Published in Mech Ageing Dev on May 13, 2008
Extending healthy life span--from yeast to humans. Science (2010) 12.12
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44
Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci (2010) 1.82
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol (2013) 1.57
Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev (2013) 1.50
Somatic mutations in aging, cancer and neurodegeneration. Mech Ageing Dev (2011) 1.39
Pleiotropic effects of growth hormone signaling in aging. Trends Endocrinol Metab (2011) 1.16
Healthy aging: is smaller better? - a mini-review. Gerontology (2012) 1.09
Metabolic characteristics of long-lived mice. Front Genet (2012) 1.04
Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster. PLoS Genet (2010) 0.99
Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell (2009) 0.93
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell (2015) 0.90
Genetic variation in responses to dietary restriction--an unbiased tool for hypothesis testing. Exp Gerontol (2013) 0.88
In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene. Exp Gerontol (2010) 0.85
Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction. PLoS One (2013) 0.84
Lifespan modulation in mice and the confounding effects of genetic background. J Genet Genomics (2014) 0.84
Starvation based differential chemotherapy: a novel approach for cancer treatment. Oman Med J (2014) 0.83
Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice. Exp Gerontol (2013) 0.80
Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene. Aging Cell (2013) 0.78
The effect of sexual harassment on lethal mutation rate in female Drosophila melanogaster. Proc Biol Sci (2013) 0.77
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biol (2017) 0.76
Overview of caloric restriction and ageing. Mech Ageing Dev (2005) 6.68
Dwarf mice and the ageing process. Nature (1996) 6.12
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57
The age of cancer. Nature (2000) 4.32
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene (2005) 3.17
Extending the lifespan of long-lived mice. Nature (2001) 2.98
Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology (2005) 2.84
Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat Genet (1997) 2.74
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67
Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci (2005) 1.85
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine. Proc Natl Acad Sci U S A (2000) 1.81
Large genome rearrangements as a primary cause of aging. Mech Ageing Dev (2002) 1.56
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res (2006) 1.43
FOXO transcription factors. Curr Biol (2007) 1.38
Catalase expression in delayed and premature aging mouse models. Exp Gerontol (2000) 1.32
Somatic mutations and aging: a re-evaluation. Mutat Res (2000) 1.29
Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Hum Mol Genet (2004) 1.26
Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice. Cancer Res (1994) 1.15
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res (2005) 1.12
Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster. Methods Mol Biol (2007) 1.11
Long-lived Ames dwarf mouse exhibits increased antioxidant defense in skeletal muscle. Mech Ageing Dev (2004) 0.98
Caloric restriction: conservation of in vivo cellular replicative capacity accompanies life-span extension in mice. Exp Cell Res (1995) 0.98
Background mutations and polymorphisms in lacZ-plasmid transgenic mice. Environ Mol Mutagen (1999) 0.98
Effect of dietary restriction on in vivo somatic mutation in mice. Mutat Res (1993) 0.97
Effect of caloric restriction on Hprt lymphocyte mutation in aging rats. Mutat Res (2003) 0.88
Ageing: chromatin unbound. Nature (2006) 0.87
Transgenic assays for mutations and cancer: current status and future perspectives. Mutat Res (1998) 0.83
Calorie restriction modulates chemically induced in vivo somatic mutation frequency. Environ Mol Mutagen (1996) 0.79
Insulin-like growth factor 1 and mammalian aging. Sci Aging Knowledge Environ (2002) 0.79
Genotyping the Prop-1 mutation in Ames dwarf mice. Mech Ageing Dev (2001) 0.78
No change in spontaneous mutation frequency or specificity in dietary restricted mice. Carcinogenesis (2000) 0.78
The endocrine regulation of aging by insulin-like signals. Science (2003) 8.10
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics (2003) 3.84
Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell (2009) 3.78
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation (2002) 3.49
Biologic prosthesis reduces recurrence after laparoscopic paraesophageal hernia repair: a multicenter, prospective, randomized trial. Ann Surg (2006) 3.34
Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci (2002) 3.11
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A (2006) 3.04
Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab (2005) 2.59
Recent clinical-pathologic research on the causes of dementia in late life: update from the Honolulu-Asia Aging Study. J Geriatr Psychiatry Neurol (2005) 2.52
DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44
AD lesions and infarcts in demented and non-demented Japanese-American men. Ann Neurol (2005) 2.31
Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J Gerontol A Biol Sci Med Sci (2005) 2.28
Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord (2006) 2.26
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Genetic mouse models of extended lifespan. Exp Gerontol (2003) 2.15
The critical role of metabolic pathways in aging. Diabetes (2012) 2.12
