) 1.01
The segmentation clock mechanism moves up a notch. Trends Cell Biol (2010) 1.01
Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis. Eur J Hum Genet (2010) 1.00
Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box, and Suppressor of Hairless proteins in the zebrafish segmentation clock. Dev Dyn (2009) 0.96
Number of active transcription factor binding sites is essential for the Hes7 oscillator. Theor Biol Med Model (2006) 0.96
Somitogenesis. Development (2012) 0.95
Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling. Nat Commun (2012) 0.93
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. J Virol (2004) 0.93
Complex dynamics of transcription regulation. Biochim Biophys Acta (2012) 0.92
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (2014) 0.92
Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes. Proc Natl Acad Sci U S A (2013) 0.91
her11 is involved in the somitogenesis clock in zebrafish. Dev Genes Evol (2004) 0.91
Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate. Dev Dyn (2009) 0.89
Comparative analysis of her genes during fish somitogenesis suggests a mouse/chick-like mode of oscillation in medaka. Dev Genes Evol (2006) 0.88
Travelling and splitting of a wave of hedgehog expression involved in spider-head segmentation. Nat Commun (2011) 0.87
Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis. Genes Dev (2016) 0.84
Genetic aspects of congenital and idiopathic scoliosis. Scientifica (Cairo) (2012) 0.84
The period of the somite segmentation clock is sensitive to Notch activity. Mol Biol Cell (2011) 0.84
Canine disorder mirrors human disease: exonic deletion in HES7 causes autosomal recessive spondylocostal dysostosis in miniature Schnauzer dogs. PLoS One (2015) 0.84
A fluorescence spotlight on the clockwork development and metabolism of bone. J Bone Miner Metab (2011) 0.84
Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM. PLoS One (2009) 0.83
Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis. PLoS One (2009) 0.83
Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex. BMC Dev Biol (2007) 0.83
The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub. Development (2012) 0.83
Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock. PLoS One (2013) 0.82
Unraveling the nature of the segmentation clock: Intrinsic disorder of clock proteins and their interaction map. Comput Biol Chem (2006) 0.81
From dynamic expression patterns to boundary formation in the presomitic mesoderm. PLoS Comput Biol (2012) 0.81
Notch signalling regulates the contribution of progenitor cells from the chick Hensen's node to the floor plate and notochord. Development (2010) 0.80
The synchrony and cyclicity of developmental events. Cold Spring Harb Perspect Biol (2012) 0.79
Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module. PLoS One (2012) 0.79
Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity. Development (2015) 0.78
The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network. BMC Dev Biol (2013) 0.78
Life rhythm as a symphony of oscillatory patterns: electromagnetic energy and sound vibration modulates gene expression for biological signaling and healing. Glob Adv Health Med (2014) 0.78
Modeling the zebrafish segmentation clock's gene regulatory network constrained by expression data suggests evolutionary transitions between oscillating and nonoscillating transcription. Genetics (2014) 0.77
Hes7 3'UTR is required for somite segmentation function. Sci Rep (2014) 0.77
Modelling coupled oscillations in the Notch, Wnt, and FGF signaling pathways during somitogenesis: a comprehensive mathematical model. Comput Intell Neurosci (2015) 0.77
Stochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch Signalling. PLoS Comput Biol (2015) 0.76
Whole Genome Sequencing Identifies a Missense Mutation in HES7 Associated with Short Tails in Asian Domestic Cats. Sci Rep (2016) 0.76
Practical lessons from theoretical models about the somitogenesis. Gene Regul Syst Bio (2007) 0.76
Circadian genes, xBmal1 and xNocturnin, modulate the timing and differentiation of somites in Xenopus laevis. PLoS One (2014) 0.76
Fast synchronization of ultradian oscillators controlled by delta-notch signaling with cis-inhibition. PLoS Comput Biol (2014) 0.75
Progress and perspective of TBX6 gene in congenital vertebral malformations. Oncotarget (2016) 0.75
Turn It Down a Notch. Front Cell Dev Biol (2017) 0.75
Delta-Notch signalling in segmentation. Arthropod Struct Dev (2016) 0.75
PAPC couples the segmentation clock to somite morphogenesis by regulating N-cadherin dependent adhesion. Development (2017) 0.75
Genetic association analysis between polymorphisms of HAIRY-AND-ENHANCER-OF SPLIT-7 and congenital scoliosis. Int J Clin Exp Med (2015) 0.75
Supt20 is required for development of the axial skeleton. Dev Biol (2016) 0.75
A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Sci Rep (2015) 0.75
A balance of positive and negative regulators determines the pace of the segmentation clock. Elife (2015) 0.75
Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Dev Biol (2017) 0.75
The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development (2017) 0.75
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell (2000) 11.10
