Published in Development on October 20, 2004
Development and evolution of the human neocortex. Cell (2011) 4.42
SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev (2006) 4.11
A functional study of miR-124 in the developing neural tube. Genes Dev (2007) 3.21
YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev (2008) 3.16
Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron (2008) 2.86
The many facets of Notch ligands. Oncogene (2008) 2.57
Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res (2007) 2.51
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
Neural stem cell self-renewal. Crit Rev Oncol Hematol (2007) 1.76
MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PLoS One (2009) 1.73
RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development (2010) 1.72
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells. Genes Dev (2005) 1.52
Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics. Sci Rep (2013) 1.51
Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell (2015) 1.50
A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. EMBO J (2006) 1.49
Notch and the skeleton. Mol Cell Biol (2009) 1.49
Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philos Trans R Soc Lond B Biol Sci (2008) 1.48
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development (2007) 1.47
Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum. Proc Natl Acad Sci U S A (2007) 1.47
Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells. Mol Cell Biol (2008) 1.42
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A (2009) 1.38
Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol (2008) 1.29
The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron (2010) 1.22
Targeting neural precursors in the adult brain rescues injured dopamine neurons. Proc Natl Acad Sci U S A (2009) 1.21
Increased expression of angiogenic genes in the brains of mouse meg3-null embryos. Endocrinology (2010) 1.19
Multiple requirements for Hes 1 during early eye formation. Dev Biol (2005) 1.19
Neurogenesis during development of the vertebrate central nervous system. EMBO Rep (2014) 1.19
Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain. Hear Res (2005) 1.15
Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn (2009) 1.13
Molecular control of neurogenesis: a view from the mammalian cerebral cortex. Cold Spring Harb Perspect Biol (2012) 1.13
Neural stem cells in the developing and adult brains. J Cell Physiol (2009) 1.11
Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One (2011) 1.10
Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas. BMC Dev Biol (2007) 1.08
Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development. Mol Syst Biol (2010) 1.08
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development. BMC Dev Biol (2008) 1.07
Notch pathway activation induces neuroblastoma tumor cell growth arrest. Pediatr Blood Cancer (2011) 1.07
Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci (2010) 1.06
Dynamic expression of notch signaling genes in neural stem/progenitor cells. Front Neurosci (2011) 1.06
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci (2009) 1.04
Nervous decision-making: to divide or differentiate. Trends Genet (2014) 1.04
Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome Biol (2009) 1.03
Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina. Brain Res (2007) 1.02
Hes1 is expressed in the second heart field and is required for outflow tract development. PLoS One (2009) 1.01
A global survey identifies novel upstream components of the Ath5 neurogenic network. Genome Biol (2009) 1.00
Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. EMBO Rep (2011) 1.00
Functions of GSK-3 Signaling in Development of the Nervous System. Front Mol Neurosci (2011) 0.99
FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis. J Neurosci (2011) 0.98
Discovery of two GLP-1/Notch target genes that account for the role of GLP-1/Notch signaling in stem cell maintenance. Proc Natl Acad Sci U S A (2014) 0.98
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation. J Biol Chem (2008) 0.98
Role for Lhx2 in corticogenesis through regulation of progenitor differentiation. Mol Cell Neurosci (2013) 0.97
Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis. J Neurosci (2008) 0.96
The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch. PLoS One (2012) 0.96
Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest Ophthalmol Vis Sci (2008) 0.96
Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1(high) intermediate progenitors. Nat Commun (2012) 0.95
Transcription factors and neural stem cell self-renewal, growth and differentiation. Cell Adh Migr (2009) 0.94
BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors. J Neurosci (2012) 0.93
HES1 (hairy and enhancer of split 1) is a determinant of bone mass. J Biol Chem (2010) 0.92
Cortical gyrification induced by fibroblast growth factor 2 in the mouse brain. J Neurosci (2013) 0.92
The establishment of B versus T cell identity. Trends Immunol (2014) 0.92
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate. J Cell Biol (2007) 0.92
Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling. J Neurosci (2013) 0.91
Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord. Development (2009) 0.91
Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear. Dev Dyn (2006) 0.91
The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway. Stem Cells Dev (2012) 0.90
Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis. Development (2010) 0.90
bHLH-Orange Transcription Factors in Development and Cancer. Transl Oncogenomics (2007) 0.89
Cell cycle regulation of proliferation versus differentiation in the central nervous system. Cell Tissue Res (2014) 0.89
Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development (2013) 0.89
Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis. Stem Cells (2012) 0.88
Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. J Neuroinflammation (2008) 0.87
Genetic visualization of notch signaling in mammalian neurogenesis. Cell Mol Life Sci (2012) 0.87
Aldh1L1 is expressed by postnatal neural stem cells in vivo. Glia (2013) 0.87
Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development (2013) 0.86
Retinoid acid specifies neuronal identity through graded expression of Ascl1. Curr Biol (2013) 0.86
The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary. Dev Biol (2011) 0.86
ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. J Biol Chem (2010) 0.86
Cholera toxin regulates a signaling pathway critical for the expansion of neural stem cell cultures from the fetal and adult rodent brains. PLoS One (2010) 0.85
Selective roles of normal and mutant huntingtin in neural induction and early neurogenesis. PLoS One (2013) 0.85
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep (2015) 0.85
Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors. BMC Biotechnol (2010) 0.85
Notch/Rbpjκ signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons. Development (2013) 0.84
Sensory neuron differentiation is regulated by notch signaling in the trigeminal placode. Dev Biol (2010) 0.83
The STAT3-Ser/Hes3 signaling axis: an emerging regulator of endogenous regeneration and cancer growth. Front Physiol (2013) 0.83
AhR-mediated gene expression in the developing mouse telencephalon. Reprod Toxicol (2009) 0.83
microRNA input into a neural ultradian oscillator controls emergence and timing of alternative cell states. Nat Commun (2014) 0.83
Notch Signaling and the Skeleton. Endocr Rev (2016) 0.82
Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation. PLoS Genet (2009) 0.82
Cerebral cortex expansion and folding: what have we learned? EMBO J (2016) 0.81
Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium. J Ophthalmol (2014) 0.81
Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries. Dev Genes Evol (2009) 0.81
Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord. PLoS One (2012) 0.81
