Published in J Cell Sci on December 01, 2001
Smad3 as a mediator of the fibrotic response. Int J Exp Pathol (2004) 3.13
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol (2003) 2.90
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J (2003) 2.67
Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol (2004) 2.57
Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal (2014) 2.42
Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A (2003) 2.37
Redox control of the cell cycle in health and disease. Antioxid Redox Signal (2009) 1.72
Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer. Nat Rev Drug Discov (2013) 1.50
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. Mol Cell Biol (2003) 1.50
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. J Vasc Res (2008) 1.42
Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints. Dev Biol (2007) 1.42
Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. Mol Cell Biol (2005) 1.41
Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. J Clin Invest (2009) 1.39
IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'. Aging (Albany NY) (2012) 1.32
Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation. J Biol Chem (2003) 1.31
Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene. PLoS Pathog (2006) 1.29
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem (2009) 1.29
Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. Am J Physiol Lung Cell Mol Physiol (2009) 1.27
Structural basis for CD44 recognition by ERM proteins. J Biol Chem (2008) 1.26
The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol (2009) 1.25
Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover. PLoS Biol (2007) 1.24
alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice. J Clin Invest (2008) 1.22
Regulation of VEGF mRNA expression and protein secretion by TGF-beta2 in human retinal pigment epithelial cells. Exp Eye Res (2007) 1.20
Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet (2011) 1.20
Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J Cell Sci (2007) 1.20
Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype. Dev Biol (2007) 1.17
Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. J Biol Chem (2010) 1.16
TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J (2003) 1.16
Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo. Mol Cell Biol (2008) 1.16
Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration. Proc Natl Acad Sci U S A (2012) 1.15
Ubiquitin-dependent regulation of TGFbeta signaling in cancer. Neoplasia (2006) 1.14
Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization. Proc Natl Acad Sci U S A (2009) 1.14
Non-degradative ubiquitination in Smad-dependent TGF-β signaling. Cell Biosci (2011) 1.14
Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells. Am J Pathol (2004) 1.13
Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol (2003) 1.13
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med (2012) 1.12
CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Mol Cell Biol (2004) 1.11
Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. Reprod Sci (2009) 1.09
SnoN functions as a tumour suppressor by inducing premature senescence. EMBO J (2009) 1.09
Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol (2007) 1.09
Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development (2009) 1.08
Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival. Invest Ophthalmol Vis Sci (2008) 1.08
Recognition of phosphorylated-Smad2-containing complexes by a novel Smad interaction motif. Mol Cell Biol (2004) 1.06
Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2. Mol Biol Cell (2010) 1.06
Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling. Am J Respir Crit Care Med (2015) 1.04
Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression. J Am Soc Nephrol (2010) 1.04
The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3. Mol Biol Cell (2005) 1.04
Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells. J Cell Physiol (2011) 1.04
A restricted spectrum of mutations in the SMAD4 tumor-suppressor gene underlies Myhre syndrome. Am J Hum Genet (2012) 1.04
Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol (2012) 1.04
CD44 modulates Smad1 activation in the BMP-7 signaling pathway. J Cell Biol (2004) 1.03
Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol (2006) 1.02
A human bone morphogenetic protein antagonist is down-regulated in renal cancer. Mol Biol Cell (2007) 1.01
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS. Nucleic Acids Res (2006) 1.01
Smad3 -signalling and Th2 cytokines in normal mouse airways and in a mouse model of asthma. Int J Biol Sci (2007) 1.00
Therapeutic targeting of the PDGF and TGF-beta-signaling pathways in hepatic stellate cells by PTK787/ZK22258. Lab Invest (2009) 1.00
Hypoxia-activated Smad3-specific dephosphorylation by PP2A. J Biol Chem (2009) 1.00
Modifiers of TGF-β1 effector function as novel therapeutic targets of pulmonary fibrosis. Korean J Intern Med (2014) 0.97
Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair. EMBO J (2002) 0.97
Molecular imaging of TGFβ-induced Smad2/3 phosphorylation reveals a role for receptor tyrosine kinases in modulating TGFβ signaling. Clin Cancer Res (2011) 0.96
Quantitative proteome analysis of pluripotent cells by iTRAQ mass tagging reveals post-transcriptional regulation of proteins required for ES cell self-renewal. Mol Cell Proteomics (2010) 0.96
HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation. PLoS One (2012) 0.95
Altered transforming growth factor-beta signaling in a murine model of thoracic aortic aneurysm. J Vasc Res (2008) 0.95
Changes in expression of genes related to cell proliferation in human mesenchymal stem cells during in vitro culture in comparison with cancer cells. J Artif Organs (2006) 0.95
BMP4 is a novel paracrine inhibitor of liver regeneration. Am J Physiol Gastrointest Liver Physiol (2012) 0.95
NFI-Ski interactions mediate transforming growth factor beta modulation of human papillomavirus type 16 early gene expression. J Virol (2004) 0.94
PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses. J Cell Mol Med (2011) 0.94
TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis. J Histochem Cytochem (2016) 0.93
Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling. Am J Physiol Lung Cell Mol Physiol (2011) 0.93
Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol (2004) 0.93
Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor kappaB pathway. Biochem J (2006) 0.93
Proteomic Profiling of Mesenchymal Stem Cell Responses to Mechanical Strain and TGF-beta1. Cell Mol Bioeng (2009) 0.93
Characterization of the basic fibroblast growth factor-evoked proliferation of the human Müller cell line, MIO-M1. Graefes Arch Clin Exp Ophthalmol (2004) 0.92
Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4. Mol Biol Cell (2003) 0.92
Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling. Tissue Eng Part A (2010) 0.92
Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability. Nucleic Acids Res (2005) 0.92
Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-β in endothelial cells. Am J Physiol Cell Physiol (2011) 0.92
Gene expression analysis of the pleiotropic effects of TGF-β1 in an in vitro model of flexor tendon healing. PLoS One (2012) 0.91
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling. J Biol Chem (2012) 0.91
Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner. Mol Cell Biol (2010) 0.91
Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein. Nucleic Acids Res (2005) 0.90
Ubiquitin-dependent degradation of Smad2 is increased in the glomeruli of rats with anti-thymocyte serum nephritis. Am J Pathol (2003) 0.90
Inhibition of the transforming growth factor beta (TGFbeta) pathway by interleukin-1beta is mediated through TGFbeta-activated kinase 1 phosphorylation of SMAD3. Mol Biol Cell (2005) 0.90
Smad ubiquitination regulatory factor 2 expression is enhanced in hypertrophic scar fibroblasts from burned children. Burns (2011) 0.90
Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes. Arthritis Res Ther (2007) 0.89
Alterations in the Smad pathway in human cancers. Front Biosci (Landmark Ed) (2012) 0.89
Sca-1 is negatively regulated by TGF-beta1 in myogenic cells. FASEB J (2010) 0.88
The Effect of Camellia sinensis on Wound Healing Potential in an Animal Model. Evid Based Complement Alternat Med (2013) 0.88
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. PLoS Genet (2015) 0.88
Smad signalling in the ovary. Reprod Biol Endocrinol (2006) 0.88
Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling. J Immunol (2012) 0.88
TGF-β1 induces EMT reprogramming of porcine bladder urothelial cells into collagen producing fibroblasts-like cells in a Smad2/Smad3-dependent manner. J Cell Commun Signal (2013) 0.88
Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells. PLoS One (2010) 0.87
Effects of TRAP-1-like protein (TLP) gene on collagen synthesis induced by TGF-β/Smad signaling in human dermal fibroblasts. PLoS One (2013) 0.87
Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer. PLoS One (2012) 0.86
Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis. PLoS One (2011) 0.86
TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development. J Invest Dermatol (2012) 0.86
IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis. J Am Soc Nephrol (2008) 0.86
Antrodin C inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via suppression of Smad2/3 and β-catenin signaling pathways. PLoS One (2015) 0.86
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature (1983) 8.60
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature (1997) 7.69
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem (1994) 6.18
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature (1986) 4.81
Growth factors: mechanism of action and relation to oncogenes. Cell (1984) 4.80
Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor. Nature (1982) 4.74
Improvement of an "In-Gel" digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing. Anal Biochem (1995) 4.49
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J (1997) 4.48
Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization. J Biol Chem (1988) 3.98
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol (2000) 3.81
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (1989) 3.80
Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature (1994) 3.67
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell (1993) 3.57
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem (1994) 3.49
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci (1999) 3.43
Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J (1999) 3.28
Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer. J Biol Chem (1998) 3.23
Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res (1992) 3.15
Platelet-derived growth factor: purification and partial characterization. Proc Natl Acad Sci U S A (1979) 3.04
Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia. Proc Natl Acad Sci U S A (1981) 3.02
The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation. FEBS Lett (1998) 3.00
Characterization of type I receptors for transforming growth factor-beta and activin. Science (1994) 2.94
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol Cell Biol (1988) 2.88
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res (2001) 2.79
The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J (1984) 2.77
A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO J (1991) 2.73
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat Cell Biol (2001) 2.70
Co-localization of NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells in the developing rat brain. J Neurosci Res (1996) 2.67
A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains. Nature (1986) 2.58
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma. EMBO J (1992) 2.47
TGF-beta signaling by Smad proteins. Adv Immunol (2000) 2.47
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. EMBO J (1993) 2.46
TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Cell (1990) 2.46
PDZ domains bind carboxy-terminal sequences of target proteins. Trends Biochem Sci (1996) 2.42
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J Biol Chem (1997) 2.39
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J Cell Biol (1995) 2.36
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proc Natl Acad Sci U S A (1989) 2.33
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines. Cancer Res (1988) 2.28
Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase. Oncogene (1994) 2.27
Signaling inputs converge on nuclear effectors in TGF-beta signaling. Trends Biochem Sci (2000) 2.24
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene (1993) 2.19
Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cells. Exp Cell Res (1977) 2.19
Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci U S A (1995) 2.19
Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. Brain (1998) 2.16
Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein. J Cell Biol (1994) 2.15
Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth. Cell (1985) 2.06
Purification and properties of an endothelial cell growth factor from human platelets. J Biol Chem (1987) 2.06
Interaction of platelet-derived growth factor with its fibroblast receptor. Demonstration of ligand degradation and receptor modulation. J Biol Chem (1982) 2.03
Role for carbohydrate structures in TGF-beta 1 latency. Nature (1989) 2.02
Platelet-derived growth factor: identification of constituent polypeptide chains. Biochem Biophys Res Commun (1982) 2.00
Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation. Cell (1984) 1.99
A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets. Cell (1988) 1.99
Platelet-derived growth factor. Isolation by a large-scale procedure and analysis of subunit composition. Biochem J (1981) 1.97
Possible positive autocrine feedback in the prereplicative phase of human fibroblasts. Nature (1987) 1.96
Inhibitory DNA ligands to platelet-derived growth factor B-chain. Biochemistry (1996) 1.91
Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. Proc Natl Acad Sci U S A (1986) 1.90
A glioma-derived analog to platelet-derived growth factor: demonstration of receptor competing activity and immunological crossreactivity. Proc Natl Acad Sci U S A (1984) 1.87
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members. Biochem Biophys Res Commun (1998) 1.85
PDGF alpha- and beta-receptors activate unique and common signal transduction pathways. EMBO J (1992) 1.85
Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor. J Biol Chem (1982) 1.84
Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus. Nature (1985) 1.83
Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: resemblance with platelet-derived growth factor. J Cell Physiol (1980) 1.82
Use of an antiserum against phosphotyrosine for the identification of phosphorylated components in human fibroblasts stimulated by platelet-derived growth factor. J Biol Chem (1984) 1.81
Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer. EMBO J (1989) 1.76
Platelet-derived growth factor. Mol Cell Endocrinol (1985) 1.75
Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein. Proc Natl Acad Sci U S A (1985) 1.74
A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain. J Biol Chem (1988) 1.73
Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor. Exp Cell Res (1988) 1.72
Transforming growth factor-beta: latent forms, binding proteins and receptors. Growth Factors (1993) 1.71
Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Proc Natl Acad Sci U S A (1988) 1.71
Identification and structural analysis of the A type receptor for platelet-derived growth factor. Similarities with the B type receptor. J Biol Chem (1989) 1.71
Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells. J Cell Biol (1993) 1.71
Platelet-derived growth factor in human glioma. Glia (1995) 1.71
Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway. J Biol Chem (1997) 1.66
Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc Natl Acad Sci U S A (1993) 1.63
Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res (1994) 1.63
Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J (1991) 1.63
Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein. Proc Natl Acad Sci U S A (1986) 1.62
Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta. J Biol Chem (1994) 1.61
Transforming growth factor beta1 induces nuclear export of inhibitory Smad7. J Biol Chem (1998) 1.61
B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase. Proc Natl Acad Sci U S A (1990) 1.60
Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site. Oncogene (2006) 1.59
Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes. J Clin Invest (1990) 1.59
Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner. Mol Biol Cell (2001) 1.58
Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor. J Biol Chem (1992) 1.55
Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor. Proc Natl Acad Sci U S A (1986) 1.54
Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Cancer Res (2001) 1.53
Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF. Proc Natl Acad Sci U S A (1991) 1.50
Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Curr Opin Cell Biol (1996) 1.50
Demonstration of an antibody against platelet-derived growth factor. Exp Cell Res (1981) 1.49
Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts. Biochem J (1989) 1.49
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science (1988) 1.47
Induction of B-type receptors for platelet-derived growth factor in vascular inflammation: possible implications for development of vascular proliferative lesions. Lancet (1988) 1.46
Expression of three recombinant homodimeric isoforms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities. Growth Factors (1989) 1.45
Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas. Cancer Res (1996) 1.44
Cultured human endothelial cells express platelet-derived growth factor A chain. Am J Pathol (1987) 1.42