Published in Nat Immunol on December 31, 2006
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73
CD4 T cells: fates, functions, and faults. Blood (2008) 7.03
Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol (2009) 5.72
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med (2008) 4.68
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol (2008) 3.88
In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest (2008) 3.35
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med (2009) 3.01
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68
Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 2.61
Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res (2011) 2.51
RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol (2009) 2.49
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med (2007) 2.39
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity (2010) 2.38
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol (2012) 2.26
ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol (2008) 2.19
IFN-γ and IL-21 Double Producing T Cells Are Bcl6-Independent and Survive into the Memory Phase in Plasmodium chabaudi Infection. PLoS One (2015) 2.09
Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu Rev Immunol (2012) 2.06
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02
Sex differences in autoimmune disease from a pathological perspective. Am J Pathol (2008) 1.94
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A (2009) 1.86
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity. Nat Immunol (2013) 1.86
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol (2013) 1.70
Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity (2014) 1.62
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev (2010) 1.61
STAT6-dependent regulation of Th9 development. J Immunol (2011) 1.60
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med (2011) 1.60
A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells. Nat Immunol (2014) 1.58
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med (2009) 1.57
CD4⁺T cells: differentiation and functions. Clin Dev Immunol (2012) 1.56
The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity (2008) 1.55
How are T(H)1 and T(H)2 effector cells made? Curr Opin Immunol (2009) 1.54
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes. Nat Immunol (2012) 1.53
An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation. Int Immunol (2011) 1.48
Metabolic shifts in immunity and inflammation. J Immunol (2010) 1.45
Runx proteins regulate Foxp3 expression. J Exp Med (2009) 1.45
T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements. Nat Commun (2012) 1.39
STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol (2010) 1.33
T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain. Mol Cell Biol (2007) 1.28
The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. Immunity (2014) 1.24
Interplay of transcription factors in T-cell differentiation and function: the role of Runx. Immunology (2010) 1.23
The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus. J Exp Med (2009) 1.22
Transcriptional regulation of innate lymphoid cell fate. Nat Rev Immunol (2015) 1.21
CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. J Immunol (2009) 1.21
Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. J Allergy Clin Immunol (2013) 1.19
Diversity and plasticity of Th cell types predicted from regulatory network modelling. PLoS Comput Biol (2010) 1.17
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. Immunity (2010) 1.17
Regulation of the Ifng locus in the context of T-lineage specification and plasticity. Immunol Rev (2010) 1.12
Cutting edge: Ikaros is a regulator of Th2 cell differentiation. J Immunol (2009) 1.12
Vitamin A and retinoic acid in T cell-related immunity. Am J Clin Nutr (2012) 1.11
Runx transcription factors in neuronal development. Neural Dev (2008) 1.11
Pathogenesis of allergic airway inflammation. Curr Allergy Asthma Rep (2010) 1.11
Differential localization of T-bet and Eomes in CD8 T cell memory populations. J Immunol (2013) 1.09
New insights into IL-12-mediated tumor suppression. Cell Death Differ (2014) 1.09
Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol (2013) 1.08
DNA methylation and childhood asthma in the inner city. J Allergy Clin Immunol (2015) 1.07
CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol (2014) 1.05
Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation. J Biol Chem (2009) 1.05
Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunol Rev (2013) 1.05
Stochastic cytokine expression induces mixed T helper cell States. PLoS Biol (2013) 1.04
Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS One (2010) 1.04
Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol (2012) 1.03
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. J Immunol (2012) 1.02
Long-range regulation of cytokine gene expression. Curr Opin Immunol (2008) 1.01
Distal regions of the human IFNG locus direct cell type-specific expression. J Immunol (2010) 0.99
Genetic and epigenetic networks controlling T helper 1 cell differentiation. Immunology (2009) 0.98
Signal transduction and Th17 cell differentiation. Microbes Infect (2009) 0.98
CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int Immunol (2016) 0.97
Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev (2014) 0.97
GATA3: a master of many trades in immune regulation. Trends Immunol (2014) 0.96
CD4-CD8 differentiation in the thymus: connecting circuits and building memories. Curr Opin Immunol (2012) 0.96
Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation. Genome Res (2012) 0.95
Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis. BMC Dev Biol (2007) 0.95
The immunogenetics of Psoriasis: A comprehensive review. J Autoimmun (2015) 0.95
'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation. Immunology (2013) 0.94
T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. J Immunol (2008) 0.94
Down-regulation of Runx1 expression by TCR signal involves an autoregulatory mechanism and contributes to IL-2 production. J Biol Chem (2011) 0.93
Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev (2014) 0.93
CD4 CTL: living up to the challenge. Semin Immunol (2013) 0.93
Transcription factor interplay in T helper cell differentiation. Brief Funct Genomics (2013) 0.92
T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine (2015) 0.92
Shaping a helper T cell identity. Nat Immunol (2007) 0.92
Lck mediates Th2 differentiation through effects on T-bet and GATA-3. J Immunol (2010) 0.92
The complex and central role of interferon-γ in graft-versus-host disease and graft-versus-tumor activity. Immunol Rev (2014) 0.91
Runx3 specifies lineage commitment of innate lymphoid cells. Nat Immunol (2015) 0.91
