Published in J Biol Chem on January 28, 2010
Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell (2013) 2.43
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease. J Hepatol (2014) 1.72
A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. Cell Rep (2014) 1.48
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol (2014) 1.21
Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma. Br J Cancer (2012) 1.11
C13orf31 (FAMIN) is a central regulator of immunometabolic function. Nat Immunol (2016) 0.90
The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity. J Biol Chem (2013) 0.88
Computational repositioning and preclinical validation of pentamidine for renal cell cancer. Mol Cancer Ther (2014) 0.87
Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming. Oncotarget (2013) 0.86
Underestimation of the Maximal Capacity of the Mitochondrial Electron Transport System in Oligomycin-Treated Cells. PLoS One (2016) 0.81
Peroxisome proliferator-activated-γ coactivator-1α-mediated mitochondrial biogenesis is important for hematopoietic recovery in response to stress. Stem Cells Dev (2013) 0.80
Mechanistic study on the nuclear modifier gene MSS1 mutation suppressing neomycin sensitivity of the mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiae. PLoS One (2014) 0.78
Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinase. J Neural Transm (Vienna) (2010) 0.77
Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics. Int J Cell Biol (2015) 0.76
Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells. PLoS One (2016) 0.76
Monitoring the dielectric response of single cells following mitochondrial adenosine triphosphate synthase inhibition by oligomycin using a dielectrophoretic cytometer. Biomicrofluidics (2014) 0.75
Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells. PLoS One (2017) 0.75
Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med (2013) 0.75
Evaluation of mitochondrial respiratory function in highly glycolytic glioma cells reveals low ADP phosphorylation in relation to oxidative capacity. J Neurooncol (2017) 0.75
Proteomic analysis of a mosquito host cell response to persistent Wolbachia infection. Res Microbiol (2017) 0.75
On the origin of cancer cells. Science (1956) 49.55
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet (2005) 16.79
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91
Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18
p53 regulates mitochondrial respiration. Science (2006) 9.06
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science (2008) 5.54
Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett (2003) 5.22
mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci U S A (2005) 4.66
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol (2000) 3.28
AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol (2006) 3.11
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol (2003) 2.96
Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol (2008) 2.85
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes (1999) 2.73
Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. Am J Physiol (1999) 2.44
The bioenergetic signature of cancer: a marker of tumor progression. Cancer Res (2002) 2.24
Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection. Proc Natl Acad Sci U S A (2001) 2.03
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem (2002) 1.78
The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res (2008) 1.53
Loss of the mitochondrial bioenergetic capacity underlies the glucose avidity of carcinomas. Cancer Res (2007) 1.36
Oxidative phosphorylation enzymes in normal and neoplastic cell growth. J Bioenerg Biomembr (1997) 0.95
Metabolic control: a new solution to an old problem. Curr Biol (2000) 0.91
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
A model of (often mixed) stereotype content: competence and warmth respectively follow from perceived status and competition. J Pers Soc Psychol (2002) 7.36
Rat toxicogenomic study reveals analytical consistency across microarray platforms. Nat Biotechnol (2006) 5.14
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94
Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping. Nature (2010) 3.53
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell (2006) 3.39
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res (2004) 3.03
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest (2015) 2.93
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat Med (2005) 2.55
Expectation-maximization-driven geodesic active contour with overlap resolution (EMaGACOR): application to lymphocyte segmentation on breast cancer histopathology. IEEE Trans Biomed Eng (2010) 2.52
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Targeted synthesis of a porous aromatic framework with high stability and exceptionally high surface area. Angew Chem Int Ed Engl (2009) 2.22
Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology (2014) 2.17
Clinical short-term results of radiofrequency ablation in liver cancers. World J Gastroenterol (2002) 2.04
Genome-wide analysis uncovers regulation of long intergenic noncoding RNAs in Arabidopsis. Plant Cell (2012) 1.99
Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology (2011) 1.94
Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc Natl Acad Sci U S A (2010) 1.79
Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice. J Neurosci (2006) 1.78
Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am J Pathol (2004) 1.70
Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB. Mol Microbiol (2004) 1.66
Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome. Am J Respir Crit Care Med (2005) 1.66
Genes that escape from X inactivation. Hum Genet (2011) 1.63
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. Proc Natl Acad Sci U S A (2002) 1.61
Ultrabroadband light absorption by a sawtooth anisotropic metamaterial slab. Nano Lett (2012) 1.59
Computer-aided detection and diagnosis of breast cancer with mammography: recent advances. IEEE Trans Inf Technol Biomed (2009) 1.58
Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. MBio (2012) 1.55
Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock (2009) 1.53
The CRISPR/Cas system mediates efficient genome engineering in Bombyx mori. Cell Res (2013) 1.52
Ribosome engineering and secondary metabolite production. Adv Appl Microbiol (2004) 1.51
Cucurbitacin B regulates immature myeloid cell differentiation and enhances antitumor immunity in patients with lung cancer. Cancer Biother Radiopharm (2012) 1.51
Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map. PLoS One (2011) 1.49
Reciprocal recruitment of DRIP/mediator and p160 coactivator complexes in vivo by estrogen receptor. J Biol Chem (2002) 1.48
Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation (2007) 1.48
Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res (2007) 1.46
Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma (2014) 1.44
Pedicled deep inferior epigastric perforator flap: an alternative method to repair groin and scrotal defects. Ann Plast Surg (2006) 1.43
Evaluation by indirect immunofluorescent assay and enzyme linked immunosorbent assay of the dynamic changes of serum antibody responses against severe acute respiratory syndrome coronavirus. Chin Med J (Engl) (2005) 1.41
Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo. Cell Stem Cell (2013) 1.40
Detection of epidermal growth factor receptor mutations in plasma by mutant-enriched PCR assay for prediction of the response to gefitinib in patients with non-small-cell lung cancer. Int J Cancer (2009) 1.40
Synthesis, characterization, antioxidant activities, and DNA-binding studies of (E)-N'-[1-(pyridin-2-yl)ethylidene]isonicotinohydrazide and its Pr(III) and Nd(III) complexes. Chem Pharm Bull (Tokyo) (2010) 1.40
Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons. J Neurophysiol (2005) 1.39
Near-infrared to mid-infrared photoluminescence of Bi2O3-GeO2 binary glasses. Opt Lett (2012) 1.38
Stacked Sparse Autoencoder (SSAE) for Nuclei Detection on Breast Cancer Histopathology Images. IEEE Trans Med Imaging (2015) 1.37
First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage. Toxicol Sci (2009) 1.37
Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release. Proc Natl Acad Sci U S A (2009) 1.37
ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. EMBO J (2004) 1.36
Two cap-binding proteins CBP20 and CBP80 are involved in processing primary MicroRNAs. Plant Cell Physiol (2008) 1.35
Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis. Int J Cancer (2007) 1.35
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nat Immunol (2006) 1.34
Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Cell Metab (2007) 1.34
Evolution and migration history of the Chinese population inferred from Chinese Y-chromosome evidence. J Hum Genet (2004) 1.33
Increased expression of ribosome recycling factor is responsible for the enhanced protein synthesis during the late growth phase in an antibiotic-overproducing Streptomyces coelicolor ribosomal rpsL mutant. Mol Microbiol (2006) 1.28
CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products. J Pharmacol Exp Ther (2004) 1.26
Treatment of advanced gastric cancer by chemotherapy combined with autologous cytokine-induced killer cells. Anticancer Res (2006) 1.25
Minireview: Sex chromosomes and brain sexual differentiation. Endocrinology (2003) 1.24
Development, repair and fibrosis: what is common and why it matters. Respirology (2009) 1.24
Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: Implications for depressive disorders and future therapies. J Neurosci Res (2004) 1.23
Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. Appl Environ Microbiol (2003) 1.22
