Published in Nat Med on March 04, 2012
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A (2012) 3.06
Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol (2013) 1.70
Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res (2012) 1.43
ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs. Genome Res (2014) 1.37
Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell (2015) 1.27
ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their sensitivity to EGFR inhibition. Cancer Res (2013) 1.17
Protein tyrosine phosphatases as potential therapeutic targets. Acta Pharmacol Sin (2014) 1.10
Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem (2014) 1.04
Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway. BMC Cancer (2012) 0.96
The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration. Mol Cancer Res (2013) 0.95
Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma. Oncotarget (2015) 0.95
Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion. Breast Cancer Res (2012) 0.93
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers. Mol Cell Biol (2012) 0.93
PKCλ/ι signaling promotes triple-negative breast cancer growth and metastasis. Cell Death Differ (2014) 0.90
Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. Proc Natl Acad Sci U S A (2013) 0.90
Targeting protein-tyrosine phosphatases in breast cancer. Oncotarget (2012) 0.89
Complexity of receptor tyrosine kinase signal processing. Cold Spring Harb Perspect Biol (2013) 0.89
Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks. Cancer Biol Med (2013) 0.89
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep (2015) 0.88
Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis. Sci Rep (2015) 0.88
Functions of Shp2 in cancer. J Cell Mol Med (2015) 0.88
Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. PLoS One (2014) 0.87
Increased expression of tyrosine phosphatase SHP-2 in Helicobacter pylori-infected gastric cancer. World J Gastroenterol (2013) 0.86
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis. Nat Commun (2015) 0.85
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat Med (2016) 0.85
Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway. Breast Cancer Res (2014) 0.84
Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene (2015) 0.84
Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis. BMC Cancer (2014) 0.84
Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression. Oncotarget (2016) 0.84
Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice. EMBO J (2015) 0.84
The role of non-coding RNAs in the regulation of stem cells and progenitors in the normal mammary gland and in breast tumors. Front Genet (2015) 0.83
Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. BMB Rep (2013) 0.83
Predicting resistance by selection of signaling pathways. Transl Lung Cancer Res (2014) 0.82
Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J Cell Sci (2014) 0.82
Expression and clinical significance of tyrosine phosphatase SHP2 in thyroid carcinoma. Oncol Lett (2015) 0.81
Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancer. Histopathology (2013) 0.81
The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis. Oncogene (2015) 0.80
Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma. Haematologica (2014) 0.80
Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis. Sci Rep (2013) 0.80
Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2. Sci Rep (2015) 0.78
Migratory gene expression signature predicts poor patient outcome: are cancer stem cells to blame? Breast Cancer Res (2012) 0.78
Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice. Oncotarget (2014) 0.78
Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery. Methods (2013) 0.78
SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer. Breast Cancer Res (2016) 0.78
A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma. Oncotarget (2016) 0.77
LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling. Breast Cancer Res (2013) 0.77
Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop. Nucleic Acids Res (2015) 0.77
Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling. Oncotarget (2015) 0.77
Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion. Nucleic Acids Res (2014) 0.76
AKT-ions with a TWIST between EMT and MET. Oncotarget (2016) 0.76
SHP2: a new target for pro-senescence cancer therapies. EMBO J (2015) 0.76
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2. Oncogene (2016) 0.76
New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract. Cell Mol Gastroenterol Hepatol (2015) 0.76
Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment. BMC Cancer (2015) 0.76
Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway. BMC Cancer (2015) 0.75
EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. Cancer Res (2016) 0.75
New insights into signalling networks regulating breast cancer stem cells. Breast Cancer Res (2012) 0.75
Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3. Int J Mol Sci (2017) 0.75
Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells. Int J Mol Sci (2017) 0.75
The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42. Nat Commun (2016) 0.75
Protein tyrosine phosphatase 4A3 (PTP4A3) is required for Xenopus laevis cranial neural crest migration in vivo. PLoS One (2013) 0.75
T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget (2016) 0.75
The seventh ENBDC workshop on methods in mammary gland development and cancer. Breast Cancer Res (2015) 0.75
Tuneable endogenous mammalian target complementation via multiplexed plasmid-based recombineering. Sci Rep (2015) 0.75
Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Controls Surface GluA1 in Synaptic Homeostasis. J Biol Chem (2017) 0.75
SHP2 regulates proliferation and tumorigenicity of glioma stem cells. J Neurooncol (2017) 0.75
Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer. Proc Jpn Acad Ser B Phys Biol Sci (2017) 0.75
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet (2005) 29.45
Cancer genes and the pathways they control. Nat Med (2004) 24.22
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res (2005) 11.52
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell (2009) 10.09
Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res (2005) 8.73
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol (2009) 8.63
Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res (2009) 7.98
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res (2008) 7.65
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell (2002) 7.35
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet (2001) 6.96
The let-7 family of microRNAs. Trends Cell Biol (2008) 6.24
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science (2001) 5.49
The increasing complexity of the cancer stem cell paradigm. Science (2009) 5.45
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet (2003) 5.16
The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation (2002) 4.64
