Published in Genome Res on November 01, 2002
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HPRT mutations in humans: biomarkers for mechanistic studies. Mutat Res (2001) 1.22
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V(D)J recombination and the transgenic brain blues. New Biol (1992) 0.91
Parsing age, mutations and time. Nat Genet (1997) 0.84
Mutation frequency and type during ageing in mouse seminiferous tubules. Mech Ageing Dev (2001) 0.84
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Simultaneous detection of multiple genetic aberrations in single cells by spectral fluorescence in situ hybridization. Cancer Res (2001) 0.79
The recovery of a B2 insertion in the lacI gene of a rat cell line containing a lambda/LIZ shuttle vector. Mutat Res (1997) 0.78
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell (2004) 2.11
Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants. Mutat Res (2011) 1.75
Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res (2011) 1.56
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A (2002) 1.54
Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Hum Mutat (2002) 1.44
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res (2006) 1.43
SNP discovery in associating genetic variation with human disease phenotypes. Mutat Res (2005) 1.42
Genome instability, cancer and aging. Biochim Biophys Acta (2009) 1.40
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Mitochondrial DNA mutations and aging: devils in the details? Trends Genet (2008) 1.30
Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues. Mech Ageing Dev (2008) 1.24
Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol (2008) 1.23
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis. Antimicrob Agents Chemother (2005) 1.22
Aging alters the apoptotic response to genotoxic stress. Nat Med (2002) 1.18
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice. Mech Ageing Dev (2003) 1.18
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis (2011) 1.17
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. Antioxid Redox Signal (2006) 1.16
Does damage to DNA and other macromolecules play a role in aging? If so, how? J Gerontol A Biol Sci Med Sci (2009) 1.16
Epigenetic factors in aging and longevity. Pflugers Arch (2009) 1.15
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Res (2008) 1.15
Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res (2005) 1.12
Intra-organ variation in age-related mutation accumulation in the mouse. PLoS One (2007) 1.11
Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster. Methods Mol Biol (2007) 1.11
Mutational fingerprints of aging. Nucleic Acids Res (2002) 1.08
The demographic and biomedical case for late-life interventions in aging. Sci Transl Med (2010) 1.08
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Res (2006) 1.08
DNA structure-induced genomic instability in vivo. J Natl Cancer Inst (2008) 1.06
Catalase transgenic mice: characterization and sensitivity to oxidative stress. Arch Biochem Biophys (2004) 1.04
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? Mech Ageing Dev (2005) 1.03
A model system for analyzing somatic mutations in Drosophila melanogaster. Nat Methods (2007) 1.02
Chromosome-specific accumulation of aneuploidy in the aging mouse brain. Hum Mol Genet (2012) 1.00
Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster. PLoS Genet (2010) 0.99
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics (2012) 0.99
Attenuation of leukocyte-endothelium interaction by antioxidant enzymes. Free Radic Biol Med (2003) 0.98
Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair (Amst) (2005) 0.98
Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging? Aging Cell (2006) 0.97
Chromosomal aneuploidy in the aging brain. Mech Ageing Dev (2011) 0.95
Detection by denaturing gradient gel electrophoresis of pncA mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis isolates from the United States-Mexico border region. Antimicrob Agents Chemother (2005) 0.94
Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes. Aging (Albany NY) (2013) 0.94
Mitochondrial DNA mutations and aging: a case closed? Nat Genet (2007) 0.93
Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell (2009) 0.93
Myc-dependent genome instability and lifespan in Drosophila. PLoS One (2013) 0.92
RAD51 mutants cause replication defects and chromosomal instability. Mol Cell Biol (2012) 0.91
Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res (2008) 0.90
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
Aging. Genomic priorities in aging. Science (2002) 0.88
Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice. Am J Hypertens (2003) 0.87
Ageing: chromatin unbound. Nature (2006) 0.87
Rebuttal to Miller: 'Accelerated aging': a primrose path to insight?'. Aging Cell (2004) 0.87
MPHASYS: a mouse phenotype analysis system. BMC Bioinformatics (2007) 0.87
Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells. PLoS One (2008) 0.86
DNA damage in normally and prematurely aged mice. Aging Cell (2013) 0.85
Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice. Mutat Res (2002) 0.84
Single-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated alleles. Mutat Res (2015) 0.84
Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell (2015) 0.84
Fast mitochondrial DNA isolation from mammalian cells for next-generation sequencing. Biotechniques (2013) 0.84
Mutation frequencies and spectra in DNA polymerase eta-deficient mice. Cancer Res (2008) 0.84
Maintaining genetic integrity in aging: a zero sum game. Antioxid Redox Signal (2006) 0.84
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila. Genome Biol (2011) 0.83
Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice. PLoS One (2008) 0.83
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Aging--lost in translation? N Engl J Med (2009) 0.82
Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice. Carcinogenesis (2003) 0.81
Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations. DNA Repair (Amst) (2008) 0.78
The long and short of fertility and longevity. Cell Metab (2010) 0.78
Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene. Aging Cell (2013) 0.78
Four-color FISH for the detection of low-level aneuploidy in interphase cells. Methods Mol Biol (2014) 0.78
The second international conference "genetics of aging and longevity". Aging (Albany NY) (2012) 0.77
High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice. PLoS One (2013) 0.77
Time, tumours and telomeres. Meeting on Cancer and Aging. EMBO Rep (2006) 0.77
Aging on a different scale--chronological versus pathology-related aging. Aging (Albany NY) (2013) 0.77
A dual-activation, adenoviral-based system for the controlled induction of DNA double-strand breaks by the restriction endonuclease SacI. Biotechniques (2009) 0.77
Rapid mitochondrial DNA isolation method for direct sequencing. Methods Mol Biol (2015) 0.75
Interview with Jan Vijg, Ph.D. [Interviewed by Vicki Glaser]. Rejuvenation Res (2010) 0.75
The Future of Human Longevity: Time for a Reality Check. Gerontology (2017) 0.75