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science (2002) 3.93
Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis. Cell (1997) 3.88
Progression of the cell cycle through mitosis leads to abortion of nascent transcripts. Cell (1991) 3.75
Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell (2003) 3.15
Notch signalling and the synchronization of the somite segmentation clock. Nature (2000) 2.84
Defects in somite formation in lunatic fringe-deficient mice. Nature (1998) 2.37
Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev (2001) 2.26
Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm. Development (2000) 2.09
lunatic fringe is an essential mediator of somite segmentation and patterning. Nature (1998) 2.09
Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity. Genes Dev (2000) 2.09
Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock. Nature (2003) 2.08
The making of the somite: molecular events in vertebrate segmentation. Nat Rev Genet (2001) 1.88
her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis. Development (2002) 1.77
Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish. Development (2002) 1.71
Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J (2000) 1.71
Vertebrate somitogenesis. Annu Rev Cell Dev Biol (2001) 1.67
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development (2002) 1.66
Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation. Curr Biol (1998) 1.65
Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Development (2000) 1.59
The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos. Curr Biol (1998) 1.58
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors. Dev Biol (2000) 1.53
Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev Cell (2002) 1.44
Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells (2001) 1.43
Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation. Dev Biol (1999) 1.39
Transcriptional oscillation of lunatic fringe is essential for somitogenesis. Genes Dev (2003) 1.29
Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries. Development (2002) 1.29
A clock-work somite. Bioessays (2000) 1.13
Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis. Dev Cell (2002) 1.10
A nomenclature for prospective somites and phases of cyclic gene expression in the presomitic mesoderm. Dev Cell (2001) 1.09
A gene that resuscitates a theory--somitogenesis and a molecular oscillator. Trends Genet (1998) 1.03
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci (2008) 6.13
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science (2002) 3.93
Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron (2008) 3.51
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development (2004) 2.65
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science (2013) 2.56
Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains. J Neurosci (2010) 2.55
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina. Proc Natl Acad Sci U S A (2004) 2.44
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet (2003) 2.42
Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet (2012) 2.33
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
Retinal cell fate determination and bHLH factors. Semin Cell Dev Biol (2004) 2.33
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev (2009) 2.19
Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells. Proc Natl Acad Sci U S A (2006) 2.10
Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS Lett (2003) 2.10
A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell (2012) 2.08
Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet (2004) 2.07
Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development (2002) 2.07
High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci (2006) 1.89
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol (2006) 1.86
The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology (2004) 1.81
Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol (2005) 1.79
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol (2003) 1.75
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev (2006) 1.60
Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci (2005) 1.59
Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Dev Cell (2007) 1.56
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell (2007) 1.54
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood (2002) 1.51
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development (2008) 1.50
Regulation of retinal cell fate specification by multiple transcription factors. Brain Res (2007) 1.50
Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development (2006) 1.48
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol (2009) 1.48
Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest (2006) 1.48
Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum. Proc Natl Acad Sci U S A (2007) 1.47
Visualization of embryonic neural stem cells using Hes promoters in transgenic mice. Mol Cell Neurosci (2005) 1.41
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem (2003) 1.41
FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr Biol (2008) 1.40
Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A (2011) 1.37