Anterior Hox genes interact with components of the neural crest specification network to induce neural crest fates. Stem Cells (2011) 0.80
Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression. Dev Dyn (2013) 0.80
Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev (2013) 0.80
Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus. Front Neuroanat (2014) 0.80
Human pluripotent stem cell-derived radial glia recapitulate developmental events and provide real-time access to cortical neurons and astrocytes. Stem Cells Transl Med (2015) 0.79
Small RNAs have a big impact on regeneration. RNA Biol (2010) 0.79
Neurovascular signals suggest a propagation mechanism for endogenous stem cell activation along blood vessels. CNS Neurol Disord Drug Targets (2012) 0.79
Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff. Development (2016) 0.79
Proneural genes and the specification of neural cell types. Nat Rev Neurosci (2002) 6.79
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci (2008) 6.13
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science (2002) 3.93
Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron (2008) 3.51
Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues. Neuron (2003) 2.92
p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev (2006) 2.89
alpha-Klotho as a regulator of calcium homeostasis. Science (2007) 2.71
Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron (2005) 2.70
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science (2013) 2.56
Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains. J Neurosci (2010) 2.55
Mash1 specifies neurons and oligodendrocytes in the postnatal brain. EMBO J (2004) 2.55
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron (2010) 2.54
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina. Proc Natl Acad Sci U S A (2004) 2.44
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet (2003) 2.42
Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling. Neuron (2011) 2.42
Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nat Genet (2012) 2.33
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
Retinal cell fate determination and bHLH factors. Semin Cell Dev Biol (2004) 2.33
Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology (2005) 2.32
Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J (2004) 2.30
Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev (2002) 2.19
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev (2009) 2.19
Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells. Proc Natl Acad Sci U S A (2006) 2.10
Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS Lett (2003) 2.10
Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Proc Natl Acad Sci U S A (2006) 2.09
A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell (2012) 2.08
Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet (2004) 2.07
Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development (2002) 2.07
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell (2006) 2.06
A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes Dev (2011) 2.04
Chemerin--a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun (2007) 2.00
Molecular mechanisms underlying cell fate specification in the developing telencephalon. Curr Opin Neurobiol (2002) 1.98
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature (2008) 1.94
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev (2003) 1.93
Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development (2002) 1.91
High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. J Neurosci (2006) 1.89
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol (2006) 1.86
The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology (2004) 1.81
Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol (2005) 1.79
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol (2003) 1.75
A role for proneural genes in the maturation of cortical progenitor cells. Cereb Cortex (2006) 1.68
Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6. Development (2003) 1.64
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev (2006) 1.60
Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci (2005) 1.59
Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol (2008) 1.59
Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development (2006) 1.58
The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes. J Neurosci (2007) 1.56
Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1. Dev Cell (2007) 1.56
Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord. Development (2007) 1.55
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell (2007) 1.54
The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J Neurosci (2012) 1.53
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood (2002) 1.51
Engraftment and tumor formation after allogeneic in utero transplantation of primate embryonic stem cells. Transplantation (2003) 1.51
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development (2008) 1.50
Regulation of retinal cell fate specification by multiple transcription factors. Brain Res (2007) 1.50
Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development (2006) 1.48
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol (2009) 1.48
Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol (2005) 1.48
Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest (2006) 1.48
Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum. Proc Natl Acad Sci U S A (2007) 1.47
FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Cell Rep (2013) 1.45
Visualization of embryonic neural stem cells using Hes promoters in transgenic mice. Mol Cell Neurosci (2005) 1.41
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem (2003) 1.41
FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr Biol (2008) 1.40
Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A (2011) 1.37
Temporal regulation of Cre recombinase activity in neural stem cells. Genesis (2006) 1.36
Ascl1/Mash1 is required for the development of central serotonergic neurons. Nat Neurosci (2004) 1.35
Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype specification. J Biol Chem (2004) 1.34
Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS One (2008) 1.28
CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo. J Neurosci (2005) 1.26
Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells. Mol Endocrinol (2006) 1.25
Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Mol Endocrinol (2007) 1.25
A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev Biol (2004) 1.24
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Proc Natl Acad Sci U S A (2011) 1.24
Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence. Genes Dev (2013) 1.23
Ascl1 is required for oligodendrocyte development in the spinal cord. Development (2008) 1.20
Six1 is essential for early neurogenesis in the development of olfactory epithelium. Dev Biol (2007) 1.19
Localization of mechanosensitive channel TRPV4 in mouse skin. Neurosci Lett (2003) 1.18
Neurogenin 2 has an essential role in development of the dentate gyrus. Development (2008) 1.18
AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nat Neurosci (2009) 1.18
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J Biol Chem (2011) 1.17
The role of Hes genes in intestinal development, homeostasis and tumor formation. Development (2012) 1.16
Conserved and acquired features of neurogenin1 regulation. Development (2004) 1.15
Rho-kinase dependent organization of stress fibers and focal adhesions in cultured fibroblasts. Genes Cells (2007) 1.14
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells. Blood (2011) 1.14
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet (2009) 1.14
Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. EMBO J (2005) 1.14
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J Exp Med (2012) 1.13
Molecular control of neurogenesis: a view from the mammalian cerebral cortex. Cold Spring Harb Perspect Biol (2012) 1.13