Published in PLoS Comput Biol on June 28, 2012
The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network. BMC Dev Biol (2013) 0.78
Modelling coupled oscillations in the Notch, Wnt, and FGF signaling pathways during somitogenesis: a comprehensive mathematical model. Comput Intell Neurosci (2015) 0.77
Rbm24a and Rbm24b are required for normal somitogenesis. PLoS One (2014) 0.76
Circadian genes, xBmal1 and xNocturnin, modulate the timing and differentiation of somites in Xenopus laevis. PLoS One (2014) 0.76
Time-Delayed Models of Gene Regulatory Networks. Comput Math Methods Med (2015) 0.75
Fast synchronization of ultradian oscillators controlled by delta-notch signaling with cis-inhibition. PLoS Comput Biol (2014) 0.75
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol (2004) 9.80
How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol (2003) 4.90
Notch signaling: the core pathway and its posttranslational regulation. Dev Cell (2009) 4.49
Notch1 is required for the coordinate segmentation of somites. Development (1995) 4.33
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science (2002) 3.93
Regulation of notch signaling activity. Curr Biol (2004) 3.88
Oscillatory behavior in enzymatic control processes. Adv Enzyme Regul (1965) 3.77
Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator. Curr Biol (2003) 3.56
Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays. Curr Biol (2003) 3.54
Maintenance of somite borders in mice requires the Delta homologue DII1. Nature (1997) 3.44
A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science (2006) 3.27
Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron (2003) 2.89
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem (2001) 2.89
Notch signalling and the synchronization of the somite segmentation clock. Nature (2000) 2.84
Control of segment number in vertebrate embryos. Nature (2008) 2.78
fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature (2004) 2.77
The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development (2005) 2.63
FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation. Cell (2001) 2.58
Segmental patterning of the vertebrate embryonic axis. Nat Rev Genet (2008) 2.55
Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev Cell (2010) 2.29
Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev (2001) 2.26
Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements. J Biol Chem (1994) 2.26
Crossing paths with Notch in the hyper-network. Curr Opin Cell Biol (2007) 2.20
Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development (1995) 2.20
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev (2009) 2.19
Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm. Development (2000) 2.09
Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock. Nature (2003) 2.08
Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet (2004) 2.07
A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nat Cell Biol (2007) 2.01
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A (2007) 1.98
Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev (1997) 1.97
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature (2005) 1.94
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev (2003) 1.93
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science (2009) 1.91
The making of the somite: molecular events in vertebrate segmentation. Nat Rev Genet (2001) 1.88
New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood (2010) 1.82
Noise-resistant and synchronized oscillation of the segmentation clock. Nature (2006) 1.80
LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev (2004) 1.76
WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev (2004) 1.74
Synchrony dynamics during initiation, failure, and rescue of the segmentation clock. Science (2007) 1.70
Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science (2005) 1.66
In vivo kinetics of mRNA splicing and transport in mammalian cells. Mol Cell Biol (2002) 1.63
Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development (2007) 1.63
A random cell motility gradient downstream of FGF controls elongation of an amniote embryo. Nature (2010) 1.58
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell (2007) 1.54
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev (2004) 1.46
Intracellular distribution of proteasomes. Curr Opin Immunol (1998) 1.45
Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells (2001) 1.43
Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling. Development (2009) 1.43
Endocytosis controls spreading and effective signaling range of Fgf8 protein. Curr Biol (2004) 1.42
Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter. Biochem J (2008) 1.42
Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways. J Theor Biol (2008) 1.41
Evolutionary plasticity of segmentation clock networks. Development (2011) 1.39
Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A (2011) 1.37
Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev Cell (2006) 1.36
Modelling transcriptional feedback loops: the role of Gro/TLE1 in Hes1 oscillations. Philos Trans A Math Phys Eng Sci (2006) 1.36
Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. J Biol Chem (2007) 1.31
Sharp developmental thresholds defined through bistability by antagonistic gradients of retinoic acid and FGF signaling. Dev Dyn (2007) 1.30
Transcriptional oscillation of lunatic fringe is essential for somitogenesis. Genes Dev (2003) 1.29
