Published in Biochem J on September 15, 2003
Glutathione transferases are structural and functional outliers in the thioredoxin fold. Biochemistry (2009) 1.30
Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J Pharmacol Exp Ther (2010) 0.98
Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Am J Pathol (2004) 0.91
S-glutathionyl-(chloro)hydroquinone reductases: a new class of glutathione transferases functioning as oxidoreductases. Drug Metab Rev (2011) 0.86
A glutathione S-transferase catalyzes the dehalogenation of inhibitory metabolites of polychlorinated biphenyls. J Bacteriol (2006) 0.81
The structural roles of a conserved small hydrophobic core in the active site and an ionic bridge in domain I of Delta class glutathione S-transferase. Biochem J (2006) 0.79
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. Pharmacol Ther (2016) 0.77
Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis. Angew Chem Int Ed Engl (2016) 0.75
Structure, catalytic mechanism, and evolution of the glutathione transferases. Chem Res Toxicol (1997) 3.59
Identification, characterization, and crystal structure of the Omega class glutathione transferases. J Biol Chem (2000) 3.17
Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes. J Mol Biol (1993) 2.66
Zeta, a novel class of glutathione transferases in a range of species from plants to humans. Biochem J (1997) 2.60
Ionisation of cysteine residues at the termini of model alpha-helical peptides. Relevance to unusual thiol pKa values in proteins of the thioredoxin family. J Mol Biol (1995) 2.01
Crystal structure of a theta-class glutathione transferase. EMBO J (1995) 1.75
Biochemical variants of glucose-6-phosphate dehydrogenase giving rise to congenital nonspherocytic hemolytic disease. Blood (1968) 1.74
Clinical pharmacology and toxicology of dichloroacetate. Environ Health Perspect (1998) 1.32
Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate. Toxicology (1990) 1.31
Functional significance of arginine 15 in the active site of human class alpha glutathione transferase A1-1. J Mol Biol (1995) 1.30
Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site. Structure (1998) 1.29
A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications. Structure (1998) 1.29
Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue. J Biol Chem (1998) 1.19
The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution. J Mol Biol (1997) 1.18
Recruitment of a double bond isomerase to serve as a reductive dehalogenase during biodegradation of pentachlorophenol. Biochemistry (2000) 1.16
Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate. Chem Res Toxicol (2000) 1.14
Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Biochem J (1998) 1.13
Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis. Pharmacogenetics (2000) 1.10
The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism. J Mol Biol (2001) 1.07
Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: catalysis with different substrates involves different residues. Biochem J (1996) 1.06
Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking alpha-haloalkanoic acids. Chem Res Toxicol (1999) 1.05
Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity. Biochemistry (2001) 1.05
Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism. Mol Cell Biol (2002) 1.02
The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat. Toxicology (1996) 1.02
Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids. Chem Res Toxicol (1998) 1.01
Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta. Chem Res Toxicol (2002) 0.90
Characterization of the initial steps in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase. Biochemistry (2002) 0.88
Active site serine promotes stabilization of the reactive glutathione thiolate in rat glutathione transferase T2-2. Evidence against proposed sulfatase activity of the corresponding human enzyme. J Biol Chem (2000) 0.88
Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/- (-)3.7.2C mouse lymphoma cells. Mutat Res (1998) 0.87
Tyrosine and its catabolites: from disease to cancer. Acta Biochim Pol (1996) 0.84
Purification and properties of maleylacetone cis-trans isomerase from vibrio 01. J Biol Chem (1973) 0.83
Effect of dichloroacetic acid and trichloroacetic acid on DNA methylation in liver and tumors of female B6C3F1 mice. Toxicol Sci (1998) 0.79
Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1). Chem Res Toxicol (2002) 0.77
Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol (2004) 7.23
Generation of hydroxyl radical by enzymes, chemicals, and human phagocytes in vitro. Detection with the anti-inflammatory agent, dimethyl sulfoxide. J Clin Invest (1979) 2.40
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nat Struct Biol (2002) 2.32
Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target? Acta Neuropathol (2014) 2.25
AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19
Ion-pair extraction and high-speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine. Drug Metab Dispos (1974) 1.94
Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein. J Immunol (2005) 1.92
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol (2005) 1.83
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell (2008) 1.83
Elucidation of the substrate binding site of Siah ubiquitin ligase. Structure (2006) 1.79
Anxiety over GABA(A) receptor structure relieved by AChBP. Trends Biochem Sci (2002) 1.74
Characterization of the omega class of glutathione transferases. Methods Enzymol (2005) 1.71
Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands. J Biol Chem (2007) 1.70
Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim Biophys Acta (2005) 1.68
The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood (2009) 1.63
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry (2006) 1.63
Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Proc Natl Acad Sci U S A (2005) 1.63
Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. J Biol Chem (2005) 1.62
Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol (2007) 1.54
Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (2005) 1.50
An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia. Arterioscler Thromb Vasc Biol (2011) 1.46
Rowe and Kahn's model of successful aging revisited: positive spirituality--the forgotten factor. Gerontologist (2002) 1.44
Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol (2002) 1.44
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci (2004) 1.41
Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses. Drugs (2009) 1.41
Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen. J Biol Chem (2008) 1.38
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem (2003) 1.38
Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr (2008) 1.33
Inhibition of skeletal muscle ClC-1 chloride channels by low intracellular pH and ATP. J Biol Chem (2007) 1.32
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle. J Biol Chem (2008) 1.30
A rivet model for channel formation by aerolysin-like pore-forming toxins. EMBO J (2006) 1.28
Molecular determinants of ginkgolide binding in the glycine receptor pore. J Neurochem (2006) 1.28
From glutathione transferase to pore in a CLIC. Eur Biophys J (2002) 1.23
The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. J Biol Chem (2004) 1.22
The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunol Rev (2012) 1.20
Deubiquitylating enzymes and disease. BMC Biochem (2008) 1.17
Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J Mol Biol (2008) 1.17
Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay. Virology (2003) 1.17
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A (2002) 1.14
Molecular evolution of glutathione S-transferases in the genus Drosophila. Genetics (2007) 1.14
Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate. Chem Res Toxicol (2000) 1.14
Glutathione conjugate mediated toxicities. Toxicol Appl Pharmacol (1990) 1.14
Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Biochem J (1998) 1.13
Enhancement and inhibition of drug metabolism. Annu Rev Pharmacol (1971) 1.12
Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem (2011) 1.12
Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis. Pharmacogenetics (2000) 1.10
Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. Biochem Pharmacol (1986) 1.09
A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. Biochem J (2005) 1.08
CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. Int J Biochem Cell Biol (2004) 1.07
Metabolic disposition of cephalothin and deacetylcephalothin in children and adults: comparison of high-performance liquid chromatographic and microbial assay procedures. Clin Pharmacol Ther (1977) 1.07
Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein. J Mol Biol (2006) 1.07
Inhibition of drug metabolism. I. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and related compounds. Mol Pharmacol (1966) 1.06
Insights into the structural basis for zinc inhibition of the glycine receptor. J Biol Chem (2003) 1.05
Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking alpha-haloalkanoic acids. Chem Res Toxicol (1999) 1.05
Metabolism of dihalomethanes to carbon monoxide--III. Studies on the mechanism of the reaction. Biochem Pharmacol (1978) 1.05
A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem (2007) 1.04
Conversion of a transmembrane to a water-soluble protein complex by a single point mutation. Nat Struct Biol (2002) 1.04
S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1. Anal Biochem (2007) 1.04
Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis. Biochem J (1998) 1.03
Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins. Mol Pharmacol (1974) 1.03
Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax. J Biol Chem (2009) 1.03
Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway. Adv Pharmacol (1994) 1.02
Metabolism of dihalomethanes to formaldehyde and inorganic halide--II. Studies on the mechanism of the reaction. Biochem Pharmacol (1978) 1.02
Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Sci Rep (2013) 1.02
Molecular basis of cytokine receptor activation. IUBMB Life (2010) 1.01
The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 1.01
Structure of the Janus protein human CLIC2. J Mol Biol (2007) 1.01
Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids. Chem Res Toxicol (1998) 1.01
GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase. Pharmacogenetics (2001) 1.00
Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity. Drug Metab Dispos (1990) 0.99
Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.99
Human glutathione transferase zeta. Methods Enzymol (2005) 0.99
Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Res (2010) 0.98
Metabolism of dihalomethanes to formaldehyde and inorganic halide. I. In vitro studies. Drug Metab Dispos (1976) 0.98
Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism. Biochem Pharmacol (2002) 0.97
Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. J Biol Chem (2012) 0.97
Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem (2002) 0.97
Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450. Chem Res Toxicol (2004) 0.96
Improving a natural enzyme activity through incorporation of unnatural amino acids. J Am Chem Soc (2010) 0.96
Hsp90 increases LIM kinase activity by promoting its homo-dimerization. FASEB J (2006) 0.96
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. J Biol Chem (2005) 0.96
TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members. PLoS One (2012) 0.95
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme. J Biol Chem (2002) 0.95
Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood (2013) 0.94
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Mol Pharmacol (2005) 0.94
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. J Neurosci (2002) 0.94
Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.94
Metabolism of dihalomethanes to carbon monoxide. I. In vivo studies. Drug Metab Dispos (1974) 0.94
Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling. J Biol Chem (2005) 0.94
Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J (2008) 0.93
The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors (2012) 0.93
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol (2006) 0.93
Molecular determinants of common gating of a ClC chloride channel. Nat Commun (2013) 0.92
Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.92
Renal processing of glutathione conjugates. Role in nephrotoxicity. Biochem Pharmacol (1984) 0.92
Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis. J Bacteriol (2003) 0.91
Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure (2012) 0.91