Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 2943322)

Published in J Biol Chem on July 21, 2010

Authors

Yasunori Watanabe1, Nobuo N Noda, Hiroyuki Kumeta, Kuninori Suzuki, Yoshinori Ohsumi, Fuyuhiko Inagaki

Author Affiliations

1: Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6 Kita-ku, Sapporo 060-0812, Japan.

Articles citing this

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05

The machinery of macroautophagy. Cell Res (2013) 3.13

A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02

Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy. EMBO J (2012) 1.83

Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78

Receptor protein complexes are in control of autophagy. Autophagy (2012) 1.49

Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae. J Biol Chem (2011) 1.17

Pexophagy: the selective degradation of peroxisomes. Int J Cell Biol (2012) 1.16

Selective autophagy in budding yeast. Cell Death Differ (2012) 1.14

The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research. Nucleic Acids Res (2010) 1.05

Regulation of autophagy by kinases. Cancers (Basel) (2011) 1.02

The role of ALFY in selective autophagy. Cell Death Differ (2012) 1.00

Mechanisms of Selective Autophagy. J Mol Biol (2016) 0.97

Receptor proteins in selective autophagy. Int J Cell Biol (2012) 0.87

Mechanistic insights into selective autophagy pathways: lessons from yeast. Nat Rev Mol Cell Biol (2016) 0.85

Propeptide of aminopeptidase 1 protein mediates aggregation and vesicle formation in cytoplasm-to-vacuole targeting pathway. J Biol Chem (2011) 0.83

Glycobiology of cell death: when glycans and lectins govern cell fate. Cell Death Differ (2013) 0.83

Post-translationally-modified structures in the autophagy machinery: an integrative perspective. FEBS J (2015) 0.82

An overview of macroautophagy in yeast. J Mol Biol (2016) 0.81

Articles cited by this

NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94

Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature (2006) 24.39

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73

Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell (2004) 12.71

Searching protein structure databases with DaliLite v.3. Bioinformatics (2008) 12.15

Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA. J Mol Biol (2002) 11.20

Autophagy defends cells against invading group A Streptococcus. Science (2004) 9.53

Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J (2001) 8.84

Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells (2007) 6.14

Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome. J Cell Biol (1997) 5.57

Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization. J Cell Biol (1994) 5.41

Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell (2002) 4.49

Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J Biol Chem (2001) 3.90

The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance. EMBO J (1995) 3.76

p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins. J Biol Chem (1996) 3.27

Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells (2008) 3.23

Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway. Mol Cell (2001) 3.12

Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. J Biol Chem (2003) 3.02

Atg8-family interacting motif crucial for selective autophagy. FEBS Lett (2010) 2.83

The fibronectin type III domain as a scaffold for novel binding proteins. J Mol Biol (1998) 2.65

Vacuolar localization of oligomeric alpha-mannosidase requires the cytoplasm to vacuole targeting and autophagy pathway components in Saccharomyces cerevisiae. J Biol Chem (2001) 2.58

alpha-D-Mannosidase of Saccharomyces cerevisiae. Characterization and modulation of activity. Biochim Biophys Acta (1978) 2.35

The Cvt pathway as a model for selective autophagy. FEBS Lett (2010) 2.26

Single domain camel antibodies: current status. J Biotechnol (2001) 2.24

Rapid protein extraction from Saccharomyces cerevisiae. Yeast (1994) 1.97

Autophagy and the degradation of mitochondria. Mitochondrion (2010) 1.75

Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae. Dev Cell (2002) 1.68

Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae. J Biol Chem (2004) 1.60

Solubilization and purification of alpha-mannosidase, a marker enzyme of vacuolar membranes in Saccharomyces cerevisiae. J Biol Chem (1988) 1.44

Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p. J Biol Chem (2010) 1.34

Molecular mechanism and physiological role of pexophagy. FEBS Lett (2010) 1.31

Molecular basis of canonical and bactericidal autophagy. Int Immunol (2009) 1.09

Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.80

Articles by these authors

The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell (2003) 17.55

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67

Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol (2009) 9.32

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20

A unified nomenclature for yeast autophagy-related genes. Dev Cell (2003) 9.18

The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol (2011) 8.18

Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell (2007) 7.11

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci (2003) 6.50

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem (2007) 6.28

Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells (2007) 6.14

Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell (2009) 5.85

Autophagosome formation in mammalian cells. Cell Struct Funct (2002) 5.58

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol Cell (2008) 5.20

Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem (2002) 4.27

Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell (2005) 4.02

Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett (2007) 3.65

Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene. Plant Physiol (2002) 3.47

Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells (2008) 3.23

Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagy. Plant Cell (2004) 3.17

Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol (2009) 2.86

Atg8-family interacting motif crucial for selective autophagy. FEBS Lett (2010) 2.83

Yeast autophagosomes: de novo formation of a membrane structure. Trends Cell Biol (2002) 2.69

Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem (2005) 2.64

Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell (2006) 2.63

Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol Biol Cell (2008) 2.49

Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem (2003) 2.45

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol (2005) 2.44

Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell (2009) 2.32

The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat Struct Mol Biol (2007) 2.22

In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J Biol Chem (2004) 2.21

Structure of Atg5.Atg16, a complex essential for autophagy. J Biol Chem (2006) 2.18

Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol (2012) 2.12

AtATG genes, homologs of yeast autophagy genes, are involved in constitutive autophagy in Arabidopsis root tip cells. Plant Cell Physiol (2006) 2.06

The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells (2004) 1.98

Autophagy in development and stress responses of plants. Autophagy (2006) 1.93

Mobilization of rubisco and stroma-localized fluorescent proteins of chloroplasts to the vacuole by an ATG gene-dependent autophagic process. Plant Physiol (2008) 1.91

The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function. J Biol Chem (2008) 1.89

X-ray crystal structure of IRF-3 and its functional implications. Nat Struct Biol (2003) 1.88

Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Biochem Biophys Res Commun (2007) 1.87

The early secretory pathway contributes to autophagy in yeast. Cell Struct Funct (2003) 1.83

Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal (2009) 1.79

The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. J Biol Chem (2003) 1.78

Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae. Genes Cells (2008) 1.74

Organelle degradation during the lens and erythroid differentiation is independent of autophagy. Biochem Biophys Res Commun (2005) 1.73

Current knowledge of the pre-autophagosomal structure (PAS). FEBS Lett (2010) 1.72

Autophagy plays a role in chloroplast degradation during senescence in individually darkened leaves. Plant Physiol (2008) 1.72

Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA. Cell Host Microbe (2012) 1.72

Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy. EMBO Rep (2006) 1.72

Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem (2005) 1.70

Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiae. Dev Cell (2002) 1.68

Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors. J Biol Chem (2009) 1.68

The crystal structure of plant ATG12 and its biological implication in autophagy. Autophagy (2005) 1.63

Starvation triggers the delivery of the endoplasmic reticulum to the vacuole via autophagy in yeast. Traffic (2005) 1.62

Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae. J Biol Chem (2004) 1.60

SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Struct Funct (2002) 1.58

The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation. J Biol Chem (2007) 1.55

Characterization of a novel autophagy-specific gene, ATG29. Biochem Biophys Res Commun (2005) 1.54

Crystallographic and NMR evidence for flexibility in oligosaccharyltransferases and its catalytic significance. Structure (2012) 1.52

Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis. Autophagy (2012) 1.52

Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction. PLoS One (2011) 1.51

Atg17 recruits Atg9 to organize the pre-autophagosomal structure. Genes Cells (2009) 1.50

PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans. J Clin Invest (2008) 1.45

Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Biochem Biophys Res Commun (2009) 1.44

An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germination. Plant Physiol (2007) 1.44

In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy. J Biol Chem (2007) 1.43