A Notch feeling of somite segmentation and beyond. Dev Biol (2004) 1.28
Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling. Mech Dev (2004) 1.27
A multi-cell, multi-scale model of vertebrate segmentation and somite formation. PLoS Comput Biol (2011) 1.19
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet (2009) 1.14
Modeling the Hes1 oscillator. J Comput Biol (2007) 1.13
Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis. Development (2008) 1.12
EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation. Proc Natl Acad Sci U S A (2009) 1.11
Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis (2005) 1.10
Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis. Dev Dyn (2007) 1.08
Oscillator mechanism of Notch pathway in the segmentation clock. Dev Dyn (2007) 1.07
Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes Dev (2008) 1.06
Cell-based simulation of dynamic expression patterns in the presomitic mesoderm. J Theor Biol (2007) 1.05
The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite. Development (2007) 1.05
Interfering with Wnt signalling alters the periodicity of the segmentation clock. Dev Biol (2009) 1.05
Regulation of Notch1/NICD and Hes1 expressions by GSK-3alpha/beta. Mol Cells (2008) 1.05
Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton. Development (2008) 1.05
Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2. Development (2006) 1.02
The role of presenilin 1 during somite segmentation. Development (2001) 1.02
Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes Dev (2011) 1.02
Dll1 is a downstream target of Tbx6 in the paraxial mesoderm. Genesis (2005) 1.01
The segmentation clock mechanism moves up a notch. Trends Cell Biol (2010) 1.01
The multiple facets of ubiquitination in the regulation of notch signaling pathway. Traffic (2010) 0.99
Redefining the role of ectoderm in somitogenesis: a player in the formation of the fibronectin matrix of presomitic mesoderm. Development (2007) 0.98
Number of active transcription factor binding sites is essential for the Hes7 oscillator. Theor Biol Med Model (2006) 0.96
Direct regulation of the Nrarp gene promoter by the Notch signaling pathway. Biochem Biophys Res Commun (2004) 0.96
Involvement of SIP1 in positioning of somite boundaries in the mouse embryo. Dev Dyn (2005) 0.95
Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activity. J Biol Chem (2011) 0.95
Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol (2009) 0.94
The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite. Development (2010) 0.94
Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2. Development (2008) 0.94
Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite. Dev Biol (2010) 0.94
Traveling wave formation in vertebrate segmentation. J Theor Biol (2009) 0.92
Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling. J Biol Chem (2011) 0.91
Ripply2 is essential for precise somite formation during mouse early development. FEBS Lett (2007) 0.89
T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm. J Biol Chem (2008) 0.88
The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis. Development (2010) 0.88
Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis (2004) 0.87
Random cell movement promotes synchronization of the segmentation clock. Proc Natl Acad Sci U S A (2010) 0.87
Assembly of a Notch transcriptional activation complex requires multimerization. Mol Cell Biol (2011) 0.87
Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest (2013) 2.23
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell (2010) 1.95
Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods (2005) 1.93
Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol (2005) 1.80
Identification of proliferative and mature β-cells in the islets of Langerhans. Nature (2016) 1.71
Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Cell (2013) 1.57
Targeted estrogen delivery reverses the metabolic syndrome. Nat Med (2012) 1.51
Genetic complexity of cellulose synthase a gene function in Arabidopsis embryogenesis. Plant Physiol (2002) 1.49
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol (2013) 1.48
Mouse phenotyping. Methods (2010) 1.43
ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet (2008) 1.37
Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43. J Biol Chem (2014) 1.37
Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality. Proc Natl Acad Sci U S A (2004) 1.35
Transcriptome and proteome analysis of early embryonic mouse brain development. Proteomics (2008) 1.29
Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysis. Mol Cell Neurosci (2008) 1.25
Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development (2003) 1.21
AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nat Neurosci (2009) 1.18
Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear. PLoS One (2011) 1.15
Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1. J Mol Biol (2003) 1.12
Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications. Mol Pharm (2010) 1.10
Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm Genome (2012) 1.09
MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma. Cancer Genet (2012) 1.08
Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells. J Mol Biol (2005) 1.08
Specificity assessment from fractionation experiments (SAFE): a novel method to evaluate microarray probe specificity based on hybridisation stringencies. Nucleic Acids Res (2003) 1.06