Genome-wide identification of long noncoding natural antisense transcripts and their responses to light in Arabidopsis. Genome Res (2014) 1.20
Essential role of Smad4 in maintaining cardiomyocyte proliferation during murine embryonic heart development. Dev Biol (2007) 1.20
Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation. Mol Endocrinol (2003) 1.17
Using tree-based recursive partitioning methods to group haplotypes for increased power in association studies. Ann Hum Genet (2005) 1.15
Pd(II)-catalyzed C-H activation/aryl-aryl coupling of phenol esters. J Am Chem Soc (2010) 1.15
C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Hum Mol Genet (2006) 1.15
Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis. MBio (2013) 1.15
Emerging chirality in nanoscience. Chem Soc Rev (2013) 1.14
The diapause hormone-pheromone biosynthesis activating neuropeptide gene of Helicoverpa armigera encodes multiple peptides that break, rather than induce, diapause. J Insect Physiol (2004) 1.11
Role of Bmi1 in H2A ubiquitylation and Hox gene silencing. J Biol Chem (2006) 1.10
Matched-case comparison of neoadjuvant chemotherapy in patients with FIGO stage IB1-IIB cervical cancer to establish selection criteria. Eur J Cancer (2012) 1.10
The diversity and anti-microbial activity of endophytic actinomycetes isolated from medicinal plants in Panxi plateau, China. Curr Microbiol (2010) 1.10
Improving the power for detecting overlapping genes from multiple DNA microarray-derived gene lists. BMC Bioinformatics (2008) 1.09
Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res (2010) 1.09
Isolation and expression of a Malassezia globosa lipase gene, LIP1. J Invest Dermatol (2007) 1.09
Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Curr Pathobiol Rep (2013) 1.08
Xiamenmycin attenuates hypertrophic scars by suppressing local inflammation and the effects of mechanical stress. J Invest Dermatol (2013) 1.08
Facile solution growth of vertically aligned ZnO nanorods sensitized with aqueous CdS and CdSe quantum dots for photovoltaic applications. Nanoscale Res Lett (2011) 1.07
Extracellular histone release in response to traumatic injury: implications for a compensatory role of activated protein C. J Trauma Acute Care Surg (2012) 1.07
Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng. J Chromatogr A (2012) 1.06
Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures. J Nutr Biochem (2005) 1.06
N'-[1-(2-Hydroxy-phen-yl)ethyl-idene]benzene-sulfonohydrazide. Acta Crystallogr Sect E Struct Rep Online (2008) 1.06
Self-powered, ultrafast, visible-blind UV detection and optical logical operation based on ZnO/GaN nanoscale p-n junctions. Adv Mater (2010) 1.06
Incorporation of graphenes in nanostructured TiO(2) films via molecular grafting for dye-sensitized solar cell application. ACS Nano (2010) 1.05
[Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. Zhongguo Zhong Xi Yi Jie He Za Zhi (2004) 1.05
Nanocone tip-film solar cells with efficient charge transport. Adv Mater (2011) 1.05
Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. Arthritis Rheum (2005) 1.04
Determination of the volatile composition in essential oil of Descurainia sophia (L.) Webb ex Prantl (Flixweed) by gas chromatography/mass spectrometry (GC/MS). Molecules (2010) 1.04
Anisotropic epitaxial ZnO/CdO core/shell heterostructure nanorods. Nanoscale Res Lett (2012) 1.03
E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network. Hepatology (2014) 1.03
Measuring ensemble-averaged surface-enhanced Raman scattering in the hotspots of colloidal nanoparticle dimers and trimers. J Am Chem Soc (2010) 1.03
Ammonium, microcystins, and hypoxia of blooms in eutrophic water cause oxidative stress and C-N imbalance in submersed and floating-leaved aquatic plants in Lake Taihu, China. Chemosphere (2010) 1.02
Anti-influenza agents from Traditional Chinese Medicine. Nat Prod Rep (2010) 1.02
2,2'-(1,1'-Azinodiethyl-idyne)diphenol. Acta Crystallogr Sect E Struct Rep Online (2008) 1.02
Neonatal mice possessing an Sry transgene show a masculinized pattern of progesterone receptor expression in the brain independent of sex chromosome status. Endocrinology (2003) 1.02
Physiological and evolutionary studies of NAP systems in Shewanella piezotolerans WP3. ISME J (2010) 1.02
Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes. Mol Vis (2011) 1.01
Contrast sensitivity of digital imaging display systems: contrast threshold dependency on object type and implications for monitor quality assurance and quality control in PACS. Med Phys (2009) 1.01
Dynamic modulation of DNA replication and gene transcription in deep-sea filamentous phage SW1 in response to changes of host growth and temperature. PLoS One (2012) 1.01
Checklist: passport, plane ticket, organ transplant. Am J Transplant (2007) 1.01