Published in Seikagaku on June 01, 2003
Historical landmarks of autophagy research. Cell Res (2013) 1.49
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18
The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol (2011) 8.18
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell (2007) 7.11
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci (2003) 6.50
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem (2007) 6.28
Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells (2007) 6.14
Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell (2009) 5.85
Autophagosome formation in mammalian cells. Cell Struct Funct (2002) 5.58
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27
Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell (2005) 4.02
Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett (2007) 3.65
Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene. Plant Physiol (2002) 3.47
Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells (2008) 3.23
Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Plant Cell (2004) 3.17
Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol (2009) 2.86
Atg8-family interacting motif crucial for selective autophagy. FEBS Lett (2010) 2.83
Yeast autophagosomes: de novo formation of a membrane structure. Trends Cell Biol (2002) 2.69
Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem (2005) 2.64
Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell (2006) 2.63
Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol Biol Cell (2008) 2.49
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol (2005) 2.44
Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell (2009) 2.32
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J Biol Chem (2004) 2.21
Structure of Atg5.Atg16, a complex essential for autophagy. J Biol Chem (2006) 2.18
Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol (2012) 2.12
AtATG genes, homologs of yeast autophagy genes, are involved in constitutive autophagy in Arabidopsis root tip cells. Plant Cell Physiol (2006) 2.06
The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells (2004) 1.98
Autophagy in development and stress responses of plants. Autophagy (2006) 1.93
Mobilization of rubisco and stroma-localized fluorescent proteins of chloroplasts to the vacuole by an ATG gene-dependent autophagic process. Plant Physiol (2008) 1.91
The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function. J Biol Chem (2008) 1.89
Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Biochem Biophys Res Commun (2007) 1.87
The early secretory pathway contributes to autophagy in yeast. Cell Struct Funct (2003) 1.83
Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae. Genes Cells (2008) 1.74
Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun (2005) 1.73
Autophagy plays a role in chloroplast degradation during senescence in individually darkened leaves. Plant Physiol (2008) 1.72
Current knowledge of the pre-autophagosomal structure (PAS). FEBS Lett (2010) 1.72
Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy. EMBO Rep (2006) 1.72
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem (2005) 1.70
Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae. Dev Cell (2002) 1.68
The crystal structure of plant ATG12 and its biological implication in autophagy. Autophagy (2005) 1.63
Starvation triggers the delivery of the endoplasmic reticulum to the vacuole via autophagy in yeast. Traffic (2005) 1.62
Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae. J Biol Chem (2004) 1.60
SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Struct Funct (2002) 1.58
The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation. J Biol Chem (2007) 1.55
Characterization of a novel autophagy-specific gene, ATG29. Biochem Biophys Res Commun (2005) 1.54
Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis. Autophagy (2012) 1.52
Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction. PLoS One (2011) 1.51
Atg17 recruits Atg9 to organize the pre-autophagosomal structure. Genes Cells (2009) 1.50
PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans. J Clin Invest (2008) 1.45
An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination. Plant Physiol (2007) 1.44
Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Biochem Biophys Res Commun (2009) 1.44
In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy. J Biol Chem (2007) 1.43
Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae. J Cell Sci (2013) 1.42
Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol Cell (2011) 1.38
Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p. J Biol Chem (2010) 1.34
Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy. Autophagy (2005) 1.32
Interrelationships among Atg proteins during autophagy in Saccharomyces cerevisiae. Yeast (2004) 1.28
A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate. Mol Biol Cell (2004) 1.26
The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy. J Biochem (2002) 1.24
Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. FEBS Lett (2002) 1.22
Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway. J Biol Chem (2010) 1.20
Modification of a ubiquitin-like protein Paz2 conducted micropexophagy through formation of a novel membrane structure. Mol Biol Cell (2003) 1.20
Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis. Plant Cell (2013) 1.18
Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy. J Biol Chem (2009) 1.17
Role of the Apg12 conjugation system in mammalian autophagy. Int J Biochem Cell Biol (2003) 1.15
Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18. J Biol Chem (2012) 1.13
PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast. J Lipids (2011) 1.11
Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site. Nat Struct Mol Biol (2013) 1.11
Lap3 is a selective target of autophagy in yeast, Saccharomyces cerevisiae. Biochem Biophys Res Commun (2008) 1.10
Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy. J Biol Chem (2012) 1.09
ATG systems from the protein structural point of view. Chem Rev (2009) 1.09
Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation. EMBO Rep (2012) 1.07
Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site. J Biol Chem (2012) 1.07
The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase. PLoS One (2008) 1.06
Atg14: a key player in orchestrating autophagy. Int J Cell Biol (2011) 1.05
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol (2013) 1.04
A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. J Biol Chem (2004) 1.02
Organ-specific quality control of plant peroxisomes is mediated by autophagy. J Cell Sci (2014) 1.01
Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34. J Biol Chem (2010) 1.01
Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. J Biol Chem (2012) 1.00
Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate. Structure (2012) 1.00
Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8. J Biol Chem (2008) 0.99
Dynamics and function of PtdIns(3)P in autophagy. Autophagy (2008) 0.98
Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7. Nat Struct Mol Biol (2012) 0.96
A landmark protein essential for mitophagy: Atg32 recruits the autophagic machinery to mitochondria. Autophagy (2009) 0.96
The NMR structure of the autophagy-related protein Atg8. J Biomol NMR (2010) 0.96
Selective autophagy regulates insertional mutagenesis by the Ty1 retrotransposon in Saccharomyces cerevisiae. Dev Cell (2011) 0.94
Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeast. Biochemistry (2004) 0.92
OsATG10b, an autophagosome component, is needed for cell survival against oxidative stresses in rice. Mol Cells (2009) 0.91
The amino-terminal region of Atg3 is essential for association with phosphatidylethanolamine in Atg8 lipidation. FEBS Lett (2009) 0.90
The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation. J Biol Chem (2012) 0.90
Novel families of vacuolar amino acid transporters. IUBMB Life (2008) 0.90
SDS-PAGE techniques to study ubiquitin-like conjugation systems in yeast autophagy. Methods Mol Biol (2012) 0.87