Systematic gene expression profiling of mouse model series reveals coexpressed genes. Proteomics (2008) 1.06
Cell-based simulation of dynamic expression patterns in the presomitic mesoderm. J Theor Biol (2007) 1.05
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. J Biol Chem (2011) 1.05
Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling. FASEB J (2010) 1.05
Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development (2010) 1.04
A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model. Arthritis Rheum (2011) 1.04
The transcription factor Otx2 regulates choroid plexus development and function. Development (2013) 1.04
Health effects of ambient particulate matter--biological mechanisms and inflammatory responses to in vitro and in vivo particle exposures. Inhal Toxicol (2008) 1.03
"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour? Front Biosci (2008) 1.01
Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis. Mol Metab (2013) 1.00
An approach to handling and interpretation of ambiguous data in transcriptome and proteome comparisons. Proteomics (2008) 0.99
Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS One (2012) 0.99
Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells. Cell Mol Life Sci (2013) 0.99
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One (2010) 0.97
Number of active transcription factor binding sites is essential for the Hes7 oscillator. Theor Biol Med Model (2006) 0.96
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity. PLoS One (2013) 0.96
A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Eur J Immunol (2012) 0.95
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner. J Biol Chem (2013) 0.95
Cytokine response of primary human myotubes in an in vitro exercise model. Am J Physiol Cell Physiol (2013) 0.94
Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res (2014) 0.94
Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2-/- mice. Physiol Genomics (2006) 0.94
Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PLoS One (2012) 0.92
Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells. J Biol Chem (2009) 0.92
Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation. Development (2013) 0.91
Novel allele of crybb2 in the mouse and its expression in the brain. Invest Ophthalmol Vis Sci (2008) 0.91
GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration. Glia (2011) 0.90
Identification of C/EBPβ target genes in ALK+ anaplastic large cell lymphoma (ALCL) by gene expression profiling and chromatin immunoprecipitation. PLoS One (2013) 0.89
A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice. PLoS One (2013) 0.89
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. Mamm Genome (2009) 0.89
Clinical chemistry of human FcRn transgenic mice. Mamm Genome (2011) 0.88
Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus. Proteomics (2008) 0.87
Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. J Immunol (2014) 0.87
Pleiotropic effects in Eya3 knockout mice. BMC Dev Biol (2008) 0.86
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. DNA Repair (Amst) (2013) 0.86
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics (2006) 0.85
Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms. Mol Cell Endocrinol (2008) 0.85
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PLoS One (2009) 0.85
Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms. Hum Mol Genet (2012) 0.85
Zebrafish and steroids: what do we know and what do we need to know? J Steroid Biochem Mol Biol (2013) 0.84
The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis. FASEB J (2012) 0.83
Assessment of a systematic expression profiling approach in ENU-induced mouse mutant lines. Mamm Genome (2005) 0.83
Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans. PLoS Genet (2012) 0.83
Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas. Acta Neuropathol (2013) 0.83
Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice. Part Fibre Toxicol (2009) 0.83
The CALM and CALM/AF10 interactor CATS is a marker for proliferation. Mol Oncol (2008) 0.82
Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus. PLoS One (2013) 0.82
Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients. Acta Neuropathol (2012) 0.81
Pitx3 directly regulates Foxe3 during early lens development. Int J Dev Biol (2013) 0.81
Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors. J Clin Endocrinol Metab (2013) 0.81
Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis. Gene Expr Patterns (2010) 0.80
Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice. PLoS One (2013) 0.80
Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma. Proc Natl Acad Sci U S A (2010) 0.80
MiR-34a deficiency accelerates medulloblastoma formation in vivo. Int J Cancer (2014) 0.79
Importance of sulfur-containing metabolites in discriminating fecal extracts between normal and type-2 diabetic mice. J Proteome Res (2014) 0.79
Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery. Diabetologia (2015) 0.79
The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival. EMBO Mol Med (2013) 0.79
In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis. PLoS One (2012) 0.79
Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints. BMC Dev Biol (2007) 0.78
Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. Blood (2010) 0.78
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. J Clin Invest (2017) 0.78
Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice. Diabetologia (2014) 0.78