Control of IL-4 expression in T helper 1 and 2 cells. Immunology (2008) 0.90
T cell immunity as a tool for studying epigenetic regulation of cellular differentiation. Front Genet (2013) 0.89
The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation. Immunity (2012) 0.88
Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor. J Biol Chem (2012) 0.88
Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development. J Biol Chem (2013) 0.88
T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol (2011) 0.88
Runx3-mediated transcriptional program in cytotoxic lymphocytes. PLoS One (2013) 0.87
MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and development. Crit Rev Immunol (2013) 0.87
Transcriptional regulatory networks for CD4 T cell differentiation. Curr Top Microbiol Immunol (2014) 0.86
Transcriptional regulation of Th2 cell differentiation. Immunol Cell Biol (2010) 0.86
Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation. Mol Cell Biol (2014) 0.86
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
Regulation of the germinal center response by microRNA-155. Science (2007) 12.25
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell (2006) 9.24
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature (2010) 8.87
Orai1 is an essential pore subunit of the CRAC channel. Nature (2006) 8.60
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One (2010) 8.10
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58
Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 6.10
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol (2007) 5.14
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
MicroRNA profiling of the murine hematopoietic system. Genome Biol (2005) 4.94
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity (2010) 4.52
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38
Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE. Nucleic Acids Res (2003) 4.29
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol (2004) 4.22
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol (2004) 4.21
Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 4.14
Transcriptional mechanisms underlying lymphocyte tolerance. Cell (2002) 4.04
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98
An epigenetic view of helper T cell differentiation. Nat Immunol (2003) 3.87
Biochemical and functional characterization of Orai proteins. J Biol Chem (2007) 3.87
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature (2006) 3.61
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47
Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol (2006) 3.19
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18
Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (2008) 3.17
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A (2011) 3.07
The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol (2002) 3.05
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med (2009) 3.01
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J (2002) 2.99
Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity (2005) 2.97
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc Natl Acad Sci U S A (2003) 2.85
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature (2013) 2.76
STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N Engl J Med (2009) 2.72
MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells. Immunity (2011) 2.71
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog (2010) 2.62
A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem (2003) 2.59
Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol (2008) 2.50
Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity (2002) 2.47
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood (2011) 2.47
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol (2004) 2.38
Calcium signaling in lymphocytes. Curr Opin Immunol (2008) 2.38
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest (2004) 2.31
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature (2013) 2.31
Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium (2007) 2.23
A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. J Exp Med (2005) 2.20
Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med (2003) 2.16
STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol (2009) 2.15
Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity (2013) 2.13
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev (2012) 2.10
ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia. J Allergy Clin Immunol (2009) 2.09
Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J (2004) 1.90
Structure and regulated expression of mammalian RUNX genes. Oncogene (2004) 1.87
Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol (2010) 1.84
The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons. Nat Neurosci (2006) 1.83
Dissecting ICRAC, a store-operated calcium current. Trends Biochem Sci (2007) 1.82
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol (2004) 1.78
Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. J Immunol (2011) 1.77
MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol (2013) 1.75
Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling. Mol Cells (2004) 1.75
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity (2002) 1.74
Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol (2004) 1.72
NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription. Eur J Immunol (2002) 1.68
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature (2013) 1.65
Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell (2008) 1.63
Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction. J Mol Biol (2007) 1.60
Pore architecture of the ORAI1 store-operated calcium channel. Proc Natl Acad Sci U S A (2010) 1.52
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev (2006) 1.52
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2014) 1.50
The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol (2013) 1.50
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A (2011) 1.47
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol (2012) 1.46
Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor. Nat Struct Biol (2002) 1.45
Ca2+/calcineurin signalling in cells of the immune system. Biochem Biophys Res Commun (2003) 1.44
A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis. Proc Natl Acad Sci U S A (2008) 1.44
Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc Natl Acad Sci U S A (2005) 1.43
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42
Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med (2012) 1.42
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell (2013) 1.40
Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A (2012) 1.39
Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol (2005) 1.37