Temporal regulation of Cre recombinase activity in neural stem cells. Genesis (2006) 1.36
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Nat Commun (2013) 1.35
Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype specification. J Biol Chem (2004) 1.34
Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. FASEB J (2005) 1.29
Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS One (2008) 1.28
CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo. J Neurosci (2005) 1.26
Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Mol Endocrinol (2007) 1.25
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Proc Natl Acad Sci U S A (2011) 1.24
Six1 is essential for early neurogenesis in the development of olfactory epithelium. Dev Biol (2007) 1.19
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J Biol Chem (2011) 1.17
The role of Hes genes in intestinal development, homeostasis and tumor formation. Development (2012) 1.16
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells. Blood (2011) 1.14
Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. EMBO J (2005) 1.14
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J Exp Med (2012) 1.13
MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain. Genes Cells (2012) 1.10
Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells. Stem Cells (2008) 1.08
Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells (2010) 1.07
Oscillator mechanism of Notch pathway in the segmentation clock. Dev Dyn (2007) 1.07
Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. Cell Rep (2012) 1.07
Oscillations, clocks and segmentation. Curr Opin Genet Dev (2003) 1.06
Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine. Biochem Biophys Res Commun (2005) 1.06
Dynamic expression of notch signaling genes in neural stem/progenitor cells. Front Neurosci (2011) 1.06
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Dev Biol (2011) 1.04
Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development. Development (2012) 1.04
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1. J Neurosci Res (2009) 1.03
Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis. J Neurosci (2004) 1.02
The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS. J Neurosci (2005) 1.02
Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes Dev (2011) 1.02
Mind bomb 1 is required for pancreatic β-cell formation. Proc Natl Acad Sci U S A (2012) 1.02
Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development (2013) 1.01
Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. Int J Dev Biol (2010) 1.00
Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling. Genes Cells (2010) 1.00
Fate of neural stem cells grafted into injured inner ears of mice. Neuroreport (2003) 1.00
Non-sense mutations in the dihydropyridine receptor beta1 gene, CACNB1, paralyze zebrafish relaxed mutants. Cell Calcium (2005) 0.98
Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Development (2010) 0.97
Genetic methods to identify and manipulate newly born neurons in the adult brain. Front Neurosci (2011) 0.97
Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. J Neurosci (2014) 0.97
Retrovirus-mediated gene transfer to retinal explants. Methods (2002) 0.97
Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors. J Neurosci (2005) 0.96
The role of Notch signaling in adult neurogenesis. Mol Neurobiol (2011) 0.96
Notch and HES5 are regulated during human cartilage differentiation. Cell Tissue Res (2006) 0.96
TRPM7 is required within zebrafish sensory neurons for the activation of touch-evoked escape behaviors. J Neurosci (2011) 0.95
Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems. Dev Neurosci (2006) 0.94
Notch1 expression is spatiotemporally correlated with neurogenesis and negatively regulated by Notch1-independent Hes genes in the developing nervous system. Cereb Cortex (2006) 0.94
Continuous neurogenesis in the adult brain. Dev Growth Differ (2009) 0.93
Developmental transition of touch response from slow muscle-mediated coilings to fast muscle-mediated burst swimming in zebrafish. Dev Biol (2011) 0.92
In vivo optogenetic tracing of functional corticocortical connections between motor forelimb areas. Front Neural Circuits (2013) 0.92
Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease. Cell Stem Cell (2013) 0.91
Roles of the bHLH gene Hes1 in retinal morphogenesis. Brain Res (2004) 0.91
Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish. Dev Dyn (2008) 0.90
The zebrafish ennui behavioral mutation disrupts acetylcholine receptor localization and motor axon stability. Dev Neurobiol (2008) 0.89
Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes. Invest Ophthalmol Vis Sci (2005) 0.89
Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue. Invest Ophthalmol Vis Sci (2004) 0.88
Mash1 is required for neuroendocrine cell development in the glandular stomach. Genes Cells (2008) 0.88
Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development. Stem Cells (2011) 0.87
Genetic visualization of notch signaling in mammalian neurogenesis. Cell Mol Life Sci (2012) 0.87
Retinoid acid specifies neuronal identity through graded expression of Ascl1. Curr Biol (2013) 0.86