Preventing heart disease in the 21st century: implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Circulation (2008) 2.11
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell (2004) 2.11
Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08
Diet and aging. Cell Metab (2008) 2.05
Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology (2004) 1.90
Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci (2013) 1.87
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med (2010) 1.86
Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci (2005) 1.85
Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet (2008) 1.76
Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants. Mutat Res (2011) 1.75
Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci (2009) 1.69
Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity. PLoS One (2009) 1.67
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell (2013) 1.67
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A (2008) 1.65
Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol (2002) 1.61
Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab (2013) 1.61
Parkinsonian signs and substantia nigra neuron density in decendents elders without PD. Ann Neurol (2004) 1.57
Large genome rearrangements as a primary cause of aging. Mech Ageing Dev (2002) 1.56
Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res (2011) 1.56
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55
Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol (2008) 1.55
Safe emergency department removal of a hardened steel penile constriction ring. J Emerg Med (2008) 1.54
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A (2002) 1.54
Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell (2006) 1.54
Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol Genomics (2004) 1.50
Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol Aging (2005) 1.49
Correcting for guessing increases validity in multiple-choice examinations in an oral and maxillofacial pathology course. J Dent Educ (2006) 1.47
Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev (2002) 1.46
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Hum Mutat (2002) 1.44
Biomarkers of aging: from primitive organisms to humans. J Gerontol A Biol Sci Med Sci (2004) 1.44
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res (2006) 1.43
Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci (2002) 1.42
Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds. Atherosclerosis (2007) 1.42
Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J Gerontol A Biol Sci Med Sci (2009) 1.42
SNP discovery in associating genetic variation with human disease phenotypes. Mutat Res (2005) 1.42
The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol (2013) 1.41
Genome instability, cancer and aging. Biochim Biophys Acta (2009) 1.40
Aging and genome maintenance. Ann N Y Acad Sci (2005) 1.39
Survival after elective transjugular intrahepatic portosystemic shunt creation: prediction with model for end-stage liver disease score. Radiology (2004) 1.38
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair (Amst) (2005) 1.38
Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. J Gerontol A Biol Sci Med Sci (2009) 1.36
Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev (2006) 1.36
Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice. J Gerontol A Biol Sci Med Sci (2006) 1.35
Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J (2010) 1.33
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
Prechemotherapy alterations in brain function in women with breast cancer. J Clin Exp Neuropsychol (2009) 1.30
Mitochondrial DNA mutations and aging: devils in the details? Trends Genet (2008) 1.30
Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2005) 1.25
MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging. Aging Cell (2009) 1.24
Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice. Exp Gerontol (2005) 1.23
Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol (2008) 1.23
Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology (2007) 1.23
Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan. Am J Physiol Endocrinol Metab (2012) 1.23
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis. Antimicrob Agents Chemother (2005) 1.22
Genome dynamics in aging mice. Genome Res (2002) 1.20
Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Exp Eye Res (2005) 1.20
GH and IGF1: roles in energy metabolism of long-living GH mutant mice. J Gerontol A Biol Sci Med Sci (2012) 1.20
Aging alters the apoptotic response to genotoxic stress. Nat Med (2002) 1.18
A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner? Aging (Albany NY) (2010) 1.18
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mech Ageing Dev (2003) 1.18
Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell (2011) 1.17
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis (2011) 1.17
Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. J Gerontol A Biol Sci Med Sci (2006) 1.16
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. Antioxid Redox Signal (2006) 1.16
PPARs in Calorie Restricted and Genetically Long-Lived Mice. PPAR Res (2007) 1.16
Does damage to DNA and other macromolecules play a role in aging? If so, how? J Gerontol A Biol Sci Med Sci (2009) 1.16
Epigenetic factors in aging and longevity. Pflugers Arch (2009) 1.15
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Res (2008) 1.15
Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol (2006) 1.13
Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice. Mol Cell Biol (2002) 1.12
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res (2005) 1.12