Stem cells in normal breast development and breast cancer. Cell Prolif (2003) 4.47
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat Rev Cancer (2007) 4.06
Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell (2008) 3.87
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A (2009) 3.76
Protein-tyrosine phosphatases and cancer. Nat Rev Cancer (2006) 3.65
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell (2008) 3.43
Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One (2010) 3.38
Tyrosine phosphorylation: thirty years and counting. Curr Opin Cell Biol (2009) 3.31
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell (2011) 3.27
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res (2004) 3.20
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway. FEBS Lett (2001) 2.83
The tyrosine phosphatase Shp2 (PTPN11) in cancer. Cancer Metastasis Rev (2008) 2.74
An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res (2009) 2.37
Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis. Cancer Res (2006) 2.36
A role for the scaffolding adapter GAB2 in breast cancer. Nat Med (2005) 2.12
Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity. Mol Cell Biol (2000) 1.94
The tyrosine phosphatase Shp2 in development and cancer. Adv Cancer Res (2010) 1.58
Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients. Int J Cancer (2008) 1.51
Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer. Mol Oncol (2010) 1.45
Kinome signaling through regulated protein-protein interactions in normal and cancer cells. Curr Opin Cell Biol (2009) 1.31
SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis. Histopathology (2008) 1.19
Focal amplification and oncogene dependency of GAB2 in breast cancer. Oncogene (2009) 1.11
The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration. Cancer Res (2007) 1.08
Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. Cell Res (2007) 1.06
The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells. Exp Cell Res (2009) 1.02
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
Dicer is essential for mouse development. Nat Genet (2003) 15.87
Identification of host proteins required for HIV infection through a functional genomic screen. Science (2008) 12.44
The DNA damage response: ten years after. Mol Cell (2007) 11.80
Principles of cancer therapy: oncogene and non-oncogene addiction. Cell (2009) 10.96
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07
A novel class of small RNAs bind to MILI protein in mouse testes. Nature (2006) 8.80
DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell (2009) 8.64
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell (2008) 7.68
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nat Methods (2007) 7.56
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial. Lancet Oncol (2013) 6.79
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A promoter-level mammalian expression atlas. Nature (2014) 6.25
An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24
Inference of miRNA targets using evolutionary conservation and pathway analysis. BMC Bioinformatics (2007) 6.21
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell (2010) 5.57
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
53BP1, a mediator of the DNA damage checkpoint. Science (2002) 5.00
RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature (2003) 4.79
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A (2007) 4.75
Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev (2004) 4.68
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev (2002) 4.58
Inactivation of the p53 pathway in retinoblastoma. Nature (2006) 4.57
Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs. RNA (2008) 4.53
Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell (2004) 4.29
Encoding of conditioned fear in central amygdala inhibitory circuits. Nature (2010) 4.29
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev (2009) 4.23
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res (2003) 4.07
MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat Struct Mol Biol (2008) 3.98
Global protein stability profiling in mammalian cells. Science (2008) 3.91
Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A (2003) 3.88
Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol (2002) 3.66
The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol (2007) 3.63
Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study. Ann Surg (2010) 3.61
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev (2003) 3.59
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell (2010) 3.57
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell (2010) 3.51
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (2011) 3.49
Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science (2012) 3.41
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A (2011) 3.40
A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A (2009) 3.37
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35
PhyloGibbs: a Gibbs sampling motif finder that incorporates phylogeny. PLoS Comput Biol (2005) 3.35
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A (2010) 3.31
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell (2011) 3.27
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog (2011) 3.26
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell (2013) 3.26
A probabilistic method to detect regulatory modules. Bioinformatics (2003) 3.24
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev (2009) 3.23
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol (2008) 3.22
Non-oncogene addiction and the stress phenotype of cancer cells. Cell (2007) 3.19
Global identification of modular cullin-RING ligase substrates. Cell (2011) 3.13
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A (2004) 3.12
Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A (2009) 3.10
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat Struct Mol Biol (2010) 3.07
Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell (2006) 3.06
IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog (2011) 2.99
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96
The developmental miRNA profiles of zebrafish as determined by small RNA cloning. Genes Dev (2005) 2.94
Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell (2004) 2.94
The nanomechanical signature of breast cancer. Nat Nanotechnol (2012) 2.89
Methods for analyzing deep sequencing expression data: constructing the human and mouse promoterome with deepCAGE data. Genome Biol (2009) 2.86
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell (2005) 2.85
The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell (2002) 2.85
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature (2008) 2.84
Multiple tumor suppressor pathways negatively regulate telomerase. Cell (2003) 2.82
Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell (2011) 2.82