PubRank

Stephen J Elledge

Author PubWeight™ 455.98‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007 20.11
2 Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003 18.29
3 The DNA damage response: making it safe to play with knives. Mol Cell 2010 16.13
4 Dicer is essential for mouse development. Nat Genet 2003 15.87
5 Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008 12.44
6 The DNA damage response: ten years after. Mol Cell 2007 11.80
7 Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009 10.96
8 Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 2002 10.96
9 A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 2008 10.07
10 A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 2009 8.64
11 Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet 2005 8.23
12 The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 2009 7.88
13 Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nat Methods 2007 7.56
14 MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 2003 6.81
15 Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 2007 6.77
16 Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell 2007 6.68
17 A resource for large-scale RNA-interference-based screens in mammals. Nature 2004 6.36
18 A genetic screen for candidate tumor suppressors identifies REST. Cell 2005 5.61
19 Cancer proliferation gene discovery through functional genomics. Science 2008 5.41
20 Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 2009 5.41
21 A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A 2005 5.29
22 53BP1, a mediator of the DNA damage checkpoint. Science 2002 5.00
23 RNA interference screen for human genes associated with West Nile virus infection. Nature 2008 4.93
24 The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science 2009 4.85
25 BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 2003 4.79
26 Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A 2007 4.75
27 Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev 2004 4.68
28 Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev 2002 4.58
29 Profiling essential genes in human mammary cells by multiplex RNAi screening. Science 2008 4.51
30 A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev 2009 4.23
31 Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 2007 4.14
32 Global protein stability profiling in mammalian cells. Science 2008 3.91
33 Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A 2003 3.88
34 Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol 2002 3.66
35 The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol 2007 3.63
36 Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev 2003 3.59
37 A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell 2010 3.51
38 A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science 2011 3.49
39 Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science 2012 3.41
40 The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A 2011 3.40
41 A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A 2009 3.37
42 SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 2003 3.35
43 A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A 2010 3.31
44 Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell 2011 3.27
45 Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog 2011 3.26
46 Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell 2013 3.26
47 NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev 2009 3.23
48 FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol 2008 3.22
49 Non-oncogene addiction and the stress phenotype of cancer cells. Cell 2007 3.19
50 Global identification of modular cullin-RING ligase substrates. Cell 2011 3.13
51 Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A 2004 3.12
52 A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 2006 3.10
53 Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol 2002 3.08
54 IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog 2011 2.99
55 Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell 2004 2.94
56 WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 2008 2.86
57 The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell 2002 2.85
58 SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 2008 2.84
59 Multiple tumor suppressor pathways negatively regulate telomerase. Cell 2003 2.82
60 Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell 2011 2.82
61 Lessons from Nature: microRNA-based shRNA libraries. Nat Methods 2006 2.80
62 Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A 2004 2.66
63 MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules. Nat Genet 2005 2.63
64 Design of 240,000 orthogonal 25mer DNA barcode probes. Proc Natl Acad Sci U S A 2009 2.61
65 The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev 2002 2.60
66 Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science 2008 2.53
67 A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol 2012 2.51
68 The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev 2009 2.44
69 Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step. Nat Genet 2001 2.21
70 An open letter to Elias Zerhouni. Science 2005 2.19
71 FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell 2008 2.14
72 Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem 2003 2.03
73 A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol 2007 2.00
74 A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev 2010 1.98
75 Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med 2012 1.97
76 CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell 2008 1.94
77 Autoantigen discovery with a synthetic human peptidome. Nat Biotechnol 2011 1.90
78 BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A 2005 1.90
79 Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication. Mol Cell 2009 1.85
80 Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep 2012 1.84
81 Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc Natl Acad Sci U S A 2006 1.81
82 RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A 2007 1.79
83 A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science 2011 1.79
84 Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell 2012 1.79
85 Systematic identification of synergistic drug pairs targeting HIV. Nat Biotechnol 2012 1.77
86 Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A 2010 1.76
87 Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem 2004 1.74
88 The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev 2010 1.74
89 Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev 2010 1.71
90 Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 2002 1.66
91 Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell 2006 1.65
92 An open letter to cancer researchers. Science 2005 1.65
93 Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev 2003 1.64
94 SLIC: a method for sequence- and ligation-independent cloning. Methods Mol Biol 2012 1.64
95 Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci U S A 2004 1.62
96 The tumor suppressor CYLD regulates entry into mitosis. Proc Natl Acad Sci U S A 2007 1.61
97 Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Science 2011 1.58
98 The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. J Virol 2013 1.54
99 Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. Genes Dev 2006 1.51
100 A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell 2010 1.50
101 Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Mol Cell 2008 1.42
102 Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association. Mol Cell Biol 2005 1.41
103 The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae. Cell Cycle 2003 1.39
104 ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J 2006 1.38
105 The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. Nature 2005 1.37
106 Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Ann Neurol 2013 1.37
107 How ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev 2008 1.30
108 Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol 2010 1.30
109 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle 2005 1.29
110 Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell 2003 1.28
111 Synthetic design of strong promoters. Proc Natl Acad Sci U S A 2010 1.27
112 Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Nat Struct Mol Biol 2013 1.26
113 Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr Biol 2002 1.19
114 Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Proc Natl Acad Sci U S A 2011 1.19
115 Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage. Proc Natl Acad Sci U S A 2011 1.18
116 Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Res 2013 1.16
117 Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proc Natl Acad Sci U S A 2007 1.16
118 Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10. PLoS Pathog 2013 1.16
119 The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell 2002 1.13
120 Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. Proc Natl Acad Sci U S A 2012 1.09
121 umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. 1985. DNA Repair (Amst) 2005 1.07
122 A role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proc Natl Acad Sci U S A 2008 1.05
123 Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proc Natl Acad Sci U S A 2009 0.99
124 A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife 2013 0.97
125 Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol 2004 0.97
126 Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 2002 0.97
127 Construction of a rationally designed antibody platform for sequencing-assisted selection. Proc Natl Acad Sci U S A 2012 0.95
128 PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. J Autoimmun 2013 0.94
129 Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants. Cell Cycle 2008 0.91
130 The two faces of BRCA2, a FANCtastic discovery. Mol Cell 2002 0.87
131 GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A 2014 0.83
132 BRCA1 as tumor suppressor: lord without its RING? Breast Cancer Res 2012 0.82
133 STOP gene Phactr4 is a tumor suppressor. Proc Natl Acad Sci U S A 2013 0.82
134 Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells 2013 0.77
135 Cancer: Deconstructing oncogenesis. Nature 2008 0.77
136 Cell biology forum: Genome-wide view of mitosis. Nature 2010 0.75
137 Cancer. BRCA2 enters the fray. Science 2002 0.75
138 Accidents and Damage Control. Cell 2015 0.75
139 Turkey must end violent response to protests. Science 2013 0.75